<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:08070f55-a90c-4c54-bedc-e300ee79f6ed,g:ea61aa5a-179a-488c-beaa-2ff0e103d3cd-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.recursion.com/role/Cover" xlink:type="simple" xlink:href="rxrx-20251231.xsd#Cover"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationTable_ae7ff26d-c68b-40f7-a4c0-c7ee53b70eb2" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentInformationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_DocumentInformationTable_ae7ff26d-c68b-40f7-a4c0-c7ee53b70eb2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_d58bc9cc-62a4-442d-8b6f-900083603274" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_DocumentInformationTable_ae7ff26d-c68b-40f7-a4c0-c7ee53b70eb2" xlink:to="loc_us-gaap_StatementClassOfStockAxis_d58bc9cc-62a4-442d-8b6f-900083603274" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_d58bc9cc-62a4-442d-8b6f-900083603274_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_d58bc9cc-62a4-442d-8b6f-900083603274" xlink:to="loc_us-gaap_ClassOfStockDomain_d58bc9cc-62a4-442d-8b6f-900083603274_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_2b402e95-46d6-49fc-854d-4e60d36aa557" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_d58bc9cc-62a4-442d-8b6f-900083603274" xlink:to="loc_us-gaap_ClassOfStockDomain_2b402e95-46d6-49fc-854d-4e60d36aa557" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_e9104a87-3452-492e-bd4f-629d0b4866c3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_2b402e95-46d6-49fc-854d-4e60d36aa557" xlink:to="loc_us-gaap_CommonClassAMember_e9104a87-3452-492e-bd4f-629d0b4866c3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_22d36687-150a-4b4f-b3be-ba85dcc95b38" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassBMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_2b402e95-46d6-49fc-854d-4e60d36aa557" xlink:to="loc_us-gaap_CommonClassBMember_22d36687-150a-4b4f-b3be-ba85dcc95b38" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_b2ad8d25-de47-4f26-84ac-b688e4f8fadd" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_DocumentType_b2ad8d25-de47-4f26-84ac-b688e4f8fadd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentAnnualReport_cf9a7763-c1e4-4d16-b497-108fda4c5ffd" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentAnnualReport"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_DocumentAnnualReport_cf9a7763-c1e4-4d16-b497-108fda4c5ffd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_dfa12e4e-eee9-4e0f-8b1c-5481e24dc3ee" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_DocumentPeriodEndDate_dfa12e4e-eee9-4e0f-8b1c-5481e24dc3ee" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_de23d317-ca1b-4626-a732-5b5dd3a39a0c" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_CurrentFiscalYearEndDate_de23d317-ca1b-4626-a732-5b5dd3a39a0c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentTransitionReport_cb5181cb-c1e9-48c3-b677-f0dcc0b935b8" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentTransitionReport"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_DocumentTransitionReport_cb5181cb-c1e9-48c3-b677-f0dcc0b935b8" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_0fea635b-0800-4ef4-817f-5323a30f3c15" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_EntityFileNumber_0fea635b-0800-4ef4-817f-5323a30f3c15" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_435f0fd6-6873-4b58-b580-22981a761197" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_EntityRegistrantName_435f0fd6-6873-4b58-b580-22981a761197" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_93ba1338-1d7d-415f-a9b8-44b8f7d5f6d8" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_EntityIncorporationStateCountryCode_93ba1338-1d7d-415f-a9b8-44b8f7d5f6d8" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_1e27eb32-4758-4d97-8f23-396d0f437689" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_EntityTaxIdentificationNumber_1e27eb32-4758-4d97-8f23-396d0f437689" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_0309636a-919f-4441-8a5b-8445f5e6fe97" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_EntityAddressAddressLine1_0309636a-919f-4441-8a5b-8445f5e6fe97" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_2c507075-01f9-4afb-9d36-270c2e193017" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_EntityAddressCityOrTown_2c507075-01f9-4afb-9d36-270c2e193017" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_624e3f08-e59d-43f1-b45b-4bb353a54778" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_EntityAddressStateOrProvince_624e3f08-e59d-43f1-b45b-4bb353a54778" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_5ad8eec0-eefa-4e5a-9bbd-b239eb672fdf" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_EntityAddressPostalZipCode_5ad8eec0-eefa-4e5a-9bbd-b239eb672fdf" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_d15b8f97-9e0d-408a-bda0-bc029d37fcb3" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_CityAreaCode_d15b8f97-9e0d-408a-bda0-bc029d37fcb3" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_9916632e-6322-42bd-ba38-8afaf0ec4d0a" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_LocalPhoneNumber_9916632e-6322-42bd-ba38-8afaf0ec4d0a" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_752bae2b-802b-46a2-a3c8-f9bbe4484f71" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_Security12bTitle_752bae2b-802b-46a2-a3c8-f9bbe4484f71" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_3483cd39-d504-46d1-96fb-d2234a76dcb4" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_TradingSymbol_3483cd39-d504-46d1-96fb-d2234a76dcb4" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_5b2a4c80-5f78-4502-a741-ee811b67632f" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_SecurityExchangeName_5b2a4c80-5f78-4502-a741-ee811b67632f" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityWellKnownSeasonedIssuer_a35f66c6-cbda-41b6-add4-fc416416c7a2" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityWellKnownSeasonedIssuer"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_EntityWellKnownSeasonedIssuer_a35f66c6-cbda-41b6-add4-fc416416c7a2" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityVoluntaryFilers_ab196f26-c97f-4a17-9a2b-931cfe52f837" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityVoluntaryFilers"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_EntityVoluntaryFilers_ab196f26-c97f-4a17-9a2b-931cfe52f837" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus_6baa5703-a710-410a-981d-f3f2e7d48728" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCurrentReportingStatus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_EntityCurrentReportingStatus_6baa5703-a710-410a-981d-f3f2e7d48728" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInteractiveDataCurrent_b1407af9-6b8d-46f1-a051-2de6b10a63d5" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityInteractiveDataCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_EntityInteractiveDataCurrent_b1407af9-6b8d-46f1-a051-2de6b10a63d5" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory_0b731412-f089-4c9b-8130-c682543e7e7a" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFilerCategory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_EntityFilerCategory_0b731412-f089-4c9b-8130-c682543e7e7a" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitySmallBusiness_ca8a0e67-5dbf-4569-876f-129e6048874f" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntitySmallBusiness"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_EntitySmallBusiness_ca8a0e67-5dbf-4569-876f-129e6048874f" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_3607f2c4-b03d-4f6b-aca2-25631a667956" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_EntityEmergingGrowthCompany_3607f2c4-b03d-4f6b-aca2-25631a667956" xlink:type="arc" order="24"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_IcfrAuditorAttestationFlag_32234479-7060-4c4c-9d63-bcd364e81fb0" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_IcfrAuditorAttestationFlag"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_IcfrAuditorAttestationFlag_32234479-7060-4c4c-9d63-bcd364e81fb0" xlink:type="arc" order="25"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFinStmtErrorCorrectionFlag_c3da1863-b35a-4c84-829e-f67f03b44da4" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentFinStmtErrorCorrectionFlag"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_DocumentFinStmtErrorCorrectionFlag_c3da1863-b35a-4c84-829e-f67f03b44da4" xlink:type="arc" order="26"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany_55ec1a45-2066-4814-99f5-3f26fc9d9291" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityShellCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_EntityShellCompany_55ec1a45-2066-4814-99f5-3f26fc9d9291" xlink:type="arc" order="27"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityPublicFloat_e281666e-f90d-40aa-9cda-b755e5ff9bcd" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityPublicFloat"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_EntityPublicFloat_e281666e-f90d-40aa-9cda-b755e5ff9bcd" xlink:type="arc" order="28"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_4b30da6b-d1fb-4984-ad40-f34b8a1a519a" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_4b30da6b-d1fb-4984-ad40-f34b8a1a519a" xlink:type="arc" order="29"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentsIncorporatedByReferenceTextBlock_36a8f475-de66-4158-9f72-b90772d39499" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentsIncorporatedByReferenceTextBlock"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_DocumentsIncorporatedByReferenceTextBlock_36a8f475-de66-4158-9f72-b90772d39499" xlink:type="arc" order="30"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_d546550a-9516-456b-a040-be8443e75e8b" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_EntityCentralIndexKey_d546550a-9516-456b-a040-be8443e75e8b" xlink:type="arc" order="31"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_7db6270d-acee-4b4b-b581-b94a96383c13" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_AmendmentFlag_7db6270d-acee-4b4b-b581-b94a96383c13" xlink:type="arc" order="32"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_91b4b780-376f-47fd-83c2-cf871af1ad23" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentFiscalYearFocus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_DocumentFiscalYearFocus_91b4b780-376f-47fd-83c2-cf871af1ad23" xlink:type="arc" order="33"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_f0c58ece-81d6-465f-b1cc-ac6e1bd31640" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_12055eca-f702-4ffb-acf0-d7b42733b6c2" xlink:to="loc_dei_DocumentFiscalPeriodFocus_f0c58ece-81d6-465f-b1cc-ac6e1bd31640" xlink:type="arc" order="34"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="simple" xlink:href="rxrx-20251231.xsd#ConsolidatedBalanceSheetsParenthetical"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_ce30a7dd-bbc2-4c2a-9a49-865e30de90e8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_b8453457-0eca-473e-b25b-930ae953c093" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_ce30a7dd-bbc2-4c2a-9a49-865e30de90e8" xlink:to="loc_us-gaap_StatementTable_b8453457-0eca-473e-b25b-930ae953c093" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_6275d217-b61d-47fe-ba87-17d3fbbd3cf6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_b8453457-0eca-473e-b25b-930ae953c093" xlink:to="loc_us-gaap_StatementClassOfStockAxis_6275d217-b61d-47fe-ba87-17d3fbbd3cf6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_6275d217-b61d-47fe-ba87-17d3fbbd3cf6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_6275d217-b61d-47fe-ba87-17d3fbbd3cf6" xlink:to="loc_us-gaap_ClassOfStockDomain_6275d217-b61d-47fe-ba87-17d3fbbd3cf6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_2e4a53f2-41db-4e5a-96fd-976acca17068" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_6275d217-b61d-47fe-ba87-17d3fbbd3cf6" xlink:to="loc_us-gaap_ClassOfStockDomain_2e4a53f2-41db-4e5a-96fd-976acca17068" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_97d6f42e-f8ad-43a6-a1e2-141f8a63f405" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_2e4a53f2-41db-4e5a-96fd-976acca17068" xlink:to="loc_us-gaap_CommonClassAMember_97d6f42e-f8ad-43a6-a1e2-141f8a63f405" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_9b7a1f56-ed40-4c23-99aa-b5a3967e1567" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassBMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_2e4a53f2-41db-4e5a-96fd-976acca17068" xlink:to="loc_us-gaap_CommonClassBMember_9b7a1f56-ed40-4c23-99aa-b5a3967e1567" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ExchangeableStockMember_c61bb70f-997c-4a7d-a423-42310961a7a1" xlink:href="rxrx-20251231.xsd#rxrx_ExchangeableStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_2e4a53f2-41db-4e5a-96fd-976acca17068" xlink:to="loc_rxrx_ExchangeableStockMember_c61bb70f-997c-4a7d-a423-42310961a7a1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_34795cef-7c0b-4e1f-a3c8-7f89866c3e68" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_ce30a7dd-bbc2-4c2a-9a49-865e30de90e8" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_34795cef-7c0b-4e1f-a3c8-7f89866c3e68" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_477a9850-4913-491e-a26c-13b5a6c83426" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_ce30a7dd-bbc2-4c2a-9a49-865e30de90e8" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_477a9850-4913-491e-a26c-13b5a6c83426" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_133686a5-e8ac-4603-bb99-5371c197c3ab" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_ce30a7dd-bbc2-4c2a-9a49-865e30de90e8" xlink:to="loc_us-gaap_CommonStockSharesIssued_133686a5-e8ac-4603-bb99-5371c197c3ab" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_8766f2de-eb66-4b12-95e2-3710ac39b5a9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_ce30a7dd-bbc2-4c2a-9a49-865e30de90e8" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_8766f2de-eb66-4b12-95e2-3710ac39b5a9" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/ConsolidatedStatementsofOperations" xlink:type="simple" xlink:href="rxrx-20251231.xsd#ConsolidatedStatementsofOperations"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/ConsolidatedStatementsofOperations" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_eab22625-20a9-4eaf-8eb6-b5ad977c56b8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_ea93ecac-26cf-4e80-a57e-e259130a3747" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_eab22625-20a9-4eaf-8eb6-b5ad977c56b8" xlink:to="loc_us-gaap_StatementTable_ea93ecac-26cf-4e80-a57e-e259130a3747" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_e40afd0e-7c51-4070-bd23-ccde582eb316" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_ea93ecac-26cf-4e80-a57e-e259130a3747" xlink:to="loc_srt_ProductOrServiceAxis_e40afd0e-7c51-4070-bd23-ccde582eb316" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_e40afd0e-7c51-4070-bd23-ccde582eb316_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_e40afd0e-7c51-4070-bd23-ccde582eb316" xlink:to="loc_srt_ProductsAndServicesDomain_e40afd0e-7c51-4070-bd23-ccde582eb316_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_f91b12a6-4c4b-40f2-9bfa-7ecad28c4c84" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_e40afd0e-7c51-4070-bd23-ccde582eb316" xlink:to="loc_srt_ProductsAndServicesDomain_f91b12a6-4c4b-40f2-9bfa-7ecad28c4c84" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LicenseAndServiceMember_1f125b58-66ae-43d2-b68b-6d127dfd6b6a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LicenseAndServiceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_f91b12a6-4c4b-40f2-9bfa-7ecad28c4c84" xlink:to="loc_us-gaap_LicenseAndServiceMember_1f125b58-66ae-43d2-b68b-6d127dfd6b6a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrantMember_754b8d6e-ec1e-4420-856a-6c25657f9745" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_f91b12a6-4c4b-40f2-9bfa-7ecad28c4c84" xlink:to="loc_us-gaap_GrantMember_754b8d6e-ec1e-4420-856a-6c25657f9745" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesAbstract_3963b302-0bd4-40e6-8ee9-4acdccc55535" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenuesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_eab22625-20a9-4eaf-8eb6-b5ad977c56b8" xlink:to="loc_us-gaap_RevenuesAbstract_3963b302-0bd4-40e6-8ee9-4acdccc55535" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_732c2f73-933e-4d5f-b044-7eff9c98bcdf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_3963b302-0bd4-40e6-8ee9-4acdccc55535" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_732c2f73-933e-4d5f-b044-7eff9c98bcdf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpensesAbstract_d4ac5d00-f89a-468b-8add-a608f85b4842" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingExpensesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_eab22625-20a9-4eaf-8eb6-b5ad977c56b8" xlink:to="loc_us-gaap_OperatingExpensesAbstract_d4ac5d00-f89a-468b-8add-a608f85b4842" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_dffab666-a12a-49d1-b006-725d9a105dd4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_d4ac5d00-f89a-468b-8add-a608f85b4842" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_dffab666-a12a-49d1-b006-725d9a105dd4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_8031aab6-cfe1-4e26-9212-6d5a46cdd399" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_d4ac5d00-f89a-468b-8add-a608f85b4842" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_8031aab6-cfe1-4e26-9212-6d5a46cdd399" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_c2608832-03e2-4e87-af9e-a0d9947f0a9f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_d4ac5d00-f89a-468b-8add-a608f85b4842" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_c2608832-03e2-4e87-af9e-a0d9947f0a9f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_aea701c6-e018-4a21-9c1f-fbb6aec9f0b4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostsAndExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_d4ac5d00-f89a-468b-8add-a608f85b4842" xlink:to="loc_us-gaap_CostsAndExpenses_aea701c6-e018-4a21-9c1f-fbb6aec9f0b4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_dabb2874-45b0-4d9e-aa97-f6a602027777" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_eab22625-20a9-4eaf-8eb6-b5ad977c56b8" xlink:to="loc_us-gaap_OperatingIncomeLoss_dabb2874-45b0-4d9e-aa97-f6a602027777" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_b60259d5-81f8-4326-8f6d-d07f974e913d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_eab22625-20a9-4eaf-8eb6-b5ad977c56b8" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_b60259d5-81f8-4326-8f6d-d07f974e913d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_fe78bc1a-b75e-456b-b93d-fcc4e7324a25" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_eab22625-20a9-4eaf-8eb6-b5ad977c56b8" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_fe78bc1a-b75e-456b-b93d-fcc4e7324a25" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_524859d0-716c-4049-a509-b127f7a23959" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_eab22625-20a9-4eaf-8eb6-b5ad977c56b8" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_524859d0-716c-4049-a509-b127f7a23959" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_1f58c1b3-592a-4c22-9c32-7f7f50bd1a31" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_eab22625-20a9-4eaf-8eb6-b5ad977c56b8" xlink:to="loc_us-gaap_NetIncomeLoss_1f58c1b3-592a-4c22-9c32-7f7f50bd1a31" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_8c784ef9-9ec6-4f22-bb80-c2302ff99bbd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_eab22625-20a9-4eaf-8eb6-b5ad977c56b8" xlink:to="loc_us-gaap_EarningsPerShareAbstract_8c784ef9-9ec6-4f22-bb80-c2302ff99bbd" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_024b40a4-baa0-4f97-bc08-5f38fce109bc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_8c784ef9-9ec6-4f22-bb80-c2302ff99bbd" xlink:to="loc_us-gaap_EarningsPerShareBasic_024b40a4-baa0-4f97-bc08-5f38fce109bc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_cdde2300-9f90-4928-821a-5b92c9d1bb78" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_8c784ef9-9ec6-4f22-bb80-c2302ff99bbd" xlink:to="loc_us-gaap_EarningsPerShareDiluted_cdde2300-9f90-4928-821a-5b92c9d1bb78" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_925be55d-7ee1-497a-a56c-c4e67dad3040" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_8c784ef9-9ec6-4f22-bb80-c2302ff99bbd" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_925be55d-7ee1-497a-a56c-c4e67dad3040" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_5080b878-ff79-4f68-bca5-a3c7bee01a4a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_8c784ef9-9ec6-4f22-bb80-c2302ff99bbd" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_5080b878-ff79-4f68-bca5-a3c7bee01a4a" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/ConsolidatedStatementsofStockholdersEquity" xlink:type="simple" xlink:href="rxrx-20251231.xsd#ConsolidatedStatementsofStockholdersEquity"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/ConsolidatedStatementsofStockholdersEquity" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_c88ebff5-acca-4d3d-863e-2c4835feb164" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_5220e34f-e5f4-4346-a8a6-cc3e91130a16" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_c88ebff5-acca-4d3d-863e-2c4835feb164" xlink:to="loc_us-gaap_StatementTable_5220e34f-e5f4-4346-a8a6-cc3e91130a16" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_29d329b3-4c4c-4349-990c-eefdc3457cc3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_5220e34f-e5f4-4346-a8a6-cc3e91130a16" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_29d329b3-4c4c-4349-990c-eefdc3457cc3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_29d329b3-4c4c-4349-990c-eefdc3457cc3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_29d329b3-4c4c-4349-990c-eefdc3457cc3" xlink:to="loc_us-gaap_EquityComponentDomain_29d329b3-4c4c-4349-990c-eefdc3457cc3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_447dfd6b-74e3-4b3f-8289-652a5625880d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_29d329b3-4c4c-4349-990c-eefdc3457cc3" xlink:to="loc_us-gaap_EquityComponentDomain_447dfd6b-74e3-4b3f-8289-652a5625880d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_b56827b3-ee43-4d55-bebb-c7ecde6a95a4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_447dfd6b-74e3-4b3f-8289-652a5625880d" xlink:to="loc_us-gaap_CommonStockMember_b56827b3-ee43-4d55-bebb-c7ecde6a95a4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_8184470c-da69-4388-bf81-1fa3c82442cc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_447dfd6b-74e3-4b3f-8289-652a5625880d" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_8184470c-da69-4388-bf81-1fa3c82442cc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_29497774-04e2-45ce-bc06-fa5fb4a127a9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_447dfd6b-74e3-4b3f-8289-652a5625880d" xlink:to="loc_us-gaap_RetainedEarningsMember_29497774-04e2-45ce-bc06-fa5fb4a127a9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_35bb2fd1-cb51-42d9-8dd1-f28c862a8e96" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_447dfd6b-74e3-4b3f-8289-652a5625880d" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_35bb2fd1-cb51-42d9-8dd1-f28c862a8e96" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_24d6ae98-91e4-40c2-bcfa-12b19a585d43" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_5220e34f-e5f4-4346-a8a6-cc3e91130a16" xlink:to="loc_us-gaap_TypeOfArrangementAxis_24d6ae98-91e4-40c2-bcfa-12b19a585d43" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_24d6ae98-91e4-40c2-bcfa-12b19a585d43_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_24d6ae98-91e4-40c2-bcfa-12b19a585d43" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_24d6ae98-91e4-40c2-bcfa-12b19a585d43_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_be1db35c-aaac-44c4-a233-49a9d882f3ec" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_24d6ae98-91e4-40c2-bcfa-12b19a585d43" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_be1db35c-aaac-44c4-a233-49a9d882f3ec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_TempusAgreementMember_a6d7da11-4c3a-4a62-bbe4-5073b1217f2f" xlink:href="rxrx-20251231.xsd#rxrx_TempusAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_be1db35c-aaac-44c4-a233-49a9d882f3ec" xlink:to="loc_rxrx_TempusAgreementMember_a6d7da11-4c3a-4a62-bbe4-5073b1217f2f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_f600ee51-c82f-4518-bccf-7485d9973336" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_c88ebff5-acca-4d3d-863e-2c4835feb164" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_f600ee51-c82f-4518-bccf-7485d9973336" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_52fc2934-fea1-4324-a67c-213197f3ca27" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_f600ee51-c82f-4518-bccf-7485d9973336" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_52fc2934-fea1-4324-a67c-213197f3ca27" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_069fe76c-6bd5-4a99-8740-9c106bcd06e5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_f600ee51-c82f-4518-bccf-7485d9973336" xlink:to="loc_us-gaap_StockholdersEquity_069fe76c-6bd5-4a99-8740-9c106bcd06e5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_959e4059-6e40-45dd-879b-6a980f42b5e8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_f600ee51-c82f-4518-bccf-7485d9973336" xlink:to="loc_us-gaap_NetIncomeLoss_959e4059-6e40-45dd-879b-6a980f42b5e8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019b253d-bc19-7733-b80c-ed1266b5da24" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_f600ee51-c82f-4518-bccf-7485d9973336" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019b253d-bc19-7733-b80c-ed1266b5da24" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_019b2540-b684-7cd7-a1de-2b602fbf1021" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_f600ee51-c82f-4518-bccf-7485d9973336" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_019b2540-b684-7cd7-a1de-2b602fbf1021" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_019b2540-b684-7efa-b860-f717f496d026" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_f600ee51-c82f-4518-bccf-7485d9973336" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_019b2540-b684-7efa-b860-f717f496d026" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_019b2540-b684-7ae1-9d8a-a773b1f7c885" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_f600ee51-c82f-4518-bccf-7485d9973336" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_019b2540-b684-7ae1-9d8a-a773b1f7c885" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_019b2540-b684-76f8-a1a8-89096537e451" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_f600ee51-c82f-4518-bccf-7485d9973336" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_019b2540-b684-76f8-a1a8-89096537e451" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_019b2540-b684-719d-bca3-45d8325d90ac" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_f600ee51-c82f-4518-bccf-7485d9973336" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_019b2540-b684-719d-bca3-45d8325d90ac" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_019b253c-a0b0-7f0d-9cf4-d6cdb92a75de" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodSharesAcquisitions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_f600ee51-c82f-4518-bccf-7485d9973336" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_019b253c-a0b0-7f0d-9cf4-d6cdb92a75de" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueAcquisitions_019b253c-6755-731a-8364-b4fb2794d8b6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodValueAcquisitions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_f600ee51-c82f-4518-bccf-7485d9973336" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueAcquisitions_019b253c-6755-731a-8364-b4fb2794d8b6" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_73a2b66b-bbb5-4890-ac22-2da32f5f8a05" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_79692217-f22c-4ec1-8fd1-690574d40e3a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/ConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="rxrx-20251231.xsd#ConsolidatedStatementsofCashFlows"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/ConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_7aaef518-fe8b-4df5-b184-50993094c76d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_1bd3e1a4-9431-42c4-aff1-02813ded31ae" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_7aaef518-fe8b-4df5-b184-50993094c76d" xlink:to="loc_us-gaap_StatementTable_1bd3e1a4-9431-42c4-aff1-02813ded31ae" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_b995a1ea-728a-479d-ad51-fe5994d294fa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_1bd3e1a4-9431-42c4-aff1-02813ded31ae" xlink:to="loc_us-gaap_TypeOfArrangementAxis_b995a1ea-728a-479d-ad51-fe5994d294fa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_b995a1ea-728a-479d-ad51-fe5994d294fa_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_b995a1ea-728a-479d-ad51-fe5994d294fa" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_b995a1ea-728a-479d-ad51-fe5994d294fa_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_f09799c1-b3cf-4c6f-9ddd-a0c29fe631ed" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_b995a1ea-728a-479d-ad51-fe5994d294fa" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_f09799c1-b3cf-4c6f-9ddd-a0c29fe631ed" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_TempusAgreementMember_856c459b-6792-4b14-bf1a-d702ba4cc007" xlink:href="rxrx-20251231.xsd#rxrx_TempusAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_f09799c1-b3cf-4c6f-9ddd-a0c29fe631ed" xlink:to="loc_rxrx_TempusAgreementMember_856c459b-6792-4b14-bf1a-d702ba4cc007" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_9297eb53-69b2-4bf4-ae67-a3fc3b772d4e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_7aaef518-fe8b-4df5-b184-50993094c76d" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_9297eb53-69b2-4bf4-ae67-a3fc3b772d4e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_9fa503a2-854a-41a1-bf88-2ebc71de619e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_9297eb53-69b2-4bf4-ae67-a3fc3b772d4e" xlink:to="loc_us-gaap_NetIncomeLoss_9fa503a2-854a-41a1-bf88-2ebc71de619e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a17f267f-3828-44a8-b11e-e446447940cd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_9297eb53-69b2-4bf4-ae67-a3fc3b772d4e" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a17f267f-3828-44a8-b11e-e446447940cd" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_7e50776e-511c-4a0c-bf27-a4c20b8dc3cf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a17f267f-3828-44a8-b11e-e446447940cd" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_7e50776e-511c-4a0c-bf27-a4c20b8dc3cf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_265ecd28-1638-4011-b703-d13d6c62f4db" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a17f267f-3828-44a8-b11e-e446447940cd" xlink:to="loc_us-gaap_ShareBasedCompensation_265ecd28-1638-4011-b703-d13d6c62f4db" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TangibleAssetImpairmentCharges_fbbf2559-4cb6-4534-80bc-69651c137357" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TangibleAssetImpairmentCharges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a17f267f-3828-44a8-b11e-e446447940cd" xlink:to="loc_us-gaap_TangibleAssetImpairmentCharges_fbbf2559-4cb6-4534-80bc-69651c137357" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseExpense_569e749b-054c-4651-b3f1-c78b1a77c3e8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a17f267f-3828-44a8-b11e-e446447940cd" xlink:to="loc_us-gaap_OperatingLeaseExpense_569e749b-054c-4651-b3f1-c78b1a77c3e8" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfBusiness_019b2556-58ba-708f-b56e-2dc8ec0897f3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GainLossOnSaleOfBusiness"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a17f267f-3828-44a8-b11e-e446447940cd" xlink:to="loc_us-gaap_GainLossOnSaleOfBusiness_019b2556-58ba-708f-b56e-2dc8ec0897f3" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_019b2556-c8fb-79dd-ba77-31f59302bf15" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a17f267f-3828-44a8-b11e-e446447940cd" xlink:to="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_019b2556-c8fb-79dd-ba77-31f59302bf15" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_0998e51f-c1cc-48f1-83b6-24917f89bfc5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a17f267f-3828-44a8-b11e-e446447940cd" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_0998e51f-c1cc-48f1-83b6-24917f89bfc5" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_0fe0c3ab-e5f0-4658-8b25-2e6c543bdfe2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a17f267f-3828-44a8-b11e-e446447940cd" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_0fe0c3ab-e5f0-4658-8b25-2e6c543bdfe2" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_b67a376c-cba6-48f3-a555-2ea98b4d973f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_0fe0c3ab-e5f0-4658-8b25-2e6c543bdfe2" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_b67