<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2025 Workiva-->
<!--r:36d447b6-988b-4e66-9422-1a9af8bc39e7,g:b5245b38-6cc4-4ffa-b33e-3706ada1f721-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.recursion.com/role/Cover" xlink:type="simple" xlink:href="rxrx-20250228.xsd#Cover"/>
  <link:presentationLink xlink:role="http://www.recursion.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_88ad4949-8753-49c9-bb6f-5bea56a78840" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_a3240bf8-5d95-4861-b65a-04d3612315d1" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_88ad4949-8753-49c9-bb6f-5bea56a78840" xlink:to="loc_dei_DocumentType_a3240bf8-5d95-4861-b65a-04d3612315d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_271981cf-5a97-4231-80a6-6b231e6d108a" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_88ad4949-8753-49c9-bb6f-5bea56a78840" xlink:to="loc_dei_DocumentPeriodEndDate_271981cf-5a97-4231-80a6-6b231e6d108a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_c3cecdeb-28dc-46b4-ad94-7581e68c7c6c" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_88ad4949-8753-49c9-bb6f-5bea56a78840" xlink:to="loc_dei_EntityRegistrantName_c3cecdeb-28dc-46b4-ad94-7581e68c7c6c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_7cafba07-ef30-419a-8458-3f9cdb7b6885" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_88ad4949-8753-49c9-bb6f-5bea56a78840" xlink:to="loc_dei_EntityIncorporationStateCountryCode_7cafba07-ef30-419a-8458-3f9cdb7b6885" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_cc63a514-dd41-4f2b-8429-77d5acbeb3e7" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_88ad4949-8753-49c9-bb6f-5bea56a78840" xlink:to="loc_dei_EntityFileNumber_cc63a514-dd41-4f2b-8429-77d5acbeb3e7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_37b43bb7-3ccf-445d-9a96-c0191497cbf5" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_88ad4949-8753-49c9-bb6f-5bea56a78840" xlink:to="loc_dei_EntityTaxIdentificationNumber_37b43bb7-3ccf-445d-9a96-c0191497cbf5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_a6d72583-a853-4bd1-bc72-678d63863f10" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_88ad4949-8753-49c9-bb6f-5bea56a78840" xlink:to="loc_dei_EntityAddressAddressLine1_a6d72583-a853-4bd1-bc72-678d63863f10" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_546e1558-e6be-44f5-8ed5-726f001f6fba" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_88ad4949-8753-49c9-bb6f-5bea56a78840" xlink:to="loc_dei_EntityAddressCityOrTown_546e1558-e6be-44f5-8ed5-726f001f6fba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_8dba0d1c-61e2-4161-a29a-29bece323d6f" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_88ad4949-8753-49c9-bb6f-5bea56a78840" xlink:to="loc_dei_EntityAddressStateOrProvince_8dba0d1c-61e2-4161-a29a-29bece323d6f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_45eb40f5-9e11-4515-a084-dbf5967d2d41" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_88ad4949-8753-49c9-bb6f-5bea56a78840" xlink:to="loc_dei_EntityAddressPostalZipCode_45eb40f5-9e11-4515-a084-dbf5967d2d41" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_a81afb3a-d69d-4f37-878f-678adfcedb26" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_88ad4949-8753-49c9-bb6f-5bea56a78840" xlink:to="loc_dei_CityAreaCode_a81afb3a-d69d-4f37-878f-678adfcedb26" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_273b6808-f3bf-44c7-9226-483ddf99ac44" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_88ad4949-8753-49c9-bb6f-5bea56a78840" xlink:to="loc_dei_LocalPhoneNumber_273b6808-f3bf-44c7-9226-483ddf99ac44" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_e645f36d-4725-4f0a-ae0a-ac1b367463c5" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_88ad4949-8753-49c9-bb6f-5bea56a78840" xlink:to="loc_dei_WrittenCommunications_e645f36d-4725-4f0a-ae0a-ac1b367463c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_ee8af2e9-4fa5-4f95-94f8-9689725e7743" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_88ad4949-8753-49c9-bb6f-5bea56a78840" xlink:to="loc_dei_SolicitingMaterial_ee8af2e9-4fa5-4f95-94f8-9689725e7743" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_e4050eea-579d-413b-baf3-a8c2d434ad1f" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_88ad4949-8753-49c9-bb6f-5bea56a78840" xlink:to="loc_dei_PreCommencementTenderOffer_e4050eea-579d-413b-baf3-a8c2d434ad1f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_44c494b9-883b-4b53-a552-e8ed1b8b7646" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_88ad4949-8753-49c9-bb6f-5bea56a78840" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_44c494b9-883b-4b53-a552-e8ed1b8b7646" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_67759bad-33e6-493d-b3f0-24803b114cbf" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_88ad4949-8753-49c9-bb6f-5bea56a78840" xlink:to="loc_dei_Security12bTitle_67759bad-33e6-493d-b3f0-24803b114cbf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_9884a97b-c3d7-42d4-b4ec-01431c79798e" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_88ad4949-8753-49c9-bb6f-5bea56a78840" xlink:to="loc_dei_TradingSymbol_9884a97b-c3d7-42d4-b4ec-01431c79798e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_d55945e9-f659-4ab2-b666-e1c32691a95f" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_88ad4949-8753-49c9-bb6f-5bea56a78840" xlink:to="loc_dei_SecurityExchangeName_d55945e9-f659-4ab2-b666-e1c32691a95f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_c32688b3-622f-4e39-a352-3a986fa1ea33" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_88ad4949-8753-49c9-bb6f-5bea56a78840" xlink:to="loc_dei_EntityEmergingGrowthCompany_c32688b3-622f-4e39-a352-3a986fa1ea33" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_414fb4c8-a890-418d-a7e2-206998e4bca6" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_88ad4949-8753-49c9-bb6f-5bea56a78840" xlink:to="loc_dei_EntityCentralIndexKey_414fb4c8-a890-418d-a7e2-206998e4bca6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_e32bd494-1ba5-4c99-a1a3-4008d40bd6c4" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_88ad4949-8753-49c9-bb6f-5bea56a78840" xlink:to="loc_dei_AmendmentFlag_e32bd494-1ba5-4c99-a1a3-4008d40bd6c4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
