<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:a3e6e3c1-1b01-4349-ac79-77f1d084b918,g:023909a0-a48f-4290-9ffd-f8843f5b583a-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.recursion.com/role/CoverPage" xlink:type="simple" xlink:href="rxrx-20211231.xsd#CoverPage"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/CoverPage" xlink:type="extended" id="id6aa71b41269425381c52934c6b29a50_CoverPage">
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_7cadb61c-f4e6-442d-8317-5ce25a974b8e" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentType"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_DocumentType_7cadb61c-f4e6-442d-8317-5ce25a974b8e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentAnnualReport_19d5e806-c5fa-47a9-b460-8ad362427761" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentAnnualReport"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_DocumentAnnualReport_19d5e806-c5fa-47a9-b460-8ad362427761" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_863fe0d7-be3f-47d8-940a-8c8a0697e3ca" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentPeriodEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_DocumentPeriodEndDate_863fe0d7-be3f-47d8-940a-8c8a0697e3ca" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_1146c549-936f-4797-b166-8a6ffb70d9cf" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_CurrentFiscalYearEndDate_1146c549-936f-4797-b166-8a6ffb70d9cf" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentTransitionReport_5452ef47-9559-48f4-bf34-e3bbe6025ca8" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentTransitionReport"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_DocumentTransitionReport_5452ef47-9559-48f4-bf34-e3bbe6025ca8" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_6ff9ff3e-7df3-4b7d-989b-897e9849e291" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityFileNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_EntityFileNumber_6ff9ff3e-7df3-4b7d-989b-897e9849e291" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_ac2bf8b3-5dc2-4385-8327-a152ab6aa4db" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityRegistrantName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_EntityRegistrantName_ac2bf8b3-5dc2-4385-8327-a152ab6aa4db" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_fe9c95f7-4d5f-416f-b2ec-50babaf8ae40" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_EntityIncorporationStateCountryCode_fe9c95f7-4d5f-416f-b2ec-50babaf8ae40" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_8ee18a00-99f3-4403-8103-3fe1d731f38c" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_EntityTaxIdentificationNumber_8ee18a00-99f3-4403-8103-3fe1d731f38c" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_7231f8a7-2f17-45be-a18f-6733d8f89409" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressAddressLine1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_EntityAddressAddressLine1_7231f8a7-2f17-45be-a18f-6733d8f89409" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_81f77f12-0219-4051-b84d-3d450e758a1f" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressCityOrTown"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_EntityAddressCityOrTown_81f77f12-0219-4051-b84d-3d450e758a1f" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_eae8493a-40b6-42d1-9493-28f7c2ad9133" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressStateOrProvince"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_EntityAddressStateOrProvince_eae8493a-40b6-42d1-9493-28f7c2ad9133" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_34f3ab36-cda0-414b-9897-82a03761e295" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressPostalZipCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_EntityAddressPostalZipCode_34f3ab36-cda0-414b-9897-82a03761e295" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_5736c611-4c33-4256-880d-20c6af27783b" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_CityAreaCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_CityAreaCode_5736c611-4c33-4256-880d-20c6af27783b" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_237cf585-c28d-4d9d-8f68-b825ffa01837" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_LocalPhoneNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_LocalPhoneNumber_237cf585-c28d-4d9d-8f68-b825ffa01837" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_38b93ebb-5994-4049-a1d1-9bdf1bcc887b" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_Security12bTitle"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_Security12bTitle_38b93ebb-5994-4049-a1d1-9bdf1bcc887b" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_18857c62-9f7f-4f15-8339-77ec1e9d72cb" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_TradingSymbol"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_TradingSymbol_18857c62-9f7f-4f15-8339-77ec1e9d72cb" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_a63c0ccd-770b-4db0-9b86-d0b815d293dc" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_SecurityExchangeName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_SecurityExchangeName_a63c0ccd-770b-4db0-9b86-d0b815d293dc" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityWellKnownSeasonedIssuer_5b561cd7-bc63-41fa-8bb1-03f3e487ff11" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityWellKnownSeasonedIssuer"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_EntityWellKnownSeasonedIssuer_5b561cd7-bc63-41fa-8bb1-03f3e487ff11" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityVoluntaryFilers_a1aae139-0997-470c-9fe4-a382729b7f67" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityVoluntaryFilers"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_EntityVoluntaryFilers_a1aae139-0997-470c-9fe4-a382729b7f67" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus_b6b9c356-a7f8-45d2-a0ce-200887558edc" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityCurrentReportingStatus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_EntityCurrentReportingStatus_b6b9c356-a7f8-45d2-a0ce-200887558edc" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInteractiveDataCurrent_8c7ed96c-e496-49a4-8c8d-4580fb12873f" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityInteractiveDataCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_EntityInteractiveDataCurrent_8c7ed96c-e496-49a4-8c8d-4580fb12873f" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory_7fe538ca-754b-4500-aaa7-fa3b0033744e" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityFilerCategory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_EntityFilerCategory_7fe538ca-754b-4500-aaa7-fa3b0033744e" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitySmallBusiness_df826493-a425-440e-b83c-c88b6063693d" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntitySmallBusiness"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_EntitySmallBusiness_df826493-a425-440e-b83c-c88b6063693d" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_5b31df05-0b62-422e-bc93-be59d5306d05" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_EntityEmergingGrowthCompany_5b31df05-0b62-422e-bc93-be59d5306d05" xlink:type="arc" order="24"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityExTransitionPeriod_f88fd009-562d-4702-8251-7f0a50525e16" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityExTransitionPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_EntityExTransitionPeriod_f88fd009-562d-4702-8251-7f0a50525e16" xlink:type="arc" order="25"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_IcfrAuditorAttestationFlag_6800da69-2ceb-48e5-b18a-8eb44b17d90a" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_IcfrAuditorAttestationFlag"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_IcfrAuditorAttestationFlag_6800da69-2ceb-48e5-b18a-8eb44b17d90a" xlink:type="arc" order="26"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany_1b911e43-64e7-4853-8f30-6de7461d215a" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityShellCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_EntityShellCompany_1b911e43-64e7-4853-8f30-6de7461d215a" xlink:type="arc" order="27"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityPublicFloat_fb20a4cf-bb4b-4a50-999b-f57a611268bd" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityPublicFloat"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_EntityPublicFloat_fb20a4cf-bb4b-4a50-999b-f57a611268bd" xlink:type="arc" order="28"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_4dbd4895-7c87-49c0-a321-bc4d47a3565c" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_4dbd4895-7c87-49c0-a321-bc4d47a3565c" xlink:type="arc" order="29"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentsIncorporatedByReferenceTextBlock_f3d6206a-da20-49b6-a252-18f28c2740a7" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentsIncorporatedByReferenceTextBlock"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_DocumentsIncorporatedByReferenceTextBlock_f3d6206a-da20-49b6-a252-18f28c2740a7" xlink:type="arc" order="30"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_6c3b07e8-34d9-4ed5-9f5d-7a22976ea7e4" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityCentralIndexKey"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_EntityCentralIndexKey_6c3b07e8-34d9-4ed5-9f5d-7a22976ea7e4" xlink:type="arc" order="31"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_1d6eda4e-be40-44f3-836a-9e24f5518ea1" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_AmendmentFlag"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_AmendmentFlag_1d6eda4e-be40-44f3-836a-9e24f5518ea1" xlink:type="arc" order="32"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_deacdf84-2d28-4022-839d-1ed902de9380" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentFiscalYearFocus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_DocumentFiscalYearFocus_deacdf84-2d28-4022-839d-1ed902de9380" xlink:type="arc" order="33"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_b539cbbd-cc91-49b7-9573-842863c729e7" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_DocumentFiscalPeriodFocus_b539cbbd-cc91-49b7-9573-842863c729e7" xlink:type="arc" order="34"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationTable_a0edfcd7-93ab-4fab-9ca0-e5c84d826940" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentInformationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_dei_DocumentInformationLineItems_8a8fe951-abfe-4ea5-93cd-7ae07ac06e55" xlink:to="loc_dei_DocumentInformationTable_a0edfcd7-93ab-4fab-9ca0-e5c84d826940" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_f46ef59f-79ee-4901-bc36-504af0d53d7e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_DocumentInformationTable_a0edfcd7-93ab-4fab-9ca0-e5c84d826940" xlink:to="loc_us-gaap_StatementClassOfStockAxis_f46ef59f-79ee-4901-bc36-504af0d53d7e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_f46ef59f-79ee-4901-bc36-504af0d53d7e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_f46ef59f-79ee-4901-bc36-504af0d53d7e" xlink:to="loc_us-gaap_ClassOfStockDomain_f46ef59f-79ee-4901-bc36-504af0d53d7e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_23705741-ea53-4fa2-a98d-9794527e7524" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_f46ef59f-79ee-4901-bc36-504af0d53d7e" xlink:to="loc_us-gaap_ClassOfStockDomain_23705741-ea53-4fa2-a98d-9794527e7524" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_b268e051-1ae2-4390-94d5-509555f4e0f0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_23705741-ea53-4fa2-a98d-9794527e7524" xlink:to="loc_us-gaap_CommonClassAMember_b268e051-1ae2-4390-94d5-509555f4e0f0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_2413d877-4513-45a2-97d4-2a3215595a81" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonClassBMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_23705741-ea53-4fa2-a98d-9794527e7524" xlink:to="loc_us-gaap_CommonClassBMember_2413d877-4513-45a2-97d4-2a3215595a81" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="simple" xlink:href="rxrx-20211231.xsd#ConsolidatedBalanceSheetsParenthetical"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="extended" id="i0b1b8df42605499da5221ddb7945703b_ConsolidatedBalanceSheetsParenthetical">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_6d3c48e8-c291-40bf-9a7a-961dae6cf7e9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_a0dfb287-f292-4485-b5f3-ae4912480b79" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_6d3c48e8-c291-40bf-9a7a-961dae6cf7e9" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_a0dfb287-f292-4485-b5f3-ae4912480b79" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_55b64604-6485-43dd-9ea7-2addf4001065" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_6d3c48e8-c291-40bf-9a7a-961dae6cf7e9" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_55b64604-6485-43dd-9ea7-2addf4001065" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_f07763fb-1a3a-41a8-84d9-95342fbfff1e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_6d3c48e8-c291-40bf-9a7a-961dae6cf7e9" xlink:to="loc_us-gaap_CommonStockSharesIssued_f07763fb-1a3a-41a8-84d9-95342fbfff1e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_3bfe6ff9-aa67-48c5-bd4e-ed266df90a15" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_6d3c48e8-c291-40bf-9a7a-961dae6cf7e9" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_3bfe6ff9-aa67-48c5-bd4e-ed266df90a15" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_7fe5d3de-ea4a-4ff8-a073-45509beca274" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_6d3c48e8-c291-40bf-9a7a-961dae6cf7e9" xlink:to="loc_us-gaap_StatementTable_7fe5d3de-ea4a-4ff8-a073-45509beca274" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_534eb2b4-15a9-4a66-9581-92792c92b1bb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_7fe5d3de-ea4a-4ff8-a073-45509beca274" xlink:to="loc_us-gaap_StatementClassOfStockAxis_534eb2b4-15a9-4a66-9581-92792c92b1bb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_534eb2b4-15a9-4a66-9581-92792c92b1bb_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_534eb2b4-15a9-4a66-9581-92792c92b1bb" xlink:to="loc_us-gaap_ClassOfStockDomain_534eb2b4-15a9-4a66-9581-92792c92b1bb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_64337b8e-06f8-4d5f-8738-73b5fbfdb06e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_534eb2b4-15a9-4a66-9581-92792c92b1bb" xlink:to="loc_us-gaap_ClassOfStockDomain_64337b8e-06f8-4d5f-8738-73b5fbfdb06e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_510b8ec0-38cc-46da-8ee4-bacf2bdbe489" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_64337b8e-06f8-4d5f-8738-73b5fbfdb06e" xlink:to="loc_us-gaap_CommonClassAMember_510b8ec0-38cc-46da-8ee4-bacf2bdbe489" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_b633d35c-429d-4044-82bb-74e96a6f198d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonClassBMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_64337b8e-06f8-4d5f-8738-73b5fbfdb06e" xlink:to="loc_us-gaap_CommonClassBMember_b633d35c-429d-4044-82bb-74e96a6f198d" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/ConsolidatedStatementsofOperations" xlink:type="simple" xlink:href="rxrx-20211231.xsd#ConsolidatedStatementsofOperations"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/ConsolidatedStatementsofOperations" xlink:type="extended" id="ibbd1cd8dde7b4d0295b96e84e84c33f2_ConsolidatedStatementsofOperations">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_5c372d9a-d926-4121-a10b-55bfd4ef4e43" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesAbstract_6acdde15-5c48-4368-bff7-a8da73a0d4cb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenuesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_5c372d9a-d926-4121-a10b-55bfd4ef4e43" xlink:to="loc_us-gaap_RevenuesAbstract_6acdde15-5c48-4368-bff7-a8da73a0d4cb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_b822fd58-e0db-4d36-b0b8-9be4f2f549c7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_6acdde15-5c48-4368-bff7-a8da73a0d4cb" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_b822fd58-e0db-4d36-b0b8-9be4f2f549c7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpensesAbstract_762e37f9-1343-40b6-aba3-731626d044d9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingExpensesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_5c372d9a-d926-4121-a10b-55bfd4ef4e43" xlink:to="loc_us-gaap_OperatingExpensesAbstract_762e37f9-1343-40b6-aba3-731626d044d9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_ef12d7c3-ce7f-43d9-9bda-06475b1aa1f1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_762e37f9-1343-40b6-aba3-731626d044d9" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_ef12d7c3-ce7f-43d9-9bda-06475b1aa1f1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_57e84006-044f-4e22-a4bc-01a7c8ef152c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_762e37f9-1343-40b6-aba3-731626d044d9" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_57e84006-044f-4e22-a4bc-01a7c8ef152c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_d469646b-7174-40e4-9bd9-685568a7438e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_762e37f9-1343-40b6-aba3-731626d044d9" xlink:to="loc_us-gaap_OperatingExpenses_d469646b-7174-40e4-9bd9-685568a7438e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_e4af793f-0b10-4202-9646-73c77d3b27b8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_5c372d9a-d926-4121-a10b-55bfd4ef4e43" xlink:to="loc_us-gaap_OperatingIncomeLoss_e4af793f-0b10-4202-9646-73c77d3b27b8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_b5aa953b-01fa-411f-86b9-53a126844852" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_5c372d9a-d926-4121-a10b-55bfd4ef4e43" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_b5aa953b-01fa-411f-86b9-53a126844852" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_59c68e34-3274-4916-a171-b4444e06c313" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_5c372d9a-d926-4121-a10b-55bfd4ef4e43" xlink:to="loc_us-gaap_NetIncomeLoss_59c68e34-3274-4916-a171-b4444e06c313" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_a70c1dbd-b2ba-4780-890d-42609c45b37e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_5c372d9a-d926-4121-a10b-55bfd4ef4e43" xlink:to="loc_us-gaap_EarningsPerShareAbstract_a70c1dbd-b2ba-4780-890d-42609c45b37e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_e81635b1-ca0c-42b0-8966-dd6b50add40d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_a70c1dbd-b2ba-4780-890d-42609c45b37e" xlink:to="loc_us-gaap_EarningsPerShareBasic_e81635b1-ca0c-42b0-8966-dd6b50add40d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_b892ef6d-6cba-4999-8881-91d1cf7f8265" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_a70c1dbd-b2ba-4780-890d-42609c45b37e" xlink:to="loc_us-gaap_EarningsPerShareDiluted_b892ef6d-6cba-4999-8881-91d1cf7f8265" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_57475a15-67be-4488-aa77-cc17a97513eb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_a70c1dbd-b2ba-4780-890d-42609c45b37e" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_57475a15-67be-4488-aa77-cc17a97513eb" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_26b27b63-0b28-42a3-b5d8-f00ef368a949" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_a70c1dbd-b2ba-4780-890d-42609c45b37e" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_26b27b63-0b28-42a3-b5d8-f00ef368a949" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_ea086aeb-5727-4830-8fc1-cdcd75f361b1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_5c372d9a-d926-4121-a10b-55bfd4ef4e43" xlink:to="loc_us-gaap_StatementTable_ea086aeb-5727-4830-8fc1-cdcd75f361b1" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_fe25e102-bc85-400c-b477-ff057ab3f7c8" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_ea086aeb-5727-4830-8fc1-cdcd75f361b1" xlink:to="loc_srt_ProductOrServiceAxis_fe25e102-bc85-400c-b477-ff057ab3f7c8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_fe25e102-bc85-400c-b477-ff057ab3f7c8_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_fe25e102-bc85-400c-b477-ff057ab3f7c8" xlink:to="loc_srt_ProductsAndServicesDomain_fe25e102-bc85-400c-b477-ff057ab3f7c8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_c8879171-9858-4e93-8f64-b701d02a9cde" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_fe25e102-bc85-400c-b477-ff057ab3f7c8" xlink:to="loc_srt_ProductsAndServicesDomain_c8879171-9858-4e93-8f64-b701d02a9cde" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrantMember_d3ee7811-d613-4dfb-8538-98f2d187204f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_c8879171-9858-4e93-8f64-b701d02a9cde" xlink:to="loc_us-gaap_GrantMember_d3ee7811-d613-4dfb-8538-98f2d187204f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LicenseAndServiceMember_fe6c4061-9ca0-4d55-916d-08bfaf93fb88" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LicenseAndServiceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_c8879171-9858-4e93-8f64-b701d02a9cde" xlink:to="loc_us-gaap_LicenseAndServiceMember_fe6c4061-9ca0-4d55-916d-08bfaf93fb88" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/ConsolidatedStatementsofConvertiblePreferredStockandStockholdersEquityDeficit" xlink:type="simple" xlink:href="rxrx-20211231.xsd#ConsolidatedStatementsofConvertiblePreferredStockandStockholdersEquityDeficit"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/ConsolidatedStatementsofConvertiblePreferredStockandStockholdersEquityDeficit" xlink:type="extended" id="i94cef47be9744b619ed200c8dda89190_ConsolidatedStatementsofConvertiblePreferredStockandStockholdersEquityDeficit">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_641169c7-41bf-4c78-8b29-95e29f6c70af" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_a8ed8b34-3b5f-4372-a6a9-be6fd080f697" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInTemporaryEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_641169c7-41bf-4c78-8b29-95e29f6c70af" xlink:to="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_a8ed8b34-3b5f-4372-a6a9-be6fd080f697" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquitySharesOutstanding_79bf238d-3dfb-4eca-8bbd-f3a82e679723" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TemporaryEquitySharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_a8ed8b34-3b5f-4372-a6a9-be6fd080f697" xlink:to="loc_us-gaap_TemporaryEquitySharesOutstanding_79bf238d-3dfb-4eca-8bbd-f3a82e679723" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquityCarryingAmountAttributableToParent_d51d04a1-924c-45aa-905a-86ef8baaab86" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TemporaryEquityCarryingAmountAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_a8ed8b34-3b5f-4372-a6a9-be6fd080f697" xlink:to="loc_us-gaap_TemporaryEquityCarryingAmountAttributableToParent_d51d04a1-924c-45aa-905a-86ef8baaab86" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_TemporaryEquityStockIssuedDuringPeriodSharesNewIssues_2db621a5-3d88-4603-9833-3638cbee0a83" xlink:href="rxrx-20211231.xsd#rxrx_TemporaryEquityStockIssuedDuringPeriodSharesNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_a8ed8b34-3b5f-4372-a6a9-be6fd080f697" xlink:to="loc_rxrx_TemporaryEquityStockIssuedDuringPeriodSharesNewIssues_2db621a5-3d88-4603-9833-3638cbee0a83" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquityStockIssuedDuringPeriodValueNewIssues_efca8396-a403-4fda-ba2d-12dd18c6336c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TemporaryEquityStockIssuedDuringPeriodValueNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_a8ed8b34-3b5f-4372-a6a9-be6fd080f697" xlink:to="loc_us-gaap_TemporaryEquityStockIssuedDuringPeriodValueNewIssues_efca8396-a403-4fda-ba2d-12dd18c6336c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_TemporaryEquitySharesConversionOfConvertibleSecurities_bed9d6eb-7a3f-4a99-bbf7-1587e9ac250d" xlink:href="rxrx-20211231.xsd#rxrx_TemporaryEquitySharesConversionOfConvertibleSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_a8ed8b34-3b5f-4372-a6a9-be6fd080f697" xlink:to="loc_rxrx_TemporaryEquitySharesConversionOfConvertibleSecurities_bed9d6eb-7a3f-4a99-bbf7-1587e9ac250d" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_TemporaryEquityValueConversionOfConvertibleSecurities_4d5ffe9c-3028-41b0-b737-3d94fc3b5c6c" xlink:href="rxrx-20211231.xsd#rxrx_TemporaryEquityValueConversionOfConvertibleSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_a8ed8b34-3b5f-4372-a6a9-be6fd080