a376c-cba6-48f3-a555-2ea98b4d973f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_IncreaseDecreaseInPrepaidDataAssets_019b2557-7362-70bb-bf6c-23e8cf163e29" xlink:href="rxrx-20251231.xsd#rxrx_IncreaseDecreaseInPrepaidDataAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_0fe0c3ab-e5f0-4658-8b25-2e6c543bdfe2" xlink:to="loc_rxrx_IncreaseDecreaseInPrepaidDataAssets_019b2557-7362-70bb-bf6c-23e8cf163e29" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_b41bed58-2a5c-4efe-82c7-e83a39c080f1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_0fe0c3ab-e5f0-4658-8b25-2e6c543bdfe2" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_b41bed58-2a5c-4efe-82c7-e83a39c080f1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_1c88605c-2dd2-4227-85a6-8af4caa9017e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_0fe0c3ab-e5f0-4658-8b25-2e6c543bdfe2" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_1c88605c-2dd2-4227-85a6-8af4caa9017e" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_IncreaseDecreaseInAccruedDevelopmentExpense_03138d62-3f7c-41d7-9b8d-8be095f90abd" xlink:href="rxrx-20251231.xsd#rxrx_IncreaseDecreaseInAccruedDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_0fe0c3ab-e5f0-4658-8b25-2e6c543bdfe2" xlink:to="loc_rxrx_IncreaseDecreaseInAccruedDevelopmentExpense_03138d62-3f7c-41d7-9b8d-8be095f90abd" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherAccruedLiabilities_ffdec2ed-f4af-4db3-93c6-27c7decd1573" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInOtherAccruedLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_0fe0c3ab-e5f0-4658-8b25-2e6c543bdfe2" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherAccruedLiabilities_ffdec2ed-f4af-4db3-93c6-27c7decd1573" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_IncreaseDecreaseInLeaseLiability_b8fddf0d-fab0-4adc-b688-a22b001c28d7" xlink:href="rxrx-20251231.xsd#rxrx_IncreaseDecreaseInLeaseLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_0fe0c3ab-e5f0-4658-8b25-2e6c543bdfe2" xlink:to="loc_rxrx_IncreaseDecreaseInLeaseLiability_b8fddf0d-fab0-4adc-b688-a22b001c28d7" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_cc3c51a6-2554-4cc2-8784-e3a453a2d4d0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_9297eb53-69b2-4bf4-ae67-a3fc3b772d4e" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_cc3c51a6-2554-4cc2-8784-e3a453a2d4d0" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_4e33bbad-f07a-405e-98b5-524c6b1c9d3a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_7aaef518-fe8b-4df5-b184-50993094c76d" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_4e33bbad-f07a-405e-98b5-524c6b1c9d3a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_e5202752-e3bf-42ad-a890-6487c0c8568b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_4e33bbad-f07a-405e-98b5-524c6b1c9d3a" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_e5202752-e3bf-42ad-a890-6487c0c8568b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_02e1cb3d-cbeb-408f-83de-888c3d977141" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_4e33bbad-f07a-405e-98b5-524c6b1c9d3a" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_02e1cb3d-cbeb-408f-83de-888c3d977141" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireIntangibleAssets_2de25138-15ef-4ab6-b2f0-f5c8ebf917bc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireIntangibleAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_4e33bbad-f07a-405e-98b5-524c6b1c9d3a" xlink:to="loc_us-gaap_PaymentsToAcquireIntangibleAssets_2de25138-15ef-4ab6-b2f0-f5c8ebf917bc" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromDivestitureOfBusinessesNetOfCashDivested_019b2558-614e-785e-af83-be186dd49b5a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromDivestitureOfBusinessesNetOfCashDivested"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_4e33bbad-f07a-405e-98b5-524c6b1c9d3a" xlink:to="loc_us-gaap_ProceedsFromDivestitureOfBusinessesNetOfCashDivested_019b2558-614e-785e-af83-be186dd49b5a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireInvestments_019b2558-614e-7991-9e85-6e4a7864b5db" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_4e33bbad-f07a-405e-98b5-524c6b1c9d3a" xlink:to="loc_us-gaap_PaymentsToAcquireInvestments_019b2558-614e-7991-9e85-6e4a7864b5db" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_481c2b8a-cf94-4076-83d9-078327c8ac2a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_4e33bbad-f07a-405e-98b5-524c6b1c9d3a" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_481c2b8a-cf94-4076-83d9-078327c8ac2a" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b37e5419-2e68-40bf-acb7-f1975eca512a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_4e33bbad-f07a-405e-98b5-524c6b1c9d3a" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b37e5419-2e68-40bf-acb7-f1975eca512a" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_1624e37f-793c-4714-a282-df961a0ab355" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_7aaef518-fe8b-4df5-b184-50993094c76d" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_1624e37f-793c-4714-a282-df961a0ab355" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_858e96f6-df1b-4a4d-a88e-0545ade10513" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_1624e37f-793c-4714-a282-df961a0ab355" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_858e96f6-df1b-4a4d-a88e-0545ade10513" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_d0e39246-79c8-418a-9138-d2f67d6aafa7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_1624e37f-793c-4714-a282-df961a0ab355" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_d0e39246-79c8-418a-9138-d2f67d6aafa7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebtAndCapitalSecurities_5b677610-93e1-4d99-bd93-d3434ccf8680" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RepaymentsOfLongTermDebtAndCapitalSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_1624e37f-793c-4714-a282-df961a0ab355" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebtAndCapitalSecurities_5b677610-93e1-4d99-bd93-d3434ccf8680" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_PaymentsToAcquireIntangibleAssetsFinancialActivities_019b255b-36c2-782d-bc06-a77d9548bec1" xlink:href="rxrx-20251231.xsd#rxrx_PaymentsToAcquireIntangibleAssetsFinancialActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_1624e37f-793c-4714-a282-df961a0ab355" xlink:to="loc_rxrx_PaymentsToAcquireIntangibleAssetsFinancialActivities_019b255b-36c2-782d-bc06-a77d9548bec1" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_331d88f2-937c-481d-ab60-b1d8a450feed" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_1624e37f-793c-4714-a282-df961a0ab355" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_331d88f2-937c-481d-ab60-b1d8a450feed" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_fc11eb43-515b-4516-a6d0-0947c2cc1842" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_7aaef518-fe8b-4df5-b184-50993094c76d" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_fc11eb43-515b-4516-a6d0-0947c2cc1842" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_25a09c0f-4aea-4b3e-b521-67e70ac696b0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_7aaef518-fe8b-4df5-b184-50993094c76d" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_25a09c0f-4aea-4b3e-b521-67e70ac696b0" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_6ea578c3-20a7-4993-830b-a8936ae5252c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_7aaef518-fe8b-4df5-b184-50993094c76d" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_6ea578c3-20a7-4993-830b-a8936ae5252c" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_47415b9e-2bcd-4aa4-9b36-fc09851419de" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncashInvestingAndFinancingItemsAbstract_65019fe7-e806-4011-b792-53c473528b9a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NoncashInvestingAndFinancingItemsAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_7aaef518-fe8b-4df5-b184-50993094c76d" xlink:to="loc_us-gaap_NoncashInvestingAndFinancingItemsAbstract_65019fe7-e806-4011-b792-53c473528b9a" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssued1_8c230f45-fce0-4377-88ef-f65281478bf2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssued1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NoncashInvestingAndFinancingItemsAbstract_65019fe7-e806-4011-b792-53c473528b9a" xlink:to="loc_us-gaap_StockIssued1_8c230f45-fce0-4377-88ef-f65281478bf2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CapitalExpendituresIncurredButNotYetPaid_35d000a2-54b4-4584-9d77-015926359b1a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CapitalExpendituresIncurredButNotYetPaid"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NoncashInvestingAndFinancingItemsAbstract_65019fe7-e806-4011-b792-53c473528b9a" xlink:to="loc_us-gaap_CapitalExpendituresIncurredButNotYetPaid_35d000a2-54b4-4584-9d77-015926359b1a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncashOrPartNoncashAcquisitionIntangibleAssetsAcquired1_3d93f9db-5bdc-4fc0-a601-941d67cf6dae" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NoncashOrPartNoncashAcquisitionIntangibleAssetsAcquired1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NoncashInvestingAndFinancingItemsAbstract_65019fe7-e806-4011-b792-53c473528b9a" xlink:to="loc_us-gaap_NoncashOrPartNoncashAcquisitionIntangibleAssetsAcquired1_3d93f9db-5bdc-4fc0-a601-941d67cf6dae" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/SummaryofSignificantAccountingPoliciesScheduleofEstimatedUsefulLivesbyAssetClassificationDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#SummaryofSignificantAccountingPoliciesScheduleofEstimatedUsefulLivesbyAssetClassificationDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/SummaryofSignificantAccountingPoliciesScheduleofEstimatedUsefulLivesbyAssetClassificationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_80e6699e-e9a4-4899-bb84-37492eff3758" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_42a01e49-4de3-455f-b580-a201ed2197d9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_80e6699e-e9a4-4899-bb84-37492eff3758" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_42a01e49-4de3-455f-b580-a201ed2197d9" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_19275896-137a-499f-bc5f-a928b101f2f2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_42a01e49-4de3-455f-b580-a201ed2197d9" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_19275896-137a-499f-bc5f-a928b101f2f2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_19275896-137a-499f-bc5f-a928b101f2f2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_19275896-137a-499f-bc5f-a928b101f2f2" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_19275896-137a-499f-bc5f-a928b101f2f2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_8802b190-af93-4391-8cc4-f1e94135549f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_19275896-137a-499f-bc5f-a928b101f2f2" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_8802b190-af93-4391-8cc4-f1e94135549f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ComputerAndOfficeEquipmentMember_0beda038-cee9-45d1-b88d-56318c989012" xlink:href="rxrx-20251231.xsd#rxrx_ComputerAndOfficeEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_8802b190-af93-4391-8cc4-f1e94135549f" xlink:to="loc_rxrx_ComputerAndOfficeEquipmentMember_0beda038-cee9-45d1-b88d-56318c989012" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LaboratoryEquipmentMember_c06659c9-bbac-4940-aceb-bf4643b7efd9" xlink:href="rxrx-20251231.xsd#rxrx_LaboratoryEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_8802b190-af93-4391-8cc4-f1e94135549f" xlink:to="loc_rxrx_LaboratoryEquipmentMember_c06659c9-bbac-4940-aceb-bf4643b7efd9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_88fd7924-d9d0-4947-be10-639a067fb90f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LeaseholdImprovementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_8802b190-af93-4391-8cc4-f1e94135549f" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_88fd7924-d9d0-4947-be10-639a067fb90f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_536441f7-9cd3-4849-8f9c-29176b48c27d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_80e6699e-e9a4-4899-bb84-37492eff3758" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_536441f7-9cd3-4849-8f9c-29176b48c27d" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/SupplementalFinancialInformationNarrativeDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#SupplementalFinancialInformationNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/SupplementalFinancialInformationNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_60737b30-66e1-4e09-8cb5-b1c404ba1f36" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_f568d110-a59f-429e-b033-668575620818" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_60737b30-66e1-4e09-8cb5-b1c404ba1f36" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_f568d110-a59f-429e-b033-668575620818" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_bce1979d-6837-48be-9cfd-553450e91797" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_f568d110-a59f-429e-b033-668575620818" xlink:to="loc_srt_CounterpartyNameAxis_bce1979d-6837-48be-9cfd-553450e91797" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_bce1979d-6837-48be-9cfd-553450e91797_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_bce1979d-6837-48be-9cfd-553450e91797" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_bce1979d-6837-48be-9cfd-553450e91797_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_3df79846-993e-441f-934c-0411d5a26ffe" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_bce1979d-6837-48be-9cfd-553450e91797" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_3df79846-993e-441f-934c-0411d5a26ffe" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_TempusLabsIncMember_e2440ae7-4e2c-4ab8-8be9-2f05282704c7" xlink:href="rxrx-20251231.xsd#rxrx_TempusLabsIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_3df79846-993e-441f-934c-0411d5a26ffe" xlink:to="loc_rxrx_TempusLabsIncMember_e2440ae7-4e2c-4ab8-8be9-2f05282704c7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_ae19134a-30cf-4346-b39b-8fd9d235604d" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_f568d110-a59f-429e-b033-668575620818" xlink:to="loc_srt_RangeAxis_ae19134a-30cf-4346-b39b-8fd9d235604d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_ae19134a-30cf-4346-b39b-8fd9d235604d_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_ae19134a-30cf-4346-b39b-8fd9d235604d" xlink:to="loc_srt_RangeMember_ae19134a-30cf-4346-b39b-8fd9d235604d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_14947ebf-1c74-4241-94b5-ba1d3ca142d0" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_ae19134a-30cf-4346-b39b-8fd9d235604d" xlink:to="loc_srt_RangeMember_14947ebf-1c74-4241-94b5-ba1d3ca142d0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_f0ad703a-d7cc-46c5-a537-7366227e9376" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_14947ebf-1c74-4241-94b5-ba1d3ca142d0" xlink:to="loc_srt_MinimumMember_f0ad703a-d7cc-46c5-a537-7366227e9376" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_bab3a404-c51b-435a-a5af-e45fd715769a" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_14947ebf-1c74-4241-94b5-ba1d3ca142d0" xlink:to="loc_srt_MaximumMember_bab3a404-c51b-435a-a5af-e45fd715769a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LicenseAgreementTerm_484a635d-8f8b-4b91-b95c-d5b4ace0f861" xlink:href="rxrx-20251231.xsd#rxrx_LicenseAgreementTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_60737b30-66e1-4e09-8cb5-b1c404ba1f36" xlink:to="loc_rxrx_LicenseAgreementTerm_484a635d-8f8b-4b91-b95c-d5b4ace0f861" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LicenseAgreementAnnualPayments_fe8446f8-5a32-4a71-9e59-8173994200e6" xlink:href="rxrx-20251231.xsd#rxrx_LicenseAgreementAnnualPayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_60737b30-66e1-4e09-8cb5-b1c404ba1f36" xlink:to="loc_rxrx_LicenseAgreementAnnualPayments_fe8446f8-5a32-4a71-9e59-8173994200e6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LicenseAgreementAggregatePayments_4fc10e72-16a5-45aa-aa2b-4d1495d2e686" xlink:href="rxrx-20251231.xsd#rxrx_LicenseAgreementAggregatePayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_60737b30-66e1-4e09-8cb5-b1c404ba1f36" xlink:to="loc_rxrx_LicenseAgreementAggregatePayments_4fc10e72-16a5-45aa-aa2b-4d1495d2e686" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LicenseAgreementTradingPeriodUsedForEquityValueDetermination_99933fdb-1bbe-44fe-ba92-e797bcd37af2" xlink:href="rxrx-20251231.xsd#rxrx_LicenseAgreementTradingPeriodUsedForEquityValueDetermination"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_60737b30-66e1-4e09-8cb5-b1c404ba1f36" xlink:to="loc_rxrx_LicenseAgreementTradingPeriodUsedForEquityValueDetermination_99933fdb-1bbe-44fe-ba92-e797bcd37af2" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LicenseAgreementAmountOfTimePriorToThePaymentDate_44369469-5451-4a92-8a88-94f56efaaf53" xlink:href="rxrx-20251231.xsd#rxrx_LicenseAgreementAmountOfTimePriorToThePaymentDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_60737b30-66e1-4e09-8cb5-b1c404ba1f36" xlink:to="loc_rxrx_LicenseAgreementAmountOfTimePriorToThePaymentDate_44369469-5451-4a92-8a88-94f56efaaf53" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LicenseAgreementIncreaseDecreaseAccruedLiabilities_019b832c-bf36-71e4-a926-b3647ce430a9" xlink:href="rxrx-20251231.xsd#rxrx_LicenseAgreementIncreaseDecreaseAccruedLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_60737b30-66e1-4e09-8cb5-b1c404ba1f36" xlink:to="loc_rxrx_LicenseAgreementIncreaseDecreaseAccruedLiabilities_019b832c-bf36-71e4-a926-b3647ce430a9" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_7550dae0-0599-4598-a43c-3756cc9e4a45" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Depreciation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_60737b30-66e1-4e09-8cb5-b1c404ba1f36" xlink:to="loc_us-gaap_Depreciation_7550dae0-0599-4598-a43c-3756cc9e4a45" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedCostNumberOfPositionsEliminatedPeriodPercent_019b258e-746a-7ecd-8c54-32580e60e6cd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestructuringAndRelatedCostNumberOfPositionsEliminatedPeriodPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_60737b30-66e1-4e09-8cb5-b1c404ba1f36" xlink:to="loc_us-gaap_RestructuringAndRelatedCostNumberOfPositionsEliminatedPeriodPercent_019b258e-746a-7ecd-8c54-32580e60e6cd" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringIncurredCostStatementOfIncomeOrComprehensiveIncomeExtensibleEnumeration_019c67ed-7691-727b-ad8b-e012016e7720" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestructuringIncurredCostStatementOfIncomeOrComprehensiveIncomeExtensibleEnumeration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_60737b30-66e1-4e09-8cb5-b1c404ba1f36" xlink:to="loc_us-gaap_RestructuringIncurredCostStatementOfIncomeOrComprehensiveIncomeExtensibleEnumeration_019c67ed-7691-727b-ad8b-e012016e7720" xlink:type="arc" order="8"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/SupplementalFinancialInformationScheduleofPropertyandEquipmentNetDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#SupplementalFinancialInformationScheduleofPropertyandEquipmentNetDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/SupplementalFinancialInformationScheduleofPropertyandEquipmentNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_e7c7c525-44ed-45e8-9bb3-953eeb3f5939" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_d6e69d68-770e-4773-a37a-5fdcdb30c8ad" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_e7c7c525-44ed-45e8-9bb3-953eeb3f5939" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_d6e69d68-770e-4773-a37a-5fdcdb30c8ad" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_ec905a5c-bca8-424e-9542-25b5ef7825b1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_d6e69d68-770e-4773-a37a-5fdcdb30c8ad" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_ec905a5c-bca8-424e-9542-25b5ef7825b1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ec905a5c-bca8-424e-9542-25b5ef7825b1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_ec905a5c-bca8-424e-9542-25b5ef7825b1" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ec905a5c-bca8-424e-9542-25b5ef7825b1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b285de99-ce3b-4141-b836-fce6461901fe" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_ec905a5c-bca8-424e-9542-25b5ef7825b1" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b285de99-ce3b-4141-b836-fce6461901fe" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LaboratoryEquipmentMember_c976955b-10e2-4a04-92bc-062ca1c1432a" xlink:href="rxrx-20251231.xsd#rxrx_LaboratoryEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b285de99-ce3b-4141-b836-fce6461901fe" xlink:to="loc_rxrx_LaboratoryEquipmentMember_c976955b-10e2-4a04-92bc-062ca1c1432a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_af1699a0-05aa-4bef-b4ea-dcc70183d89b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LeaseholdImprovementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b285de99-ce3b-4141-b836-fce6461901fe" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_af1699a0-05aa-4bef-b4ea-dcc70183d89b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OfficeEquipmentMember_2216ff74-3db6-4054-9add-63cf044e8967" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OfficeEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b285de99-ce3b-4141-b836-fce6461901fe" xlink:to="loc_us-gaap_OfficeEquipmentMember_2216ff74-3db6-4054-9add-63cf044e8967" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetUnderConstructionMember_3310871b-b7c4-479b-af3e-b163d0f2f588" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetUnderConstructionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b285de99-ce3b-4141-b836-fce6461901fe" xlink:to="loc_us-gaap_AssetUnderConstructionMember_3310871b-b7c4-479b-af3e-b163d0f2f588" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_0f426719-8cd5-4a10-aa72-494f6021a1f8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_e7c7c525-44ed-45e8-9bb3-953eeb3f5939" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_0f426719-8cd5-4a10-aa72-494f6021a1f8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_51a201a2-2862-4af4-8a52-2c32856c692f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_e7c7c525-44ed-45e8-9bb3-953eeb3f5939" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_51a201a2-2862-4af4-8a52-2c32856c692f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_08cfb6b1-334d-4d08-9ef9-ce37795636bc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_e7c7c525-44ed-45e8-9bb3-953eeb3f5939" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_08cfb6b1-334d-4d08-9ef9-ce37795636bc" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/AcquisitionsNarrativeDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#AcquisitionsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/AcquisitionsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_019b25b0-19a5-712e-8771-c1e6422532b8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019b25b0-19a5-7950-93ec-fede451fe6be" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b0-19a5-712e-8771-c1e6422532b8" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019b25b0-19a5-7950-93ec-fede451fe6be" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionAxis_019b25b0-19a5-7e21-a079-b32e3d98df2d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019b25b0-19a5-7950-93ec-fede451fe6be" xlink:to="loc_us-gaap_AssetAcquisitionAxis_019b25b0-19a5-7e21-a079-b32e3d98df2d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionDomain_019b25b0-19a5-7e21-a079-b32e3d98df2d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AssetAcquisitionAxis_019b25b0-19a5-7e21-a079-b32e3d98df2d" xlink:to="loc_us-gaap_AssetAcquisitionDomain_019b25b0-19a5-7e21-a079-b32e3d98df2d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionDomain_019b25b0-19a5-7fdb-9b3a-c34b2ca91d9d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AssetAcquisitionAxis_019b25b0-19a5-7e21-a079-b32e3d98df2d" xlink:to="loc_us-gaap_AssetAcquisitionDomain_019b25b0-19a5-7fdb-9b3a-c34b2ca91d9d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_REVenturesIMember_019b25b0-19a5-7a2f-b8a7-2b920f54ab1c" xlink:href="rxrx-20251231.xsd#rxrx_REVenturesIMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetAcquisitionDomain_019b25b0-19a5-7fdb-9b3a-c34b2ca91d9d" xlink:to="loc_rxrx_REVenturesIMember_019b25b0-19a5-7a2f-b8a7-2b920f54ab1c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_019b25b0-19a5-7602-a7f7-f90bc8a6827f" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019b25b0-19a5-7950-93ec-fede451fe6be" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_019b25b0-19a5-7602-a7f7-f90bc8a6827f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_019b25b0-19a5-7602-a7f7-f90bc8a6827f_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_019b25b0-19a5-7602-a7f7-f90bc8a6827f" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_019b25b0-19a5-7602-a7f7-f90bc8a6827f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_019b25b0-19a5-7a4a-8c02-2f6d8909381b" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_019b25b0-19a5-7602-a7f7-f90bc8a6827f" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_019b25b0-19a5-7a4a-8c02-2f6d8909381b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_AlphaBiotechnologyGmbHAlphaMember_019b25b0-19a5-729c-a3ae-93ce67c8ba1d" xlink:href="rxrx-20251231.xsd#rxrx_AlphaBiotechnologyGmbHAlphaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_019b25b0-19a5-7a4a-8c02-2f6d8909381b" xlink:to="loc_rxrx_AlphaBiotechnologyGmbHAlphaMember_019b25b0-19a5-729c-a3ae-93ce67c8ba1d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationAxis_019b25b0-19a5-7551-bf53-fa88ff92a459" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupClassificationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019b25b0-19a5-7950-93ec-fede451fe6be" xlink:to="loc_us-gaap_DisposalGroupClassificationAxis_019b25b0-19a5-7551-bf53-fa88ff92a459" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_019b25b0-19a5-7551-bf53-fa88ff92a459_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupClassificationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_019b25b0-19a5-7551-bf53-fa88ff92a459" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_019b25b0-19a5-7551-bf53-fa88ff92a459_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_019b25b0-19a5-7606-81be-2bd9f3a87ca3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupClassificationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_019b25b0-19a5-7551-bf53-fa88ff92a459" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_019b25b0-19a5-7606-81be-2bd9f3a87ca3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember_019b25b0-19a5-7b3d-88df-3338fb0de7fb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupClassificationDomain_019b25b0-19a5-7606-81be-2bd9f3a87ca3" xlink:to="loc_us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember_019b25b0-19a5-7b3d-88df-3338fb0de7fb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_019b25b0-19a5-7fbd-ab0a-f993f5b5d63d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019b25b0-19a5-7950-93ec-fede451fe6be" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_019b25b0-19a5-7fbd-ab0a-f993f5b5d63d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_019b25b0-19a5-7fbd-ab0a-f993f5b5d63d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_019b25b0-19a5-7fbd-ab0a-f993f5b5d63d" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_019b25b0-19a5-7fbd-ab0a-f993f5b5d63d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_019b25b0-19a5-74be-90d0-8b03c3c3e9cc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_019b25b0-19a5-7fbd-ab0a-f993f5b5d63d" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_019b25b0-19a5-74be-90d0-8b03c3c3e9cc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ExscientiaGmbHMember_019b25b0-19a5-7a78-8399-3e445c28669c" xlink:href="rxrx-20251231.xsd#rxrx_ExscientiaGmbHMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_019b25b0-19a5-74be-90d0-8b03c3c3e9cc" xlink:to="loc_rxrx_ExscientiaGmbHMember_019b25b0-19a5-7a78-8399-3e445c28669c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_019b25b0-19a5-7d3f-b7e2-e4dd47662259" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019b25b0-19a5-7950-93ec-fede451fe6be" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_019b25b0-19a5-7d3f-b7e2-e4dd47662259" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b25b0-19a5-7d3f-b7e2-e4dd47662259_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019b25b0-19a5-7d3f-b7e2-e4dd47662259" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b25b0-19a5-7d3f-b7e2-e4dd47662259_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b25b0-19a5-765d-8144-c8f46b6d82a6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019b25b0-19a5-7d3f-b7e2-e4dd47662259" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b25b0-19a5-765d-8144-c8f46b6d82a6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ExscientiaPlcMember_019b25b0-19a5-726f-bc8a-a358791b0c23" xlink:href="rxrx-20251231.xsd#rxrx_ExscientiaPlcMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b25b0-19a5-765d-8144-c8f46b6d82a6" xlink:to="loc_rxrx_ExscientiaPlcMember_019b25b0-19a5-726f-bc8a-a358791b0c23" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019b25b0-19a5-7ac5-9c0b-ac5913df3bdf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019b25b0-19a5-7950-93ec-fede451fe6be" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019b25b0-19a5-7ac5-9c0b-ac5913df3bdf" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019b25b0-19a5-7ac5-9c0b-ac5913df3bdf_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019b25b0-19a5-7ac5-9c0b-ac5913df3bdf" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019b25b0-19a5-7ac5-9c0b-ac5913df3bdf_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019b25b0-19a5-78e4-952c-bab4f66ef610" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019b25b0-19a5-7ac5-9c0b-ac5913df3bdf" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019b25b0-19a5-78e4-952c-bab4f66ef610" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TechnologyBasedIntangibleAssetsMember_019b25b0-19a5-7412-ab17-a5c00792fb60" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TechnologyBasedIntangibleAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019b25b0-19a5-78e4-952c-bab4f66ef610" xlink:to="loc_us-gaap_TechnologyBasedIntangibleAssetsMember_019b25b0-19a5-7412-ab17-a5c00792fb60" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_AssetAcquisitionEquityOwnershipPercentage_019b25b0-19a5-7ea0-8f1a-663af7f5186c" xlink:href="rxrx-20251231.xsd#rxrx_AssetAcquisitionEquityOwnershipPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b0-19a5-712e-8771-c1e6422532b8" xlink:to="loc_rxrx_AssetAcquisitionEquityOwnershipPercentage_019b25b0-19a5-7ea0-8f1a-663af7f5186c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionConsiderationTransferred_019b25b0-19a5-7854-b654-c882c58aa67c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionConsiderationTransferred"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b0-19a5-712e-8771-c1e6422532b8" xlink:to="loc_us-gaap_AssetAcquisitionConsiderationTransferred_019b25b0-19a5-7854-b654-c882c58aa67c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireInProcessResearchAndDevelopment_019b25b0-19a5-718e-b6fb-07d5b819c394" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireInProcessResearchAndDevelopment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b0-19a5-712e-8771-c1e6422532b8" xlink:to="loc_us-gaap_PaymentsToAcquireInProcessResearchAndDevelopment_019b25b0-19a5-718e-b6fb-07d5b819c394" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_019b25b0-19a5-73db-a0a7-873a10bf0138" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b0-19a5-712e-8771-c1e6422532b8" xlink:to="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_019b25b0-19a5-73db-a0a7-873a10bf0138" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfBusiness_019b25b0-19a5-7514-9938-4b7b6b1412d0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GainLossOnSaleOfBusiness"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b0-19a5-712e-8771-c1e6422532b8" xlink:to="loc_us-gaap_GainLossOnSaleOfBusiness_019b25b0-19a5-7514-9938-4b7b6b1412d0" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestments_019b25b0-19a5-718b-8924-74c410616561" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityMethodInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b0-19a5-712e-8771-c1e6422532b8" xlink:to="loc_us-gaap_EquityMethodInvestments_019b25b0-19a5-718b-8924-74c410616561" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_019b25b0-19a5-7338-a127-c93da0be7c51" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationConsiderationTransferred1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b0-19a5-712e-8771-c1e6422532b8" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferred1_019b25b0-19a5-7338-a127-c93da0be7c51" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_019b25b0-19a5-7b4e-af75-861bf69c4d58" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