<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2023 Workiva-->
<!--r:2be6e3a7-53d0-42d2-a4bf-9ce448727330,g:d37b8111-acd0-4959-a0ff-2c13d231aeee-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.recursion.com/role/ConsolidatedBalanceSheets" xlink:type="simple" xlink:href="rxrx-20221231.xsd#ConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://www.recursion.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_cf05cdeb-e264-4373-b80c-2567440a53b8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashNoncurrent_ffa4dfbd-7782-4ab1-b517-eeabe95ad43c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_cf05cdeb-e264-4373-b80c-2567440a53b8" xlink:to="loc_us-gaap_RestrictedCashNoncurrent_ffa4dfbd-7782-4ab1-b517-eeabe95ad43c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_0687ce21-2b69-48e1-bbcd-e84d72ce54f5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_cf05cdeb-e264-4373-b80c-2567440a53b8" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_0687ce21-2b69-48e1-bbcd-e84d72ce54f5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_de84fa9b-0ad4-4265-bd47-9cd45ae849d6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_cf05cdeb-e264-4373-b80c-2567440a53b8" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_de84fa9b-0ad4-4265-bd47-9cd45ae849d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_60065fac-f529-4f15-9b68-32c1fd3443fe" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_cf05cdeb-e264-4373-b80c-2567440a53b8" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_60065fac-f529-4f15-9b68-32c1fd3443fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_8d032712-dd41-46cb-87c3-2a0adf8728cb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_cf05cdeb-e264-4373-b80c-2567440a53b8" xlink:to="loc_us-gaap_Goodwill_8d032712-dd41-46cb-87c3-2a0adf8728cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_70b31b5b-a992-4a88-be26-5b7104666438" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_cf05cdeb-e264-4373-b80c-2567440a53b8" xlink:to="loc_us-gaap_AssetsCurrent_70b31b5b-a992-4a88-be26-5b7104666438" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_49eeae07-08e1-4af7-91b5-eb77e9955869" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_cf05cdeb-e264-4373-b80c-2567440a53b8" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_49eeae07-08e1-4af7-91b5-eb77e9955869" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_f30b046f-9f26-48f1-9546-750491d8690e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_92d835ca-c288-4188-a48e-138ef1b5cc20" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_f30b046f-9f26-48f1-9546-750491d8690e" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_92d835ca-c288-4188-a48e-138ef1b5cc20" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_1f0c32b5-361e-4788-a256-3bd8fbd13e0a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_f30b046f-9f26-48f1-9546-750491d8690e" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_1f0c32b5-361e-4788-a256-3bd8fbd13e0a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesPayableCurrent_007af560-4c3a-407b-b8cc-8e037a299117" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NotesPayableCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_f30b046f-9f26-48f1-9546-750491d8690e" xlink:to="loc_us-gaap_NotesPayableCurrent_007af560-4c3a-407b-b8cc-8e037a299117" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LeaseIncentiveObligation_84f4d64e-94e0-4204-aa16-2f176539eb88" xlink:href="rxrx-20221231.xsd#rxrx_LeaseIncentiveObligation"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_f30b046f-9f26-48f1-9546-750491d8690e" xlink:to="loc_rxrx_LeaseIncentiveObligation_84f4d64e-94e0-4204-aa16-2f176539eb88" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_4e286f2c-93df-4c80-a87e-56ed85587024" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_f30b046f-9f26-48f1-9546-750491d8690e" xlink:to="loc_us-gaap_AccountsPayableCurrent_4e286f2c-93df-4c80-a87e-56ed85587024" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_4e56f38a-78ef-45c0-b933-bc0e537887a1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_f30b046f-9f26-48f1-9546-750491d8690e" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_4e56f38a-78ef-45c0-b933-bc0e537887a1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_3ab7a648-a60f-4c8b-9bc1-c700e0f853a1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermNotesPayable_47757a8a-3812-4dac-b13b-0c2eee06e054" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermNotesPayable"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_3ab7a648-a60f-4c8b-9bc1-c700e0f853a1" xlink:to="loc_us-gaap_LongTermNotesPayable_47757a8a-3812-4dac-b13b-0c2eee06e054" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LeaseIncentivePayableNoncurrent_7d7133a1-832d-422c-9e12-10322f243e6d" xlink:href="rxrx-20221231.xsd#rxrx_LeaseIncentivePayableNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_3ab7a648-a60f-4c8b-9bc1-c700e0f853a1" xlink:to="loc_rxrx_LeaseIncentivePayableNoncurrent_7d7133a1-832d-422c-9e12-10322f243e6d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_ad81ac13-41ee-4ec2-8b2a-7e13187858d9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_3ab7a648-a60f-4c8b-9bc1-c700e0f853a1" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_ad81ac13-41ee-4ec2-8b2a-7e13187858d9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredRentCreditNoncurrent_7a8345b1-4306-4d59-b5af-3e5291753f29" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredRentCreditNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_3ab7a648-a60f-4c8b-9bc1-c700e0f853a1" xlink:to="loc_us-gaap_DeferredRentCreditNoncurrent_7a8345b1-4306-4d59-b5af-3e5291753f29" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_a1bf434c-5e3d-4c2d-9dd6-9049156dbc62" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_3ab7a648-a60f-4c8b-9bc1-c700e0f853a1" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_a1bf434c-5e3d-4c2d-9dd6-9049156dbc62" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_955ac578-3630-48d5-860b-5c986be74260" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_3ab7a648-a60f-4c8b-9bc1-c700e0f853a1" xlink:to="loc_us-gaap_LiabilitiesCurrent_955ac578-3630-48d5-860b-5c986be74260" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_f03057b3-5648-421b-ae0c-552cfae34d0e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_0f91f7ad-cd5b-443a-83c1-52f67ae70c03" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_f03057b3-5648-421b-ae0c-552cfae34d0e" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_0f91f7ad-cd5b-443a-83c1-52f67ae70c03" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashCurrent_bca8a162-5b98-4512-a781-780d3370182d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_f03057b3-5648-421b-ae0c-552cfae34d0e" xlink:to="loc_us-gaap_RestrictedCashCurrent_bca8a162-5b98-4512-a781-780d3370182d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_59be6430-d904-4abc-b40e-222c3cea9ed6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