f697" xlink:to="loc_rxrx_TemporaryEquityValueConversionOfConvertibleSecurities_4d5ffe9c-3028-41b0-b737-3d94fc3b5c6c" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquitySharesOutstanding_4be4d0e8-9cb1-4bc0-9534-75b16ffd9647" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TemporaryEquitySharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquityCarryingAmountAttributableToParent_24ac3053-61b9-4d5f-aaed-c81d05f2f8fd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TemporaryEquityCarryingAmountAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_28d9822f-e0df-4408-8613-faf2b81049c9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_641169c7-41bf-4c78-8b29-95e29f6c70af" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_28d9822f-e0df-4408-8613-faf2b81049c9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_ef5c517d-6644-450d-b485-e54cf4162a43" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_28d9822f-e0df-4408-8613-faf2b81049c9" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_ef5c517d-6644-450d-b485-e54cf4162a43" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_4ef3e7ae-65c7-4166-ab93-c44feab9a0e4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_28d9822f-e0df-4408-8613-faf2b81049c9" xlink:to="loc_us-gaap_StockholdersEquity_4ef3e7ae-65c7-4166-ab93-c44feab9a0e4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_4a2b82b8-4042-4902-ba35-c2cae3636430" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_28d9822f-e0df-4408-8613-faf2b81049c9" xlink:to="loc_us-gaap_NetIncomeLoss_4a2b82b8-4042-4902-ba35-c2cae3636430" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_APICShareBasedPaymentArrangementOptionEarlyExercise_30e37b87-8ac3-4a46-806c-a45b680a3a75" xlink:href="rxrx-20211231.xsd#rxrx_APICShareBasedPaymentArrangementOptionEarlyExercise"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_28d9822f-e0df-4408-8613-faf2b81049c9" xlink:to="loc_rxrx_APICShareBasedPaymentArrangementOptionEarlyExercise_30e37b87-8ac3-4a46-806c-a45b680a3a75" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_c13aa944-2bf2-4d71-b081-f4d11f3e2d6f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_28d9822f-e0df-4408-8613-faf2b81049c9" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_c13aa944-2bf2-4d71-b081-f4d11f3e2d6f" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_c0737324-db04-43e5-a81a-fd5d81bb246f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_28d9822f-e0df-4408-8613-faf2b81049c9" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_c0737324-db04-43e5-a81a-fd5d81bb246f" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_b1e700c6-a25d-4dea-8e85-4595e0e2a5f5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_28d9822f-e0df-4408-8613-faf2b81049c9" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_b1e700c6-a25d-4dea-8e85-4595e0e2a5f5" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_a2c33e90-802e-40c0-8f6c-779c3249cc87" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_28d9822f-e0df-4408-8613-faf2b81049c9" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_a2c33e90-802e-40c0-8f6c-779c3249cc87" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_92ba0f85-dbb1-4142-8718-dea72ebfd10b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_28d9822f-e0df-4408-8613-faf2b81049c9" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_92ba0f85-dbb1-4142-8718-dea72ebfd10b" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities_e6a68882-885f-4ab9-afd9-7a8215815a3a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_28d9822f-e0df-4408-8613-faf2b81049c9" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities_e6a68882-885f-4ab9-afd9-7a8215815a3a" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_080c87db-f868-44bb-be62-2ea71e1c1898" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_28d9822f-e0df-4408-8613-faf2b81049c9" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_080c87db-f868-44bb-be62-2ea71e1c1898" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_89c5cd2a-587b-4516-8070-c6de8dee84f1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_28d9822f-e0df-4408-8613-faf2b81049c9" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_89c5cd2a-587b-4516-8070-c6de8dee84f1" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_e33cd059-03b2-4fbc-b911-91f7ed6d2cb7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_476bca3a-b0f6-4ab1-885d-3081f266c76c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_397a0a4f-7b76-4e01-ba56-749322b7b213" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_641169c7-41bf-4c78-8b29-95e29f6c70af" xlink:to="loc_us-gaap_StatementTable_397a0a4f-7b76-4e01-ba56-749322b7b213" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_99797410-2476-46b0-bd30-d231a80c4e1d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_397a0a4f-7b76-4e01-ba56-749322b7b213" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_99797410-2476-46b0-bd30-d231a80c4e1d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_99797410-2476-46b0-bd30-d231a80c4e1d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_99797410-2476-46b0-bd30-d231a80c4e1d" xlink:to="loc_us-gaap_EquityComponentDomain_99797410-2476-46b0-bd30-d231a80c4e1d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_0e297296-b856-4e0c-8349-e2f80501aedc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_99797410-2476-46b0-bd30-d231a80c4e1d" xlink:to="loc_us-gaap_EquityComponentDomain_0e297296-b856-4e0c-8349-e2f80501aedc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_0a249d85-766d-40cb-a4f7-3ca1e7ac0540" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_0e297296-b856-4e0c-8349-e2f80501aedc" xlink:to="loc_us-gaap_CommonStockMember_0a249d85-766d-40cb-a4f7-3ca1e7ac0540" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_09818d59-2389-425f-84ac-bece14424446" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_0e297296-b856-4e0c-8349-e2f80501aedc" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_09818d59-2389-425f-84ac-bece14424446" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_0650a785-bba7-4dbe-835e-381015f392ca" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_0e297296-b856-4e0c-8349-e2f80501aedc" xlink:to="loc_us-gaap_RetainedEarningsMember_0650a785-bba7-4dbe-835e-381015f392ca" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_5b444a24-7a35-416c-b4a1-baef9ec328b9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_0e297296-b856-4e0c-8349-e2f80501aedc" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_5b444a24-7a35-416c-b4a1-baef9ec328b9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_eebcb4c3-60f8-497c-a50d-60009c205e09" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_397a0a4f-7b76-4e01-ba56-749322b7b213" xlink:to="loc_us-gaap_StatementClassOfStockAxis_eebcb4c3-60f8-497c-a50d-60009c205e09" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_eebcb4c3-60f8-497c-a50d-60009c205e09_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_eebcb4c3-60f8-497c-a50d-60009c205e09" xlink:to="loc_us-gaap_ClassOfStockDomain_eebcb4c3-60f8-497c-a50d-60009c205e09_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_246eb482-9463-490b-aa1f-9b85cf33564d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_eebcb4c3-60f8-497c-a50d-60009c205e09" xlink:to="loc_us-gaap_ClassOfStockDomain_246eb482-9463-490b-aa1f-9b85cf33564d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertiblePreferredStockMember_b168c2b1-4756-4fcc-a3f1-fe95b13a50d0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConvertiblePreferredStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_246eb482-9463-490b-aa1f-9b85cf33564d" xlink:to="loc_us-gaap_ConvertiblePreferredStockMember_b168c2b1-4756-4fcc-a3f1-fe95b13a50d0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_4ae78d1c-dbae-4456-9590-3b92e0783ac8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfWarrantOrRightAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_397a0a4f-7b76-4e01-ba56-749322b7b213" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_4ae78d1c-dbae-4456-9590-3b92e0783ac8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_4ae78d1c-dbae-4456-9590-3b92e0783ac8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_4ae78d1c-dbae-4456-9590-3b92e0783ac8" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_4ae78d1c-dbae-4456-9590-3b92e0783ac8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_2bb2ee5c-11d1-45b8-8b7c-3254ab3efede" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_4ae78d1c-dbae-4456-9590-3b92e0783ac8" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_2bb2ee5c-11d1-45b8-8b7c-3254ab3efede" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_SeriesASeriesBAndSeriesCWarrantsMember_cdda7636-5bda-4394-8ced-9caf0c1ef3e2" xlink:href="rxrx-20211231.xsd#rxrx_SeriesASeriesBAndSeriesCWarrantsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_2bb2ee5c-11d1-45b8-8b7c-3254ab3efede" xlink:to="loc_rxrx_SeriesASeriesBAndSeriesCWarrantsMember_cdda7636-5bda-4394-8ced-9caf0c1ef3e2" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/SummaryofSignificantAccountingPoliciesNarrativeDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#SummaryofSignificantAccountingPoliciesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/SummaryofSignificantAccountingPoliciesNarrativeDetails" xlink:type="extended" id="ice9a417a04a04606b534b551493c63be_SummaryofSignificantAccountingPoliciesNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_06c84351-17b8-4724-befe-b02b9b4694fd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteStockSplitConversionRatio1_21c75d41-a2f1-456b-95c1-35c79f8799ea" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityNoteStockSplitConversionRatio1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_06c84351-17b8-4724-befe-b02b9b4694fd" xlink:to="loc_us-gaap_StockholdersEquityNoteStockSplitConversionRatio1_21c75d41-a2f1-456b-95c1-35c79f8799ea" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ProceedsFromGrantsAwarded_c3f0491e-c8ec-4b5b-b5ba-922e837a1362" xlink:href="rxrx-20211231.xsd#rxrx_ProceedsFromGrantsAwarded"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_06c84351-17b8-4724-befe-b02b9b4694fd" xlink:to="loc_rxrx_ProceedsFromGrantsAwarded_c3f0491e-c8ec-4b5b-b5ba-922e837a1362" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiability_fbb28499-fba4-40eb-9ecc-461a2aa15985" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ContractWithCustomerLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_06c84351-17b8-4724-befe-b02b9b4694fd" xlink:to="loc_us-gaap_ContractWithCustomerLiability_fbb28499-fba4-40eb-9ecc-461a2aa15985" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_56937e5b-46a9-4e71-b104-b635beeb26c4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ContractWithCustomerLiabilityRevenueRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_06c84351-17b8-4724-befe-b02b9b4694fd" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_56937e5b-46a9-4e71-b104-b635beeb26c4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrantsReceivable_b1ac665b-107c-443f-88d6-17ca908c8ff8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GrantsReceivable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_06c84351-17b8-4724-befe-b02b9b4694fd" xlink:to="loc_us-gaap_GrantsReceivable_b1ac665b-107c-443f-88d6-17ca908c8ff8" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_1ba8843b-ad77-4ca8-84ad-6635c7409f52" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_06c84351-17b8-4724-befe-b02b9b4694fd" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_1ba8843b-ad77-4ca8-84ad-6635c7409f52" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_1be6626d-c5e8-49ab-86fb-1e848daa0281" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_06c84351-17b8-4724-befe-b02b9b4694fd" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_1be6626d-c5e8-49ab-86fb-1e848daa0281" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_c8214f97-e0fd-43b0-826e-854d000a8e9b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_06c84351-17b8-4724-befe-b02b9b4694fd" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_c8214f97-e0fd-43b0-826e-854d000a8e9b" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_0930911d-a57f-40ff-a9f9-8cf662461a26" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_06c84351-17b8-4724-befe-b02b9b4694fd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_0930911d-a57f-40ff-a9f9-8cf662461a26" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_c940043e-f346-44bf-b2a7-c51ad7d51b21" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_06c84351-17b8-4724-befe-b02b9b4694fd" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_c940043e-f346-44bf-b2a7-c51ad7d51b21" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_19bd4617-99ce-4353-9144-fe1c7c3468e8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_06c84351-17b8-4724-befe-b02b9b4694fd" xlink:to="loc_us-gaap_OperatingLeaseLiability_19bd4617-99ce-4353-9144-fe1c7c3468e8" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_069d5f54-e152-4283-9b83-29460002986b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_06c84351-17b8-4724-befe-b02b9b4694fd" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_069d5f54-e152-4283-9b83-29460002986b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MajorCustomersAxis_95b0120c-7dfd-4389-82f5-62d3c8282a33" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MajorCustomersAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_069d5f54-e152-4283-9b83-29460002986b" xlink:to="loc_srt_MajorCustomersAxis_95b0120c-7dfd-4389-82f5-62d3c8282a33" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_95b0120c-7dfd-4389-82f5-62d3c8282a33_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_MajorCustomersAxis_95b0120c-7dfd-4389-82f5-62d3c8282a33" xlink:to="loc_srt_NameOfMajorCustomerDomain_95b0120c-7dfd-4389-82f5-62d3c8282a33_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_c8f7943a-428f-41df-9dbb-01d198b335a9" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_MajorCustomersAxis_95b0120c-7dfd-4389-82f5-62d3c8282a33" xlink:to="loc_srt_NameOfMajorCustomerDomain_c8f7943a-428f-41df-9dbb-01d198b335a9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_USNationalInstituteOfHealthMember_8f37b0eb-76e6-4e14-a0cc-a15b51fa7783" xlink:href="rxrx-20211231.xsd#rxrx_USNationalInstituteOfHealthMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_c8f7943a-428f-41df-9dbb-01d198b335a9" xlink:to="loc_rxrx_USNationalInstituteOfHealthMember_8f37b0eb-76e6-4e14-a0cc-a15b51fa7783" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_BillAndMelindaGatesFoundationMember_cc12d3c3-687f-46de-b463-913aa9b3a834" xlink:href="rxrx-20211231.xsd#rxrx_BillAndMelindaGatesFoundationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_c8f7943a-428f-41df-9dbb-01d198b335a9" xlink:to="loc_rxrx_BillAndMelindaGatesFoundationMember_cc12d3c3-687f-46de-b463-913aa9b3a834" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_d5405b68-91e0-41e8-8acd-100d7ebda559" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_069d5f54-e152-4283-9b83-29460002986b" xlink:to="loc_srt_ProductOrServiceAxis_d5405b68-91e0-41e8-8acd-100d7ebda559" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_d5405b68-91e0-41e8-8acd-100d7ebda559_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_d5405b68-91e0-41e8-8acd-100d7ebda559" xlink:to="loc_srt_ProductsAndServicesDomain_d5405b68-91e0-41e8-8acd-100d7ebda559_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_997fbc69-135c-46ed-a418-1a7a055249b9" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_d5405b68-91e0-41e8-8acd-100d7ebda559" xlink:to="loc_srt_ProductsAndServicesDomain_997fbc69-135c-46ed-a418-1a7a055249b9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrantMember_b1869071-7b33-4bcb-b5fd-2e6d417da201" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_997fbc69-135c-46ed-a418-1a7a055249b9" xlink:to="loc_us-gaap_GrantMember_b1869071-7b33-4bcb-b5fd-2e6d417da201" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_f0bac316-0487-42bb-ab73-9ae18504dbe7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_069d5f54-e152-4283-9b83-29460002986b" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_f0bac316-0487-42bb-ab73-9ae18504dbe7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_f0bac316-0487-42bb-ab73-9ae18504dbe7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_f0bac316-0487-42bb-ab73-9ae18504dbe7" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_f0bac316-0487-42bb-ab73-9ae18504dbe7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_815e6544-866c-44d6-9999-eb149fc31609" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_f0bac316-0487-42bb-ab73-9ae18504dbe7" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_815e6544-866c-44d6-9999-eb149fc31609" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LetterOfCreditMember_36bf021e-d137-41da-800b-d97e37b6c047" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LetterOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_815e6544-866c-44d6-9999-eb149fc31609" xlink:to="loc_us-gaap_LetterOfCreditMember_36bf021e-d137-41da-800b-d97e37b6c047" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_3e0368e9-11a0-4b27-bce0-8f904255a3fc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_069d5f54-e152-4283-9b83-29460002986b" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_3e0368e9-11a0-4b27-bce0-8f904255a3fc" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_3e0368e9-11a0-4b27-bce0-8f904255a3fc_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_3e0368e9-11a0-4b27-bce0-8f904255a3fc" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_3e0368e9-11a0-4b27-bce0-8f904255a3fc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_5924b9eb-6dd6-46bf-83bc-3fc3047ab040" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_3e0368e9-11a0-4b27-bce0-8f904255a3fc" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_5924b9eb-6dd6-46bf-83bc-3fc3047ab040" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_16bac82a-acc6-41c8-8f7b-67a420afb3e9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_5924b9eb-6dd6-46bf-83bc-3fc3047ab040" xlink:to="loc_us-gaap_SubsequentEventMember_16bac82a-acc6-41c8-8f7b-67a420afb3e9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_9768d8c0-fc0c-4335-8fa4-98a86b04fefe" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_069d5f54-e152-4283-9b83-29460002986b" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_9768d8c0-fc0c-4335-8fa4-98a86b04fefe" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_9768d8c0-fc0c-4335-8fa4-98a86b04fefe_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_9768d8c0-fc0c-4335-8fa4-98a86b04fefe" xlink:to="loc_us-gaap_EquityComponentDomain_9768d8c0-fc0c-4335-8fa4-98a86b04fefe_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_a79b99d5-0da3-4abc-b231-7db5ec9a360a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_9768d8c0-fc0c-4335-8fa4-98a86b04fefe" xlink:to="loc_us-gaap_EquityComponentDomain_a79b99d5-0da3-4abc-b231-7db5ec9a360a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_50c4a871-f424-43c8-8c05-152ae780eaa6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_a79b99d5-0da3-4abc-b231-7db5ec9a360a" xlink:to="loc_us-gaap_CommonStockMember_50c4a871-f424-43c8-8c05-152ae780eaa6" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/SummaryofSignificantAccountingPoliciesEstimatedUsefulLivesDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#SummaryofSignificantAccountingPoliciesEstimatedUsefulLivesDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/SummaryofSignificantAccountingPoliciesEstimatedUsefulLivesDetails" xlink:type="extended" id="ica7766e1521c47d58e57c7889a0c3db0_SummaryofSignificantAccountingPoliciesEstimatedUsefulLivesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_72d5accc-6cc9-43f6-ae27-5bfc31be0a89" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_038f9a61-1572-4b17-8f1f-9560d7691e1e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_72d5accc-6cc9-43f6-ae27-5bfc31be0a89" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_038f9a61-1572-4b17-8f1f-9560d7691e1e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_c2f4d3d1-4343-4e22-9ab8-a5fdebd5ce17" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_72d5accc-6cc9-43f6-ae27-5bfc31be0a89" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_c2f4d3d1-4343-4e22-9ab8-a5fdebd5ce17" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_6bc86f22-95c1-451c-9fe4-9daa345ec94b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_c2f4d3d1-4343-4e22-9ab8-a5fdebd5ce17" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_6bc86f22-95c1-451c-9fe4-9daa345ec94b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_6bc86f22-95c1-451c-9fe4-9daa345ec94b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_6bc86f22-95c1-451c-9fe4-9daa345ec94b" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_6bc86f22-95c1-451c-9fe4-9daa345ec94b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_32a3f499-e022-481a-9006-c263e7d75952" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_6bc86f22-95c1-451c-9fe4-9daa345ec94b" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_32a3f499-e022-481a-9006-c263e7d75952" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_4802cd1d-1118-424f-a062-3167ef02f02f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SoftwareAndSoftwareDevelopmentCostsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_32a3f499-e022-481a-9006-c263e7d75952" xlink:to="loc_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_4802cd1d-1118-424f-a062-3167ef02f02f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OfficeEquipmentMember_87764fc6-0929-4a63-abba-413e21c3db98" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OfficeEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_32a3f499-e022-481a-9006-c263e7d75952" xlink:to="loc_us-gaap_OfficeEquipmentMember_87764fc6-0929-4a63-abba-413e21c3db98" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComputerEquipmentMember_d1b2f824-1d80-4404-b725-18c7d989810c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ComputerEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_32a3f499-e022-481a-9006-c263e7d75952" xlink:to="loc_us-gaap_ComputerEquipmentMember_d1b2f824-1d80-4404-b725-18c7d989810c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LaboratoryEquipmentMember_6f6d87b1-fa5c-4771-9d12-1acb62b2130c" xlink:href="rxrx-20211231.xsd#rxrx_LaboratoryEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_32a3f499-e022-481a-9006-c263e7d75952" xlink:to="loc_rxrx_LaboratoryEquipmentMember_6f6d87b1-fa5c-4771-9d12-1acb62b2130c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_1816b0b3-7afa-4240-943e-7910c7080f62" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LeaseholdImprovementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_32a3f499-e022-481a-9006-c263e7d75952" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_1816b0b3-7afa-4240-943e-7910c7080f62" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/AcquisitionsDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#AcquisitionsDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/AcquisitionsDetails" xlink:type="extended" id="i81f19c3ec9e44bbf9c132c6b342a255b_AcquisitionsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_7c45f723-6479-423d-91d0-6f99994cb41e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_33d1de00-2e32-43ca-bea5-a46899d39464" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7c45f723-6479-423d-91d0-6f99994cb41e" xlink:to="loc_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_33d1de00-2e32-43ca-bea5-a46899d39464" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_55b308f1-31b9-4715-a364-2608c3af2b5b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferred1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7c45f723-6479-423d-91d0-6f99994cb41e" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferred1_55b308f1-31b9-4715-a364-2608c3af2b5b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNetAbstract_a2bc8e3e-1227-4c32-9d00-192c838998ec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNetAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7c45f723-6479-423d-91d0-6f99994cb41e" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNetAbstract_a2bc8e3e-1227-4c32-9d00-192c838998ec" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_cfe64830-9585-4b1b-a30f-aec37ccad974" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNetAbstract_a2bc8e3e-1227-4c32-9d00