_f03057b3-5648-421b-ae0c-552cfae34d0e" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_59be6430-d904-4abc-b40e-222c3cea9ed6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherReceivablesNetCurrent_2b719a43-c965-4f49-ab11-331773c3c0ca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherReceivablesNetCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_f03057b3-5648-421b-ae0c-552cfae34d0e" xlink:to="loc_us-gaap_OtherReceivablesNetCurrent_2b719a43-c965-4f49-ab11-331773c3c0ca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_8b477eaa-d798-47d0-b029-02da2101cfef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShortTermInvestments"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_f03057b3-5648-421b-ae0c-552cfae34d0e" xlink:to="loc_us-gaap_ShortTermInvestments_8b477eaa-d798-47d0-b029-02da2101cfef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent_94033ffb-7e43-4d4c-9e44-2e3598098a1e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_f03057b3-5648-421b-ae0c-552cfae34d0e" xlink:to="loc_us-gaap_OtherAssetsCurrent_94033ffb-7e43-4d4c-9e44-2e3598098a1e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_b3966021-b42b-4ba1-8bb4-577f55a49eb9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_2489b61a-a0a9-4444-a36d-d045957a6225" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_b3966021-b42b-4ba1-8bb4-577f55a49eb9" xlink:to="loc_us-gaap_Liabilities_2489b61a-a0a9-4444-a36d-d045957a6225" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_c2c70e12-f41a-40b0-a0bb-289117a786e4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_b3966021-b42b-4ba1-8bb4-577f55a49eb9" xlink:to="loc_us-gaap_CommitmentsAndContingencies_c2c70e12-f41a-40b0-a0bb-289117a786e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_c3f8641b-db7a-4d7a-813d-3766ecfc558b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_b3966021-b42b-4ba1-8bb4-577f55a49eb9" xlink:to="loc_us-gaap_StockholdersEquity_c3f8641b-db7a-4d7a-813d-3766ecfc558b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_8d8bf38e-0d8e-4fec-a8e0-f7caa44efccc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_04c71639-ad1d-4dba-b0bc-8e8a2b5fd96b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_8d8bf38e-0d8e-4fec-a8e0-f7caa44efccc" xlink:to="loc_us-gaap_CommonStockValue_04c71639-ad1d-4dba-b0bc-8e8a2b5fd96b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_49168753-022f-4c71-a940-4c1b8357736e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_8d8bf38e-0d8e-4fec-a8e0-f7caa44efccc" xlink:to="loc_us-gaap_AdditionalPaidInCapital_49168753-022f-4c71-a940-4c1b8357736e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_76cd14d1-beef-448e-a536-bba36534e8b4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_8d8bf38e-0d8e-4fec-a8e0-f7caa44efccc" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_76cd14d1-beef-448e-a536-bba36534e8b4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_468b85e2-f011-41a1-bcd1-0458fbe74dba" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_8d8bf38e-0d8e-4fec-a8e0-f7caa44efccc" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_468b85e2-f011-41a1-bcd1-0458fbe74dba" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.recursion.com/role/ConsolidatedStatementsofOperations" xlink:type="simple" xlink:href="rxrx-20221231.xsd#ConsolidatedStatementsofOperations"/>
  <link:calculationLink xlink:role="http://www.recursion.com/role/ConsolidatedStatementsofOperations" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_92542698-9be5-40d7-bf85-b920b5b2b023" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_cf7f4d2b-2b6b-4d27-8171-62cc071fa403" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_92542698-9be5-40d7-bf85-b920b5b2b023" xlink:to="loc_us-gaap_OperatingIncomeLoss_cf7f4d2b-2b6b-4d27-8171-62cc071fa403" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_a7a9ed86-cb40-45e3-b706-3950baafb34c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_92542698-9be5-40d7-bf85-b920b5b2b023" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_a7a9ed86-cb40-45e3-b706-3950baafb34c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_9fbfd6f8-95fc-4104-86e4-685aa0d58b68" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_73bc6276-dc00-4be3-8dd9-0f61481c4847" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_9fbfd6f8-95fc-4104-86e4-685aa0d58b68" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_73bc6276-dc00-4be3-8dd9-0f61481c4847" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_20550ef5-f591-4077-9e24-22023f025c1c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostsAndExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_9fbfd6f8-95fc-4104-86e4-685aa0d58b68" xlink:to="loc_us-gaap_CostsAndExpenses_20550ef5-f591-4077-9e24-22023f025c1c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_a66ac6c9-b4a7-47a6-be74-ae7bea0fae76" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostsAndExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_b95197df-fa3c-4139-a87a-c47448ac37c8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_a66ac6c9-b4a7-47a6-be74-ae7bea0fae76" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_b95197df-fa3c-4139-a87a-c47448ac37c8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_2dee89a8-4737-4f4d-8ed2-83c829a03f6f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_a66ac6c9-b4a7-47a6-be74-ae7bea0fae76" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_2dee89a8-4737-4f4d-8ed2-83c829a03f6f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_d2ce3f42-3b8a-451c-8e95-d7257827454b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_a66ac6c9-b4a7-47a6-be74-ae7bea0fae76" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_d2ce3f42-3b8a-451c-8e95-d7257827454b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.recursion.com/role/ConsolidatedStatementsofComprehensiveLoss" xlink:type="simple" xlink:href="rxrx-20221231.xsd#ConsolidatedStatementsofComprehensiveLoss"/>