-192c838998ec" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_cfe64830-9585-4b1b-a30f-aec37ccad974" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_b769f33b-517b-4391-a9b0-21b4f2727129" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNetAbstract_a2bc8e3e-1227-4c32-9d00-192c838998ec" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_b769f33b-517b-4391-a9b0-21b4f2727129" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_7637aa0d-6079-496f-849a-347182285935" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNetAbstract_a2bc8e3e-1227-4c32-9d00-192c838998ec" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_7637aa0d-6079-496f-849a-347182285935" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_7a30f8a4-ac0c-4f6e-9659-2d353dbb38bc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNetAbstract_a2bc8e3e-1227-4c32-9d00-192c838998ec" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_7a30f8a4-ac0c-4f6e-9659-2d353dbb38bc" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_d63e5dfe-6c66-4411-9517-e9962f6511bb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNetAbstract_a2bc8e3e-1227-4c32-9d00-192c838998ec" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_d63e5dfe-6c66-4411-9517-e9962f6511bb" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_5691a308-a8e0-4de6-8a38-71727925ca0a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNetAbstract_a2bc8e3e-1227-4c32-9d00-192c838998ec" xlink:to="loc_us-gaap_Goodwill_5691a308-a8e0-4de6-8a38-71727925ca0a" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_a86f278d-eae3-448b-930c-87fe96546751" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNetAbstract_a2bc8e3e-1227-4c32-9d00-192c838998ec" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_a86f278d-eae3-448b-930c-87fe96546751" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_d61be361-637c-49b5-956a-f17e3515cd59" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7c45f723-6479-423d-91d0-6f99994cb41e" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_d61be361-637c-49b5-956a-f17e3515cd59" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireIntangibleAssets_36142aca-6b73-459a-aab9-3f74086c76ed" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireIntangibleAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7c45f723-6479-423d-91d0-6f99994cb41e" xlink:to="loc_us-gaap_PaymentsToAcquireIntangibleAssets_36142aca-6b73-459a-aab9-3f74086c76ed" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_cdae94a5-28a4-4bf1-a2b8-57957008d18f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_7c45f723-6479-423d-91d0-6f99994cb41e" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_cdae94a5-28a4-4bf1-a2b8-57957008d18f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_ca362b0e-67a3-45fa-b34b-865630340e2c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_cdae94a5-28a4-4bf1-a2b8-57957008d18f" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_ca362b0e-67a3-45fa-b34b-865630340e2c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_ca362b0e-67a3-45fa-b34b-865630340e2c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_ca362b0e-67a3-45fa-b34b-865630340e2c" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_ca362b0e-67a3-45fa-b34b-865630340e2c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_cbba0d9d-14e3-431f-8594-bef701b0ab36" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_ca362b0e-67a3-45fa-b34b-865630340e2c" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_cbba0d9d-14e3-431f-8594-bef701b0ab36" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ViumIncMember_9a07806b-1896-4bd9-b5d4-be20a25486f0" xlink:href="rxrx-20211231.xsd#rxrx_ViumIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_cbba0d9d-14e3-431f-8594-bef701b0ab36" xlink:to="loc_rxrx_ViumIncMember_9a07806b-1896-4bd9-b5d4-be20a25486f0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_ce901fa1-4a7e-4521-8159-afa684a54f39" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_cdae94a5-28a4-4bf1-a2b8-57957008d18f" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_ce901fa1-4a7e-4521-8159-afa684a54f39" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_ce901fa1-4a7e-4521-8159-afa684a54f39_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_ce901fa1-4a7e-4521-8159-afa684a54f39" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_ce901fa1-4a7e-4521-8159-afa684a54f39_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_277cdd0a-ff10-43c9-9f96-ad296156862f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_ce901fa1-4a7e-4521-8159-afa684a54f39" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_277cdd0a-ff10-43c9-9f96-ad296156862f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TechnologyBasedIntangibleAssetsMember_08f429dd-dc27-463a-8553-dd9519c579ee" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TechnologyBasedIntangibleAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_277cdd0a-ff10-43c9-9f96-ad296156862f" xlink:to="loc_us-gaap_TechnologyBasedIntangibleAssetsMember_08f429dd-dc27-463a-8553-dd9519c579ee" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_d287859b-ff16-488f-88cf-46ce40fdae7b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_cdae94a5-28a4-4bf1-a2b8-57957008d18f" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_d287859b-ff16-488f-88cf-46ce40fdae7b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_d287859b-ff16-488f-88cf-46ce40fdae7b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_d287859b-ff16-488f-88cf-46ce40fdae7b" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_d287859b-ff16-488f-88cf-46ce40fdae7b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_ea6df8cc-bea1-4526-a1f3-e15a4d96137e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_d287859b-ff16-488f-88cf-46ce40fdae7b" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_ea6df8cc-bea1-4526-a1f3-e15a4d96137e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InternetDomainNamesMember_e09ce91e-c1ca-4334-9e0f-3995ffdd9d56" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InternetDomainNamesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_ea6df8cc-bea1-4526-a1f3-e15a4d96137e" xlink:to="loc_us-gaap_InternetDomainNamesMember_e09ce91e-c1ca-4334-9e0f-3995ffdd9d56" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/SupplementalFinancialInformationPPEDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#SupplementalFinancialInformationPPEDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/SupplementalFinancialInformationPPEDetails" xlink:type="extended" id="ib71e22b4481146d6a558d8343281a6b0_SupplementalFinancialInformationPPEDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3281cfd2-bc80-4d01-a571-f6903edaab50" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_a4150650-8a6d-44fd-ac67-1bc6d4bc64d6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3281cfd2-bc80-4d01-a571-f6903edaab50" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_a4150650-8a6d-44fd-ac67-1bc6d4bc64d6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_d932cc70-b949-44df-ba86-2e7906947456" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3281cfd2-bc80-4d01-a571-f6903edaab50" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_d932cc70-b949-44df-ba86-2e7906947456" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_5287c38e-04d5-4d47-8319-37da7cb899d8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3281cfd2-bc80-4d01-a571-f6903edaab50" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_5287c38e-04d5-4d47-8319-37da7cb899d8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_c463d0b4-0ef6-4e9b-a9c0-e207dbf45fa8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Depreciation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3281cfd2-bc80-4d01-a571-f6903edaab50" xlink:to="loc_us-gaap_Depreciation_c463d0b4-0ef6-4e9b-a9c0-e207dbf45fa8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAdditions_795e3671-6cdd-4f3a-896e-ff90f60dda22" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAdditions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3281cfd2-bc80-4d01-a571-f6903edaab50" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAdditions_795e3671-6cdd-4f3a-896e-ff90f60dda22" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_6495861d-8d0c-4809-9675-2c26d5b7369b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3281cfd2-bc80-4d01-a571-f6903edaab50" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_6495861d-8d0c-4809-9675-2c26d5b7369b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_f8c0f996-6c1f-4051-8dae-a16536f8218a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_6495861d-8d0c-4809-9675-2c26d5b7369b" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_f8c0f996-6c1f-4051-8dae-a16536f8218a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_f8c0f996-6c1f-4051-8dae-a16536f8218a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_f8c0f996-6c1f-4051-8dae-a16536f8218a" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_f8c0f996-6c1f-4051-8dae-a16536f8218a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_52547e26-0fd8-43cb-857c-f745e415189c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_f8c0f996-6c1f-4051-8dae-a16536f8218a" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_52547e26-0fd8-43cb-857c-f745e415189c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LaboratoryEquipmentMember_a03cc93a-f6a9-4174-8172-c4c6ce008435" xlink:href="rxrx-20211231.xsd#rxrx_LaboratoryEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_52547e26-0fd8-43cb-857c-f745e415189c" xlink:to="loc_rxrx_LaboratoryEquipmentMember_a03cc93a-f6a9-4174-8172-c4c6ce008435" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_55843198-317a-4443-be3f-523f4e0878dd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LeaseholdImprovementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_52547e26-0fd8-43cb-857c-f745e415189c" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_55843198-317a-4443-be3f-523f4e0878dd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OfficeEquipmentMember_63e17e20-27ee-4562-8b01-e244e52f1592" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OfficeEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_52547e26-0fd8-43cb-857c-f745e415189c" xlink:to="loc_us-gaap_OfficeEquipmentMember_63e17e20-27ee-4562-8b01-e244e52f1592" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetUnderConstructionMember_94a8a421-b02e-4c6e-8ecd-a0d5bf20ca59" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetUnderConstructionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_52547e26-0fd8-43cb-857c-f745e415189c" xlink:to="loc_us-gaap_AssetUnderConstructionMember_94a8a421-b02e-4c6e-8ecd-a0d5bf20ca59" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/InvestmentsTypeofSecurityDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#InvestmentsTypeofSecurityDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/InvestmentsTypeofSecurityDetails" xlink:type="extended" id="i4088548fff1549cca68db489a6cef283_InvestmentsTypeofSecurityDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_931412ad-1ed8-460a-9bb9-926066846601" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_6f07f502-b168-4f30-b0ee-3e95f9277e42" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_931412ad-1ed8-460a-9bb9-926066846601" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_6f07f502-b168-4f30-b0ee-3e95f9277e42" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_3e581f67-262c-417d-b78e-50ecac224e94" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_931412ad-1ed8-460a-9bb9-926066846601" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_3e581f67-262c-417d-b78e-50ecac224e94" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_984d680a-50e2-4d96-aa0b-e7a8b2c4f466" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_931412ad-1ed8-460a-9bb9-926066846601" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_984d680a-50e2-4d96-aa0b-e7a8b2c4f466" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_a3046fe2-c6df-49b2-818f-7524ab69c247" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_931412ad-1ed8-460a-9bb9-926066846601" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_a3046fe2-c6df-49b2-818f-7524ab69c247" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_a71d0b4a-7a30-4edf-8043-8bbef9a54d17" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_931412ad-1ed8-460a-9bb9-926066846601" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_a71d0b4a-7a30-4edf-8043-8bbef9a54d17" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_422f86f6-5114-4c5c-b27b-157fd465efc1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_a71d0b4a-7a30-4edf-8043-8bbef9a54d17" xlink:to="loc_us-gaap_FinancialInstrumentAxis_422f86f6-5114-4c5c-b27b-157fd465efc1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_422f86f6-5114-4c5c-b27b-157fd465efc1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_422f86f6-5114-4c5c-b27b-157fd465efc1" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_422f86f6-5114-4c5c-b27b-157fd465efc1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_50e9df9b-fac4-4a86-b21f-01432780059b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_422f86f6-5114-4c5c-b27b-157fd465efc1" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_50e9df9b-fac4-4a86-b21f-01432780059b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_5831e711-c513-48a1-9b74-f82a871c2746" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_50e9df9b-fac4-4a86-b21f-01432780059b" xlink:to="loc_us-gaap_MoneyMarketFundsMember_5831e711-c513-48a1-9b74-f82a871c2746" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_b731f535-3cb0-4d70-ab83-4201036a027c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_50e9df9b-fac4-4a86-b21f-01432780059b" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_b731f535-3cb0-4d70-ab83-4201036a027c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_CorporateBondsMember_aebd93ee-aea6-492b-9c7d-d00eafb1826a" xlink:href="rxrx-20211231.xsd#rxrx_CorporateBondsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_50e9df9b-fac4-4a86-b21f-01432780059b" xlink:to="loc_rxrx_CorporateBondsMember_aebd93ee-aea6-492b-9c7d-d00eafb1826a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CertificatesOfDepositMember_d38e6fd1-22a3-4aff-bef4-59352b82fe0c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CertificatesOfDepositMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_50e9df9b-fac4-4a86-b21f-01432780059b" xlink:to="loc_us-gaap_CertificatesOfDepositMember_d38e6fd1-22a3-4aff-bef4-59352b82fe0c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_9d1d18b6-3f91-4253-be50-bd688f11daef" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommercialPaperMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_50e9df9b-fac4-4a86-b21f-01432780059b" xlink:to="loc_us-gaap_CommercialPaperMember_9d1d18b6-3f91-4253-be50-bd688f11daef" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/InvestmentsBalanceSheetClassificationDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#InvestmentsBalanceSheetClassificationDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/InvestmentsBalanceSheetClassificationDetails" xlink:type="extended" id="iad51fa9db6c940cebc15eaa552fcc6aa_InvestmentsBalanceSheetClassificationDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_4576d709-ce9e-444a-98cb-4a51e6526d4b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_695137dc-9901-493f-9d5f-3bb9ce209ed0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_4576d709-ce9e-444a-98cb-4a51e6526d4b" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_695137dc-9901-493f-9d5f-3bb9ce209ed0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_3125efcc-dab3-4a0a-8685-427c5c2f66e6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_4576d709-ce9e-444a-98cb-4a51e6526d4b" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_3125efcc-dab3-4a0a-8685-427c5c2f66e6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_35f41ab8-9c8a-4ab6-982b-f0539880f5a6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_3125efcc-dab3-4a0a-8685-427c5c2f66e6" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_35f41ab8-9c8a-4ab6-982b-f0539880f5a6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_35f41ab8-9c8a-4ab6-982b-f0539880f5a6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_35f41ab8-9c8a-4ab6-982b-f0539880f5a6" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_35f41ab8-9c8a-4ab6-982b-f0539880f5a6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_522b663f-e95b-46e3-b453-42ddea3b108f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_35f41ab8-9c8a-4ab6-982b-f0539880f5a6" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_522b663f-e95b-46e3-b453-42ddea3b108f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsMember_497875b8-0542-4e7b-b46c-b28269608e88" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_522b663f-e95b-46e3-b453-42ddea3b108f" xlink:to="loc_us-gaap_CashAndCashEquivalentsMember_497875b8-0542-4e7b-b46c-b28269608e88" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestmentsMember_95ebba8c-7def-48d5-8a41-9172eb649540" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortTermInvestmentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_522b663f-e95b-46e3-b453-42ddea3b108f" xlink:to="loc_us-gaap_ShortTermInvestmentsMember_95ebba8c-7def-48d5-8a41-9172eb649540" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/NotesPayableMidcapFinancialDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#NotesPayableMidcapFinancialDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/NotesPayableMidcapFinancialDetails" xlink:type="extended" id="i13b2c9a4339b40c1892921685a5c9df3_NotesPayableMidcapFinancialDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_0ff96f7c-3f54-41ae-8683-1b1c1ba39187" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_a7c67591-edc3-47a8-8952-d7486c5741df" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0ff96f7c-3f54-41ae-8683-1b1c1ba39187" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_a7c67591-edc3-47a8-8952-d7486c5741df" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfDebt_5bd3e0f5-6503-4227-85b5-abf905a41391" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepaymentsOfDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0ff96f7c-3f54-41ae-8683-1b1c1ba39187" xlink:to="loc_us-gaap_RepaymentsOfDebt_5bd3e0f5-6503-4227-85b5-abf905a41391" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_9e3be688-38b0-41f3-a636-d137a6d15a72" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0ff96f7c-3f54-41ae-8683-1b1c1ba39187" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_9e3be688-38b0-41f3-a636-d137a6d15a72" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCredit_cfe3f4c4-e94e-4e0b-8cf5-daa4771e26de" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LineOfCredit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0ff96f7c-3f54-41ae-8683-1b1c1ba39187" xlink:to="loc_us-gaap_LineOfCredit_cfe3f4c4-e94e-4e0b-8cf5-daa4771e26de" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_761c2b01-1fb9-4120-967d-ccf6d2951475" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfDebtIssuanceCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0ff96f7c-3f54-41ae-8683-1b1c1ba39187" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_761c2b01-1fb9-4120-967d-ccf6d2951475" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_ecf618bc-061f-4470-96d9-3c3dadbf35fd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0ff96f7c-3f54-41ae-8683-1b1c1ba39187" xlink:to="loc_us-gaap_DebtInstrumentTable_ecf618bc-061f-4470-96d9-3c3dadbf35fd" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_e084716a-acb1-4a44-ad72-a83e02796edb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_ecf618bc-061f-4470-96d9-3c3dadbf35fd" xlink:to="loc_us-gaap_DebtInstrumentAxis_e084716a-acb1-4a44-ad72-a83e02796edb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_e084716a-acb1-4a44-ad72-a83e02796edb_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_e084716a-acb1-4a44-ad72-a83e02796edb" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_e084716a-acb1-4a44-ad72-a83e02796edb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_605df71c-9f36-49e3-b9db-3927640a0ec7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_e084716a-acb1-4a44-ad72-a83e02796edb" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_605df71c-9f36-49e3-b9db-3927640a0ec7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_MidcapLoanAgreementTermLoanFacilityTrancheOneMemberMember_a74aba7c-73be-4228-9a11-65803412b111" xlink:href="rxrx-20211231.xsd#rxrx_MidcapLoanAgreementTermLoanFacilityTrancheOneMemberMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_605df71c-9f36-49e3-b9db-3927640a0ec7" xlink:to="loc_rxrx_MidcapLoanAgreementTermLoanFacilityTrancheOneMemberMember_a74aba7c-73be-4228-9a11-65803412b111" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_PacificWesternBankLoanMember_0e98fd31-97a8-4233-9889-320ccf71f7c5" xlink:href="rxrx-20211231.xsd#rxrx_PacificWesternBankLoanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_605df71c-9f36-49e3-b9db-3927640a0ec7" xlink:to="loc_rxrx_PacificWesternBankLoanMember_0e98fd31-97a8-4233-9889-320ccf71f7c5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_MidcapLoanAgreementMember_bb373f0b-9d9e-4ed3-9e5b-9b04b080ac86" xlink:href="rxrx-20211231.xsd#rxrx_MidcapLoanAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_605df71c-9f36-49e3-b9db-3927640a0ec7" xlink:to="loc_rxrx_MidcapLoanAgreementMember_bb373f0b-9d9e-4ed3-9e5b-9b04b080ac86" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_d2789d8e-caf6-436f-9313-0a167b855806" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_ecf618bc-061f-4470-96d9-3c3dadbf35fd" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_d2789d8e-caf6-436f-9313-0a167b855806" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_d2789d8e-caf6-436f-9313-0a167b855806_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_d2789d8e-caf6-436f-9313-0a167b855806" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_d2789d8e-caf6-436f-9313-0a167b855806_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_a894e145-ea34-49d4-8e05-2efdb2bf6586" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_d2789d8e-caf6-436f-9313-0a167b855806" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_a894e145-ea34-49d4-8e05-2efdb2bf6586" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditMember_eb97c902-d18f-48f9-a795-247016c8cdb5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LineOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_a894e145-ea34-49d4-8e05-2efdb2bf6586" xlink:to="loc_us-gaap_LineOfCreditMember_eb97c902-d18f-48f9-a795-247016c8cdb5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansPayableMember_79afb660-c62d-4742-a2f2-9ad328cd0ae8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoansPayableMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_a894e145-ea34-49d4-8e05-2efdb2bf6586" xlink:to="loc_us-gaap_LoansPayableMember_79afb660-c62d-4742-a2f2-9ad328cd0ae8" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/NotesPayablePacificWesternDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#NotesPayablePacificWesternDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/NotesPayablePacificWesternDetails" xlink:type="extended" id="i4ca0356e6bb6470f9529fecc8759bbde_NotesPayablePacificWesternDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_08499903-cf19-4dae-8725-c90ef593bc55" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_ff88dc2e-e915-4ca8-a381-91d9296cc92f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_08499903-cf19-4dae-8725-c90ef593bc55" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_ff88dc2e-e915-4ca8-a381-91d9296cc92f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCredit_2f9254d7-3fd3-4b94-b41b-054c7350fe41" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LineOfCredit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_08499903-cf19-4dae-8725-c90ef593bc55" xlink:to="loc_us-gaap_LineOfCredit_2f9254d7-3fd3-4b94-b41b-054c7350fe41" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCash_be132785-8368-48c9-b2b4-5a170ec5536a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_08499903-cf19-4dae-8725-c90ef593bc55" xlink:to="loc_us-gaap_RestrictedCash_be132785-8368-48c9-b2b4-5a170ec5536a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_372fdbbf-fc1a-41e6-9a81-97ae07039748" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_08499903-cf19-4dae-8725-c90ef593bc55" xlink:to="loc_us-gaap_DebtInstrumentTable_372fdbbf-fc1a-41e6-9a81-97ae07039748" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityAxis_0003f2b5-b723-4e60-9ea8-8d552477adc5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CreditFacilityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_372fdbbf-fc1a-41e6-9a81-97ae07039748" xlink:to="loc_us-gaap_CreditFacilityAxis_0003f2b5-b723-4e60-9ea8-8d552477adc5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_0003f2b5-b723-4e60-9ea8-8d552477adc5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CreditFacilityAxis_0003f2b5-b723-4e60-9ea8-8d552477adc5" xlink:to="loc_us-gaap_CreditFacilityDomain_0003f2b5-b723-4e60-9ea8-8d552477adc5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_cb98f11b-8aae-491b-8424-b03e30e17e4b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CreditFacilityAxis_0003f2b5-b723-4e60-9ea8-8d552477adc5" xlink:to="loc_us-gaap_CreditFacilityDomain_cb98f11b-8aae-491b-8424-b03e30e17e4b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LetterOfCreditMember_c4e9b217-3730-440e-a89e-eee8cc4073f1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LetterOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_cb98f11b-8aae-491b-8424-b03e30e17e4b" xlink:to="loc_us-gaap_LetterOfCreditMember_c4e9b217-3730-440e-a89e-eee8cc4073f1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_6b93a4a0-abc0-4a1f-a87d-e647fc6ffff4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_372fdbbf-fc1a-41e6-9a81-97ae07039748" xlink:to="loc_us-gaap_DebtInstrumentAxis_6b93a4a0-abc0-4a1f-a87d-e647fc6ffff4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_6b93a4a0-abc0-4a1f-a87d-e647fc6ffff4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_6b93a4a0-abc0-4a1f-a87d-e647fc6ffff4" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_6b93a4a0-abc0-4a1f-a87d-e647fc6ffff4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_043ea369-6e89-4d43-ac00-9786f8cb3177" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_6b93a4a0-abc0-4a1f-a87d-e647fc6ffff4" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_043ea369-6e89-4d43-ac00-9786f8cb3177" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_PacificWesternLetterOfCreditMember_a654e4ec-c748-409f-adf9-f4fa374115cb" xlink:href="rxrx-20211231.xsd#rxrx_PacificWesternLetterOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_043ea369-6e89-4d43-ac00-9786f8cb3177" xlink:to="loc_rxrx_PacificWesternLetterOfCreditMember_a654e4ec-c748-409f-adf9-f4fa374115cb" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/NotesPayableConvertibleNotesDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#NotesPayableConvertibleNotesDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/NotesPayableConvertibleNotesDetails" xlink:type="extended" id="i9c189049a4314562815edbd4b919772a_NotesPayableConvertibleNotesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_e0c6d546-03d5-4c32-b8dd-dcf5fe2dab88" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_4b41aaa8-696b-4a24-96cb-a9a1ddf3776c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_e0c6d546-03d5-4c32-b8dd-dcf5fe2dab88" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_4b41aaa8-696b-4a24-96cb-a9a1ddf3776c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_09e96a30-e314-4cd0-bfd8-de2fe0b64128" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_e0c6d546-03d5-4c32-b8dd-dcf5fe2dab88" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_09e96a30-e314-4cd0-bfd8-de2fe0b64128" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities_e9681b73-6024-45d9-ad74-152ffda7b130" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_e0c6d546-03d5-4c32-b8dd-dcf5fe2dab88" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities_e9681b73-6024-45d9-ad74-152ffda7b130" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_9fa62c91-9d98-49c2-a1cd-486da8b5be5b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainLossOnDerivativeInstrumentsNetPretax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_e0c6d546-03d5-4c32-b8dd-dcf5fe2dab88" xlink:to="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_9fa62c91-9d98-49c2-a1cd-486da8b5be5b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_f070181f-2e5e-4b5e-873f-b5ae5922e522" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_e0c6d546-03d5-4c32-b8dd-dcf5fe2dab88" xlink:to="loc_us-gaap_DebtInstrumentTable_f070181f-2e5e-4b5e-873f-b5ae5922e522" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_322a4ffd-b08c-40c8-b8af-ccf3a64e9819" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_f070181f-2e5e-4b5e-873f-b5ae5922e522" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_322a4ffd-b08c-40c8-b8af-ccf3a64e9819" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_322a4ffd-b08c-40c8-b8af-ccf3a64e9819_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_322a4ffd-b08c-40c8-b8af-ccf3a64e9819" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_322a4ffd-b08c-40c8-b8af-ccf3a64e9819_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_53b5f186-d800-4dd6-a21c-0ca0d31fee77" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_322a4ffd-b08c-40c8-b8af-ccf3a64e9819" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_53b5f186-d800-4dd6-a21c-0ca0d31fee77" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleNotesPayableMember_db80a2af-2872-4673-b34b-15400085b66f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConvertibleNotesPayableMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_53b5f186-d800-4dd6-a21c-0ca0d31fee77" xlink:to="loc_us-gaap_ConvertibleNotesPayableMember_db80a2af-2872-4673-b34b-15400085b66f" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/NotesPayableNotesPayableforTenantImprovementAllowanceDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#NotesPayableNotesPayableforTenantImprovementAllowanceDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/NotesPayableNotesPayableforTenantImprovementAllowanceDetails" xlink:type="extended" id="i0fec935318a64ccb9e0326a947f76526_NotesPayableNotesPayableforTenantImprovementAllowanceDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_1aebf665-be0f-464d-ae9c-e22eeae37131" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_475b2666-d323-45d0-bfb9-c0b37afdb645" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1aebf665-be0f-464d-ae9c-e22eeae37131" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_475b2666-d323-45d0-bfb9-c0b37afdb645" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTerm_2077fe20-2534-4540-a99e-aa4698ba0b3c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1aebf665-be0f-464d-ae9c-e22eeae37131" xlink:to="loc_us-gaap_DebtInstrumentTerm_2077fe20-2534-4540-a99e-aa4698ba0b3c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_29e2b670-6508-487a-8a6c-ed28c6fa7cc8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1aebf665-be0f-464d-ae9c-e22eeae37131" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_29e2b670-6508-487a-8a6c-ed28c6fa7cc8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_21daf92d-9aa7-4aa5-93bd-38653586df03" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1aebf665-be0f-464d-ae9c-e22eeae37131" xlink:to="loc_us-gaap_DebtInstrumentTable_21daf92d-9aa7-4aa5-93bd-38653586df03" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_43c7daec-3cd4-4da5-b577-93d48cdb24e3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_21daf92d-9aa7-4aa5-93bd-38653586df03" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_43c7daec-3cd4-4da5-b577-93d48cdb24e3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_43c7daec-3cd4-4da5-b577-93d48cdb24e3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_43c7daec-3cd4-4da5-b577-93d48cdb24e3" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_43c7daec-3cd4-4da5-b577-93d48cdb24e3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_5d500475-1680-443d-86e1-4d91de41224b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_43c7daec-3cd4-4da5-b577-93d48cdb24e3" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_5d500475-1680-443d-86e1-4d91de41224b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesPayableOtherPayablesMember_a422a78b-d600-4958-a7c9-40e1b6f7879c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NotesPayableOtherPayablesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_5d500475-1680-443d-86e1-4d91de41224b" xlink:to="loc_us-gaap_NotesPayableOtherPayablesMember_a422a78b-d600-4958-a7c9-40e1b6f7879c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_a4999033-3c50-47df-ba51-7f91f0f8fb49" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_21daf92d-9aa7-4aa5-93bd-38653586df03" xlink:to="loc_us-gaap_DebtInstrumentAxis_a4999033-3c50-47df-ba51-7f91f0f8fb49" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_a4999033-3c50-47df-ba51-7f91f0f8fb49_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_a4999033-3c50-47df-ba51-7f91f0f8fb49" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_a4999033-3c50-47df-ba51-7f91f0f8fb49_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_adf60960-3f6b-404b-98f3-ecdd79dc3055" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_a4999033-3c50-47df-ba51-7f91f0f8fb49" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_adf60960-3f6b-404b-98f3-ecdd79dc3055" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_Station41LeaseMember_f397c5cf-1667-4e3b-9818-74648edc6c5a" xlink:href="rxrx-20211231.xsd#rxrx_Station41LeaseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_adf60960-3f6b-404b-98f3-ecdd79dc3055" xlink:to="loc_rxrx_Station41LeaseMember_f397c5cf-1667-4e3b-9818-74648edc6c5a" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/NotesPayableCurrentNoncurrentDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#NotesPayableCurrentNoncurrentDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/NotesPayableCurrentNoncurrentDetails" xlink:type="extended" id="ib1d22e789b5e497abe21d99c6be86fb6_NotesPayableCurrentNoncurrentDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_635fc528-d53c-43aa-b9c4-45c5daadb8ad" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_c6ad374c-6331-499f-94d1-6a723a120c98" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_635fc528-d53c-43aa-b9c4-45c5daadb8ad" xlink:to="loc_us-gaap_LongTermDebtCurrent_c6ad374c-6331-499f-94d1-6a723a120c98" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_f225989c-bea9-4253-9754-b136452654c8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_635fc528-d53c-43aa-b9c4-45c5daadb8ad" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_f225989c-bea9-4253-9754-b136452654c8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_b78a1525-c86f-401b-9081-e60c4dd86bd6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_635fc528-d53c-43aa-b9c4-45c5daadb8ad" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_b78a1525-c86f-401b-9081-e60c4dd86bd6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_458d3062-58e9-4a67-906b-09f690025daa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_635fc528-d53c-43aa-b9c4-45c5daadb8ad" xlink:to="loc_us-gaap_LongTermDebt_458d3062-58e9-4a67-906b-09f690025daa" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_41d58566-c645-40ce-bc43-dcacc7bff6cd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_635fc528-d53c-43aa-b9c4-45c5daadb8ad" xlink:to="loc_us-gaap_DebtInstrumentTable_41d58566-c645-40ce-bc43-dcacc7bff6cd" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_de853512-ce17-4fa7-9af1-5ea2bafb2d5b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_41d58566-c645-40ce-bc43-dcacc7bff6cd" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_de853512-ce17-4fa7-9af1-5ea2bafb2d5b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_de853512-ce17-4fa7-9af1-5ea2bafb2d5b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_de853512-ce17-4fa7-9af1-5ea2bafb2d5b" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_de853512-ce17-4fa7-9af1-5ea2bafb2d5b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_1a02fa9c-2559-4d84-8908-e3413ded171f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_de853512-ce17-4fa7-9af1-5ea2bafb2d5b" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_1a02fa9c-2559-4d84-8908-e3413ded171f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesPayableOtherPayablesMember_5d1b3609-bd23-44d9-9e80-0e731bfe47fe" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NotesPayableOtherPayablesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_1a02fa9c-2559-4d84-8908-e3413ded171f" xlink:to="loc_us-gaap_NotesPayableOtherPayablesMember_5d1b3609-bd23-44d9-9e80-0e731bfe47fe" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/CommitmentsandContingenciesNarrativeDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#CommitmentsandContingenciesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/CommitmentsandContingenciesNarrativeDetails" xlink:type="extended" id="ic5e8919056bb4e77a2c5c1405c5c70dd_CommitmentsandContingenciesNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionLineItems_dabc8420-e02c-4c12-9b9e-2fc29ae37d1c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeLeaseDescriptionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseAndRentalExpense_238fddba-51c7-4e52-b185-4d50a1788a68" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LeaseAndRentalExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_dabc8420-e02c-4c12-9b9e-2fc29ae37d1c" xlink:to="loc_us-gaap_LeaseAndRentalExpense_238fddba-51c7-4e52-b185-4d50a1788a68" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseTermOfContract_a5a5f5f5-e66c-43f2-b2d1-ec663c8780a0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseTermOfContract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_dabc8420-e02c-4c12-9b9e-2fc29ae37d1c" xlink:to="loc_us-gaap_LesseeOperatingLeaseTermOfContract_a5a5f5f5-e66c-43f2-b2d1-ec663c8780a0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncentiveFromLessor_7f6b1477-4e80-4835-9703-38d681aad28a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncentiveFromLessor"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_dabc8420-e02c-4c12-9b9e-2fc29ae37d1c" xlink:to="loc_us-gaap_IncentiveFromLessor_7f6b1477-4e80-4835-9703-38d681aad28a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseIncentivePayableCurrentAndNoncurrent_3f8cc3b7-7d4e-451e-8776-0a62fe788ba6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LeaseIncentivePayableCurrentAndNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_dabc8420-e02c-4c12-9b9e-2fc29ae37d1c" xlink:to="loc_us-gaap_LeaseIncentivePayableCurrentAndNoncurrent_3f8cc3b7-7d4e-451e-8776-0a62fe788ba6" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LesseeOperatingLeaseNumberOfRenewalOptions_c70d5bc2-3656-4163-b930-de53e70d5ce3" xlink:href="rxrx-20211231.xsd#rxrx_LesseeOperatingLeaseNumberOfRenewalOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_dabc8420-e02c-4c12-9b9e-2fc29ae37d1c" xlink:to="loc_rxrx_LesseeOperatingLeaseNumberOfRenewalOptions_c70d5bc2-3656-4163-b930-de53e70d5ce3" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_19dbd2b3-0d56-4c23-b7a9-b8b6b1002904" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseRenewalTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_dabc8420-e02c-4c12-9b9e-2fc29ae37d1c" xlink:to="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_19dbd2b3-0d56-4c23-b7a9-b8b6b1002904" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_68ab60e4-b7de-4c4d-9523-70351935276d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_dabc8420-e02c-4c12-9b9e-2fc29ae37d1c" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_68ab60e4-b7de-4c4d-9523-70351935276d" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_b61c346f-9bc4-4f47-87ef-b867d7f85051" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_dabc8420-e02c-4c12-9b9e-2fc29ae37d1c" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_b61c346f-9bc4-4f47-87ef-b867d7f85051" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LesseeOperatingLeaseSizeOfLeasedAsset_ff8ceff0-7589-42f4-b591-619572d48e92" xlink:href="rxrx-20211231.xsd#rxrx_LesseeOperatingLeaseSizeOfLeasedAsset"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_dabc8420-e02c-4c12-9b9e-2fc29ae37d1c" xlink:to="loc_rxrx_LesseeOperatingLeaseSizeOfLeasedAsset_ff8ceff0-7589-42f4-b591-619572d48e92" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LesseeOperatingLeaseTenantImprovementAllowance_763c854f-d8ce-4dd4-9d28-92ae73dfc4e4" xlink:href="rxrx-20211231.xsd#rxrx_LesseeOperatingLeaseTenantImprovementAllowance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_dabc8420-e02c-4c12-9b9e-2fc29ae37d1c" xlink:to="loc_rxrx_LesseeOperatingLeaseTenantImprovementAllowance_763c854f-d8ce-4dd4-9d28-92ae73dfc4e4" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseObligation_06f7e342-4bc7-4d05-b47d-412266adee78" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PurchaseObligation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_dabc8420-e02c-4c12-9b9e-2fc29ae37d1c" xlink:to="loc_us-gaap_PurchaseObligation_06f7e342-4bc7-4d05-b47d-412266adee78" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseObligationDueInNextTwelveMonths_7bde4165-3912-4f67-918d-8c1c40961220" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PurchaseObligationDueInNextTwelveMonths"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_dabc8420-e02c-4c12-9b9e-2fc29ae37d1c" xlink:to="loc_us-gaap_PurchaseObligationDueInNextTwelveMonths_7bde4165-3912-4f67-918d-8c1c40961220" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionTable_5ba774bc-d233-4fce-ad89-48e316b5ce64" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeLeaseDescriptionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_dabc8420-e02c-4c12-9b9e-2fc29ae37d1c" xlink:to="loc_us-gaap_LesseeLeaseDescriptionTable_5ba774bc-d233-4fce-ad89-48e316b5ce64" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LeaseArrangementNameAxis_cd60c016-b784-4e2c-9dd0-e679b993d467" xlink:href="rxrx-20211231.xsd#rxrx_LeaseArrangementNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_5ba774bc-d233-4fce-ad89-48e316b5ce64" xlink:to="loc_rxrx_LeaseArrangementNameAxis_cd60c016-b784-4e2c-9dd0-e679b993d467" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LeaseArrangementNameDomain_cd60c016-b784-4e2c-9dd0-e679b993d467_default" xlink:href="rxrx-20211231.xsd#rxrx_LeaseArrangementNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_rxrx_LeaseArrangementNameAxis_cd60c016-b784-4e2c-9dd0-e679b993d467" xlink:to="loc_rxrx_LeaseArrangementNameDomain_cd60c016-b784-4e2c-9dd0-e679b993d467_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LeaseArrangementNameDomain_fd4cb084-e1f5-4205-a1a8-1521583ea465" xlink:href="rxrx-20211231.xsd#rxrx_LeaseArrangementNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_rxrx_LeaseArrangementNameAxis_cd60c016-b784-4e2c-9dd0-e679b993d467" xlink:to="loc_rxrx_LeaseArrangementNameDomain_fd4cb084-e1f5-4205-a1a8-1521583ea465" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_KomasMember_b8039ec8-e84c-455e-bd08-d0e3d7f76b7f" xlink:href="rxrx-20211231.xsd#rxrx_KomasMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_LeaseArrangementNameDomain_fd4cb084-e1f5-4205-a1a8-1521583ea465" xlink:to="loc_rxrx_KomasMember_b8039ec8-e84c-455e-bd08-d0e3d7f76b7f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_Station41Member_2eea557f-13d7-4600-be50-80bd7f299478" xlink:href="rxrx-20211231.xsd#rxrx_Station41Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_LeaseArrangementNameDomain_fd4cb084-e1f5-4205-a1a8-1521583ea465" xlink:to="loc_rxrx_Station41Member_2eea557f-13d7-4600-be50-80bd7f299478" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_Station56Member_a2bba98d-3ea1-4d88-a600-8ff36ec63745" xlink:href="rxrx-20211231.xsd#rxrx_Station56Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_LeaseArrangementNameDomain_fd4cb084-e1f5-4205-a1a8-1521583ea465" xlink:to="loc_rxrx_Station56Member_a2bba98d-3ea1-4d88-a600-8ff36ec63745" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_fae7e94d-d13d-43c3-8c76-986a075ef25f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_5ba774bc-d233-4fce-ad89-48e316b5ce64" xlink:to="loc_us-gaap_DebtInstrumentAxis_fae7e94d-d13d-43c3-8c76-986a075ef25f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_fae7e94d-d13d-43c3-8c76-986a075ef25f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_fae7e94d-d13d-43c3-8c76-986a075ef25f" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_fae7e94d-d13d-43c3-8c76-986a075ef25f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_d8722707-3daf-45d7-b9b4-f97357c2f666" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_fae7e94d-d13d-43c3-8c76-986a075ef25f" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_d8722707-3daf-45d7-b9b4-f97357c2f666" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_Station41LeaseMember_f76f5461-1bb6-48aa-9e39-1809d17db970" xlink:href="rxrx-20211231.xsd#rxrx_Station41LeaseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_d8722707-3daf-45d7-b9b4-f97357c2f666" xlink:to="loc_rxrx_Station41LeaseMember_f76f5461-1bb6-48aa-9e39-1809d17db970" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_c1af0233-475b-4d5d-a6e7-8454c57e78f5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_5ba774bc-d233-4fce-ad89-48e316b5ce64" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_c1af0233-475b-4d5d-a6e7-8454c57e78f5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_c1af0233-475b-4d5d-a6e7-8454c57e78f5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_c1af0233-475b-4d5d-a6e7-8454c57e78f5" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_c1af0233-475b-4d5d-a6e7-8454c57e78f5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_4c9bc8fd-f3a6-4933-8556-0837f23fc791" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_c1af0233-475b-4d5d-a6e7-8454c57e78f5" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_4c9bc8fd-f3a6-4933-8556-0837f23fc791" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesPayableOtherPayablesMember_284ec4d9-c0d7-4145-9173-6b3b41ae783d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NotesPayableOtherPayablesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_4c9bc8fd-f3a6-4933-8556-0837f23fc791" xlink:to="loc_us-gaap_NotesPayableOtherPayablesMember_284ec4d9-c0d7-4145-9173-6b3b41ae783d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertySubjectToOrAvailableForOperatingLeaseAxis_49b74a69-4620-4c6d-935f-04b65e604a89" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertySubjectToOrAvailableForOperatingLeaseAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_5ba774bc-d233-4fce-ad89-48e316b5ce64" xlink:to="loc_us-gaap_PropertySubjectToOrAvailableForOperatingLeaseAxis_49b74a69-4620-4c6d-935f-04b65e604a89" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertySubjectToOrAvailableForOperatingLeaseDomain_49b74a69-4620-4c6d-935f-04b65e604a89_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertySubjectToOrAvailableForOperatingLeaseDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertySubjectToOrAvailableForOperatingLeaseAxis_49b74a69-4620-4c6d-935f-04b65e604a89" xlink:to="loc_us-gaap_PropertySubjectToOrAvailableForOperatingLeaseDomain_49b74a69-4620-4c6d-935f-04b65e604a89_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertySubjectToOrAvailableForOperatingLeaseDomain_4820b356-81d8-40bb-802a-dd16bd56cae4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertySubjectToOrAvailableForOperatingLeaseDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertySubjectToOrAvailableForOperatingLeaseAxis_49b74a69-4620-4c6d-935f-04b65e604a89" xlink:to="loc_us-gaap_PropertySubjectToOrAvailableForOperatingLeaseDomain_4820b356-81d8-40bb-802a-dd16bd56cae4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_Station41Member_c4a49d05-4047-47e1-b836-cbfaf14464d7" xlink:href="rxrx-20211231.xsd#rxrx_Station41Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertySubjectToOrAvailableForOperatingLeaseDomain_4820b356-81d8-40bb-802a-dd16bd56cae4" xlink:to="loc_rxrx_Station41Member_c4a49d05-4047-47e1-b836-cbfaf14464d7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_MilpitasMember_fc1a40f2-75ec-47e1-a734-b7aa8afdd327" xlink:href="rxrx-20211231.xsd#rxrx_MilpitasMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertySubjectToOrAvailableForOperatingLeaseDomain_4820b356-81d8-40bb-802a-dd16bd56cae4" xlink:to="loc_rxrx_MilpitasMember_fc1a40f2-75ec-47e1-a734-b7aa8afdd327" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_Station56Member_ba2ddf