  <link:calculationLink xlink:role="http://www.recursion.com/role/ConsolidatedStatementsofComprehensiveLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_c3921f60-7398-43dd-9d31-4e56013d7090" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_348c063a-9b32-491f-96de-77b738b8a16a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_c3921f60-7398-43dd-9d31-4e56013d7090" xlink:to="loc_us-gaap_NetIncomeLoss_348c063a-9b32-491f-96de-77b738b8a16a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_ecff275a-84f7-499c-8177-ec5c6329d8af" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_c3921f60-7398-43dd-9d31-4e56013d7090" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_ecff275a-84f7-499c-8177-ec5c6329d8af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_3f136380-1d31-4111-8885-c5b925df905c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_9bfc3466-11e6-410a-98f8-395f97640d13" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_3f136380-1d31-4111-8885-c5b925df905c" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_9bfc3466-11e6-410a-98f8-395f97640d13" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_c7d9b4f8-1f12-407b-8a26-3dc8398959c1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_3f136380-1d31-4111-8885-c5b925df905c" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_c7d9b4f8-1f12-407b-8a26-3dc8398959c1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.recursion.com/role/ConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="rxrx-20221231.xsd#ConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://www.recursion.com/role/ConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_0479b5cf-8ff1-450b-bdc1-0e122c25c50e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_51afd800-3435-47d4-8608-f658e8e6db56" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_0479b5cf-8ff1-450b-bdc1-0e122c25c50e" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_51afd800-3435-47d4-8608-f658e8e6db56" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_f537a3e0-2fa2-40af-b90d-90ebce33cb3b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_0479b5cf-8ff1-450b-bdc1-0e122c25c50e" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_f537a3e0-2fa2-40af-b90d-90ebce33cb3b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_079a4665-a2ab-4c5d-a35a-b90f7d2ac0d8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_0479b5cf-8ff1-450b-bdc1-0e122c25c50e" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_079a4665-a2ab-4c5d-a35a-b90f7d2ac0d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_IncreaseDecreaseInAccruedDevelopmentExpense_3d764115-ff14-4c61-ab36-6e670018c196" xlink:href="rxrx-20221231.xsd#rxrx_IncreaseDecreaseInAccruedDevelopmentExpense"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_0479b5cf-8ff1-450b-bdc1-0e122c25c50e" xlink:to="loc_rxrx_IncreaseDecreaseInAccruedDevelopmentExpense_3d764115-ff14-4c61-ab36-6e670018c196" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TangibleAssetImpairmentCharges_38010fc2-3c60-4529-986f-39f8071957d6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TangibleAssetImpairmentCharges"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_0479b5cf-8ff1-450b-bdc1-0e122c25c50e" xlink:to="loc_us-gaap_TangibleAssetImpairmentCharges_38010fc2-3c60-4529-986f-39f8071957d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_9fd900fb-a9fd-4c1b-9328-2099b735b8b8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_0479b5cf-8ff1-450b-bdc1-0e122c25c50e" xlink:to="loc_us-gaap_NetIncomeLoss_9fd900fb-a9fd-4c1b-9328-2099b735b8b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_521eb6e5-bfcd-4395-ac35-5b62a9350612" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_0479b5cf-8ff1-450b-bdc1-0e122c25c50e" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_521eb6e5-bfcd-4395-ac35-5b62a9350612" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherAccruedLiabilities_0bf3ade0-e91e-4854-b8b0-1e6a711890ef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOtherAccruedLiabilities"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_0479b5cf-8ff1-450b-bdc1-0e122c25c50e" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherAccruedLiabilities_0bf3ade0-e91e-4854-b8b0-1e6a711890ef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_999e66a7-d62d-43b7-bac2-2bc071e02315" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_0479b5cf-8ff1-450b-bdc1-0e122c25c50e" xlink:to="loc_us-gaap_ShareBasedCompensation_999e66a7-d62d-43b7-bac2-2bc071e02315" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseExpense_27ef6358-cb90-448e-97be-ae0c06def281" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseExpense"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_0479b5cf-8ff1-450b-bdc1-0e122c25c50e" xlink:to="loc_us-gaap_OperatingLeaseExpense_27ef6358-cb90-448e-97be-ae0c06def281" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_c4ff9aa4-bb83-4acd-bc4c-c07fdfb706f8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_0479b5cf-8ff1-450b-bdc1-0e122c25c50e" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_c4ff9aa4-bb83-4acd-bc4c-c07fdfb706f8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_cf812825-b03e-4a5a-b47b-b70f188b2813" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_0479b5cf-8ff1-450b-bdc1-0e122c25c50e" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_cf812825-b03e-4a5a-b47b-b70f188b2813" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_c05c532c-bb78-4f2d-84d1-0d94fda63c17" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOperatingLeaseLiability"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_0479b5cf-8ff1-450b-bdc1-0e122c25c50e" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_c05c532c-bb78-4f2d-84d1-0d94fda63c17" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e025ab70-a0d3-411a-b5e1-9f8fe3f243c3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfRedeemableConvertiblePreferredStock_69551d09-ba71-4719-a1b7-796181eb445d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfRedeemableConvertiblePreferredStock"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e025ab70-a0d3-411a-b5e1-9f8fe3f243c3" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfRedeemableConvertiblePreferredStock_69551d09-ba71-4719-a1b7-796181eb445d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_6ce80115-0ef9-45ee-a769-6dcfba1997ca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RepaymentsOfLongTermDebt"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e025ab70-a0d3-411a-b5e1-9f8fe3f243c3" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_6ce80115-0ef9-45ee-a769-6dcfba1997ca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceInitialPublicOffering_4aeec98c-1340-41b0-93d6-f1faf1ff0cfa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceInitialPublicOffering"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e025ab70-a0d3-411a-b5e1-9f8fe3f243c3" xlink:to="loc_us-gaap_ProceedsFromIssuanceInitialPublicOffering_4aeec98c-1340-41b0-93d6-f1faf1ff0cfa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromConvertibleDebt_efdf41fb-0644-43c1-9c62-114d3f6662ed" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromConvertibleDebt"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e025ab70-a0d3-411a-b5e1-9f8fe3f243c3" xlink:to="loc_us-gaap_ProceedsFromConvertibleDebt_efdf41fb-0644-43c1-9c62-114d3f6662ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_196d660e-1ac8-4e94-846c-0081587732a8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e025ab70-a0d3-411a-b5e1-9f8fe3f243c3" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_196d660e-1ac8-4e94-846c-0081587732a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_3f0d9031-9553-4b19-b78b-94c2544576c6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e025ab70-a0d3-411a-b5e1-9f8fe3f243c3" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_3f0d9031-9553-4b19-b78b-94c2544576c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_31b01cb9-90d7-4006-b3c7-bffe335caaf8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_07f040b7-0801-4d66-9c2d-f6ed831e4bee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_31b01cb9-90d7-4006-b3c7-bffe335caaf8" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_07f040b7-0801-4d66-9c2d-f6ed831e4bee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireIntangibleAssets_be88d0b3-1c93-4e0c-bf7b-3497a02ec637" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireIntangibleAssets"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_31b01cb9-90d7-4006-b3c7-bffe335caaf8" xlink:to="loc_us-gaap_PaymentsToAcquireIntangibleAssets_be88d0b3-1c93-4e0c-bf7b-3497a02ec637" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromCollectionOfNotesReceivable_23c4a887-3a54-4e4a-b2a7-5a6d200dda2f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromCollectionOfNotesReceivable"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_31b01cb9-90d7-4006-b3c7-bffe335caaf8" xlink:to="loc_us-gaap_ProceedsFromCollectionOfNotesReceivable_23c4a887-3a54-4e4a-b2a7-5a6d200dda2f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_57d19953-7116-433a-a952-98c642ad817d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_31b01cb9-90d7-4006-b3c7-bffe335caaf8" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_57d19953-7116-433a-a952-98c642ad817d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities_e22c5f8d-2ba4-434d-8329-2fe9d38f37e9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_31b01cb9-90d7-4006-b3c7-bffe335caaf8" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities_e22c5f8d-2ba4-434d-8329-2fe9d38f37e9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_6ca1f461-5bd0-41fb-af13-faf97e944a12" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_31b01cb9-90d7-4006-b3c7-bffe335caaf8" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_6ca1f461-5bd0-41fb-af13-faf97e944a12" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_999f1109-bf1b-4f5b-848c-473412c4e094" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_58415ece-897a-4fc4-b22d-f11d6345b1cb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_999f1109-bf1b-4f5b-848c-473412c4e094" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_58415ece-897a-4fc4-b22d-f11d6345b1cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_e7e8c0f4-d576-4635-9a79-ce24ef1d065b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_999f1109-bf1b-4f5b-848c-473412c4e094" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_e7e8c0f4-d576-4635-9a79-ce24ef1d065b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_74f19c41-dd08-4f59-b50d-481928845885" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_999f1109-bf1b-4f5b-848c-473412c4e094" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_74f19c41-dd08-4f59-b50d-481928845885" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_f13ee18a-c72f-4ab9-a463-91e2b61882c4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_999f1109-bf1b-4f5b-848c-473412c4e094" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_f13ee18a-c72f-4ab9-a463-91e2b61882c4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.recursion.com/role/AcquisitionsDetails" xlink:type="simple" xlink:href="rxrx-20221231.xsd#AcquisitionsDetails"/>
  <link:calculationLink xlink:role="http://www.recursion.com/role/AcquisitionsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_dda59034-9571-46a8-82f4-196dd82eb5e2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_b33ae944-394d-42dd-8542-1ff6c0cd361f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_dda59034-9571-46a8-82f4-196dd82eb5e2" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_b33ae944-394d-42dd-8542-1ff6c0cd361f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_92db168f-91d2-4d93-8b57-cf651595e7c5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_dda59034-9571-46a8-82f4-196dd82eb5e2" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_92db168f-91d2-4d93-8b57-cf651595e7c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_a5a9aa86-1763-4aa2-8ecf-1da15b55acbb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_dda59034-9571-46a8-82f4-196dd82eb5e2" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_a5a9aa86-1763-4aa2-8ecf-1da15b55acbb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_5fbeb6f1-9dc4-423a-8322-9ac262c9c16d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_dda59034-9571-46a8-82f4-196dd82eb5e2" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_5fbeb6f1-9dc4-423a-8322-9ac262c9c16d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_be9abb6d-281f-45e9-b6a7-d0a8161119db" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_aabea3dc-4fb6-4fba-b6a1-0d08051f7a3c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_be9abb6d-281f-45e9-b6a7-d0a8161119db" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_aabea3dc-4fb6-4fba-b6a1-0d08051f7a3c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_906bfba1-9e47-4f73-aa0e-e5a01ae2b996" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_be9abb6d-281f-45e9-b6a7-d0a8161119db" xlink:to="loc_us-gaap_Goodwill_906bfba1-9e47-4f73-aa0e-e5a01ae2b996" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.recursion.com/role/SupplementalFinancialInformationPPEDetails" xlink:type="simple" xlink:href="rxrx-20221231.xsd#SupplementalFinancialInformationPPEDetails"/>
  <link:calculationLink xlink:role="http://www.recursion.com/role/SupplementalFinancialInformationPPEDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_f83214c3-771b-4c75-9e8d-ec8e264c105b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_37bf4c3b-efb9-4cd9-ad8f-db4628f0468b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_f83214c3-771b-4c75-9e8d-ec8e264c105b" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_37bf4c3b-efb9-4cd9-ad8f-db4628f0468b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_dc984d50-1ba4-43ae-9da7-9ee76b1aca90" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_f83214c3-771b-4c75-9e8d-ec8e264c105b" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_dc984d50-1ba4-43ae-9da7-9ee76b1aca90" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.recursion.com/role/SupplementalFinancialInformationAccrualsDetails" xlink:type="simple" xlink:href="rxrx-20221231.xsd#SupplementalFinancialInformationAccrualsDetails"/>