80-b089-4fdb-8b0b-bd829c115aac" xlink:href="rxrx-20211231.xsd#rxrx_Station56Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertySubjectToOrAvailableForOperatingLeaseDomain_4820b356-81d8-40bb-802a-dd16bd56cae4" xlink:to="loc_rxrx_Station56Member_ba2ddf80-b089-4fdb-8b0b-bd829c115aac" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/ConvertiblePreferredStockNarrativeDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#ConvertiblePreferredStockNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/ConvertiblePreferredStockNarrativeDetails" xlink:type="extended" id="ibba20c0fdfd84ea29c00d1fdd5b9ed9e_ConvertiblePreferredStockNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredUnitsLineItems_391473cf-8b61-4102-9ec8-9e0ddc0a1199" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredUnitsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_20f09415-06aa-4513-89d1-be3f4f6be8ed" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PreferredUnitsLineItems_391473cf-8b61-4102-9ec8-9e0ddc0a1199" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_20f09415-06aa-4513-89d1-be3f4f6be8ed" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquitySharesOutstanding_d15e6fd4-d6f1-436b-89bb-95866dac75e5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TemporaryEquitySharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PreferredUnitsLineItems_391473cf-8b61-4102-9ec8-9e0ddc0a1199" xlink:to="loc_us-gaap_TemporaryEquitySharesOutstanding_d15e6fd4-d6f1-436b-89bb-95866dac75e5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquityStockIssuedDuringPeriodValueNewIssues_a77fdfa9-c144-4e44-adbc-bce5a5dac7c7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TemporaryEquityStockIssuedDuringPeriodValueNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PreferredUnitsLineItems_391473cf-8b61-4102-9ec8-9e0ddc0a1199" xlink:to="loc_us-gaap_TemporaryEquityStockIssuedDuringPeriodValueNewIssues_a77fdfa9-c144-4e44-adbc-bce5a5dac7c7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_6481cf04-33d4-4a1d-b921-ae8132266381" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PreferredUnitsLineItems_391473cf-8b61-4102-9ec8-9e0ddc0a1199" xlink:to="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_6481cf04-33d4-4a1d-b921-ae8132266381" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_b79da922-a604-4aa7-96c2-496cfa95f60c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SaleOfStockConsiderationReceivedOnTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PreferredUnitsLineItems_391473cf-8b61-4102-9ec8-9e0ddc0a1199" xlink:to="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_b79da922-a604-4aa7-96c2-496cfa95f60c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_e06607b8-c8ed-4044-86ee-e671bb8b196d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SaleOfStockPricePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PreferredUnitsLineItems_391473cf-8b61-4102-9ec8-9e0ddc0a1199" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_e06607b8-c8ed-4044-86ee-e671bb8b196d" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_SaleOfStockConvertedPricePerShare_33d1c9c3-c136-4877-84af-2a836ea55ffd" xlink:href="rxrx-20211231.xsd#rxrx_SaleOfStockConvertedPricePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PreferredUnitsLineItems_391473cf-8b61-4102-9ec8-9e0ddc0a1199" xlink:to="loc_rxrx_SaleOfStockConvertedPricePerShare_33d1c9c3-c136-4877-84af-2a836ea55ffd" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPreferredUnitsTable_0ff4c6dd-76fc-4489-8beb-25ee2efd6aa9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfPreferredUnitsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PreferredUnitsLineItems_391473cf-8b61-4102-9ec8-9e0ddc0a1199" xlink:to="loc_us-gaap_ScheduleOfPreferredUnitsTable_0ff4c6dd-76fc-4489-8beb-25ee2efd6aa9" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_7ff98e8c-1dc0-446c-a2ca-97d030883b3e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPreferredUnitsTable_0ff4c6dd-76fc-4489-8beb-25ee2efd6aa9" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_7ff98e8c-1dc0-446c-a2ca-97d030883b3e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_7ff98e8c-1dc0-446c-a2ca-97d030883b3e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_7ff98e8c-1dc0-446c-a2ca-97d030883b3e" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_7ff98e8c-1dc0-446c-a2ca-97d030883b3e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_b0f893fa-2ebf-4d28-9e2e-9f44501ed102" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_7ff98e8c-1dc0-446c-a2ca-97d030883b3e" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_b0f893fa-2ebf-4d28-9e2e-9f44501ed102" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IPOMember_74c3ccd5-1bc6-4f28-9d99-3952963308d3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IPOMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_b0f893fa-2ebf-4d28-9e2e-9f44501ed102" xlink:to="loc_us-gaap_IPOMember_74c3ccd5-1bc6-4f28-9d99-3952963308d3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_5f835b23-e261-4ca7-bfaf-fcd1348b22e6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPreferredUnitsTable_0ff4c6dd-76fc-4489-8beb-25ee2efd6aa9" xlink:to="loc_us-gaap_StatementClassOfStockAxis_5f835b23-e261-4ca7-bfaf-fcd1348b22e6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_5f835b23-e261-4ca7-bfaf-fcd1348b22e6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_5f835b23-e261-4ca7-bfaf-fcd1348b22e6" xlink:to="loc_us-gaap_ClassOfStockDomain_5f835b23-e261-4ca7-bfaf-fcd1348b22e6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_e2fb6591-ebbc-454c-be25-8f9618f17e10" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_5f835b23-e261-4ca7-bfaf-fcd1348b22e6" xlink:to="loc_us-gaap_ClassOfStockDomain_e2fb6591-ebbc-454c-be25-8f9618f17e10" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ConvertibleSeriesDPreferredStockMember_583d437a-d2ff-43f4-86be-ba3a7f2c569b" xlink:href="rxrx-20211231.xsd#rxrx_ConvertibleSeriesDPreferredStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_e2fb6591-ebbc-454c-be25-8f9618f17e10" xlink:to="loc_rxrx_ConvertibleSeriesDPreferredStockMember_583d437a-d2ff-43f4-86be-ba3a7f2c569b" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/ConvertiblePreferredStockSummaryDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#ConvertiblePreferredStockSummaryDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/ConvertiblePreferredStockSummaryDetails" xlink:type="extended" id="i3607655a8f234046940533c840747509_ConvertiblePreferredStockSummaryDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredUnitsLineItems_4e2e3ceb-c8c4-4cad-a7e3-38328f54aed4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredUnitsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquitySharesAuthorized_1f1454e2-1bd5-483e-a075-85d9009de177" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TemporaryEquitySharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PreferredUnitsLineItems_4e2e3ceb-c8c4-4cad-a7e3-38328f54aed4" xlink:to="loc_us-gaap_TemporaryEquitySharesAuthorized_1f1454e2-1bd5-483e-a075-85d9009de177" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquitySharesIssued_e586922b-0cf8-4d50-8274-596940988762" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TemporaryEquitySharesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PreferredUnitsLineItems_4e2e3ceb-c8c4-4cad-a7e3-38328f54aed4" xlink:to="loc_us-gaap_TemporaryEquitySharesIssued_e586922b-0cf8-4d50-8274-596940988762" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquitySharesOutstanding_546b0504-7709-4b68-9a02-0b2ee21d2fc0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TemporaryEquitySharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PreferredUnitsLineItems_4e2e3ceb-c8c4-4cad-a7e3-38328f54aed4" xlink:to="loc_us-gaap_TemporaryEquitySharesOutstanding_546b0504-7709-4b68-9a02-0b2ee21d2fc0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquityCarryingAmountAttributableToParent_3bfef6aa-f372-4293-b5a7-d99cdb9c0976" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TemporaryEquityCarryingAmountAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PreferredUnitsLineItems_4e2e3ceb-c8c4-4cad-a7e3-38328f54aed4" xlink:to="loc_us-gaap_TemporaryEquityCarryingAmountAttributableToParent_3bfef6aa-f372-4293-b5a7-d99cdb9c0976" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquityLiquidationPreference_f1a74f24-b5df-4b37-a6b9-3e8920c3bfa6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TemporaryEquityLiquidationPreference"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PreferredUnitsLineItems_4e2e3ceb-c8c4-4cad-a7e3-38328f54aed4" xlink:to="loc_us-gaap_TemporaryEquityLiquidationPreference_f1a74f24-b5df-4b37-a6b9-3e8920c3bfa6" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquitySharesSubscribedButUnissued_2150516e-b59b-42d0-a3d5-ed1688ac15fa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TemporaryEquitySharesSubscribedButUnissued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PreferredUnitsLineItems_4e2e3ceb-c8c4-4cad-a7e3-38328f54aed4" xlink:to="loc_us-gaap_TemporaryEquitySharesSubscribedButUnissued_2150516e-b59b-42d0-a3d5-ed1688ac15fa" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPreferredUnitsTable_9b3b00bc-98fb-4d4c-82dc-0c9b8779ff62" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfPreferredUnitsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PreferredUnitsLineItems_4e2e3ceb-c8c4-4cad-a7e3-38328f54aed4" xlink:to="loc_us-gaap_ScheduleOfPreferredUnitsTable_9b3b00bc-98fb-4d4c-82dc-0c9b8779ff62" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_97ee7eb7-707e-444d-adb8-e555595f7c83" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPreferredUnitsTable_9b3b00bc-98fb-4d4c-82dc-0c9b8779ff62" xlink:to="loc_us-gaap_StatementClassOfStockAxis_97ee7eb7-707e-444d-adb8-e555595f7c83" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_97ee7eb7-707e-444d-adb8-e555595f7c83_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_97ee7eb7-707e-444d-adb8-e555595f7c83" xlink:to="loc_us-gaap_ClassOfStockDomain_97ee7eb7-707e-444d-adb8-e555595f7c83_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_c871d2b6-5da4-485d-b2d3-3458e31125c6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_97ee7eb7-707e-444d-adb8-e555595f7c83" xlink:to="loc_us-gaap_ClassOfStockDomain_c871d2b6-5da4-485d-b2d3-3458e31125c6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ConvertibleSeriesAPreferredStockMember_823916df-8150-45e3-9f5a-e65fa8917441" xlink:href="rxrx-20211231.xsd#rxrx_ConvertibleSeriesAPreferredStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_c871d2b6-5da4-485d-b2d3-3458e31125c6" xlink:to="loc_rxrx_ConvertibleSeriesAPreferredStockMember_823916df-8150-45e3-9f5a-e65fa8917441" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ConvertibleSeriesA1PreferredStockMember_91304b6b-a4f7-4996-9a06-309029d94236" xlink:href="rxrx-20211231.xsd#rxrx_ConvertibleSeriesA1PreferredStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_c871d2b6-5da4-485d-b2d3-3458e31125c6" xlink:to="loc_rxrx_ConvertibleSeriesA1PreferredStockMember_91304b6b-a4f7-4996-9a06-309029d94236" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ConvertibleSeriesBPreferredStockMember_a686d77a-145c-4489-869e-f92ad9ae6e3b" xlink:href="rxrx-20211231.xsd#rxrx_ConvertibleSeriesBPreferredStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_c871d2b6-5da4-485d-b2d3-3458e31125c6" xlink:to="loc_rxrx_ConvertibleSeriesBPreferredStockMember_a686d77a-145c-4489-869e-f92ad9ae6e3b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ConvertibleSeriesCPreferredStockMember_57181fd2-7fe1-47cf-bf36-699477973a00" xlink:href="rxrx-20211231.xsd#rxrx_ConvertibleSeriesCPreferredStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_c871d2b6-5da4-485d-b2d3-3458e31125c6" xlink:to="loc_rxrx_ConvertibleSeriesCPreferredStockMember_57181fd2-7fe1-47cf-bf36-699477973a00" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ConvertibleSeriesDPreferredStockMember_bba63a4c-ea04-4171-a1fa-02274921118e" xlink:href="rxrx-20211231.xsd#rxrx_ConvertibleSeriesDPreferredStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_c871d2b6-5da4-485d-b2d3-3458e31125c6" xlink:to="loc_rxrx_ConvertibleSeriesDPreferredStockMember_bba63a4c-ea04-4171-a1fa-02274921118e" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/CommonStockNarrativeDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#CommonStockNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/CommonStockNarrativeDetails" xlink:type="extended" id="if37b7a3075bc4bcab7693001acea7140_CommonStockNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_dc309020-1d94-4574-ac5c-312d6ea99238" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_CommonStockVotePerShare_fd292a19-955b-427c-81d1-db20de5c02a9" xlink:href="rxrx-20211231.xsd#rxrx_CommonStockVotePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_dc309020-1d94-4574-ac5c-312d6ea99238" xlink:to="loc_rxrx_CommonStockVotePerShare_fd292a19-955b-427c-81d1-db20de5c02a9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_08261e71-48b5-4a31-9782-92e5c5d1d933" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_dc309020-1d94-4574-ac5c-312d6ea99238" xlink:to="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_08261e71-48b5-4a31-9782-92e5c5d1d933" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_0b97ac69-e3b5-444f-bc9f-b13d8c163265" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SaleOfStockPricePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_dc309020-1d94-4574-ac5c-312d6ea99238" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_0b97ac69-e3b5-444f-bc9f-b13d8c163265" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_c11e90f5-9cd4-41c1-b107-0b4be38c7e37" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SaleOfStockConsiderationReceivedOnTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_dc309020-1d94-4574-ac5c-312d6ea99238" xlink:to="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_c11e90f5-9cd4-41c1-b107-0b4be38c7e37" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfStockIssuanceCosts_8cd4386d-c1ad-4d79-820b-0210313a6357" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfStockIssuanceCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_dc309020-1d94-4574-ac5c-312d6ea99238" xlink:to="loc_us-gaap_PaymentsOfStockIssuanceCosts_8cd4386d-c1ad-4d79-820b-0210313a6357" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_PaymentsOfStockIssuanceExpenses_0552f8f4-da93-45ee-b98a-bf3abded61cb" xlink:href="rxrx-20211231.xsd#rxrx_PaymentsOfStockIssuanceExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_dc309020-1d94-4574-ac5c-312d6ea99238" xlink:to="loc_rxrx_PaymentsOfStockIssuanceExpenses_0552f8f4-da93-45ee-b98a-bf3abded61cb" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_bb84bf4f-adc4-411e-b374-4e2160b522b6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_dc309020-1d94-4574-ac5c-312d6ea99238" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_bb84bf4f-adc4-411e-b374-4e2160b522b6" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteStockSplitConversionRatio1_cfcd60e1-fae1-4be4-8919-0be2c8becd92" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityNoteStockSplitConversionRatio1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_dc309020-1d94-4574-ac5c-312d6ea99238" xlink:to="loc_us-gaap_StockholdersEquityNoteStockSplitConversionRatio1_cfcd60e1-fae1-4be4-8919-0be2c8becd92" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_AffiliatedHoldersOwnershipPercentage_2bb22e73-f865-489c-8c7e-2f965db94e28" xlink:href="rxrx-20211231.xsd#rxrx_AffiliatedHoldersOwnershipPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_dc309020-1d94-4574-ac5c-312d6ea99238" xlink:to="loc_rxrx_AffiliatedHoldersOwnershipPercentage_2bb22e73-f865-489c-8c7e-2f965db94e28" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_AffiliatedHoldersPotentialOwnershipPercentageWhenOutstandingEquityAwardsVest_d83b38d6-ccb0-4365-913b-c9040b332b43" xlink:href="rxrx-20211231.xsd#rxrx_AffiliatedHoldersPotentialOwnershipPercentageWhenOutstandingEquityAwardsVest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_dc309020-1d94-4574-ac5c-312d6ea99238" xlink:to="loc_rxrx_AffiliatedHoldersPotentialOwnershipPercentageWhenOutstandingEquityAwardsVest_d83b38d6-ccb0-4365-913b-c9040b332b43" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_1e6207ac-cc33-457e-83c1-bcad52015e6c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_dc309020-1d94-4574-ac5c-312d6ea99238" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_1e6207ac-cc33-457e-83c1-bcad52015e6c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_619e55be-ef2e-4273-bedf-5b6ee119cfd3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_1e6207ac-cc33-457e-83c1-bcad52015e6c" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_619e55be-ef2e-4273-bedf-5b6ee119cfd3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_619e55be-ef2e-4273-bedf-5b6ee119cfd3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_619e55be-ef2e-4273-bedf-5b6ee119cfd3" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_619e55be-ef2e-4273-bedf-5b6ee119cfd3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_e5a578e9-e38b-47cd-bd73-b4b96e06ccba" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_619e55be-ef2e-4273-bedf-5b6ee119cfd3" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_e5a578e9-e38b-47cd-bd73-b4b96e06ccba" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IPOMember_1a029de7-6efd-4fe5-a2e8-e3d2d5ec1790" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IPOMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_e5a578e9-e38b-47cd-bd73-b4b96e06ccba" xlink:to="loc_us-gaap_IPOMember_1a029de7-6efd-4fe5-a2e8-e3d2d5ec1790" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_a0a12b92-29cd-491c-aa8c-26bef1b95719" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_1e6207ac-cc33-457e-83c1-bcad52015e6c" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_a0a12b92-29cd-491c-aa8c-26bef1b95719" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_a0a12b92-29cd-491c-aa8c-26bef1b95719_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_a0a12b92-29cd-491c-aa8c-26bef1b95719" xlink:to="loc_us-gaap_RelatedPartyDomain_a0a12b92-29cd-491c-aa8c-26bef1b95719_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_eaa5bb7d-265c-423c-97aa-c59700acdab3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_a0a12b92-29cd-491c-aa8c-26bef1b95719" xlink:to="loc_us-gaap_RelatedPartyDomain_eaa5bb7d-265c-423c-97aa-c59700acdab3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ChristopherGibsonAndAffiliatesMember_f4d5c08a-5596-40de-b1f4-f4dfce4408d3" xlink:href="rxrx-20211231.xsd#rxrx_ChristopherGibsonAndAffiliatesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_eaa5bb7d-265c-423c-97aa-c59700acdab3" xlink:to="loc_rxrx_ChristopherGibsonAndAffiliatesMember_f4d5c08a-5596-40de-b1f4-f4dfce4408d3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_c40ce82b-55f1-4b06-a62b-5c652306e896" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_1e6207ac-cc33-457e-83c1-bcad52015e6c" xlink:to="loc_us-gaap_StatementClassOfStockAxis_c40ce82b-55f1-4b06-a62b-5c652306e896" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_c40ce82b-55f1-4b06-a62b-5c652306e896_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_c40ce82b-55f1-4b06-a62b-5c652306e896" xlink:to="loc_us-gaap_ClassOfStockDomain_c40ce82b-55f1-4b06-a62b-5c652306e896_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_97cbabc0-3626-46ab-926d-0e293f9cac8a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_c40ce82b-55f1-4b06-a62b-5c652306e896" xlink:to="loc_us-gaap_ClassOfStockDomain_97cbabc0-3626-46ab-926d-0e293f9cac8a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_3a14124c-5ad8-4a14-b1cf-4d0ab88287bd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_97cbabc0-3626-46ab-926d-0e293f9cac8a" xlink:to="loc_us-gaap_CommonClassAMember_3a14124c-5ad8-4a14-b1cf-4d0ab88287bd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_f8ef536a-5a23-4e9f-b04c-585113db09bd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonClassBMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_97cbabc0-3626-46ab-926d-0e293f9cac8a" xlink:to="loc_us-gaap_CommonClassBMember_f8ef536a-5a23-4e9f-b04c-585113db09bd" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/CollaborativeDevelopmentContractsBayerAGDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#CollaborativeDevelopmentContractsBayerAGDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/CollaborativeDevelopmentContractsBayerAGDetails" xlink:type="extended" id="i4bf81842cac340f7a43b6549eebc0864_CollaborativeDevelopmentContractsBayerAGDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_ed7026e1-ad75-4a78-9430-7f02e8d65e5f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_CollaborativeAgreementTerm_76e29663-e567-416f-a593-a5b4d29e0214" xlink:href="rxrx-20211231.xsd#rxrx_CollaborativeAgreementTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_ed7026e1-ad75-4a78-9430-7f02e8d65e5f" xlink:to="loc_rxrx_CollaborativeAgreementTerm_76e29663-e567-416f-a593-a5b4d29e0214" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_RevenueRemainingPerformanceObligationNumberOfProjectsThatMayBeInitiated_57f68c97-db5f-416a-b105-f6c9c1985708" xlink:href="rxrx-20211231.xsd#rxrx_RevenueRemainingPerformanceObligationNumberOfProjectsThatMayBeInitiated"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_ed7026e1-ad75-4a78-9430-7f02e8d65e5f" xlink:to="loc_rxrx_RevenueRemainingPerformanceObligationNumberOfProjectsThatMayBeInitiated_57f68c97-db5f-416a-b105-f6c9c1985708" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_RevenueRemainingPerformanceObligationVariableConsiderationAmount_75c81cd5-0ba5-429d-a856-06844f1d6330" xlink:href="rxrx-20211231.xsd#rxrx_RevenueRemainingPerformanceObligationVariableConsiderationAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_ed7026e1-ad75-4a78-9430-7f02e8d65e5f" xlink:to="loc_rxrx_RevenueRemainingPerformanceObligationVariableConsiderationAmount_75c81cd5-0ba5-429d-a856-06844f1d6330" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_CollaborativeAgreementResearchProjectMaximumFeesAndMilestonesPaymentsReceivableForAnOptionOnADevelopmentCandidate_5f45b11d-487e-4fb0-81dd-cc8a9dafabc4" xlink:href="rxrx-20211231.xsd#rxrx_CollaborativeAgreementResearchProjectMaximumFeesAndMilestonesPaymentsReceivableForAnOptionOnADevelopmentCandidate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_ed7026e1-ad75-4a78-9430-7f02e8d65e5f" xlink:to="loc_rxrx_CollaborativeAgreementResearchProjectMaximumFeesAndMilestonesPaymentsReceivableForAnOptionOnADevelopmentCandidate_5f45b11d-487e-4fb0-81dd-cc8a9dafabc4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_CollaborativeAgreementNonRefundableUpfrontPaymentReceived_e5cd3107-5721-4358-89aa-c5ed295841d2" xlink:href="rxrx-20211231.xsd#rxrx_CollaborativeAgreementNonRefundableUpfrontPaymentReceived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_ed7026e1-ad75-4a78-9430-7f02e8d65e5f" xlink:to="loc_rxrx_CollaborativeAgreementNonRefundableUpfrontPaymentReceived_e5cd3107-5721-4358-89aa-c5ed295841d2" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_6a6a1c05-7afc-4574-a3bd-fda8efbe1e1e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_ed7026e1-ad75-4a78-9430-7f02e8d65e5f" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_6a6a1c05-7afc-4574-a3bd-fda8efbe1e1e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_bb75b298-5fcb-45dc-9c03-2df534ae3487" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_ed7026e1-ad75-4a78-9430-7f02e8d65e5f" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_bb75b298-5fcb-45dc-9c03-2df534ae3487" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_4f24b3cd-105a-4d7e-96bf-f0e666c07d78" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_ed7026e1-ad75-4a78-9430-7f02e8d65e5f" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_4f24b3cd-105a-4d7e-96bf-f0e666c07d78" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_1dcaafe5-f58d-4fa7-a35b-763c7072d4a4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_ed7026e1-ad75-4a78-9430-7f02e8d65e5f" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_1dcaafe5-f58d-4fa7-a35b-763c7072d4a4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_0aa56cd1-1e6c-43cc-beb9-ea42136b0882" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_1dcaafe5-f58d-4fa7-a35b-763c7072d4a4" xlink:to="loc_srt_CounterpartyNameAxis_0aa56cd1-1e6c-43cc-beb9-ea42136b0882" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_0aa56cd1-1e6c-43cc-beb9-ea42136b0882_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_0aa56cd1-1e6c-43cc-beb9-ea42136b0882" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_0aa56cd1-1e6c-43cc-beb9-ea42136b0882_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_b962c2a9-09b2-454d-9638-ef73aca1cd91" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_0aa56cd1-1e6c-43cc-beb9-ea42136b0882" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_b962c2a9-09b2-454d-9638-ef73aca1cd91" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_BayerAGMember_6b5e8350-435f-4457-a3c7-6d622d94d288" xlink:href="rxrx-20211231.xsd#rxrx_BayerAGMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_b962c2a9-09b2-454d-9638-ef73aca1cd91" xlink:to="loc_rxrx_BayerAGMember_6b5e8350-435f-4457-a3c7-6d622d94d288" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_TakedaPharmaceuticalCompanyMember_2dc73004-b7f2-4543-bbe6-9b909c042e04" xlink:href="rxrx-20211231.xsd#rxrx_TakedaPharmaceuticalCompanyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_b962c2a9-09b2-454d-9638-ef73aca1cd91" xlink:to="loc_rxrx_TakedaPharmaceuticalCompanyMember_2dc73004-b7f2-4543-bbe6-9b909c042e04" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_99edb0fd-910e-41ab-b0e9-3f9db764533b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_1dcaafe5-f58d-4fa7-a35b-763c7072d4a4" xlink:to="loc_us-gaap_TypeOfArrangementAxis_99edb0fd-910e-41ab-b0e9-3f9db764533b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_99edb0fd-910e-41ab-b0e9-3f9db764533b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_99edb0fd-910e-41ab-b0e9-3f9db764533b" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_99edb0fd-910e-41ab-b0e9-3f9db764533b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_8f416d83-27a8-42b8-82b5-738206c625a9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_99edb0fd-910e-41ab-b0e9-3f9db764533b" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_8f416d83-27a8-42b8-82b5-738206c625a9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementMember_4e43a015-b803-4021-b0d4-a708011f81ae" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CollaborativeArrangementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_8f416d83-27a8-42b8-82b5-738206c625a9" xlink:to="loc_us-gaap_CollaborativeArrangementMember_4e43a015-b803-4021-b0d4-a708011f81ae" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/StockBasedCompensationNarrativeDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#StockBasedCompensationNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/StockBasedCompensationNarrativeDetails" xlink:type="extended" id="ie7a0976a4cba430d89c72de79083d628_StockBasedCompensationNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b2b9e186-e4f0-4cc4-89e7-ab23f65f8aeb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_343dea92-32cb-478f-a755-9a01a80b2bf0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockCapitalSharesReservedForFutureIssuance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b2b9e186-e4f0-4cc4-89e7-ab23f65f8aeb" xlink:to="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_343dea92-32cb-478f-a755-9a01a80b2bf0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_e8ae604d-ff93-4080-8a21-564a5a9d1321" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b2b9e186-e4f0-4cc4-89e7-ab23f65f8aeb" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_e8ae604d-ff93-4080-8a21-564a5a9d1321" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_07781ddf-1249-4864-bb6c-930fa89d7d41" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b2b9e186-e4f0-4cc4-89e7-ab23f65f8aeb" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_07781ddf-1249-4864-bb6c-930fa89d7d41" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_ea8ee64e-8314-4194-9ed0-ef27c4f6a582" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b2b9e186-e4f0-4cc4-89e7-ab23f65f8aeb" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_ea8ee64e-8314-4194-9ed0-ef27c4f6a582" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_40280ae9-1d02-45e1-820c-3d1459e1b563" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b2b9e186-e4f0-4cc4-89e7-ab23f65f8aeb" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_40280ae9-1d02-45e1-820c-3d1459e1b563" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_8dc8f318-aff2-444e-b4d4-f9aa2aec6e66" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b2b9e186-e4f0-4cc4-89e7-ab23f65f8aeb" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_8dc8f318-aff2-444e-b4d4-f9aa2aec6e66" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodFairValue_cff6d9af-e659-4108-a531-68f824b961a8" xlink:href="rxrx-20211231.xsd#rxrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b2b9e186-e4f0-4cc4-89e7-ab23f65f8aeb" xlink:to="loc_rxrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodFairValue_cff6d9af-e659-4108-a531-68f824b961a8" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_f297681c-3a58-42ca-b7bc-22fd839ddaf7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b2b9e186-e4f0-4cc4-89e7-ab23f65f8aeb" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_f297681c-3a58-42ca-b7bc-22fd839ddaf7" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_4becd94c-3e13-4026-af6d-1b1888bda801" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b2b9e186-e4f0-4cc4-89e7-ab23f65f8aeb" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_4becd94c-3e13-4026-af6d-1b1888bda801" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodTotalFairValue_ef146ff7-be23-4ca3-b270-cf6c8f53b88d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodTotalFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b2b9e186-e4f0-4cc4-89e7-ab23f65f8aeb" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodTotalFairValue_ef146ff7-be23-4ca3-b270-cf6c8f53b88d" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_4def8b46-3a30-4d1a-8620-dbe6a3163ce2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b2b9e186-e4f0-4cc4-89e7-ab23f65f8aeb" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_4def8b46-3a30-4d1a-8620-dbe6a3163ce2" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions_44f5fb10-c335-46bb-b380-ddc442228116" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b2b9e186-e4f0-4cc4-89e7-ab23f65f8aeb" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions_44f5fb10-c335-46bb-b380-ddc442228116" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardPurchasePeriod_56471f8e-986d-4838-be50-421c99d9ca22" xlink:href="rxrx-20211231.xsd#rxrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardPurchasePeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b2b9e186-e4f0-4cc4-89e7-ab23f65f8aeb" xlink:to="loc_rxrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardPurchasePeriod_56471f8e-986d-4838-be50-421c99d9ca22" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent_6e27b8b6-7fe3-422d-bb2d-365f6c296873" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b2b9e186-e4f0-4cc4-89e7-ab23f65f8aeb" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent_6e27b8b6-7fe3-422d-bb2d-365f6c296873" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_c96a1d23-fef7-4c70-8584-c626160055dc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b2b9e186-e4f0-4cc4-89e7-ab23f65f8aeb" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_c96a1d23-fef7-4c70-8584-c626160055dc" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_4c418a79-3895-4516-8733-f063ad3bc06c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b2b9e186-e4f0-4cc4-89e7-ab23f65f8aeb" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_4c418a79-3895-4516-8733-f063ad3bc06c" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_23acc15f-1f93-44ce-a933-4e1cc7daf118" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b2b9e186-e4f0-4cc4-89e7-ab23f65f8aeb" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_23acc15f-1f93-44ce-a933-4e1cc7daf118" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_45ac568a-c8d4-4ccb-bf2e-6818dbea3032" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_23acc15f-1f93-44ce-a933-4e1cc7daf118" xlink:to="loc_us-gaap_PlanNameAxis_45ac568a-c8d4-4ccb-bf2e-6818dbea3032" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_45ac568a-c8d4-4ccb-bf2e-6818dbea3032_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_45ac568a-c8d4-4ccb-bf2e-6818dbea3032" xlink:to="loc_us-gaap_PlanNameDomain_45ac568a-c8d4-4ccb-bf2e-6818dbea3032_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_94e90266-bded-4306-a616-09eb92d06d7a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_45ac568a-c8d4-4ccb-bf2e-6818dbea3032" xlink:to="loc_us-gaap_PlanNameDomain_94e90266-bded-4306-a616-09eb92d06d7a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_A2021EquityIncentivePlanMember_fd0ad242-bbc0-4e52-8957-0cf18c83feae" xlink:href="rxrx-20211231.xsd#rxrx_A2021EquityIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_94e90266-bded-4306-a616-09eb92d06d7a" xlink:to="loc_rxrx_A2021EquityIncentivePlanMember_fd0ad242-bbc0-4e52-8957-0cf18c83feae" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_A2021EmployeeStockPurchasePlanMember_e46e498d-6ac9-494c-b76a-b8261303f8a5" xlink:href="rxrx-20211231.xsd#rxrx_A2021EmployeeStockPurchasePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_94e90266-bded-4306-a616-09eb92d06d7a" xlink:to="loc_rxrx_A2021EmployeeStockPurchasePlanMember_e46e498d-6ac9-494c-b76a-b8261303f8a5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_53f8718c-f37d-4424-adf2-0c8556b488f8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_23acc15f-1f93-44ce-a933-4e1cc7daf118" xlink:to="loc_us-gaap_AwardTypeAxis_53f8718c-f37d-4424-adf2-0c8556b488f8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_53f8718c-f37d-4424-adf2-0c8556b488f8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_53f8718c-f37d-4424-adf2-0c8556b488f8" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_53f8718c-f37d-4424-adf2-0c8556b488f8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_cc46be4a-58a2-4d6f-a824-e805849e04e5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_53f8718c-f37d-4424-adf2-0c8556b488f8" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_cc46be4a-58a2-4d6f-a824-e805849e04e5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PerformanceSharesMember_b8cf3c44-f4b5-4405-8d35-9a6c0f6ed168" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PerformanceSharesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_cc46be4a-58a2-4d6f-a824-e805849e04e5" xlink:to="loc_us-gaap_PerformanceSharesMember_b8cf3c44-f4b5-4405-8d35-9a6c0f6ed168" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockMember_64fac255-eff9-4c21-9e23-18ee00c5677d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_cc46be4a-58a2-4d6f-a824-e805849e04e5" xlink:to="loc_us-gaap_RestrictedStockMember_64fac255-eff9-4c21-9e23-18ee00c5677d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_82d6e95d-b6f6-4b30-a65c-68341329ea20" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_cc46be4a-58a2-4d6f-a824-e805849e04e5" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_82d6e95d-b6f6-4b30-a65c-68341329ea20" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockMember_0df6e81f-a927-4bc7-b861-bdac948e07ab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_cc46be4a-58a2-4d6f-a824-e805849e04e5" xlink:to="loc_us-gaap_EmployeeStockMember_0df6e81f-a927-4bc7-b861-bdac948e07ab" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GranteeStatusAxis_af7edd81-78ad-4f38-a299-5666b2729e6d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GranteeStatusAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_23acc15f-1f93-44ce-a933-4e1cc7daf118" xlink:to="loc_us-gaap_GranteeStatusAxis_af7edd81-78ad-4f38-a299-5666b2729e6d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GranteeStatusDomain_af7edd81-78ad-4f38-a299-5666b2729e6d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GranteeStatusDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_GranteeStatusAxis_af7edd81-78ad-4f38-a299-5666b2729e6d" xlink:to="loc_us-gaap_GranteeStatusDomain_af7edd81-78ad-4f38-a299-5666b2729e6d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GranteeStatusDomain_0d245dee-b987-47c3-ad02-bc405e3946c9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GranteeStatusDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_GranteeStatusAxis_af7edd81-78ad-4f38-a299-5666b2729e6d" xlink:to="loc_us-gaap_GranteeStatusDomain_0d245dee-b987-47c3-ad02-bc405e3946c9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedPaymentArrangementEmployeeMember_78d0ded8-7d4d-41e4-b5dd-d88822b455bc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedPaymentArrangementEmployeeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GranteeStatusDomain_0d245dee-b987-47c3-ad02-bc405e3946c9" xlink:to="loc_us-gaap_ShareBasedPaymentArrangementEmployeeMember_78d0ded8-7d4d-41e4-b5dd-d88822b455bc" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/StockBasedCompensationSummaryofStockbasedCompensationExpensesDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#StockBasedCompensationSummaryofStockbasedCompensationExpensesDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/StockBasedCompensationSummaryofStockbasedCompensationExpensesDetails" xlink:type="extended" id="ief0b323d73fb4da99b8af199c484e70c_StockBasedCompensationSummaryofStockbasedCompensationExpensesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_9cdfe809-6bf7-43ac-8187-7c6462f8e8c6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_11d57807-dd7f-4ec6-851f-d39c420e0c9f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_9cdfe809-6bf7-43ac-8187-7c6462f8e8c6" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_11d57807-dd7f-4ec6-851f-d39c420e0c9f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_c8fddfe4-3101-4a53-b740-6339c205c681" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_9cdfe809-6bf7-43ac-8187-7c6462f8e8c6" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_c8fddfe4-3101-4a53-b740-6339c205c681" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_589984d4-7b76-49ce-916a-a38fce73154f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_c8fddfe4-3101-4a53-b740-6339c205c681" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_589984d4-7b76-49ce-916a-a38fce73154f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_589984d4-7b76-49ce-916a-a38fce73154f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_589984d4-7b76-49ce-916a-a38fce73154f" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_589984d4-7b76-49ce-916a-a38fce73154f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_abeb7231-22be-41e3-9667-f5837677d0f9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_589984d4-7b76-49ce-916a-a38fce73154f" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_abeb7231-22be-41e3-9667-f5837677d0f9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_587f3226-f04b-4e10-811a-423cfdec867c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_abeb7231-22be-41e3-9667-f5837677d0f9" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_587f3226-f04b-4e10-811a-423cfdec867c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpenseMember_109f541d-0422-4c19-ab32-3e3276e20039" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GeneralAndAdministrativeExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_abeb7231-22be-41e3-9667-f5837677d0f9" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpenseMember_109f541d-0422-4c19-ab32-3e3276e20039" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/StockBasedCompensationScheduleofSharebasedPaymentAwardStockOptionsValuationAssumptionDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#StockBasedCompensationScheduleofSharebasedPaymentAwardStockOptionsValuationAssumptionDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/StockBasedCompensationScheduleofSharebasedPaymentAwardStockOptionsValuationAssumptionDetails" xlink:type="extended" id="if35ce48ad8624b7ba90ba5993935cc62_StockBasedCompensationScheduleofSharebasedPaymentAwardStockOptionsValuationAssumptionDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_026fceb3-90b4-4194-8f34-ba6c5a587665" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_7755e978-71f3-47a5-a71a-6589e0432982" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_026fceb3-90b4-4194-8f34-ba6c5a587665" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_7755e978-71f3-47a5-a71a-6589e0432982" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_87e81ac7-a7de-4bfd-8aa3-304ab13bf347" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_026fceb3-90b4-4194-8f34-ba6c5a587665" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_87e81ac7-a7de-4bfd-8aa3-304ab13bf347" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_b3f7bb1a-3f51-451b-b7dd-4a787888ff2a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_026fceb3-90b4-4194-8f34-ba6c5a587665" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_b3f7bb1a-3f51-451b-b7dd-4a787888ff2a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_68e09787-f71e-4bda-828b-58543743a135" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_026fceb3-90b4-4194-8f34-ba6c5a587665" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_68e09787-f71e-4bda-828b-58543743a135" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_360f4e3b-821b-4c4f-a463-6cc53a9209ea" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_026fceb3-90b4-4194-8f34-ba6c5a587665" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_360f4e3b-821b-4c4f-a463-6cc53a9209ea" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_1e5f9486-acb9-45a9-9451-97b6b7d5f1d4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_360f4e3b-821b-4c4f-a463-6cc53a9209ea" xlink:to="loc_us-gaap_AwardTypeAxis_1e5f9486-acb9-45a9-9451-97b6b7d5f1d4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_1e5f9486-acb9-45a9-9451-97b6b7d5f1d4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_1e5f9486-acb9-45a9-9451-97b6b7d5f1d4" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_1e5f9486-acb9-45a9-9451-97b6b7d5f1d4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_187e237e-1146-4656-a44b-f64658d62461" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_1e5f9486-acb9-45a9-9451-97b6b7d5f1d4" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_187e237e-1146-4656-a44b-f64658d62461" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_dc35d4be-f103-4c71-97ee-b5512bb272cb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_187e237e-1146-4656-a44b-f64658d62461" xlink:to="loc_us-gaap_EmployeeStockOptionMember_dc35d4be-f103-4c71-97ee-b5512bb272cb" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/StockBasedCompensationScheduleofRSUActivityDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#StockBasedCompensationScheduleofRSUActivityDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/StockBasedCompensationScheduleofRSUActivityDetails" xlink:type="extended" id="i073d2600991d4cb2a6795c3403900af9_StockBasedCompensationScheduleofRSUActivityDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ea045528-b4b9-4e85-b264-3316623e45b2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_9119514b-c504-462b-befd-de9425d1cfea" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ea045528-b4b9-4e85-b264-3316623e45b2" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_9119514b-c504-462b-befd-de9425d1cfea" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_288f55ec-3bde-478b-b659-ddc58e3a1070" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_9119514b-c504-462b-befd-de9425d1cfea" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_288f55ec-3bde-478b-b659-ddc58e3a1070" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_d4d70fb3-af6e-4359-b64a-59a73859faa2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_9119514b-c504-462b-befd-de9425d1cfea" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_d4d70fb3-af6e-4359-b64a-59a73859faa2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_76a02255-338c-43b1-ae30-61244ba9be11" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_9119514b-c504-462b-befd-de9425d1cfea" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_76a02255-338c-43b1-ae30-61244ba9be11" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_40501c26-bf20-43ff-9f7c-10cb6bbabe33" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_9119514b-c504-462b-befd-de9425d1cfea" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_40501c26-bf20-43ff-9f7c-10cb6bbabe33" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_f4805695-e89f-4907-acb9-56f28d141192" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_13c4dea1-ee87-4f9d-a6bf-b5ed90fd438c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ea045528-b4b9-4e85-b264-3316623e45b2" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_13c4dea1-ee87-4f9d-a6bf-b5ed90fd438c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_920c5dbf-7c83-4059-9c2d-76d56ad7abb7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_13c4dea1-ee87-4f9d-a6bf-b5ed90fd438c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_920c5dbf-7c83-4059-9c2d-76d56ad7abb7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_3bcb54da-f273-434f-9370-daf8dbc49f01" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_13c4dea1-ee87-4f9d-a6bf-b5ed90fd438c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_3bcb54da-f273-434f-9370-daf8dbc49f01" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_7d60d90c-f44e-4666-b795-b2cba49093fe" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_13c4dea1-ee87-4f9d-a6bf-b5ed90fd438c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_7d60d90c-f44e-4666-b795-b2cba49093fe" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_f55852c7-eef4-4f80-bd13-ee229c421d41" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_13c4dea1-ee87-4f9d-a6bf-b5ed90fd438c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_f55852c7-eef4-4f80-bd13-ee229c421d41" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_53166964-3424-4024-b08c-a49b79427331" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_fb02bf8c-222d-424b-87ec-50f02b881cec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ea045528-b4b9-4e85-b264-3316623e45b2" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_fb02bf8c-222d-424b-87ec-50f02b881cec" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_16cbe576-5998-499b-83c2-02c8f2585af1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_fb02bf8c-222d-424b-87ec-50f02b881cec" xlink:to="loc_us-gaap_AwardTypeAxis_16cbe576-5998-499b-83c2-02c8f2585af1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_16cbe576-5998-499b-83c2-02c8f2585af1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_16cbe576-5998-499b-83c2-02c8f2585af1" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_16cbe576-5998-499b-83c2-02c8f2585af1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_a62ee0d1-9cae-4316-8f14-ae47cdb94d67" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_16cbe576-5998-499b-83c2-02c8f2585af1" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_a62ee0d1-9cae-4316-8f14-ae47cdb94d67" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockMember_ca8e7e6f-2988-4705-9392-76b8064ef183" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_a62ee0d1-9cae-4316-8f14-ae47cdb94d67" xlink:to="loc_us-gaap_RestrictedStockMember_ca8e7e6f-2988-4705-9392-76b8064ef183" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/StockBasedCompensationScheduleofSharebasedPaymentAwardESPPValuationAssumptionsDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#StockBasedCompensationScheduleofSharebasedPaymentAwardESPPValuationAssumptionsDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/StockBasedCompensationScheduleofSharebasedPaymentAwardESPPValuationAssumptionsDetails" xlink:type="extended" id="ia5c741da53094a6ba65b1c9b368d825c_StockBasedCompensationScheduleofSharebasedPaymentAwardESPPValuationAssumptionsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_5a043aef-d974-4310-b19b-eb1d6ecbe349" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_28cc768d-86e4-4a8e-88e7-ad016f9a6dab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_5a043aef-d974-4310-b19b-eb1d6ecbe349" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_28cc768d-86e4-4a8e-88e7-ad016f9a6dab" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_da7d2d4b-5d5e-44e8-9ef3-cd6f75dd68f6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_5a043aef-d974