  <link:calculationLink xlink:role="http://www.recursion.com/role/SupplementalFinancialInformationAccrualsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_b3864b05-3975-4120-9628-49aed651f4d2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_3f6a499a-f5cf-483c-aac4-8bbbbc21b53b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_b3864b05-3975-4120-9628-49aed651f4d2" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_3f6a499a-f5cf-483c-aac4-8bbbbc21b53b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_AccruedDevelopmentCostsCurrent_262d41fb-95fa-4d27-bfc8-0b54a56b6c4d" xlink:href="rxrx-20221231.xsd#rxrx_AccruedDevelopmentCostsCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_b3864b05-3975-4120-9628-49aed651f4d2" xlink:to="loc_rxrx_AccruedDevelopmentCostsCurrent_262d41fb-95fa-4d27-bfc8-0b54a56b6c4d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_AccruedEarlyDiscoveryExpensesCurrent_e050ad92-bb78-432a-aa2c-f27172e96954" xlink:href="rxrx-20221231.xsd#rxrx_AccruedEarlyDiscoveryExpensesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_b3864b05-3975-4120-9628-49aed651f4d2" xlink:to="loc_rxrx_AccruedEarlyDiscoveryExpensesCurrent_e050ad92-bb78-432a-aa2c-f27172e96954" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionPayableCurrent_0e5310a6-3179-463d-a8e2-17f397f57b4b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConstructionPayableCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_b3864b05-3975-4120-9628-49aed651f4d2" xlink:to="loc_us-gaap_ConstructionPayableCurrent_0e5310a6-3179-463d-a8e2-17f397f57b4b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_9e758433-94c0-487d-b103-49dc2efa3ac1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_b3864b05-3975-4120-9628-49aed651f4d2" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_9e758433-94c0-487d-b103-49dc2efa3ac1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_3863c7d7-28af-43f0-a9fc-0c401b28f431" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_b3864b05-3975-4120-9628-49aed651f4d2" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_3863c7d7-28af-43f0-a9fc-0c401b28f431" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.recursion.com/role/SupplementalFinancialInformationInterestDetails" xlink:type="simple" xlink:href="rxrx-20221231.xsd#SupplementalFinancialInformationInterestDetails"/>
  <link:calculationLink xlink:role="http://www.recursion.com/role/SupplementalFinancialInformationInterestDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRevenueExpenseNet_1bb825c7-7f1b-46f5-be60-4b4d5fc1dffd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestRevenueExpenseNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_e133fc80-2c7c-47ba-ad2d-2bf230170268" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestRevenueExpenseNet_1bb825c7-7f1b-46f5-be60-4b4d5fc1dffd" xlink:to="loc_us-gaap_InterestExpense_e133fc80-2c7c-47ba-ad2d-2bf230170268" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeNonoperating_201af2d7-5578-4ccb-b0c7-05f840b11731" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentIncomeNonoperating"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestRevenueExpenseNet_1bb825c7-7f1b-46f5-be60-4b4d5fc1dffd" xlink:to="loc_us-gaap_InvestmentIncomeNonoperating_201af2d7-5578-4ccb-b0c7-05f840b11731" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.recursion.com/role/InvestmentsTypeofSecurityDetails" xlink:type="simple" xlink:href="rxrx-20221231.xsd#InvestmentsTypeofSecurityDetails"/>
  <link:calculationLink xlink:role="http://www.recursion.com/role/InvestmentsTypeofSecurityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_f1c17bff-d1a8-4f9b-b738-1adf01146f84" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_b746574a-fbd8-42a3-aff6-ffae9d8161d4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_f1c17bff-d1a8-4f9b-b738-1adf01146f84" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_b746574a-fbd8-42a3-aff6-ffae9d8161d4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_94a6ac37-e3f2-44f9-bd4d-d62d4e39dd87" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_f1c17bff-d1a8-4f9b-b738-1adf01146f84" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_94a6ac37-e3f2-44f9-bd4d-d62d4e39dd87" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_89eca0a7-602e-498c-8086-13e9f51dbc06" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_f1c17bff-d1a8-4f9b-b738-1adf01146f84" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_89eca0a7-602e-498c-8086-13e9f51dbc06" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.recursion.com/role/LeasesComponentsofLeaseCostDetails" xlink:type="simple" xlink:href="rxrx-20221231.xsd#LeasesComponentsofLeaseCostDetails"/>
  <link:calculationLink xlink:role="http://www.recursion.com/role/LeasesComponentsofLeaseCostDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCost_5a3eef2c-7e27-4f60-912d-72fe9af5220e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableLeaseCost_1c362f50-d6ec-4b85-bcd6-94386ad21736" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VariableLeaseCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_5a3eef2c-7e27-4f60-912d-72fe9af5220e" xlink:to="loc_us-gaap_VariableLeaseCost_1c362f50-d6ec-4b85-bcd6-94386ad21736" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseCost_cf547c26-9e01-49a4-a88d-5b5523f3a273" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_5a3eef2c-7e27-4f60-912d-72fe9af5220e" xlink:to="loc_us-gaap_OperatingLeaseCost_cf547c26-9e01-49a4-a88d-5b5523f3a273" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.recursion.com/role/LeasesMaturitiesofOperatingLeaseLiabilitiesDetails" xlink:type="simple" xlink:href="rxrx-20221231.xsd#LeasesMaturitiesofOperatingLeaseLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.recursion.com/role/LeasesMaturitiesofOperatingLeaseLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_d082d136-0dbc-48d9-9c8e-ea8f3555f20a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_c920cea7-5524-4d81-a709-701742e668e1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_d082d136-0dbc-48d9-9c8e-ea8f3555f20a" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_c920cea7-5524-4d81-a709-701742e668e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_884ab2e4-bfa8-4467-af56-d15f65fa1772" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_d082d136-0dbc-48d9-9c8e-ea8f3555f20a" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_884ab2e4-bfa8-4467-af56-d15f65fa1772" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_e54a861e-1d23-48ff-9957-0359bbea24ff" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_d082d136-0dbc-48d9-9c8e-ea8f3555f20a" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_e54a861e-1d23-48ff-9957-0359bbea24ff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_9c7a208c-d1cf-40d6-983e-167104e70c4d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_d082d136-0dbc-48d9-9c8e-ea8f3555f20a" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_9c7a208c-d1cf-40d6-983e-167104e70c4d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_ed52731c-5e6b-42dd-9143-5d0d8f418a45" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_d082d136-0dbc-48d9-9c8e-ea8f3555f20a" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_ed52731c-5e6b-42dd-9143-5d0d8f418a45" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_e3d0c866-8f99-4e65-99e5-cae4c73acfe3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_d082d136-0dbc-48d9-9c8e-ea8f3555f20a" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_e3d0c866-8f99-4e65-99e5-cae4c73acfe3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.recursion.com/role/LeasesMaturitiesofOperatingLeaseLiabilitiesDetails_1" xlink:type="simple" xlink:href="rxrx-20221231.xsd#LeasesMaturitiesofOperatingLeaseLiabilitiesDetails_1"/>