-4310-b19b-eb1d6ecbe349" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_da7d2d4b-5d5e-44e8-9ef3-cd6f75dd68f6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_3810b450-6803-40fd-8152-2098670881f0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_5a043aef-d974-4310-b19b-eb1d6ecbe349" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_3810b450-6803-40fd-8152-2098670881f0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_e1272c0f-69e3-47fe-a3fa-27ad26e8511d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_5a043aef-d974-4310-b19b-eb1d6ecbe349" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_e1272c0f-69e3-47fe-a3fa-27ad26e8511d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_d23c4bd1-bb5c-4c4f-a96e-6554b2208691" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_5a043aef-d974-4310-b19b-eb1d6ecbe349" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_d23c4bd1-bb5c-4c4f-a96e-6554b2208691" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_d8b5f683-73e2-455c-9526-8d875561f1af" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_d23c4bd1-bb5c-4c4f-a96e-6554b2208691" xlink:to="loc_us-gaap_AwardTypeAxis_d8b5f683-73e2-455c-9526-8d875561f1af" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_d8b5f683-73e2-455c-9526-8d875561f1af_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_d8b5f683-73e2-455c-9526-8d875561f1af" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_d8b5f683-73e2-455c-9526-8d875561f1af_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_ce64f3c5-e1ed-4f75-a0a6-1fd988b1f1f3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_d8b5f683-73e2-455c-9526-8d875561f1af" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_ce64f3c5-e1ed-4f75-a0a6-1fd988b1f1f3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockMember_a63a8457-c37e-40f1-bd7e-bb9bd5fa541e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_ce64f3c5-e1ed-4f75-a0a6-1fd988b1f1f3" xlink:to="loc_us-gaap_EmployeeStockMember_a63a8457-c37e-40f1-bd7e-bb9bd5fa541e" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/StockBasedCompensationWarrantsDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#StockBasedCompensationWarrantsDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/StockBasedCompensationWarrantsDetails" xlink:type="extended" id="i8ce653f104444c93bb2dcb09bf28f16e_StockBasedCompensationWarrantsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_WarrantsArrangementsLineItems_64c4c563-e54b-47cf-9163-b7c2229bf97a" xlink:href="rxrx-20211231.xsd#rxrx_WarrantsArrangementsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightOutstanding_063b98fe-76de-4a03-8a94-940e997de446" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfWarrantOrRightOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_WarrantsArrangementsLineItems_64c4c563-e54b-47cf-9163-b7c2229bf97a" xlink:to="loc_us-gaap_ClassOfWarrantOrRightOutstanding_063b98fe-76de-4a03-8a94-940e997de446" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_e16b30de-bacd-42d1-98c7-10e170bf90e2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_WarrantsArrangementsLineItems_64c4c563-e54b-47cf-9163-b7c2229bf97a" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_e16b30de-bacd-42d1-98c7-10e170bf90e2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ClassOfWarrantOrRightIssued_71a8a4e4-0128-413b-95ec-a3ae8d002f9b" xlink:href="rxrx-20211231.xsd#rxrx_ClassOfWarrantOrRightIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_WarrantsArrangementsLineItems_64c4c563-e54b-47cf-9163-b7c2229bf97a" xlink:to="loc_rxrx_ClassOfWarrantOrRightIssued_71a8a4e4-0128-413b-95ec-a3ae8d002f9b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ClassOfWarrantOrRightGrantDateFairValue_d9c1877c-75fd-4335-88ed-f7c35f92cd1f" xlink:href="rxrx-20211231.xsd#rxrx_ClassOfWarrantOrRightGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_WarrantsArrangementsLineItems_64c4c563-e54b-47cf-9163-b7c2229bf97a" xlink:to="loc_rxrx_ClassOfWarrantOrRightGrantDateFairValue_d9c1877c-75fd-4335-88ed-f7c35f92cd1f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_WarrantsArrangementsTable_14bf6e1a-cd1f-460e-bf80-e85ba861b572" xlink:href="rxrx-20211231.xsd#rxrx_WarrantsArrangementsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_rxrx_WarrantsArrangementsLineItems_64c4c563-e54b-47cf-9163-b7c2229bf97a" xlink:to="loc_rxrx_WarrantsArrangementsTable_14bf6e1a-cd1f-460e-bf80-e85ba861b572" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_f7ab42c3-270c-4691-bd83-408a2de808e7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfWarrantOrRightAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_rxrx_WarrantsArrangementsTable_14bf6e1a-cd1f-460e-bf80-e85ba861b572" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_f7ab42c3-270c-4691-bd83-408a2de808e7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_f7ab42c3-270c-4691-bd83-408a2de808e7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_f7ab42c3-270c-4691-bd83-408a2de808e7" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_f7ab42c3-270c-4691-bd83-408a2de808e7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_ff0d7df0-2c5b-4dcf-bafe-05eae0b08a69" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_f7ab42c3-270c-4691-bd83-408a2de808e7" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_ff0d7df0-2c5b-4dcf-bafe-05eae0b08a69" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_A2016WarrantsMember_915a629e-3c79-40ef-9347-d0eb814bd90d" xlink:href="rxrx-20211231.xsd#rxrx_A2016WarrantsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_ff0d7df0-2c5b-4dcf-bafe-05eae0b08a69" xlink:to="loc_rxrx_A2016WarrantsMember_915a629e-3c79-40ef-9347-d0eb814bd90d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_A2017WarrantsMember_ea10037c-88cd-4c82-a72e-7a4dd82b39ab" xlink:href="rxrx-20211231.xsd#rxrx_A2017WarrantsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_ff0d7df0-2c5b-4dcf-bafe-05eae0b08a69" xlink:to="loc_rxrx_A2017WarrantsMember_ea10037c-88cd-4c82-a72e-7a4dd82b39ab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_A2018WarrantsMember_423d996a-79a6-4b72-aa1c-320e65d0f1cb" xlink:href="rxrx-20211231.xsd#rxrx_A2018WarrantsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_ff0d7df0-2c5b-4dcf-bafe-05eae0b08a69" xlink:to="loc_rxrx_A2018WarrantsMember_423d996a-79a6-4b72-aa1c-320e65d0f1cb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_WarrantsIssuedInJanuary2020Member_eee74a5b-2ab8-4338-bced-2c13e0a6a614" xlink:href="rxrx-20211231.xsd#rxrx_WarrantsIssuedInJanuary2020Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_ff0d7df0-2c5b-4dcf-bafe-05eae0b08a69" xlink:to="loc_rxrx_WarrantsIssuedInJanuary2020Member_eee74a5b-2ab8-4338-bced-2c13e0a6a614" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_903fa1ce-bc5e-41f2-93d7-f2ad3d959cab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_rxrx_WarrantsArrangementsTable_14bf6e1a-cd1f-460e-bf80-e85ba861b572" xlink:to="loc_us-gaap_StatementClassOfStockAxis_903fa1ce-bc5e-41f2-93d7-f2ad3d959cab" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_903fa1ce-bc5e-41f2-93d7-f2ad3d959cab_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_903fa1ce-bc5e-41f2-93d7-f2ad3d959cab" xlink:to="loc_us-gaap_ClassOfStockDomain_903fa1ce-bc5e-41f2-93d7-f2ad3d959cab_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_2e5b3209-39eb-4a70-85fe-d814b20d8128" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_903fa1ce-bc5e-41f2-93d7-f2ad3d959cab" xlink:to="loc_us-gaap_ClassOfStockDomain_2e5b3209-39eb-4a70-85fe-d814b20d8128" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ConvertibleSeriesCPreferredStockMember_af9c3c26-8b54-4927-bcae-c680a95c544c" xlink:href="rxrx-20211231.xsd#rxrx_ConvertibleSeriesCPreferredStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_2e5b3209-39eb-4a70-85fe-d814b20d8128" xlink:to="loc_rxrx_ConvertibleSeriesCPreferredStockMember_af9c3c26-8b54-4927-bcae-c680a95c544c" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/StockBasedCompensationSummaryOfChangesInCompanysWarrantLiabilityDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#StockBasedCompensationSummaryOfChangesInCompanysWarrantLiabilityDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/StockBasedCompensationSummaryOfChangesInCompanysWarrantLiabilityDetails" xlink:type="extended" id="i361adc2e4075470ab3504e729b183514_StockBasedCompensationSummaryOfChangesInCompanysWarrantLiabilityDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_f3b6db30-169b-4a6b-9139-7edda6ac7852" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_7025d834-6f9e-4bc3-9b24-8da1bab6b0b3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_f3b6db30-169b-4a6b-9139-7edda6ac7852" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_7025d834-6f9e-4bc3-9b24-8da1bab6b0b3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_863fa3bc-468e-4076-8952-bcf2a7b57960" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_7025d834-6f9e-4bc3-9b24-8da1bab6b0b3" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_863fa3bc-468e-4076-8952-bcf2a7b57960" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_b451cc4e-7c97-4006-83c0-1372644d386d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_7025d834-6f9e-4bc3-9b24-8da1bab6b0b3" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_b451cc4e-7c97-4006-83c0-1372644d386d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_29d66fde-8076-4be3-af16-1f11d762e7c2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_7025d834-6f9e-4bc3-9b24-8da1bab6b0b3" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySettlements_29d66fde-8076-4be3-af16-1f11d762e7c2" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_8886d41a-c03b-477d-afc1-119429f56705" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_a16299ad-ab15-4d60-a492-a7cd7dce99ae" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_f3b6db30-169b-4a6b-9139-7edda6ac7852" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_a16299ad-ab15-4d60-a492-a7cd7dce99ae" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByLiabilityClassAxis_c22f0223-d71d-4158-acfb-8f91f639958e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByLiabilityClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_a16299ad-ab15-4d60-a492-a7cd7dce99ae" xlink:to="loc_us-gaap_FairValueByLiabilityClassAxis_c22f0223-d71d-4158-acfb-8f91f639958e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_c22f0223-d71d-4158-acfb-8f91f639958e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_c22f0223-d71d-4158-acfb-8f91f639958e" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_c22f0223-d71d-4158-acfb-8f91f639958e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_4020ee5d-41e0-4d06-9d8e-ee05252cb620" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_c22f0223-d71d-4158-acfb-8f91f639958e" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_4020ee5d-41e0-4d06-9d8e-ee05252cb620" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_c08d9623-c80d-44b1-98dd-72ed9b95d231" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WarrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_4020ee5d-41e0-4d06-9d8e-ee05252cb620" xlink:to="loc_us-gaap_WarrantMember_c08d9623-c80d-44b1-98dd-72ed9b95d231" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/IncomeTaxesNarrativeDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#IncomeTaxesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/IncomeTaxesNarrativeDetails" xlink:type="extended" id="i214df1edd3ef45359858894c4b1891c5_IncomeTaxesNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxContingencyLineItems_96f5746f-94ca-4cdb-ba82-47f80c8e773d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxContingencyLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_417948fb-0cda-43f4-9d7f-675fd035673f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_96f5746f-94ca-4cdb-ba82-47f80c8e773d" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_417948fb-0cda-43f4-9d7f-675fd035673f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_e50347ee-69ba-4c1e-9adb-122b33c7865a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsValuationAllowance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_96f5746f-94ca-4cdb-ba82-47f80c8e773d" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_e50347ee-69ba-4c1e-9adb-122b33c7865a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_b4d409fb-8a1a-4d16-ace9-9549acb939ca" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_96f5746f-94ca-4cdb-ba82-47f80c8e773d" xlink:to="loc_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_b4d409fb-8a1a-4d16-ace9-9549acb939ca" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsDomestic_4ee84868-35f2-43ca-ad33-41ac83261579" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsDomestic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_96f5746f-94ca-4cdb-ba82-47f80c8e773d" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsDomestic_4ee84868-35f2-43ca-ad33-41ac83261579" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsSubjectToExpiration_a5248161-1e8c-4907-9fa0-628411f1f1dd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsSubjectToExpiration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_96f5746f-94ca-4cdb-ba82-47f80c8e773d" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsSubjectToExpiration_a5248161-1e8c-4907-9fa0-628411f1f1dd" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsNotSubjectToExpiration_e056b818-fc5d-4406-b974-7c341d3f9f2b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsNotSubjectToExpiration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_96f5746f-94ca-4cdb-ba82-47f80c8e773d" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsNotSubjectToExpiration_e056b818-fc5d-4406-b974-7c341d3f9f2b" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsStateAndLocal_d22d8477-0029-4153-98d8-31a358a96952" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsStateAndLocal"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_96f5746f-94ca-4cdb-ba82-47f80c8e773d" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsStateAndLocal_d22d8477-0029-4153-98d8-31a358a96952" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardAmount_7eabdf94-b511-4187-befa-e879d79da15b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TaxCreditCarryforwardAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_96f5746f-94ca-4cdb-ba82-47f80c8e773d" xlink:to="loc_us-gaap_TaxCreditCarryforwardAmount_7eabdf94-b511-4187-befa-e879d79da15b" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardValuationAllowance_e5453142-64c6-41b0-b641-5ff29e37edfb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TaxCreditCarryforwardValuationAllowance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_96f5746f-94ca-4cdb-ba82-47f80c8e773d" xlink:to="loc_us-gaap_TaxCreditCarryforwardValuationAllowance_e5453142-64c6-41b0-b641-5ff29e37edfb" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxContingencyTable_b50bcbfe-9c4d-4beb-aa21-20f29ee36043" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxContingencyTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_96f5746f-94ca-4cdb-ba82-47f80c8e773d" xlink:to="loc_us-gaap_IncomeTaxContingencyTable_b50bcbfe-9c4d-4beb-aa21-20f29ee36043" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_cf8d1a86-2bfc-4950-96db-c8b4db734b69" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxAuthorityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeTaxContingencyTable_b50bcbfe-9c4d-4beb-aa21-20f29ee36043" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_cf8d1a86-2bfc-4950-96db-c8b4db734b69" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_cf8d1a86-2bfc-4950-96db-c8b4db734b69_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_cf8d1a86-2bfc-4950-96db-c8b4db734b69" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_cf8d1a86-2bfc-4950-96db-c8b4db734b69_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_45f5ade0-b986-4871-bd31-6de032dfcc12" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_cf8d1a86-2bfc-4950-96db-c8b4db734b69" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_45f5ade0-b986-4871-bd31-6de032dfcc12" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DomesticCountryMember_38cb1465-4f54-4cb4-9b5c-f05e9a8bf136" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DomesticCountryMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_45f5ade0-b986-4871-bd31-6de032dfcc12" xlink:to="loc_us-gaap_DomesticCountryMember_38cb1465-4f54-4cb4-9b5c-f05e9a8bf136" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StateAndLocalJurisdictionMember_fca2e122-d98e-4d58-b199-53b91f237b0e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StateAndLocalJurisdictionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_45f5ade0-b986-4871-bd31-6de032dfcc12" xlink:to="loc_us-gaap_StateAndLocalJurisdictionMember_fca2e122-d98e-4d58-b199-53b91f237b0e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardAxis_16733379-836e-45d6-b6dc-6cf2f3ebcd08" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TaxCreditCarryforwardAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeTaxContingencyTable_b50bcbfe-9c4d-4beb-aa21-20f29ee36043" xlink:to="loc_us-gaap_TaxCreditCarryforwardAxis_16733379-836e-45d6-b6dc-6cf2f3ebcd08" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardNameDomain_16733379-836e-45d6-b6dc-6cf2f3ebcd08_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TaxCreditCarryforwardNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TaxCreditCarryforwardAxis_16733379-836e-45d6-b6dc-6cf2f3ebcd08" xlink:to="loc_us-gaap_TaxCreditCarryforwardNameDomain_16733379-836e-45d6-b6dc-6cf2f3ebcd08_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardNameDomain_188a63ce-2807-49f4-b9cf-37ac9dd9c0ac" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TaxCreditCarryforwardNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TaxCreditCarryforwardAxis_16733379-836e-45d6-b6dc-6cf2f3ebcd08" xlink:to="loc_us-gaap_TaxCreditCarryforwardNameDomain_188a63ce-2807-49f4-b9cf-37ac9dd9c0ac" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchMember_6307d4f3-f906-4047-b1b5-9590c569c31a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ResearchMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_188a63ce-2807-49f4-b9cf-37ac9dd9c0ac" xlink:to="loc_us-gaap_ResearchMember_6307d4f3-f906-4047-b1b5-9590c569c31a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_OrphanDrugCreditCarryforwardMember_5335da27-4908-477c-974b-fd985b6b24e6" xlink:href="rxrx-20211231.xsd#rxrx_OrphanDrugCreditCarryforwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_188a63ce-2807-49f4-b9cf-37ac9dd9c0ac" xlink:to="loc_rxrx_OrphanDrugCreditCarryforwardMember_5335da27-4908-477c-974b-fd985b6b24e6" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/NetLossPerShareScheduleofBasicandDilutedNetLossperShareDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#NetLossPerShareScheduleofBasicandDilutedNetLossperShareDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/NetLossPerShareScheduleofBasicandDilutedNetLossperShareDetails" xlink:type="extended" id="i7e8aa4a5e895490c80d4531e84cd0897_NetLossPerShareScheduleofBasicandDilutedNetLossperShareDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasicLineItems_a3ab6cdc-699f-4acd-8571-3aeae588d4a5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareBasicLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDilutedAbstract_8e13c280-2cad-4a03-988f-96eedb8b0b0c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersDilutedAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareBasicLineItems_a3ab6cdc-699f-4acd-8571-3aeae588d4a5" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDilutedAbstract_8e13c280-2cad-4a03-988f-96eedb8b0b0c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UndistributedEarnings_bba09a12-6400-47cb-90ad-d89b761b0ec6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UndistributedEarnings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDilutedAbstract_8e13c280-2cad-4a03-988f-96eedb8b0b0c" xlink:to="loc_us-gaap_UndistributedEarnings_bba09a12-6400-47cb-90ad-d89b761b0ec6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UndistributedEarningsDiluted_da9c6fc7-d60a-4838-90d6-e074cbe6f8c9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UndistributedEarningsDiluted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDilutedAbstract_8e13c280-2cad-4a03-988f-96eedb8b0b0c" xlink:to="loc_us-gaap_UndistributedEarningsDiluted_da9c6fc7-d60a-4838-90d6-e074cbe6f8c9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_8b88bac8-a78d-498f-9919-54786e8c18f9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDilutedAbstract_8e13c280-2cad-4a03-988f-96eedb8b0b0c" xlink:to="loc_us-gaap_NetIncomeLoss_8b88bac8-a78d-498f-9919-54786e8c18f9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_079451b2-320d-44c5-a088-3a9ce0e35b41" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareBasicLineItems_a3ab6cdc-699f-4acd-8571-3aeae588d4a5" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_079451b2-320d-44c5-a088-3a9ce0e35b41" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_850c9263-5fc5-46a8-a4d7-aeb1b443970c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_079451b2-320d-44c5-a088-3a9ce0e35b41" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_850c9263-5fc5-46a8-a4d7-aeb1b443970c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_4e4574f6-6f67-4c13-a667-311f96098d63" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_079451b2-320d-44c5-a088-3a9ce0e35b41" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_4e4574f6-6f67-4c13-a667-311f96098d63" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_e8b4d5e9-94e5-482c-876e-ff288a57577c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareBasicLineItems_a3ab6cdc-699f-4acd-8571-3aeae588d4a5" xlink:to="loc_us-gaap_EarningsPerShareBasic_e8b4d5e9-94e5-482c-876e-ff288a57577c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_2c35bd21-b9e3-4914-8801-b55842d5ea87" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareBasicLineItems_a3ab6cdc-699f-4acd-8571-3aeae588d4a5" xlink:to="loc_us-gaap_EarningsPerShareDiluted_2c35bd21-b9e3-4914-8801-b55842d5ea87" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable_0e89cf10-171d-4162-8016-a8a5932a51f7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EarningsPerShareBasicLineItems_a3ab6cdc-699f-4acd-8571-3aeae588d4a5" xlink:to="loc_us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable_0e89cf10-171d-4162-8016-a8a5932a51f7" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_3028374d-ba9d-4870-a829-b6862f506505" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable_0e89cf10-171d-4162-8016-a8a5932a51f7" xlink:to="loc_us-gaap_StatementClassOfStockAxis_3028374d-ba9d-4870-a829-b6862f506505" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_3028374d-ba9d-4870-a829-b6862f506505_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_3028374d-ba9d-4870-a829-b6862f506505" xlink:to="loc_us-gaap_ClassOfStockDomain_3028374d-ba9d-4870-a829-b6862f506505_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_e609b069-904a-460b-b80e-b9b04b049a9e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_3028374d-ba9d-4870-a829-b6862f506505" xlink:to="loc_us-gaap_ClassOfStockDomain_e609b069-904a-460b-b80e-b9b04b049a9e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_e04ad8b9-c3c9-4ffb-87cd-6d362e56e215" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_e609b069-904a-460b-b80e-b9b04b049a9e" xlink:to="loc_us-gaap_CommonClassAMember_e04ad8b9-c3c9-4ffb-87cd-6d362e56e215" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_64deee5f-03a7-4d79-b275-714b16c5455c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonClassBMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_e609b069-904a-460b-b80e-b9b04b049a9e" xlink:to="loc_us-gaap_CommonClassBMember_64deee5f-03a7-4d79-b275-714b16c5455c" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/NetLossPerShareScheduleofAntidilutiveSecuritiesExcludedfromComputationofNetLossPerShareDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#NetLossPerShareScheduleofAntidilutiveSecuritiesExcludedfromComputationofNetLossPerShareDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/NetLossPerShareScheduleofAntidilutiveSecuritiesExcludedfromComputationofNetLossPerShareDetails" xlink:type="extended" id="i700d21a1f9c74372914319819995d0a7_NetLossPerShareScheduleofAntidilutiveSecuritiesExcludedfromComputationofNetLossPerShareDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