  <link:calculationLink xlink:role="http://www.recursion.com/role/LeasesMaturitiesofOperatingLeaseLiabilitiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_f01384c9-fd5d-48e8-9fdc-628328763a96" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_fd35ec3f-1fde-4cd0-880a-f471d804b383" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_f01384c9-fd5d-48e8-9fdc-628328763a96" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_fd35ec3f-1fde-4cd0-880a-f471d804b383" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_7249f162-c368-4a37-aa51-f6e589239cd0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_f01384c9-fd5d-48e8-9fdc-628328763a96" xlink:to="loc_us-gaap_OperatingLeaseLiability_7249f162-c368-4a37-aa51-f6e589239cd0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.recursion.com/role/LeasesFutureMinimumPaymentsPriortoASC842AdoptionDetails" xlink:type="simple" xlink:href="rxrx-20221231.xsd#LeasesFutureMinimumPaymentsPriortoASC842AdoptionDetails"/>
  <link:calculationLink xlink:role="http://www.recursion.com/role/LeasesFutureMinimumPaymentsPriortoASC842AdoptionDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_04b1ad2d-539a-4f68-b030-d172d9fe2a40" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter_1294be50-c03e-47d3-9702-b6fa48868d02" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_04b1ad2d-539a-4f68-b030-d172d9fe2a40" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter_1294be50-c03e-47d3-9702-b6fa48868d02" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_1a8a08c7-1765-49ab-bfbd-3a93745853ab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_04b1ad2d-539a-4f68-b030-d172d9fe2a40" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_1a8a08c7-1765-49ab-bfbd-3a93745853ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_31f29eea-42d9-4ee6-8594-be1c95f1b2c5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_04b1ad2d-539a-4f68-b030-d172d9fe2a40" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_31f29eea-42d9-4ee6-8594-be1c95f1b2c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_3ea10856-7225-4a42-a4be-f33efbf295ac" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_04b1ad2d-539a-4f68-b030-d172d9fe2a40" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_3ea10856-7225-4a42-a4be-f33efbf295ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_e2454011-5371-43ab-b4a3-206aa58c2a1d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_04b1ad2d-539a-4f68-b030-d172d9fe2a40" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_e2454011-5371-43ab-b4a3-206aa58c2a1d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_60c37702-bf2f-4799-b3f5-1c9943c95474" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_04b1ad2d-539a-4f68-b030-d172d9fe2a40" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_60c37702-bf2f-4799-b3f5-1c9943c95474" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.recursion.com/role/GoodwillandIntangibleAssetsDetails" xlink:type="simple" xlink:href="rxrx-20221231.xsd#GoodwillandIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.recursion.com/role/GoodwillandIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_d429616f-1d12-41e7-867c-22cf416e7cf3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_6d84e224-92ab-491a-b749-67918b946cf1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_d429616f-1d12-41e7-867c-22cf416e7cf3" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_6d84e224-92ab-491a-b749-67918b946cf1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_04ba153e-4126-4367-aa5b-47764290c313" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_d429616f-1d12-41e7-867c-22cf416e7cf3" xlink:to="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_04ba153e-4126-4367-aa5b-47764290c313" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_0283be9c-68f4-4c58-9491-a9c1855b3d95" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_21ad6c7f-760d-4da2-a084-368feaf1940b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_0283be9c-68f4-4c58-9491-a9c1855b3d95" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_21ad6c7f-760d-4da2-a084-368feaf1940b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_976f24b9-6d35-43e7-9613-a77286b5a18e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_0283be9c-68f4-4c58-9491-a9c1855b3d95" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_976f24b9-6d35-43e7-9613-a77286b5a18e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_c7346ee7-954a-47f6-a8b0-48043ed1f27c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_95c14cf6-a3ef-4de9-a0f2-ace6bd4fb330" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_c7346ee7-954a-47f6-a8b0-48043ed1f27c" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_95c14cf6-a3ef-4de9-a0f2-ace6bd4fb330" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_7e1b6292-9ecc-4f61-8d8b-d7e4c5ee5f76" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_c7346ee7-954a-47f6-a8b0-48043ed1f27c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_7e1b6292-9ecc-4f61-8d8b-d7e4c5ee5f76" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.recursion.com/role/GoodwillandIntangibleAssetsDetails_1" xlink:type="simple" xlink:href="rxrx-20221231.xsd#GoodwillandIntangibleAssetsDetails_1"/>
  <link:calculationLink xlink:role="http://www.recursion.com/role/GoodwillandIntangibleAssetsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_0b2adf67-68bb-42da-8264-e01a69f78455" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_80d7a260-af29-4b82-a6eb-168ebeda61c0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_0b2adf67-68bb-42da-8264-e01a69f78455" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_80d7a260-af29-4b82-a6eb-168ebeda61c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_5e7eee47-c478-480e-8ed7-41d2d967d4e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_0b2adf67-68bb-42da-8264-e01a69f78455" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_5e7eee47-c478-480e-8ed7-41d2d967d4e0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.recursion.com/role/IncomeTaxesIncomeTaxProvisionComponentsDetails" xlink:type="simple" xlink:href="rxrx-20221231.xsd#IncomeTaxesIncomeTaxProvisionComponentsDetails"/>
  <link:calculationLink xlink:role="http://www.recursion.com/role/IncomeTaxesIncomeTaxProvisionComponentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_58ce741a-c8ae-4620-932b-5d7afd22873c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_67c91f0b-f4af-4895-81a9-f64d265cc890" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredFederalIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_58ce741a-c8ae-4620-932b-5d7afd22873c" xlink:to="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_67c91f0b-f4af-4895-81a9-f64d265cc890" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_c47631d1-59df-448d-a54c-2d80159742d4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_58ce741a-c8ae-4620-932b-5d7afd22873c" xlink:to="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_c47631d1-59df-448d-a54c-2d80159742d4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_7e6e1d1a-c474-46b1-8e97-d71d69f47e6f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredForeignIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_58ce741a-c8ae-4620-932b-5d7afd22873c" xlink:to="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_7e6e1d1a-c474-46b1-8e97-d71d69f47e6f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsAdjustmentOfDeferredTaxAssetLiability_11f16f70-c409-4440-b527-37608be3350e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExpenseBenefitContinuingOperationsAdjustmentOfDeferredTaxAssetLiability"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_58ce741a-c8ae-4620-932b-5d7afd22873c" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsAdjustmentOfDeferredTaxAssetLiability_11f16f70-c409-4440-b527-37608be3350e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.recursion.com/role/IncomeTaxesEffectiveIncomeTaxRateReconciliationDetails" xlink:type="simple" xlink:href="rxrx-20221231.xsd#IncomeTaxesEffectiveIncomeTaxRateReconciliationDetails"/>
  <link:calculationLink xlink:role="http://www.recursion.com/role/IncomeTaxesEffectiveIncomeTaxRateReconciliationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_037b44b2-a45f-4449-93a2-f489fff494be" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_95339b03-daf5-48c8-942f-3a23e1e38169" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_037b44b2-a45f-4449-93a2-f489fff494be" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_95339b03-daf5-48c8-942f-3a23e1e38169" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCreditsResearch_ff48a517-2cd5-4910-a4a5-718d7b1f0506" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationTaxCreditsResearch"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_037b44b2-a45f-4449-93a2-f489fff494be" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCreditsResearch_ff48a517-2cd5-4910-a4a5-718d7b1f0506" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_EffectiveIncomeTaxRateReconciliationTaxCreditOrphanDrugPercent_d19861a6-1056-4239-b717-5401cdc4d578" xlink:href="rxrx-20221231.xsd#rxrx_EffectiveIncomeTaxRateReconciliationTaxCreditOrphanDrugPercent"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_037b44b2-a45f-4449-93a2-f489fff494be" xlink:to="loc_rxrx_EffectiveIncomeTaxRateReconciliationTaxCreditOrphanDrugPercent_d19861a6-1056-4239-b717-5401cdc4d578" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxContingencies_83bea9c8-3a4a-48b9-b278-3e8576cef34f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationTaxContingencies"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_037b44b2-a45f-4449-93a2-f489fff494be" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxContingencies_83bea9c8-3a4a-48b9-b278-3e8576cef34f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther_e47f7312-9c48-4213-a31b-b5f4358ba71f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_037b44b2-a45f-4449-93a2-f489fff494be" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther_e47f7312-9c48-4213-a31b-b5f4358ba71f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_12e58c90-7ac4-44a6-8fce-53cb5d49aeee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_037b44b2-a45f-4449-93a2-f489fff494be" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_12e58c90-7ac4-44a6-8fce-53cb5d49aeee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost_22db4497-c6d3-4771-9cce-c36ed7217f76" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_037b44b2-a45f-4449-93a2-f489fff494be" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost_22db4497-c6d3-4771-9cce-c36ed7217f76" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.recursion.com/role/IncomeTaxesDeferredTaxAssetsandLiabilitiesDetails" xlink:type="simple" xlink:href="rxrx-20221231.xsd#IncomeTaxesDeferredTaxAssetsandLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.recursion.com/role/IncomeTaxesDeferredTaxAssetsandLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_40a03882-89ef-4827-a361-22e83ab2a03d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGoodwillAndIntangibleAssets_5d146709-65fb-4f21-9ccd-a9b843945228" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxAssetsGoodwillAndIntangibleAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_40a03882-89ef-4827-a361-22e83ab2a03d" xlink:to="loc_us-gaap_DeferredTaxAssetsGoodwillAndIntangibleAssets_5d146709-65fb-4f21-9ccd-a9b843945228" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOther_724bbffb-cc1e-4b37-82a9-3abb4f605f90" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxAssetsOther"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_40a03882-89ef-4827-a361-22e83ab2a03d" xlink:to="loc_us-gaap_DeferredTaxAssetsOther_724bbffb-cc1e-4b37-82a9-3abb4f605f90" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_15747009-ca66-468d-863f-65d1c8c50521" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_40a03882-89ef-4827-a361-22e83ab2a03d" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_15747009-ca66-468d-863f-65d1c8c50521" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards_c9e5e0eb-e429-452c-85b8-a6b6934ae13a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxAssetsTaxCreditCarryforwards"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_40a03882-89ef-4827-a361-22e83ab2a03d" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards_c9e5e0eb-e429-452c-85b8-a6b6934ae13a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsInProcessResearchAndDevelopment_5ca97994-4b70-4099-adf5-45a932262f1d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxAssetsInProcessResearchAndDevelopment"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_40a03882-89ef-4827-a361-22e83ab2a03d" xlink:to="loc_us-gaap_DeferredTaxAssetsInProcessResearchAndDevelopment_5ca97994-4b70-4099-adf5-45a932262f1d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsDeferredRent_89ef939d-4954-462a-b0c7-c20943315cf9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsDeferredRent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_40a03882-89ef-4827-a361-22e83ab2a03d" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsDeferredRent_89ef939d-4954-462a-b0c7-c20943315cf9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_DeferredTaxAssetsLeaseLiabilities_673d505b-950a-4d5f-8d88-0370629fc60b" xlink:href="rxrx-20221231.xsd#rxrx_DeferredTaxAssetsLeaseLiabilities"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_40a03882-89ef-4827-a361-22e83ab2a03d" xlink:to="loc_rxrx_DeferredTaxAssetsLeaseLiabilities_673d505b-950a-4d5f-8d88-0370629fc60b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals_2db2741e-378a-4c95-9109-45ca08c31582" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_40a03882-89ef-4827-a361-22e83ab2a03d" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals_2db2741e-378a-4c95-9109-45ca08c31582" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_1fd2bc36-7343-4574-adea-fe0bf7a54ff7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwards"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_40a03882-89ef-4827-a361-22e83ab2a03d" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_1fd2bc36-7343-4574-adea-fe0bf7a54ff7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_af378518-7296-441c-bc4a-069d72cc690e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxAssetsLiabilitiesNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_0467e1fb-5c7e-4dd2-83bf-1f15439f010f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxAssetsNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_af378518-7296-441c-bc4a-069d72cc690e" xlink:to="loc_us-gaap_DeferredTaxAssetsNet_0467e1fb-5c7e-4dd2-83bf-1f15439f010f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_a516d02b-1af9-4439-a6da-1768c881bb1f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_af378518-7296-441c-bc4a-069d72cc690e" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilities_a516d02b-1af9-4439-a6da-1768c881bb1f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_74dee0c4-1579-46b6-a091-5b4fd10caadd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesLeasingArrangements_612b70da-ea2e-415e-a5b8-7816496dc7a8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxLiabilitiesLeasingArrangements"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_74dee0c4-1579-46b6-a091-5b4fd10caadd" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesLeasingArrangements_612b70da-ea2e-415e-a5b8-7816496dc7a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_9e558096-f6aa-4bd5-b4d2-ba754ad26c4a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_74dee0c4-1579-46b6-a091-5b4fd10caadd" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_9e558096-f6aa-4bd5-b4d2-ba754ad26c4a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_DeferredTaxLiabilitiesRightOfUseAssets_268fd6d8-71d5-4609-a76a-6d37156677ec" xlink:href="rxrx-20221231.xsd#rxrx_DeferredTaxLiabilitiesRightOfUseAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_74dee0c4-1579-46b6-a091-5b4fd10caadd" xlink:to="loc_rxrx_DeferredTaxLiabilitiesRightOfUseAssets_268fd6d8-71d5-4609-a76a-6d37156677ec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_cc695f34-ff16-4a61-8339-ded77b254f96" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_f6d3cf94-c400-4a6f-9dee-77ab9b49a01e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_cc695f34-ff16-4a61-8339-ded77b254f96" xlink:to="loc_us-gaap_DeferredTaxAssetsGross_f6d3cf94-c400-4a6f-9dee-77ab9b49a01e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_a47bef31-2924-45c8-9586-2388a7712bb4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_cc695f34-ff16-4a61-8339-ded77b254f96" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_a47bef31-2924-45c8-9586-2388a7712bb4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.recursion.com/role/IncomeTaxesNarrativeDetails" xlink:type="simple" xlink:href="rxrx-20221231.xsd#IncomeTaxesNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.recursion.com/role/IncomeTaxesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwards_c3e10e47-08eb-4ff1-bd6b-fc1883db5b32" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLossCarryforwards"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_OperatingLossCarryforwardsSubjectToExpiration_c9bc3af7-2f74-4f89-94a8-485061cbad1e" xlink:href="rxrx-20221231.xsd#rxrx_OperatingLossCarryforwardsSubjectToExpiration"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLossCarryforwards_c3e10e47-08eb-4ff1-bd6b-fc1883db5b32" xlink:to="loc_rxrx_OperatingLossCarryforwardsSubjectToExpiration_c9bc3af7-2f74-4f89-94a8-485061cbad1e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_OperatingLossCarryforwardsNotSubjectToExpiration_4bc10bcf-45c9-491b-a1d2-f163091f1e0e" xlink:href="rxrx-20221231.xsd#rxrx_OperatingLossCarryforwardsNotSubjectToExpiration"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLossCarryforwards_c3e10e47-08eb-4ff1-bd6b-fc1883db5b32" xlink:to="loc_rxrx_OperatingLossCarryforwardsNotSubjectToExpiration_4bc10bcf-45c9-491b-a1d2-f163091f1e0e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.recursion.com/role/FairValueMeasurementsAssetsandLiabilitiesMeasuredonRecurringBasisDetails" xlink:type="simple" xlink:href="rxrx-20221231.xsd#FairValueMeasurementsAssetsandLiabilitiesMeasuredonRecurringBasisDetails"/>
  <link:calculationLink xlink:role="http://www.recursion.com/role/FairValueMeasurementsAssetsandLiabilitiesMeasuredonRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_1527cb9e-8f21-434e-b32c-0bc62b52f885" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_6dc3ecd5-1fe8-4170-89b8-cd225e9e270d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_1527cb9e-8f21-434e-b32c-0bc62b52f885" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_6dc3ecd5-1fe8-4170-89b8-cd225e9e270d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_RestrictedCashAndCashEquivalentsFairValueDisclosure_14aa3102-9d0b-4064-a653-1ec52fbdfe6d" xlink:href="rxrx-20221231.xsd#rxrx_RestrictedCashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_1527cb9e-8f21-434e-b32c-0bc62b52f885" xlink:to="loc_rxrx_RestrictedCashAndCashEquivalentsFairValueDisclosure_14aa3102-9d0b-4064-a653-1ec52fbdfe6d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsFairValueDisclosure_eb4828ea-12d3-4a83-9cf0-144838450925" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentsFairValueDisclosure"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_1527cb9e-8f21-434e-b32c-0bc62b52f885" xlink:to="loc_us-gaap_InvestmentsFairValueDisclosure_eb4828ea-12d3-4a83-9cf0-144838450925" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_1cb57196-842f-4645-8e6e-f58320b5e7ca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesFairValueDisclosure"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.recursion.com/role/FairValueMeasurementsAssetandLiabilityNotMeasuredatFairValueDetails" xlink:type="simple" xlink:href="rxrx-20221231.xsd#FairValueMeasurementsAssetandLiabilityNotMeasuredatFairValueDetails"/>
  <link:calculationLink xlink:role="http://www.recursion.com/role/FairValueMeasurementsAssetandLiabilityNotMeasuredatFairValueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtFairValue_3517e176-9219-4c9f-8bf1-cc089ea5af3e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_ff5e5edd-96de-449d-bf5a-542246cf30d0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtFairValue_3517e176-9219-4c9f-8bf1-cc089ea5af3e" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_ff5e5edd-96de-449d-bf5a-542246cf30d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_87c593eb-71b0-44a1-b91e-367d6e970f52" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtFairValue_3517e176-9219-4c9f-8bf1-cc089ea5af3e" xlink:to="loc_us-gaap_LongTermDebtCurrent_87c593eb-71b0-44a1-b91e-367d6e970f52" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