_f4b39cba-101f-474c-82ee-78d7f16a4312" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_b283d9ef-7194-4354-b4c8-92cb051dd5aa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_f4b39cba-101f-474c-82ee-78d7f16a4312" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_b283d9ef-7194-4354-b4c8-92cb051dd5aa" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_9d432d24-3234-48e8-8eb0-389269ca70cb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_f4b39cba-101f-474c-82ee-78d7f16a4312" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_9d432d24-3234-48e8-8eb0-389269ca70cb" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_563af2e5-43ec-410a-b163-92b9f37fd6f7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_9d432d24-3234-48e8-8eb0-389269ca70cb" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_563af2e5-43ec-410a-b163-92b9f37fd6f7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_563af2e5-43ec-410a-b163-92b9f37fd6f7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_563af2e5-43ec-410a-b163-92b9f37fd6f7" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_563af2e5-43ec-410a-b163-92b9f37fd6f7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_1fe045ec-67a0-4981-8fc0-397050fbb551" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_563af2e5-43ec-410a-b163-92b9f37fd6f7" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_1fe045ec-67a0-4981-8fc0-397050fbb551" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertiblePreferredStockMember_ef441380-73ec-47dc-9d36-611be4d51b29" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConvertiblePreferredStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_1fe045ec-67a0-4981-8fc0-397050fbb551" xlink:to="loc_us-gaap_ConvertiblePreferredStockMember_ef441380-73ec-47dc-9d36-611be4d51b29" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_4eaed055-7f63-4e22-b499-0e81cacd1068" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_1fe045ec-67a0-4981-8fc0-397050fbb551" xlink:to="loc_us-gaap_EmployeeStockOptionMember_4eaed055-7f63-4e22-b499-0e81cacd1068" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_35f7b136-5c1b-410d-ba3c-ec03afc229f3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WarrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_1fe045ec-67a0-4981-8fc0-397050fbb551" xlink:to="loc_us-gaap_WarrantMember_35f7b136-5c1b-410d-ba3c-ec03afc229f3" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/FairValueMeasurementsAssetsandLiabilitiesMeasuredonRecurringBasisDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#FairValueMeasurementsAssetsandLiabilitiesMeasuredonRecurringBasisDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/FairValueMeasurementsAssetsandLiabilitiesMeasuredonRecurringBasisDetails" xlink:type="extended" id="ib7f49f7a966a47a7843d94da41855913_FairValueMeasurementsAssetsandLiabilitiesMeasuredonRecurringBasisDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_0c8dbf62-e086-4e72-aad9-70060516fdd3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_ec463f64-006d-4ce4-a324-186348fd7299" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_0c8dbf62-e086-4e72-aad9-70060516fdd3" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_ec463f64-006d-4ce4-a324-186348fd7299" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_RestrictedCashAndCashEquivalentsFairValueDisclosure_7dcfb481-260b-4efc-8d7c-a18eddcadb30" xlink:href="rxrx-20211231.xsd#rxrx_RestrictedCashAndCashEquivalentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_0c8dbf62-e086-4e72-aad9-70060516fdd3" xlink:to="loc_rxrx_RestrictedCashAndCashEquivalentsFairValueDisclosure_7dcfb481-260b-4efc-8d7c-a18eddcadb30" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsFairValueDisclosure_8a5f0022-0537-493d-beda-e4053f700ddb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_0c8dbf62-e086-4e72-aad9-70060516fdd3" xlink:to="loc_us-gaap_InvestmentsFairValueDisclosure_8a5f0022-0537-493d-beda-e4053f700ddb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_b29784de-1242-4328-8f49-eb65b4020fe2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_0c8dbf62-e086-4e72-aad9-70060516fdd3" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_b29784de-1242-4328-8f49-eb65b4020fe2" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantsAndRightsOutstanding_f8d8faad-9266-447e-9699-9c1ea8dec856" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WarrantsAndRightsOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_0c8dbf62-e086-4e72-aad9-70060516fdd3" xlink:to="loc_us-gaap_WarrantsAndRightsOutstanding_f8d8faad-9266-447e-9699-9c1ea8dec856" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_17646591-b3e0-4d80-b0ce-559fa9a15c19" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_0c8dbf62-e086-4e72-aad9-70060516fdd3" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosure_17646591-b3e0-4d80-b0ce-559fa9a15c19" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByBalanceSheetGroupingTable_e81c488c-11bc-44f5-bb1b-7a75e30ead03" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByBalanceSheetGroupingTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_0c8dbf62-e086-4e72-aad9-70060516fdd3" xlink:to="loc_us-gaap_FairValueByBalanceSheetGroupingTable_e81c488c-11bc-44f5-bb1b-7a75e30ead03" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_1efa669b-5011-415b-ba7d-7e9b4c2ad02d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_e81c488c-11bc-44f5-bb1b-7a75e30ead03" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_1efa669b-5011-415b-ba7d-7e9b4c2ad02d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_1efa669b-5011-415b-ba7d-7e9b4c2ad02d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_1efa669b-5011-415b-ba7d-7e9b4c2ad02d" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_1efa669b-5011-415b-ba7d-7e9b4c2ad02d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_9d71cece-c53e-4dcb-b3e8-711c370a0d96" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_1efa669b-5011-415b-ba7d-7e9b4c2ad02d" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_9d71cece-c53e-4dcb-b3e8-711c370a0d96" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_749f2b77-7948-4c94-99c9-7f56ccd25d32" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_9d71cece-c53e-4dcb-b3e8-711c370a0d96" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_749f2b77-7948-4c94-99c9-7f56ccd25d32" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_913aa19d-7a44-4f5e-816f-f0e4987cf6e5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_e81c488c-11bc-44f5-bb1b-7a75e30ead03" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_913aa19d-7a44-4f5e-816f-f0e4987cf6e5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_913aa19d-7a44-4f5e-816f-f0e4987cf6e5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_913aa19d-7a44-4f5e-816f-f0e4987cf6e5" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_913aa19d-7a44-4f5e-816f-f0e4987cf6e5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_ed7388c1-d36e-4b04-b93d-30912ecabaa8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_913aa19d-7a44-4f5e-816f-f0e4987cf6e5" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_ed7388c1-d36e-4b04-b93d-30912ecabaa8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_44f0d43a-52fa-4988-b780-2101f18d4e47" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_ed7388c1-d36e-4b04-b93d-30912ecabaa8" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_44f0d43a-52fa-4988-b780-2101f18d4e47" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_d525c993-3558-473e-a6d0-89ff111a4abf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_ed7388c1-d36e-4b04-b93d-30912ecabaa8" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_d525c993-3558-473e-a6d0-89ff111a4abf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_4f817be4-c441-4780-9ec5-bf8ded328bca" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_ed7388c1-d36e-4b04-b93d-30912ecabaa8" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_4f817be4-c441-4780-9ec5-bf8ded328bca" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAxis_bb0128aa-e0b2-4b3b-bd35-c79cf551852d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_e81c488c-11bc-44f5-bb1b-7a75e30ead03" xlink:to="loc_us-gaap_CashAndCashEquivalentsAxis_bb0128aa-e0b2-4b3b-bd35-c79cf551852d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_bb0128aa-e0b2-4b3b-bd35-c79cf551852d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_bb0128aa-e0b2-4b3b-bd35-c79cf551852d" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_bb0128aa-e0b2-4b3b-bd35-c79cf551852d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_b48346e6-dee9-4234-bef0-7a1f4d0cefaf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_bb0128aa-e0b2-4b3b-bd35-c79cf551852d" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_b48346e6-dee9-4234-bef0-7a1f4d0cefaf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_3e60d2f0-dfc3-4300-8826-be702563ee7d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_b48346e6-dee9-4234-bef0-7a1f4d0cefaf" xlink:to="loc_us-gaap_MoneyMarketFundsMember_3e60d2f0-dfc3-4300-8826-be702563ee7d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_1755a92c-0cf9-437a-80ea-6cdeaee377fb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommercialPaperMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_b48346e6-dee9-4234-bef0-7a1f4d0cefaf" xlink:to="loc_us-gaap_CommercialPaperMember_1755a92c-0cf9-437a-80ea-6cdeaee377fb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_4dbac51a-7c5a-4328-9428-c210a8f8cc2e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CorporateDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_b48346e6-dee9-4234-bef0-7a1f4d0cefaf" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_4dbac51a-7c5a-4328-9428-c210a8f8cc2e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_2e7f00f3-f910-4e2d-b895-019185f185c7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_e81c488c-11bc-44f5-bb1b-7a75e30ead03" xlink:to="loc_us-gaap_FinancialInstrumentAxis_2e7f00f3-f910-4e2d-b895-019185f185c7" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2e7f00f3-f910-4e2d-b895-019185f185c7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_2e7f00f3-f910-4e2d-b895-019185f185c7" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2e7f00f3-f910-4e2d-b895-019185f185c7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_373bd318-1bf5-4aeb-8c5f-4dd82c2e6be4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_2e7f00f3-f910-4e2d-b895-019185f185c7" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_373bd318-1bf5-4aeb-8c5f-4dd82c2e6be4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_595f8c2f-4e02-489a-a3f5-0ec9e6c70e36" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_373bd318-1bf5-4aeb-8c5f-4dd82c2e6be4" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_595f8c2f-4e02-489a-a3f5-0ec9e6c70e36" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_8324f2c7-a917-40d8-88af-41806d63db8a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CorporateDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_373bd318-1bf5-4aeb-8c5f-4dd82c2e6be4" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_8324f2c7-a917-40d8-88af-41806d63db8a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CertificatesOfDepositMember_8e0a8cf4-11f7-429c-afa5-9dbc2e32911b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CertificatesOfDepositMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_373bd318-1bf5-4aeb-8c5f-4dd82c2e6be4" xlink:to="loc_us-gaap_CertificatesOfDepositMember_8e0a8cf4-11f7-429c-afa5-9dbc2e32911b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperNotIncludedWithCashAndCashEquivalentsMember_1a416c41-0822-4e7e-a873-bf8839375c1a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommercialPaperNotIncludedWithCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_373bd318-1bf5-4aeb-8c5f-4dd82c2e6be4" xlink:to="loc_us-gaap_CommercialPaperNotIncludedWithCashAndCashEquivalentsMember_1a416c41-0822-4e7e-a873-bf8839375c1a" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/FairValueMeasurementsAssetandLiabilityNotMeasuredatFairValueDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#FairValueMeasurementsAssetandLiabilityNotMeasuredatFairValueDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/FairValueMeasurementsAssetandLiabilityNotMeasuredatFairValueDetails" xlink:type="extended" id="i72942e04a9f24f79bb385efc451bbec4_FairValueMeasurementsAssetandLiabilityNotMeasuredatFairValueDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosureAssetAndLiabilityNotMeasuredAtFairValueLineItems_fba0ebc6-cf2d-48fd-b3f7-79f368140d23" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueDisclosureAssetAndLiabilityNotMeasuredAtFairValueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_9a2e70cc-17d1-4e1a-bc1c-1ea6c5cbe32d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureAssetAndLiabilityNotMeasuredAtFairValueLineItems_fba0ebc6-cf2d-48fd-b3f7-79f368140d23" xlink:to="loc_us-gaap_LongTermDebtCurrent_9a2e70cc-17d1-4e1a-bc1c-1ea6c5cbe32d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_72992d0b-1be7-4fae-a317-2ca67cf6c13c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureAssetAndLiabilityNotMeasuredAtFairValueLineItems_fba0ebc6-cf2d-48fd-b3f7-79f368140d23" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_72992d0b-1be7-4fae-a317-2ca67cf6c13c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtFairValue_64a9e616-8be2-4590-a5e4-2a6a08be1579" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureAssetAndLiabilityNotMeasuredAtFairValueLineItems_fba0ebc6-cf2d-48fd-b3f7-79f368140d23" xlink:to="loc_us-gaap_LongTermDebtFairValue_64a9e616-8be2-4590-a5e4-2a6a08be1579" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosureOfAssetAndLiabilityNotMeasuredAtFairValueTable_80b39b36-6a7b-471a-af14-602d81627091" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueDisclosureOfAssetAndLiabilityNotMeasuredAtFairValueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueDisclosureAssetAndLiabilityNotMeasuredAtFairValueLineItems_fba0ebc6-cf2d-48fd-b3f7-79f368140d23" xlink:to="loc_us-gaap_FairValueDisclosureOfAssetAndLiabilityNotMeasuredAtFairValueTable_80b39b36-6a7b-471a-af14-602d81627091" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_331ef6e0-ada6-40d3-b8f0-62a66b88b270" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByMeasurementBasisAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueDisclosureOfAssetAndLiabilityNotMeasuredAtFairValueTable_80b39b36-6a7b-471a-af14-602d81627091" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_331ef6e0-ada6-40d3-b8f0-62a66b88b270" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_331ef6e0-ada6-40d3-b8f0-62a66b88b270_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_331ef6e0-ada6-40d3-b8f0-62a66b88b270" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_331ef6e0-ada6-40d3-b8f0-62a66b88b270_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_90d3b1bf-f55e-49ae-91e2-6e9b0998b084" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueDisclosureItemAmountsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_331ef6e0-ada6-40d3-b8f0-62a66b88b270" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_90d3b1bf-f55e-49ae-91e2-6e9b0998b084" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_9ce8c3d6-4e48-4f6f-9734-2442d1b3c99a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_90d3b1bf-f55e-49ae-91e2-6e9b0998b084" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_9ce8c3d6-4e48-4f6f-9734-2442d1b3c99a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtOtherThanFairValueFairValueDisclosureMember_47f14504-e9a9-4883-a769-bfdc0b62a933" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PortionAtOtherThanFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_9ce8c3d6-4e48-4f6f-9734-2442d1b3c99a" xlink:to="loc_us-gaap_PortionAtOtherThanFairValueFairValueDisclosureMember_47f14504-e9a9-4883-a769-bfdc0b62a933" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_9d918f59-486d-441c-acb9-0fd5b42aefcb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EstimateOfFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_9ce8c3d6-4e48-4f6f-9734-2442d1b3c99a" xlink:to="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_9d918f59-486d-441c-acb9-0fd5b42aefcb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_5af5ca41-04b3-4964-b689-42e32483eb70" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueDisclosureOfAssetAndLiabilityNotMeasuredAtFairValueTable_80b39b36-6a7b-471a-af14-602d81627091" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_5af5ca41-04b3-4964-b689-42e32483eb70" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_5af5ca41-04b3-4964-b689-42e32483eb70_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_5af5ca41-04b3-4964-b689-42e32483eb70" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_5af5ca41-04b3-4964-b689-42e32483eb70_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_5e95ed87-4ae0-4ede-b3d7-3d5177dc8775" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_5af5ca41-04b3-4964-b689-42e32483eb70" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_5e95ed87-4ae0-4ede-b3d7-3d5177dc8775" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesPayableOtherPayablesMember_8b5f4269-94de-4b9c-940f-859f4bf39722" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NotesPayableOtherPayablesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_5e95ed87-4ae0-4ede-b3d7-3d5177dc8775" xlink:to="loc_us-gaap_NotesPayableOtherPayablesMember_8b5f4269-94de-4b9c-940f-859f4bf39722" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/RelatedPartyTransactionsDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#RelatedPartyTransactionsDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/RelatedPartyTransactionsDetails" xlink:type="extended" id="i24f30e97e04441ff997d9a0d85cfe8c9_RelatedPartyTransactionsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionLineItems_960459ba-3483-4eb6-9a83-d645a3885616" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyTransactionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansAndLeasesReceivableRelatedParties_9125c89b-701d-42da-aaeb-0de7b8c69a87" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoansAndLeasesReceivableRelatedParties"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_960459ba-3483-4eb6-9a83-d645a3885616" xlink:to="loc_us-gaap_LoansAndLeasesReceivableRelatedParties_9125c89b-701d-42da-aaeb-0de7b8c69a87" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTerm_93164b75-c70f-4bea-b408-fe364cd75710" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_960459ba-3483-4eb6-9a83-d645a3885616" xlink:to="loc_us-gaap_DebtInstrumentTerm_93164b75-c70f-4bea-b408-fe364cd75710" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_efec7f3f-27da-4bd2-b78a-af3e7efcf554" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_960459ba-3483-4eb6-9a83-d645a3885616" xlink:to="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_efec7f3f-27da-4bd2-b78a-af3e7efcf554" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_e669e9f2-f915-4766-833a-2499803f42da" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_efec7f3f-27da-4bd2-b78a-af3e7efcf554" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_e669e9f2-f915-4766-833a-2499803f42da" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_e669e9f2-f915-4766-833a-2499803f42da_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_e669e9f2-f915-4766-833a-2499803f42da" xlink:to="loc_us-gaap_RelatedPartyDomain_e669e9f2-f915-4766-833a-2499803f42da_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_5d075e2e-58ba-41d0-a71b-3bd356f14c1a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_e669e9f2-f915-4766-833a-2499803f42da" xlink:to="loc_us-gaap_RelatedPartyDomain_5d075e2e-58ba-41d0-a71b-3bd356f14c1a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ChiefExecutiveOfficerMember_18ede2e5-db1f-4dd3-b8ff-cb5565529bd7" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ChiefExecutiveOfficerMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_5d075e2e-58ba-41d0-a71b-3bd356f14c1a" xlink:to="loc_srt_ChiefExecutiveOfficerMember_18ede2e5-db1f-4dd3-b8ff-cb5565529bd7" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/SubsequentEventsDetails" xlink:type="simple" xlink:href="rxrx-20211231.xsd#SubsequentEventsDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/SubsequentEventsDetails" xlink:type="extended" id="if571627532ac47a1b31bae4929850c41_SubsequentEventsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventLineItems_9d04a3e0-1f06-4d7c-afbc-d4ec539929ca" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiability_11eb120b-c92d-4e16-8caa-3d600d635298" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ContractWithCustomerLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_9d04a3e0-1f06-4d7c-afbc-d4ec539929ca" xlink:to="loc_us-gaap_ContractWithCustomerLiability_11eb120b-c92d-4e16-8caa-3d600d635298" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_RevenueRemainingPerformanceObligationNumberOfProjectsThatMayBeInitiated_ba70e87a-6d48-4151-969c-1528b5d902f3" xlink:href="rxrx-20211231.xsd#rxrx_RevenueRemainingPerformanceObligationNumberOfProjectsThatMayBeInitiated"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_9d04a3e0-1f06-4d7c-afbc-d4ec539929ca" xlink:to="loc_rxrx_RevenueRemainingPerformanceObligationNumberOfProjectsThatMayBeInitiated_ba70e87a-6d48-4151-969c-1528b5d902f3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_RevenueRemainingPerformanceObligationVariableConsiderationAmount_1daae5f2-30fd-426d-8d60-3eeab76d9ea6" xlink:href="rxrx-20211231.xsd#rxrx_RevenueRemainingPerformanceObligationVariableConsiderationAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_9d04a3e0-1f06-4d7c-afbc-d4ec539929ca" xlink:to="loc_rxrx_RevenueRemainingPerformanceObligationVariableConsiderationAmount_1daae5f2-30fd-426d-8d60-3eeab76d9ea6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTable_6bf120fd-c591-4c32-a2b7-0636e8dd5281" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SubsequentEventLineItems_9d04a3e0-1f06-4d7c-afbc-d4ec539929ca" xlink:to="loc_us-gaap_SubsequentEventTable_6bf120fd-c591-4c32-a2b7-0636e8dd5281" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_33ef01ab-320a-4fb4-9dfd-06a38b898019" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_6bf120fd-c591-4c32-a2b7-0636e8dd5281" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_33ef01ab-320a-4fb4-9dfd-06a38b898019" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_33ef01ab-320a-4fb4-9dfd-06a38b898019_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_33ef01ab-320a-4fb4-9dfd-06a38b898019" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_33ef01ab-320a-4fb4-9dfd-06a38b898019_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_70717da0-d26d-4a92-959c-78efe72bb132" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_33ef01ab-320a-4fb4-9dfd-06a38b898019" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_70717da0-d26d-4a92-959c-78efe72bb132" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_95826d76-6812-4c33-9b61-0ccbd90ac4b1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_70717da0-d26d-4a92-959c-78efe72bb132" xlink:to="loc_us-gaap_SubsequentEventMember_95826d76-6812-4c33-9b61-0ccbd90ac4b1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_5b058c93-0a26-4dfa-a388-8fe51dec3eb1" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_6bf120fd-c591-4c32-a2b7-0636e8dd5281" xlink:to="loc_srt_CounterpartyNameAxis_5b058c93-0a26-4dfa-a388-8fe51dec3eb1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_5b058c93-0a26-4dfa-a388-8fe51dec3eb1_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_5b058c93-0a26-4dfa-a388-8fe51dec3eb1" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_5b058c93-0a26-4dfa-a388-8fe51dec3eb1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_920f436a-3590-4870-ad4d-47f95ad2ba69" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_5b058c93-0a26-4dfa-a388-8fe51dec3eb1" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_920f436a-3590-4870-ad4d-47f95ad2ba69" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_RocheAndGenentechMember_85328d58-ee57-4001-8faa-ac98257fffbd" xlink:href="rxrx-20211231.xsd#rxrx_RocheAndGenentechMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_920f436a-3590-4870-ad4d-47f95ad2ba69" xlink:to="loc_rxrx_RocheAndGenentechMember_85328d58-ee57-4001-8faa-ac98257fffbd" xlink:type="arc" order="0"/>
  </link:definitionLink>
</link:linkbase>