b0-19a5-712e-8771-c1e6422532b8" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_019b25b0-19a5-7b4e-af75-861bf69c4d58" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_BusinessCombinationConsiderationTransferredEquityInterestsIssuable_019b25b0-19a5-7dac-9863-ff0ff3f423b2" xlink:href="rxrx-20251231.xsd#rxrx_BusinessCombinationConsiderationTransferredEquityInterestsIssuable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b0-19a5-712e-8771-c1e6422532b8" xlink:to="loc_rxrx_BusinessCombinationConsiderationTransferredEquityInterestsIssuable_019b25b0-19a5-7dac-9863-ff0ff3f423b2" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_019b25b0-19a5-7b95-8a8a-2901f45d0ca6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b0-19a5-712e-8771-c1e6422532b8" xlink:to="loc_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_019b25b0-19a5-7b95-8a8a-2901f45d0ca6" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_BusinessCombinationEquityInterestIssuedOrIssuableSharesOfAcquirerStockPerShareOfAcquireeStockOutstanding_019b25b0-19a5-78c8-af77-17a6d16a9ba1" xlink:href="rxrx-20251231.xsd#rxrx_BusinessCombinationEquityInterestIssuedOrIssuableSharesOfAcquirerStockPerShareOfAcquireeStockOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b0-19a5-712e-8771-c1e6422532b8" xlink:to="loc_rxrx_BusinessCombinationEquityInterestIssuedOrIssuableSharesOfAcquirerStockPerShareOfAcquireeStockOutstanding_019b25b0-19a5-78c8-af77-17a6d16a9ba1" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharePrice_019b25b0-19a5-76af-825b-59f1277dd305" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SharePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b0-19a5-712e-8771-c1e6422532b8" xlink:to="loc_us-gaap_SharePrice_019b25b0-19a5-76af-825b-59f1277dd305" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAcquiredDuringPeriod_019b25b0-19a5-745a-a5b2-912fcdb4a2c1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GoodwillAcquiredDuringPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b0-19a5-712e-8771-c1e6422532b8" xlink:to="loc_us-gaap_GoodwillAcquiredDuringPeriod_019b25b0-19a5-745a-a5b2-912fcdb4a2c1" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_019b25b0-19a5-7820-b054-e9170205f2f2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInDeferredIncomeTaxes"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b0-19a5-712e-8771-c1e6422532b8" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_019b25b0-19a5-7820-b054-e9170205f2f2" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_NumberOfAcquiredCustomerContractsWithContractLiabilities_019b25b0-19a5-710a-87df-c5c33bf17741" xlink:href="rxrx-20251231.xsd#rxrx_NumberOfAcquiredCustomerContractsWithContractLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b0-19a5-712e-8771-c1e6422532b8" xlink:to="loc_rxrx_NumberOfAcquiredCustomerContractsWithContractLiabilities_019b25b0-19a5-710a-87df-c5c33bf17741" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_NumberOfInProcessResearchAndDevelopmentAssets_019b25b0-19a5-72c1-b97e-f468d35b0857" xlink:href="rxrx-20251231.xsd#rxrx_NumberOfInProcessResearchAndDevelopmentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b0-19a5-712e-8771-c1e6422532b8" xlink:to="loc_rxrx_NumberOfInProcessResearchAndDevelopmentAssets_019b25b0-19a5-72c1-b97e-f468d35b0857" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_FiniteLivedIntangibleAssetDiscountRate_019b25b0-19a5-79f0-9302-b5c0006c7882" xlink:href="rxrx-20251231.xsd#rxrx_FiniteLivedIntangibleAssetDiscountRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b0-19a5-712e-8771-c1e6422532b8" xlink:to="loc_rxrx_FiniteLivedIntangibleAssetDiscountRate_019b25b0-19a5-79f0-9302-b5c0006c7882" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_019b25b0-19a5-7ee9-8286-38cbe300103a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b0-19a5-712e-8771-c1e6422532b8" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_019b25b0-19a5-7ee9-8286-38cbe300103a" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationProFormaInformationRevenueOfAcquireeSinceAcquisitionDateActual_019b25b0-19a5-76e9-941f-64aa14abbd39" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationProFormaInformationRevenueOfAcquireeSinceAcquisitionDateActual"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b0-19a5-712e-8771-c1e6422532b8" xlink:to="loc_us-gaap_BusinessCombinationProFormaInformationRevenueOfAcquireeSinceAcquisitionDateActual_019b25b0-19a5-76e9-941f-64aa14abbd39" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationProFormaInformationEarningsOrLossOfAcquireeSinceAcquisitionDateActual_019b25b0-19a5-75e6-9bdd-660cb4e69c8c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationProFormaInformationEarningsOrLossOfAcquireeSinceAcquisitionDateActual"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b0-19a5-712e-8771-c1e6422532b8" xlink:to="loc_us-gaap_BusinessCombinationProFormaInformationEarningsOrLossOfAcquireeSinceAcquisitionDateActual_019b25b0-19a5-75e6-9bdd-660cb4e69c8c" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionCostOfAcquiredEntityTransactionCosts_019b25b3-7d3c-7e18-8c52-2aa3ee9e1cea" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionCostOfAcquiredEntityTransactionCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b0-19a5-712e-8771-c1e6422532b8" xlink:to="loc_us-gaap_BusinessAcquisitionCostOfAcquiredEntityTransactionCosts_019b25b3-7d3c-7e18-8c52-2aa3ee9e1cea" xlink:type="arc" order="20"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/AcquisitionsScheduleofAssetAcquisitionDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#AcquisitionsScheduleofAssetAcquisitionDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/AcquisitionsScheduleofAssetAcquisitionDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionLineItems_019b25ae-3602-7f91-ad1a-c88c914d4ae6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionTable_019b25ae-3602-78bc-bedf-fb1f5ac34028" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_019b25ae-3602-7f91-ad1a-c88c914d4ae6" xlink:to="loc_us-gaap_AssetAcquisitionTable_019b25ae-3602-78bc-bedf-fb1f5ac34028" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionAxis_019b25ae-3602-782a-b317-84eb05fe49c3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AssetAcquisitionTable_019b25ae-3602-78bc-bedf-fb1f5ac34028" xlink:to="loc_us-gaap_AssetAcquisitionAxis_019b25ae-3602-782a-b317-84eb05fe49c3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionDomain_019b25ae-3602-782a-b317-84eb05fe49c3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AssetAcquisitionAxis_019b25ae-3602-782a-b317-84eb05fe49c3" xlink:to="loc_us-gaap_AssetAcquisitionDomain_019b25ae-3602-782a-b317-84eb05fe49c3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionDomain_019b25ae-3602-7cc2-8df9-d869e91c9445" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AssetAcquisitionAxis_019b25ae-3602-782a-b317-84eb05fe49c3" xlink:to="loc_us-gaap_AssetAcquisitionDomain_019b25ae-3602-7cc2-8df9-d869e91c9445" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_REVenturesIMember_019b25ae-3602-7ab5-b41e-fdad9aee5cbd" xlink:href="rxrx-20251231.xsd#rxrx_REVenturesIMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetAcquisitionDomain_019b25ae-3602-7cc2-8df9-d869e91c9445" xlink:to="loc_rxrx_REVenturesIMember_019b25ae-3602-7ab5-b41e-fdad9aee5cbd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionConsiderationTransferredEquityInterestIssuedAndIssuable_019b25ae-3602-7916-9c7e-bcdbd32a8b89" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionConsiderationTransferredEquityInterestIssuedAndIssuable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_019b25ae-3602-7f91-ad1a-c88c914d4ae6" xlink:to="loc_us-gaap_AssetAcquisitionConsiderationTransferredEquityInterestIssuedAndIssuable_019b25ae-3602-7916-9c7e-bcdbd32a8b89" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionConsiderationTransferredContingentConsideration_019b25ae-3602-7f55-b8d7-23bbe260965f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionConsiderationTransferredContingentConsideration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_019b25ae-3602-7f91-ad1a-c88c914d4ae6" xlink:to="loc_us-gaap_AssetAcquisitionConsiderationTransferredContingentConsideration_019b25ae-3602-7f55-b8d7-23bbe260965f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionConsiderationTransferredTransactionCost_019b25ae-3602-7f98-ad10-d7864b55c27b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionConsiderationTransferredTransactionCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_019b25ae-3602-7f91-ad1a-c88c914d4ae6" xlink:to="loc_us-gaap_AssetAcquisitionConsiderationTransferredTransactionCost_019b25ae-3602-7f98-ad10-d7864b55c27b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireProductiveAssets_019b25ae-3602-767b-b879-7c8014e059df" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireProductiveAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_019b25ae-3602-7f91-ad1a-c88c914d4ae6" xlink:to="loc_us-gaap_PaymentsToAcquireProductiveAssets_019b25ae-3602-767b-b879-7c8014e059df" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionConsiderationTransferred_019b25ae-3602-78df-b112-a529cbe9ee4d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionConsiderationTransferred"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_019b25ae-3602-7f91-ad1a-c88c914d4ae6" xlink:to="loc_us-gaap_AssetAcquisitionConsiderationTransferred_019b25ae-3602-78df-b112-a529cbe9ee4d" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/AcquisitionsScheduleofContingentConsiderationTransferredDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#AcquisitionsScheduleofContingentConsiderationTransferredDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/AcquisitionsScheduleofContingentConsiderationTransferredDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionLineItems_019b25ae-d356-7787-8341-422072297766" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionTable_019b25ae-d356-7d02-ab7d-f6383f06b45b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_019b25ae-d356-7787-8341-422072297766" xlink:to="loc_us-gaap_AssetAcquisitionTable_019b25ae-d356-7d02-ab7d-f6383f06b45b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionAxis_019b25ae-d356-7fa8-8ff0-86b6828d61c9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AssetAcquisitionTable_019b25ae-d356-7d02-ab7d-f6383f06b45b" xlink:to="loc_us-gaap_AssetAcquisitionAxis_019b25ae-d356-7fa8-8ff0-86b6828d61c9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionDomain_019b25ae-d356-7fa8-8ff0-86b6828d61c9_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AssetAcquisitionAxis_019b25ae-d356-7fa8-8ff0-86b6828d61c9" xlink:to="loc_us-gaap_AssetAcquisitionDomain_019b25ae-d356-7fa8-8ff0-86b6828d61c9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionDomain_019b25ae-d356-7ad7-a6c8-0cbbca52ba7d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AssetAcquisitionAxis_019b25ae-d356-7fa8-8ff0-86b6828d61c9" xlink:to="loc_us-gaap_AssetAcquisitionDomain_019b25ae-d356-7ad7-a6c8-0cbbca52ba7d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_REVenturesIMember_019b25ae-d356-7497-b94c-297d945b9aad" xlink:href="rxrx-20251231.xsd#rxrx_REVenturesIMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetAcquisitionDomain_019b25ae-d356-7ad7-a6c8-0cbbca52ba7d" xlink:to="loc_rxrx_REVenturesIMember_019b25ae-d356-7497-b94c-297d945b9aad" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_AssetAcquisitionContingentConsiderationEquityInterestIssuedAndIssuable_019b25ae-d356-7600-b125-3dd3b9b7992e" xlink:href="rxrx-20251231.xsd#rxrx_AssetAcquisitionContingentConsiderationEquityInterestIssuedAndIssuable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_019b25ae-d356-7787-8341-422072297766" xlink:to="loc_rxrx_AssetAcquisitionContingentConsiderationEquityInterestIssuedAndIssuable_019b25ae-d356-7600-b125-3dd3b9b7992e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_AssetAcquisitionContingentConsiderationCashPaid_019b25ae-d356-74c8-b86d-920d308b7931" xlink:href="rxrx-20251231.xsd#rxrx_AssetAcquisitionContingentConsiderationCashPaid"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_019b25ae-d356-7787-8341-422072297766" xlink:to="loc_rxrx_AssetAcquisitionContingentConsiderationCashPaid_019b25ae-d356-74c8-b86d-920d308b7931" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionConsiderationTransferredContingentConsideration_019b25ae-d356-7cad-bc24-90cc0fe17878" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionConsiderationTransferredContingentConsideration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_019b25ae-d356-7787-8341-422072297766" xlink:to="loc_us-gaap_AssetAcquisitionConsiderationTransferredContingentConsideration_019b25ae-d356-7cad-bc24-90cc0fe17878" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/AcquisitionsScheduleofFairValueofAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#AcquisitionsScheduleofFairValueofAssetsAcquiredandLiabilitiesAssumedDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/AcquisitionsScheduleofFairValueofAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_019b25b5-900e-7324-aeb5-0975799b3370" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019b25b5-900e-725b-a820-2045bc7bc2d0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b5-900e-7324-aeb5-0975799b3370" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019b25b5-900e-725b-a820-2045bc7bc2d0" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_019b25b5-900e-7375-ada8-4820955e7fe5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019b25b5-900e-725b-a820-2045bc7bc2d0" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_019b25b5-900e-7375-ada8-4820955e7fe5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b25b5-900e-7375-ada8-4820955e7fe5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019b25b5-900e-7375-ada8-4820955e7fe5" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b25b5-900e-7375-ada8-4820955e7fe5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b25b5-900e-7af4-b0aa-9edfaca7eb52" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019b25b5-900e-7375-ada8-4820955e7fe5" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b25b5-900e-7af4-b0aa-9edfaca7eb52" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ExscientiaPlcMember_019b25b5-900e-7015-823c-12ec9f29135b" xlink:href="rxrx-20251231.xsd#rxrx_ExscientiaPlcMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b25b5-900e-7af4-b0aa-9edfaca7eb52" xlink:to="loc_rxrx_ExscientiaPlcMember_019b25b5-900e-7015-823c-12ec9f29135b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_019b25b5-900e-73b6-91be-dead62add1ee" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b5-900e-7324-aeb5-0975799b3370" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_019b25b5-900e-73b6-91be-dead62add1ee" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherReceivables_019b25b5-900e-72d0-a56e-768c596afa74" xlink:href="rxrx-20251231.xsd#rxrx_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherReceivables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b5-900e-7324-aeb5-0975799b3370" xlink:to="loc_rxrx_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherReceivables_019b25b5-900e-72d0-a56e-768c596afa74" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_019b25b5-900e-7b4b-89c0-9f7fc4652116" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b5-900e-7324-aeb5-0975799b3370" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_019b25b5-900e-7b4b-89c0-9f7fc4652116" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_019b25b5-900e-7efb-a28d-8d8b1fcac0c7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b5-900e-7324-aeb5-0975799b3370" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_019b25b5-900e-7efb-a28d-8d8b1fcac0c7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingLeaseRightOfUseAssets_019b25b5-900e-7783-9ae1-20f15b7d5024" xlink:href="rxrx-20251231.xsd#rxrx_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingLeaseRightOfUseAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b5-900e-7324-aeb5-0975799b3370" xlink:to="loc_rxrx_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingLeaseRightOfUseAssets_019b25b5-900e-7783-9ae1-20f15b7d5024" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_019b25b5-900e-76cd-aee6-1805d717166e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b5-900e-7324-aeb5-0975799b3370" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_019b25b5-900e-76cd-aee6-1805d717166e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIndefiniteLivedIntangibleAssets_019b25b5-900e-7625-9353-0a86060f2d2c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIndefiniteLivedIntangibleAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b5-900e-7324-aeb5-0975799b3370" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIndefiniteLivedIntangibleAssets_019b25b5-900e-7625-9353-0a86060f2d2c" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxAssets_019b25b5-900e-796d-a8f6-314f3fbc2537" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b5-900e-7324-aeb5-0975799b3370" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxAssets_019b25b5-900e-796d-a8f6-314f3fbc2537" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_019b25b5-900e-7a1d-bd0d-94a22c184544" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b5-900e-7324-aeb5-0975799b3370" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_019b25b5-900e-7a1d-bd0d-94a22c184544" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_019b25b5-900e-7a14-a001-efa23e521313" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b5-900e-7324-aeb5-0975799b3370" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_019b25b5-900e-7a14-a001-efa23e521313" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLeaseLiabilities_019b25b5-900e-7694-b6fe-93febd71e832" xlink:href="rxrx-20251231.xsd#rxrx_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLeaseLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b5-900e-7324-aeb5-0975799b3370" xlink:to="loc_rxrx_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLeaseLiabilities_019b25b5-900e-7694-b6fe-93febd71e832" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue_019b25b5-900e-771a-a4e4-28d8c5f7a2fb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b5-900e-7324-aeb5-0975799b3370" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue_019b25b5-900e-771a-a4e4-28d8c5f7a2fb" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_019b25b5-900e-7185-b8aa-f0113f97f87f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b5-900e-7324-aeb5-0975799b3370" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_019b25b5-900e-7185-b8aa-f0113f97f87f" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther_019b25b5-900e-7601-b76f-86bf777bf2ea" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b5-900e-7324-aeb5-0975799b3370" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther_019b25b5-900e-7601-b76f-86bf777bf2ea" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019b25b5-900e-72a5-970a-1389aca68d3a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b5-900e-7324-aeb5-0975799b3370" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019b25b5-900e-72a5-970a-1389aca68d3a" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019b25b5-900e-7191-bed4-a1e3168fc79c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b5-900e-7324-aeb5-0975799b3370" xlink:to="loc_us-gaap_Goodwill_019b25b5-900e-7191-bed4-a1e3168fc79c" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_019b25b5-900e-75d4-a96d-42d5c8e4e071" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b5-900e-7324-aeb5-0975799b3370" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_019b25b5-900e-75d4-a96d-42d5c8e4e071" xlink:type="arc" order="16"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/AcquisitionsScheduleofProFormaFinancialInformationDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#AcquisitionsScheduleofProFormaFinancialInformationDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/AcquisitionsScheduleofProFormaFinancialInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_019b25b7-7df2-77d3-9089-a5fcfc79f10b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019b25b7-7df2-72e8-a3cd-9978ae8c0919" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b7-7df2-77d3-9089-a5fcfc79f10b" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019b25b7-7df2-72e8-a3cd-9978ae8c0919" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_019b25b7-7df2-7e1a-99ba-f9e149fb3e38" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019b25b7-7df2-72e8-a3cd-9978ae8c0919" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_019b25b7-7df2-7e1a-99ba-f9e149fb3e38" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b25b7-7df2-7e1a-99ba-f9e149fb3e38_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019b25b7-7df2-7e1a-99ba-f9e149fb3e38" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b25b7-7df2-7e1a-99ba-f9e149fb3e38_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b25b7-7df2-7287-8758-940d4cf0be9d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019b25b7-7df2-7e1a-99ba-f9e149fb3e38" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b25b7-7df2-7287-8758-940d4cf0be9d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ExscientiaPlcMember_019b25b7-7df2-7949-b8b7-e98c6f99577a" xlink:href="rxrx-20251231.xsd#rxrx_ExscientiaPlcMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019b25b7-7df2-7287-8758-940d4cf0be9d" xlink:to="loc_rxrx_ExscientiaPlcMember_019b25b7-7df2-7949-b8b7-e98c6f99577a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionsProFormaRevenue_019b25b7-7df2-7e5e-a1bc-22316b01d2ae" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionsProFormaRevenue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b7-7df2-77d3-9089-a5fcfc79f10b" xlink:to="loc_us-gaap_BusinessAcquisitionsProFormaRevenue_019b25b7-7df2-7e5e-a1bc-22316b01d2ae" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionsProFormaNetIncomeLoss_019b25b7-7df2-700c-b03f-f6dfbf8c63be" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionsProFormaNetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019b25b7-7df2-77d3-9089-a5fcfc79f10b" xlink:to="loc_us-gaap_BusinessAcquisitionsProFormaNetIncomeLoss_019b25b7-7df2-700c-b03f-f6dfbf8c63be" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/LeasesNarrativeDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#LeasesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/LeasesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionLineItems_019b25e0-5a76-7d6e-b384-aa16cce990e2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeLeaseDescriptionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionTable_019b25e0-5a76-7463-a594-8c71df716b8b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeLeaseDescriptionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019b25e0-5a76-7d6e-b384-aa16cce990e2" xlink:to="loc_us-gaap_LesseeLeaseDescriptionTable_019b25e0-5a76-7463-a594-8c71df716b8b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019b25e0-5a76-77ed-adfc-2720048a9e68" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_019b25e0-5a76-7463-a594-8c71df716b8b" xlink:to="loc_srt_RangeAxis_019b25e0-5a76-77ed-adfc-2720048a9e68" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019b25e0-5a76-77ed-adfc-2720048a9e68_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019b25e0-5a76-77ed-adfc-2720048a9e68" xlink:to="loc_srt_RangeMember_019b25e0-5a76-77ed-adfc-2720048a9e68_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019b25e0-5a76-7694-9097-d02a338beeec" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019b25e0-5a76-77ed-adfc-2720048a9e68" xlink:to="loc_srt_RangeMember_019b25e0-5a76-7694-9097-d02a338beeec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_019b25e0-5a76-7a9f-a739-7f31edc7919d" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019b25e0-5a76-7694-9097-d02a338beeec" xlink:to="loc_srt_MinimumMember_019b25e0-5a76-7a9f-a739-7f31edc7919d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019b25e0-5a76-70ce-9a8b-56790b56f4c3" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019b25e0-5a76-7694-9097-d02a338beeec" xlink:to="loc_srt_MaximumMember_019b25e0-5a76-70ce-9a8b-56790b56f4c3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LeaseDescriptionAxis_019b25e0-5a76-7db7-8aa6-29fc1193ec34" xlink:href="rxrx-20251231.xsd#rxrx_LeaseDescriptionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_019b25e0-5a76-7463-a594-8c71df716b8b" xlink:to="loc_rxrx_LeaseDescriptionAxis_019b25e0-5a76-7db7-8aa6-29fc1193ec34" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LeaseDescriptionDomain_019b25e0-5a76-7db7-8aa6-29fc1193ec34_default" xlink:href="rxrx-20251231.xsd#rxrx_LeaseDescriptionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_rxrx_LeaseDescriptionAxis_019b25e0-5a76-7db7-8aa6-29fc1193ec34" xlink:to="loc_rxrx_LeaseDescriptionDomain_019b25e0-5a76-7db7-8aa6-29fc1193ec34_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LeaseDescriptionDomain_019b25e0-5a76-7e15-834f-8aca004a4619" xlink:href="rxrx-20251231.xsd#rxrx_LeaseDescriptionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_rxrx_LeaseDescriptionAxis_019b25e0-5a76-7db7-8aa6-29fc1193ec34" xlink:to="loc_rxrx_LeaseDescriptionDomain_019b25e0-5a76-7e15-834f-8aca004a4619" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ViennaFacilitiesOfExscientiaGmbHMember_019b25e0-5a76-7c40-a4b1-7877db8e2f93" xlink:href="rxrx-20251231.xsd#rxrx_ViennaFacilitiesOfExscientiaGmbHMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_LeaseDescriptionDomain_019b25e0-5a76-7e15-834f-8aca004a4619" xlink:to="loc_rxrx_ViennaFacilitiesOfExscientiaGmbHMember_019b25e0-5a76-7c40-a4b1-7877db8e2f93" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_SchrodingerLeasesMember_019b25e0-5a76-7d9f-8d5f-2b635aa1ae11" xlink:href="rxrx-20251231.xsd#rxrx_SchrodingerLeasesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_LeaseDescriptionDomain_019b25e0-5a76-7e15-834f-8aca004a4619" xlink:to="loc_rxrx_SchrodingerLeasesMember_019b25e0-5a76-7d9f-8d5f-2b635aa1ae11" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseRemainingLeaseTerm_019b25e0-5a76-7e1d-87b5-9272919e0171" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseRemainingLeaseTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019b25e0-5a76-7d6e-b384-aa16cce990e2" xlink:to="loc_us-gaap_LesseeOperatingLeaseRemainingLeaseTerm_019b25e0-5a76-7e1d-87b5-9272919e0171" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_019b25e0-5a76-787f-bec0-9153ad306fd0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseRenewalTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019b25e0-5a76-7d6e-b384-aa16cce990e2" xlink:to="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_019b25e0-5a76-787f-bec0-9153ad306fd0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_IncreaseDecreaseInOperatingLeaseRightOfUseAssets_019b25e0-5a76-7aff-b021-5e44baa9a134" xlink:href="rxrx-20251231.xsd#rxrx_IncreaseDecreaseInOperatingLeaseRightOfUseAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019b25e0-5a76-7d6e-b384-aa16cce990e2" xlink:to="loc_rxrx_IncreaseDecreaseInOperatingLeaseRightOfUseAssets_019b25e0-5a76-7aff-b021-5e44baa9a134" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LesseeOperatingLeaseIncreaseDecreaseInOperatingLeaseLiabilityDueToLeaseModifications_019b25e0-5a76-7044-a8d0-de0ea7de1726" xlink:href="rxrx-20251231.xsd#rxrx_LesseeOperatingLeaseIncreaseDecreaseInOperatingLeaseLiabilityDueToLeaseModifications"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019b25e0-5a76-7d6e-b384-aa16cce990e2" xlink:to="loc_rxrx_LesseeOperatingLeaseIncreaseDecreaseInOperatingLeaseLiabilityDueToLeaseModifications_019b25e0-5a76-7044-a8d0-de0ea7de1726" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LesseeOperatingLeaseIncreaseDecreaseInRightOfUseAssetsDueToLeaseModifications_019c6802-c981-7411-a98a-4145eceb05b5" xlink:href="rxrx-20251231.xsd#rxrx_LesseeOperatingLeaseIncreaseDecreaseInRightOfUseAssetsDueToLeaseModifications"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019b25e0-5a76-7d6e-b384-aa16cce990e2" xlink:to="loc_rxrx_LesseeOperatingLeaseIncreaseDecreaseInRightOfUseAssetsDueToLeaseModifications_019c6802-c981-7411-a98a-4145eceb05b5" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_TerminationOfLeaseFee_019b25e0-5a76-7d03-a98f-7339660e5667" xlink:href="rxrx-20251231.xsd#rxrx_TerminationOfLeaseFee"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019b25e0-5a76-7d6e-b384-aa16cce990e2" xlink:to="loc_rxrx_TerminationOfLeaseFee_019b25e0-5a76-7d03-a98f-7339660e5667" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfLeasehold_019b25e0-5a76-70b9-bdf2-bd03db4dc74d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ImpairmentOfLeasehold"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019b25e0-5a76-7d6e-b384-aa16cce990e2" xlink:to="loc_us-gaap_ImpairmentOfLeasehold_019b25e0-5a76-70b9-bdf2-bd03db4dc74d" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_IncreaseDecreaseInRightOfUseAssetsForFinanceLeases_019b25e0-5a76-794a-b81b-1c3fc8bff5f7" xlink:href="rxrx-20251231.xsd#rxrx_IncreaseDecreaseInRightOfUseAssetsForFinanceLeases"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019b25e0-5a76-7d6e-b384-aa16cce990e2" xlink:to="loc_rxrx_IncreaseDecreaseInRightOfUseAssetsForFinanceLeases_019b25e0-5a76-794a-b81b-1c3fc8bff5f7" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LesseeFinanceLeaseIncreaseDecreaseInFinanceLeaseLiabilityDueToLeaseModifications_019b25e0-5a76-7dbd-9da0-c5b5c38a2ab5" xlink:href="rxrx-20251231.xsd#rxrx_LesseeFinanceLeaseIncreaseDecreaseInFinanceLeaseLiabilityDueToLeaseModifications"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019b25e0-5a76-7d6e-b384-aa16cce990e2" xlink:to="loc_rxrx_LesseeFinanceLeaseIncreaseDecreaseInFinanceLeaseLiabilityDueToLeaseModifications_019b25e0-5a76-7dbd-9da0-c5b5c38a2ab5" xlink:type="arc" order="8"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/GoodwillandIntangibleAssetsScheduleofIntangibleAssetsDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#GoodwillandIntangibleAssetsScheduleofIntangibleAssetsDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/GoodwillandIntangibleAssetsScheduleofIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_4ae3d601-3a6f-4ed4-b658-e966751eea2c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_c2eb2bf2-761e-452b-9e6d-97d08ee92e2e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_4ae3d601-3a6f-4ed4-b658-e966751eea2c" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_c2eb2bf2-761e-452b-9e6d-97d08ee92e2e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_2ae7c940-7d92-41c9-8950-6482ba8cd274" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_c2eb2bf2-761e-452b-9e6d-97d08ee92e2e" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_2ae7c940-7d92-41c9-8950-6482ba8cd274" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_2ae7c940-7d92-41c9-8950-6482ba8cd274_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_2ae7c940-7d92-41c9-8950-6482ba8cd274" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_2ae7c940-7d92-41c9-8950-6482ba8cd274_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_55665110-abbb-452d-8b3c-f117bbb77e91" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_2ae7c940-7d92-41c9-8950-6482ba8cd274" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_55665110-abbb-452d-8b3c-f117bbb77e91" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TechnologyBasedIntangibleAssetsMember_a9a37b4b-a0c7-4072-bfea-517b240143bb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TechnologyBasedIntangibleAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_55665110-abbb-452d-8b3c-f117bbb77e91" xlink:to="loc_us-gaap_TechnologyBasedIntangibleAssetsMember_a9a37b4b-a0c7-4072-bfea-517b240143bb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LicensingAgreementsMember_59b57e85-629b-4f04-abed-415b3bfe6706" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LicensingAgreementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_55665110-abbb-452d-8b3c-f117bbb77e91" xlink:to="loc_us-gaap_LicensingAgreementsMember_59b57e85-629b-4f04-abed-415b3bfe6706" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_538541be-148b-4400-9d94-701902d61bcd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_4ae3d601-3a6f-4ed4-b658-e966751eea2c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_538541be-148b-4400-9d94-701902d61bcd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_12557f7c-ba22-4967-9963-9d99a74ee9a0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_4ae3d601-3a6f-4ed4-b658-e966751eea2c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_12557f7c-ba22-4967-9963-9d99a74ee9a0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_ae4949a7-4007-476d-ba69-4475c8ab7cd4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_4ae3d601-3a6f-4ed4-b658-e966751eea2c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_ae4949a7-4007-476d-ba69-4475c8ab7cd4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_2e99d08c-1790-4b73-8250-24a833a47063" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_4ae3d601-3a6f-4ed4-b658-e966751eea2c" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_2e99d08c-1790-4b73-8250-24a833a47063" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_8cafc836-bece-43ff-88ce-8eae76b95b62" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_4ae3d601-3a6f-4ed4-b658-e966751eea2c" xlink:to="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_8cafc836-bece-43ff-88ce-8eae76b95b62" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_36edefb0-51f5-4d72-8b7d-d26b6f0cfcb2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_4ae3d601-3a6f-4ed4-b658-e966751eea2c" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_36edefb0-51f5-4d72-8b7d-d26b6f0cfcb2" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/CommonStockNarrativeDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#CommonStockNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/CommonStockNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_98d9c641-6984-4f55-ab4b-188de23b5f0f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_a90e0bfc-cf66-4570-b386-a05e595d956c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_98d9c641-6984-4f55-ab4b-188de23b5f0f" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_a90e0bfc-cf66-4570-b386-a05e595d956c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_4cebc87d-1e74-436b-8731-ca20b892e296" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_a90e0bfc-cf66-4570-b386-a05e595d956c" xlink:to="loc_us-gaap_StatementClassOfStockAxis_4cebc87d-1e74-436b-8731-ca20b892e296" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_4cebc87d-1e74-436b-8731-ca20b892e296_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_4cebc87d-1e74-436b-8731-ca20b892e296" xlink:to="loc_us-gaap_ClassOfStockDomain_4cebc87d-1e74-436b-8731-ca20b892e296_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_e83cec93-e6e0-4673-95e6-59d95076584e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_4cebc87d-1e74-436b-8731-ca20b892e296" xlink:to="loc_us-gaap_ClassOfStockDomain_e83cec93-e6e0-4673-95e6-59d95076584e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_1e746a8a-9909-4717-afb0-8444e020f5ae" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_e83cec93-e6e0-4673-95e6-59d95076584e" xlink:to="loc_us-gaap_CommonClassAMember_1e746a8a-9909-4717-afb0-8444e020f5ae" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_687fdf6e-4869-4a75-be3c-7530d78fb57e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassBMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_e83cec93-e6e0-4673-95e6-59d95076584e" xlink:to="loc_us-gaap_CommonClassBMember_687fdf6e-4869-4a75-be3c-7530d78fb57e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_CommonStockVotePerShare_80e0f860-414f-4202-aaba-ec011808ac4f" xlink:href="rxrx-20251231.xsd#rxrx_CommonStockVotePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_98d9c641-6984-4f55-ab4b-188de23b5f0f" xlink:to="loc_rxrx_CommonStockVotePerShare_80e0f860-414f-4202-aaba-ec011808ac4f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsStock_ee952379-7582-449c-8903-edcb6daec0b5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DividendsStock"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_98d9c641-6984-4f55-ab4b-188de23b5f0f" xlink:to="loc_us-gaap_DividendsStock_ee952379-7582-449c-8903-edcb6daec0b5" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/CommonStockAtTheMarketOfferingNarrativeDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#CommonStockAtTheMarketOfferingNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/CommonStockAtTheMarketOfferingNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_019b2616-0b5e-760f-b621-7b5b3df9b36f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_019b2616-0b5e-7ebb-a7be-d2fe397ee7ab" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_019b2616-0b5e-760f-b621-7b5b3df9b36f" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_019b2616-0b5e-7ebb-a7be-d2fe397ee7ab" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019b2616-0b5e-73e5-aa5e-cd9b5ad1f3ad" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019b2616-0b5e-7ebb-a7be-d2fe397ee7ab" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019b2616-0b5e-73e5-aa5e-cd9b5ad1f3ad" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019b2616-0b5e-73e5-aa5e-cd9b5ad1f3ad_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019b2616-0b5e-73e5-aa5e-cd9b5ad1f3ad" xlink:to="loc_us-gaap_ClassOfStockDomain_019b2616-0b5e-73e5-aa5e-cd9b5ad1f3ad_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019b2616-0b5e-7b1c-bf16-d79adbb17ddf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019b2616-0b5e-73e5-aa5e-cd9b5ad1f3ad" xlink:to="loc_us-gaap_ClassOfStockDomain_019b2616-0b5e-7b1c-bf16-d79adbb17ddf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_019b2616-0b5e-7886-906a-86d52c30b454" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019b2616-0b5e-7b1c-bf16-d79adbb17ddf" xlink:to="loc_us-gaap_CommonClassAMember_019b2616-0b5e-7886-906a-86d52c30b454" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_019b2616-0b5e-7d57-8cd8-cbb2aa3720f4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019b2616-0b5e-7ebb-a7be-d2fe397ee7ab" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_019b2616-0b5e-7d57-8cd8-cbb2aa3720f4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019b2616-0b5e-7d57-8cd8-cbb2aa3720f4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_019b2616-0b5e-7d57-8cd8-cbb2aa3720f4" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019b2616-0b5e-7d57-8cd8-cbb2aa3720f4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019b2616-0b5e-7c55-b66c-93d725718449" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_019b2616-0b5e-7d57-8cd8-cbb2aa3720f4" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019b2616-0b5e-7c55-b66c-93d725718449" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_AtTheMarketOfferingProgramCitiMember_019b2616-0b5e-76b3-93ac-c79ee570b14c" xlink:href="rxrx-20251231.xsd#rxrx_AtTheMarketOfferingProgramCitiMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019b2616-0b5e-7c55-b66c-93d725718449" xlink:to="loc_rxrx_AtTheMarketOfferingProgramCitiMember_019b2616-0b5e-76b3-93ac-c79ee570b14c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_AtTheMarketOfferingProgramJefferiesMember_019b2616-0b5e-751a-846b-9cc11193c1f8" xlink:href="rxrx-20251231.xsd#rxrx_AtTheMarketOfferingProgramJefferiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019b2616-0b5e-7c55-b66c-93d725718449" xlink:to="loc_rxrx_AtTheMarketOfferingProgramJefferiesMember_019b2616-0b5e-751a-846b-9cc11193c1f8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_SaleOfStockValueAuthorized_019b2616-0b5e-7af2-8d31-424266911036" xlink:href="rxrx-20251231.xsd#rxrx_SaleOfStockValueAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019b2616-0b5e-760f-b621-7b5b3df9b36f" xlink:to="loc_rxrx_SaleOfStockValueAuthorized_019b2616-0b5e-7af2-8d31-424266911036" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_019b2616-0b5e-7bc2-92ce-d7c1a4e41b3d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019b2616-0b5e-760f-b621-7b5b3df9b36f" xlink:to="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_019b2616-0b5e-7bc2-92ce-d7c1a4e41b3d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_019b2616-0b5e-7833-8678-994556a95080" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockConsiderationReceivedOnTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019b2616-0b5e-760f-b621-7b5b3df9b36f" xlink:to="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_019b2616-0b5e-7833-8678-994556a95080" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_SaleOfStockValueRemainingAuthorized_019b2616-0b5e-73eb-a623-bae1658ec531" xlink:href="rxrx-20251231.xsd#rxrx_SaleOfStockValueRemainingAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019b2616-0b5e-760f-b621-7b5b3df9b36f" xlink:to="loc_rxrx_SaleOfStockValueRemainingAuthorized_019b2616-0b5e-73eb-a623-bae1658ec531" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_SaleOfStockPercentageOfCommission_019b2616-0b5e-70fe-8881-f9d34db3b9a2" xlink:href="rxrx-20251231.xsd#rxrx_SaleOfStockPercentageOfCommission"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019b2616-0b5e-760f-b621-7b5b3df9b36f" xlink:to="loc_rxrx_SaleOfStockPercentageOfCommission_019b2616-0b5e-70fe-8881-f9d34db3b9a2" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/CommonStockPublicOfferingofCommonStockNarrativeDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#CommonStockPublicOfferingofCommonStockNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/CommonStockPublicOfferingofCommonStockNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_1fcccf3d-c4cc-42e1-94a9-9a9cf8996c44" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_320bb169-31c1-4033-8149-643619aeab19" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_1fcccf3d-c4cc-42e1-94a9-9a9cf8996c44" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_320bb169-31c1-4033-8149-643619aeab19" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_ec9f8e84-e5a6-4737-8ef2-cf7f11eb406d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_320bb169-31c1-4033-8149-643619aeab19" xlink:to="loc_us-gaap_StatementClassOfStockAxis_ec9f8e84-e5a6-4737-8ef2-cf7f11eb406d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_ec9f8e84-e5a6-4737-8ef2-cf7f11eb406d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_ec9f8e84-e5a6-4737-8ef2-cf7f11eb406d" xlink:to="loc_us-gaap_ClassOfStockDomain_ec9f8e84-e5a6-4737-8ef2-cf7f11eb406d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_75179e71-a3ef-411f-b8e2-5589b033163a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_ec9f8e84-e5a6-4737-8ef2-cf7f11eb406d" xlink:to="loc_us-gaap_ClassOfStockDomain_75179e71-a3ef-411f-b8e2-5589b033163a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_ef68b576-f497-4148-a180-ee38e5fb20a2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_75179e71-a3ef-411f-b8e2-5589b033163a" xlink:to="loc_us-gaap_CommonClassAMember_ef68b576-f497-4148-a180-ee38e5fb20a2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_36a4941f-fc15-4bbb-b50f-0e0b4ddafb26" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_320bb169-31c1-4033-8149-643619aeab19" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_36a4941f-fc15-4bbb-b50f-0e0b4ddafb26" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_36a4941f-fc15-4bbb-b50f-0e0b4ddafb26_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_36a4941f-fc15-4bbb-b50f-0e0b4ddafb26" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_36a4941f-fc15-4bbb-b50f-0e0b4ddafb26_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_e56321d5-a06e-4088-a07c-fab8137d638b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_36a4941f-fc15-4bbb-b50f-0e0b4ddafb26" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_e56321d5-a06e-4088-a07c-fab8137d638b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_PublicOfferingOfCommonStockMember_b3e4813e-ac75-4bf1-b952-e163b1f5558f" xlink:href="rxrx-20251231.xsd#rxrx_PublicOfferingOfCommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_e56321d5-a06e-4088-a07c-fab8137d638b" xlink:to="loc_rxrx_PublicOfferingOfCommonStockMember_b3e4813e-ac75-4bf1-b952-e163b1f5558f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_PublicOfferingOfCommonStockUnderwritingAgreementMember_1099d8d1-e587-4312-b7a1-1920281dced4" xlink:href="rxrx-20251231.xsd#rxrx_PublicOfferingOfCommonStockUnderwritingAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_e56321d5-a06e-4088-a07c-fab8137d638b" xlink:to="loc_rxrx_PublicOfferingOfCommonStockUnderwritingAgreementMember_1099d8d1-e587-4312-b7a1-1920281dced4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OverAllotmentOptionMember_0c7737b4-b2fe-4a1c-ba66-5f4f1977b0c7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OverAllotmentOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_e56321d5-a06e-4088-a07c-fab8137d638b" xlink:to="loc_us-gaap_OverAllotmentOptionMember_0c7737b4-b2fe-4a1c-ba66-5f4f1977b0c7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_776d073d-92d4-4a48-a63e-fee6fcdb47bd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_1fcccf3d-c4cc-42e1-94a9-9a9cf8996c44" xlink:to="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_776d073d-92d4-4a48-a63e-fee6fcdb47bd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_a9c7662c-11c3-431d-9913-84312cbd6682" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockPricePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_1fcccf3d-c4cc-42e1-94a9-9a9cf8996c44" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_a9c7662c-11c3-431d-9913-84312cbd6682" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_57375cf6-4d9f-4888-9f71-45e0c2ec39f3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockConsiderationReceivedOnTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_1fcccf3d-c4cc-42e1-94a9-9a9cf8996c44" xlink:to="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_57375cf6-4d9f-4888-9f71-45e0c2ec39f3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfStockIssuanceCosts_7ea3cd7e-5bf4-48a7-b854-c44d015eaa23" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsOfStockIssuanceCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_1fcccf3d-c4cc-42e1-94a9-9a9cf8996c44" xlink:to="loc_us-gaap_PaymentsOfStockIssuanceCosts_7ea3cd7e-5bf4-48a7-b854-c44d015eaa23" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_SaleOfStockUnderwritersOptionPeriodFromTheDateOfTheAgreement_bbad8646-c642-4306-a62a-b5388efd052a" xlink:href="rxrx-20251231.xsd#rxrx_SaleOfStockUnderwritersOptionPeriodFromTheDateOfTheAgreement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_1fcccf3d-c4cc-42e1-94a9-9a9cf8996c44" xlink:to="loc_rxrx_SaleOfStockUnderwritersOptionPeriodFromTheDateOfTheAgreement_bbad8646-c642-4306-a62a-b5388efd052a" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/CommonStockValenceAcquisitionExchangeableSharesNarrativeDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#CommonStockValenceAcquisitionExchangeableSharesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/CommonStockValenceAcquisitionExchangeableSharesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_57e87f4f-bcb5-4a71-b8ad-0977f8ea18c6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_da2cacf9-9bf8-47ab-b854-a6890988e3ec" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_57e87f4f-bcb5-4a71-b8ad-0977f8ea18c6" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_da2cacf9-9bf8-47ab-b854-a6890988e3ec" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_98d72769-c596-480f-806c-096ab1b3d3f4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_da2cacf9-9bf8-47ab-b854-a6890988e3ec" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_98d72769-c596-480f-806c-096ab1b3d3f4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_98d72769-c596-480f-806c-096ab1b3d3f4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_98d72769-c596-480f-806c-096ab1b3d3f4" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_98d72769-c596-480f-806c-096ab1b3d3f4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_b82dc674-f2c8-4ada-aa43-92663dfbdb3f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_98d72769-c596-480f-806c-096ab1b3d3f4" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_b82dc674-f2c8-4ada-aa43-92663dfbdb3f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ValenceDiscoveryIncMember_9317688a-68dc-42fe-b596-552e16fd4b21" xlink:href="rxrx-20251231.xsd#rxrx_ValenceDiscoveryIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_b82dc674-f2c8-4ada-aa43-92663dfbdb3f" xlink:to="loc_rxrx_ValenceDiscoveryIncMember_9317688a-68dc-42fe-b596-552e16fd4b21" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_eac88678-fc81-45cf-916a-d920ccf40314" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_da2cacf9-9bf8-47ab-b854-a6890988e3ec" xlink:to="loc_us-gaap_StatementClassOfStockAxis_eac88678-fc81-45cf-916a-d920ccf40314" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_eac88678-fc81-45cf-916a-d920ccf40314_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_eac88678-fc81-45cf-916a-d920ccf40314" xlink:to="loc_us-gaap_ClassOfStockDomain_eac88678-fc81-45cf-916a-d920ccf40314_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_3581dbed-4f22-4493-b9f5-124ab1aca6c6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_eac88678-fc81-45cf-916a-d920ccf40314" xlink:to="loc_us-gaap_ClassOfStockDomain_3581dbed-4f22-4493-b9f5-124ab1aca6c6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ExchangeableStockMember_b310af83-382f-4896-8254-da74145eaa15" xlink:href="rxrx-20251231.xsd#rxrx_ExchangeableStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_3581dbed-4f22-4493-b9f5-124ab1aca6c6" xlink:to="loc_rxrx_ExchangeableStockMember_b310af83-382f-4896-8254-da74145eaa15" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_0b0a9dcc-14a7-4c0a-b14b-313ba524b22c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_3581dbed-4f22-4493-b9f5-124ab1aca6c6" xlink:to="loc_us-gaap_CommonClassAMember_0b0a9dcc-14a7-4c0a-b14b-313ba524b22c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_BusinessAcquisitionContingentConsiderationEquityInterestsIssuableNumberOfShares_2845699d-e43e-41f6-8dd3-c7ef95a04b5e" xlink:href="rxrx-20251231.xsd#rxrx_BusinessAcquisitionContingentConsiderationEquityInterestsIssuableNumberOfShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_57e87f4f-bcb5-4a71-b8ad-0977f8ea18c6" xlink:to="loc_rxrx_BusinessAcquisitionContingentConsiderationEquityInterestsIssuableNumberOfShares_2845699d-e43e-41f6-8dd3-c7ef95a04b5e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_CommonStockConversionRatio_d23c34e5-a46d-4172-85bf-e231ee9283ff" xlink:href="rxrx-20251231.xsd#rxrx_CommonStockConversionRatio"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_57e87f4f-bcb5-4a71-b8ad-0977f8ea18c6" xlink:to="loc_rxrx_CommonStockConversionRatio_d23c34e5-a46d-4172-85bf-e231ee9283ff" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_a743985c-58bb-4a43-9055-bb9367b7d2a5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_57e87f4f-bcb5-4a71-b8ad-0977f8ea18c6" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_a743985c-58bb-4a43-9055-bb9367b7d2a5" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/CommonStockRegistrationRightsAgreementsNarrativeDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#CommonStockRegistrationRightsAgreementsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/CommonStockRegistrationRightsAgreementsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_019bfdc3-c2ee-78ba-a33c-9097695cff74" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_019bfdc3-c2ee-7bcc-a653-ab235c1d6f7a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_019bfdc3-c2ee-78ba-a33c-9097695cff74" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_019bfdc3-c2ee-7bcc-a653-ab235c1d6f7a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_019bfdc3-c2ee-7880-bd48-300b7044a3c0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019bfdc3-c2ee-7bcc-a653-ab235c1d6f7a" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_019bfdc3-c2ee-7880-bd48-300b7044a3c0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019bfdc3-c2ee-7880-bd48-300b7044a3c0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019bfdc3-c2ee-7880-bd48-300b7044a3c0" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019bfdc3-c2ee-7880-bd48-300b7044a3c0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019bfdc3-c2ee-7262-96bb-17caf743631d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019bfdc3-c2ee-7880-bd48-300b7044a3c0" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019bfdc3-c2ee-7262-96bb-17caf743631d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ValenceDiscoveryIncMember_019bfdc3-c2ee-7340-9032-2fe7e8ec2b6a" xlink:href="rxrx-20251231.xsd#rxrx_ValenceDiscoveryIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019bfdc3-c2ee-7262-96bb-17caf743631d" xlink:to="loc_rxrx_ValenceDiscoveryIncMember_019bfdc3-c2ee-7340-9032-2fe7e8ec2b6a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_RegistrationRightsAgreementTerm_019bfdc3-c2ee-7719-9e3e-2c96a7ed5a97" xlink:href="rxrx-20251231.xsd#rxrx_RegistrationRightsAgreementTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019bfdc3-c2ee-78ba-a33c-9097695cff74" xlink:to="loc_rxrx_RegistrationRightsAgreementTerm_019bfdc3-c2ee-7719-9e3e-2c96a7ed5a97" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/CommonStockClassAandBCommonSharesAuthorizationNarrativeDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#CommonStockClassAandBCommonSharesAuthorizationNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/CommonStockClassAandBCommonSharesAuthorizationNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_019bfdc4-2833-74fe-94be-c37dfa582574" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_019bfdc4-2833-7291-9be9-46852c795960" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_019bfdc4-2833-74fe-94be-c37dfa582574" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_019bfdc4-2833-7291-9be9-46852c795960" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019bfdc4-2833-717a-a4b4-cd4521f9d0d4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019bfdc4-2833-7291-9be9-46852c795960" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019bfdc4-2833-717a-a4b4-cd4521f9d0d4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019bfdc4-2833-717a-a4b4-cd4521f9d0d4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019bfdc4-2833-717a-a4b4-cd4521f9d0d4" xlink:to="loc_us-gaap_ClassOfStockDomain_019bfdc4-2833-717a-a4b4-cd4521f9d0d4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019bfdc4-2833-7a4b-949d-e3737d6d080b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019bfdc4-2833-717a-a4b4-cd4521f9d0d4" xlink:to="loc_us-gaap_ClassOfStockDomain_019bfdc4-2833-7a4b-949d-e3737d6d080b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_019bfdc4-2833-771f-8d74-7ac044a98119" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019bfdc4-2833-7a4b-949d-e3737d6d080b" xlink:to="loc_us-gaap_CommonClassAMember_019bfdc4-2833-771f-8d74-7ac044a98119" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_019bfdc4-2833-7ea4-b9dc-04de4831ed59" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassBMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019bfdc4-2833-7a4b-949d-e3737d6d080b" xlink:to="loc_us-gaap_CommonClassBMember_019bfdc4-2833-7ea4-b9dc-04de4831ed59" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_NumberOfClassesOfCommonStockAuthorized_019bfdc4-2833-7a42-abb1-68f2d02ce876" xlink:href="rxrx-20251231.xsd#rxrx_NumberOfClassesOfCommonStockAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019bfdc4-2833-74fe-94be-c37dfa582574" xlink:to="loc_rxrx_NumberOfClassesOfCommonStockAuthorized_019bfdc4-2833-7a42-abb1-68f2d02ce876" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_CommonStockVotePerShare_019bfdc4-2833-7482-8f27-0360043821d2" xlink:href="rxrx-20251231.xsd#rxrx_CommonStockVotePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019bfdc4-2833-74fe-94be-c37dfa582574" xlink:to="loc_rxrx_CommonStockVotePerShare_019bfdc4-2833-7482-8f27-0360043821d2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_CommonStockConversionRatio_019bfdc4-2833-7be6-8da8-060e621685af" xlink:href="rxrx-20251231.xsd#rxrx_CommonStockConversionRatio"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019bfdc4-2833-74fe-94be-c37dfa582574" xlink:to="loc_rxrx_CommonStockConversionRatio_019bfdc4-2833-7be6-8da8-060e621685af" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/CollaborativeDevelopmentContractsDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#CollaborativeDevelopmentContractsDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/CollaborativeDevelopmentContractsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019b263e-832a-740c-ad7f-225a2bbfe183" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019b263e-832a-7ae8-a81a-688538f698fe" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019b263e-832a-740c-ad7f-225a2bbfe183" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019b263e-832a-7ae8-a81a-688538f698fe" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_019b263e-832a-7546-8d51-24d63fc8568b" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019b263e-832a-7ae8-a81a-688538f698fe" xlink:to="loc_srt_CounterpartyNameAxis_019b263e-832a-7546-8d51-24d63fc8568b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019b263e-832a-7546-8d51-24d63fc8568b_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_019b263e-832a-7546-8d51-24d63fc8568b" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019b263e-832a-7546-8d51-24d63fc8568b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019b263e-832a-7dd3-91cb-2968284b1413" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_019b263e-832a-7546-8d51-24d63fc8568b" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019b263e-832a-7dd3-91cb-2968284b1413" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_SanofiMember_019b263e-832a-7321-814e-ebd1cc73fbdc" xlink:href="rxrx-20251231.xsd#rxrx_SanofiMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019b263e-832a-7dd3-91cb-2968284b1413" xlink:to="loc_rxrx_SanofiMember_019b263e-832a-7321-814e-ebd1cc73fbdc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_MerckKGaAMerckMember_019b263e-832a-7773-ab61-5ec8556fa4de" xlink:href="rxrx-20251231.xsd#rxrx_MerckKGaAMerckMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019b263e-832a-7dd3-91cb-2968284b1413" xlink:to="loc_rxrx_MerckKGaAMerckMember_019b263e-832a-7773-ab61-5ec8556fa4de" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_RocheAndGenentechMember_019b263e-832a-7539-a0f9-731169b9b471" xlink:href="rxrx-20251231.xsd#rxrx_RocheAndGenentechMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019b263e-832a-7dd3-91cb-2968284b1413" xlink:to="loc_rxrx_RocheAndGenentechMember_019b263e-832a-7539-a0f9-731169b9b471" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_019b263e-832a-724d-9e82-573150fab2a6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019b263e-832a-7ae8-a81a-688538f698fe" xlink:to="loc_us-gaap_TypeOfArrangementAxis_019b263e-832a-724d-9e82-573150fab2a6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019b263e-832a-724d-9e82-573150fab2a6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019b263e-832a-724d-9e82-573150fab2a6" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019b263e-832a-724d-9e82-573150fab2a6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019b263e-832a-7151-9ead-9aed9de5b5c7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019b263e-832a-724d-9e82-573150fab2a6" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019b263e-832a-7151-9ead-9aed9de5b5c7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementMember_019b263e-832a-7d6d-b6a7-2dc8b5f39865" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CollaborativeArrangementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019b263e-832a-7151-9ead-9aed9de5b5c7" xlink:to="loc_us-gaap_CollaborativeArrangementMember_019b263e-832a-7d6d-b6a7-2dc8b5f39865" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_MilestoneTypeAxis_019b263e-832a-74d0-808a-44930a629ce3" xlink:href="rxrx-20251231.xsd#rxrx_MilestoneTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019b263e-832a-7ae8-a81a-688538f698fe" xlink:to="loc_rxrx_MilestoneTypeAxis_019b263e-832a-74d0-808a-44930a629ce3" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_MilestoneTypeDomain_019b263e-832a-74d0-808a-44930a629ce3_default" xlink:href="rxrx-20251231.xsd#rxrx_MilestoneTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_rxrx_MilestoneTypeAxis_019b263e-832a-74d0-808a-44930a629ce3" xlink:to="loc_rxrx_MilestoneTypeDomain_019b263e-832a-74d0-808a-44930a629ce3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_MilestoneTypeDomain_019b263e-832a-74d0-9364-4c9863556a74" xlink:href="rxrx-20251231.xsd#rxrx_MilestoneTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_rxrx_MilestoneTypeAxis_019b263e-832a-74d0-808a-44930a629ce3" xlink:to="loc_rxrx_MilestoneTypeDomain_019b263e-832a-74d0-9364-4c9863556a74" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ResearchMilestonesMember_019b263e-832a-727a-8b2c-fe23e62ae2f6" xlink:href="rxrx-20251231.xsd#rxrx_ResearchMilestonesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_MilestoneTypeDomain_019b263e-832a-74d0-9364-4c9863556a74" xlink:to="loc_rxrx_ResearchMilestonesMember_019b263e-832a-727a-8b2c-fe23e62ae2f6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_DevelopmentAndRegulatoryMilestonesMember_019b263e-832a-79d5-8ddf-0bce0cea48bd" xlink:href="rxrx-20251231.xsd#rxrx_DevelopmentAndRegulatoryMilestonesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_MilestoneTypeDomain_019b263e-832a-74d0-9364-4c9863556a74" xlink:to="loc_rxrx_DevelopmentAndRegulatoryMilestonesMember_019b263e-832a-79d5-8ddf-0bce0cea48bd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_DiscoveryDevelopmentAndSalesMilestonesMember_019b263e-832a-7f4a-9cc7-e66bf6b63027" xlink:href="rxrx-20251231.xsd#rxrx_DiscoveryDevelopmentAndSalesMilestonesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_MilestoneTypeDomain_019b263e-832a-74d0-9364-4c9863556a74" xlink:to="loc_rxrx_DiscoveryDevelopmentAndSalesMilestonesMember_019b263e-832a-7f4a-9cc7-e66bf6b63027" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_RevenueRemainingPerformanceObligationAxis_019b263e-832a-7c63-93f3-da75d3bbdc82" xlink:href="rxrx-20251231.xsd#rxrx_RevenueRemainingPerformanceObligationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019b263e-832a-7ae8-a81a-688538f698fe" xlink:to="loc_rxrx_RevenueRemainingPerformanceObligationAxis_019b263e-832a-7c63-93f3-da75d3bbdc82" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_RevenueRemainingPerformanceObligationDomain_019b263e-832a-7c63-93f3-da75d3bbdc82_default" xlink:href="rxrx-20251231.xsd#rxrx_RevenueRemainingPerformanceObligationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_rxrx_RevenueRemainingPerformanceObligationAxis_019b263e-832a-7c63-93f3-da75d3bbdc82" xlink:to="loc_rxrx_RevenueRemainingPerformanceObligationDomain_019b263e-832a-7c63-93f3-da75d3bbdc82_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_RevenueRemainingPerformanceObligationDomain_019b263e-832a-7588-83b6-25aac6f5ae34" xlink:href="rxrx-20251231.xsd#rxrx_RevenueRemainingPerformanceObligationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_rxrx_RevenueRemainingPerformanceObligationAxis_019b263e-832a-7c63-93f3-da75d3bbdc82" xlink:to="loc_rxrx_RevenueRemainingPerformanceObligationDomain_019b263e-832a-7588-83b6-25aac6f5ae34" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_PhenomapsCreationMember_019b263e-832a-7550-8e45-7d458dcff75d" xlink:href="rxrx-20251231.xsd#rxrx_PhenomapsCreationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_RevenueRemainingPerformanceObligationDomain_019b263e-832a-7588-83b6-25aac6f5ae34" xlink:to="loc_rxrx_PhenomapsCreationMember_019b263e-832a-7550-8e45-7d458dcff75d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_PhenomapsRawImagesMember_019b263e-832a-753a-b06a-29f4490aa5b2" xlink:href="rxrx-20251231.xsd#rxrx_PhenomapsRawImagesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_RevenueRemainingPerformanceObligationDomain_019b263e-832a-7588-83b6-25aac6f5ae34" xlink:to="loc_rxrx_PhenomapsRawImagesMember_019b263e-832a-753a-b06a-29f4490aa5b2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_DevelopedAndCommercializedProgramsMember_019b263e-832a-7834-b0fc-3ea8c2bbb94e" xlink:href="rxrx-20251231.xsd#rxrx_DevelopedAndCommercializedProgramsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_RevenueRemainingPerformanceObligationDomain_019b263e-832a-7588-83b6-25aac6f5ae34" xlink:to="loc_rxrx_DevelopedAndCommercializedProgramsMember_019b263e-832a-7834-b0fc-3ea8c2bbb94e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_GastrointestinalCancerMember_019b263e-832a-7213-bed1-3f73315cf8e6" xlink:href="rxrx-20251231.xsd#rxrx_GastrointestinalCancerMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_RevenueRemainingPerformanceObligationDomain_019b263e-832a-7588-83b6-25aac6f5ae34" xlink:to="loc_rxrx_GastrointestinalCancerMember_019b263e-832a-7213-bed1-3f73315cf8e6" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_NeuroscienceMember_019b263e-832a-7b68-88e1-678cfcf32161" xlink:href="rxrx-20251231.xsd#rxrx_NeuroscienceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_RevenueRemainingPerformanceObligationDomain_019b263e-832a-7588-83b6-25aac6f5ae34" xlink:to="loc_rxrx_NeuroscienceMember_019b263e-832a-7b68-88e1-678cfcf32161" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MajorCustomersAxis_019b2641-c652-70cb-9b87-61595c4870e1" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MajorCustomersAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019b263e-832a-7ae8-a81a-688538f698fe" xlink:to="loc_srt_MajorCustomersAxis_019b2641-c652-70cb-9b87-61595c4870e1" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_019b2641-c652-70cb-9b87-61595c4870e1_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_MajorCustomersAxis_019b2641-c652-70cb-9b87-61595c4870e1" xlink:to="loc_srt_NameOfMajorCustomerDomain_019b2641-c652-70cb-9b87-61595c4870e1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_019b2641-c652-771c-aed3-b3efe012f8a2" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_MajorCustomersAxis_019b2641-c652-70cb-9b87-61595c4870e1" xlink:to="loc_srt_NameOfMajorCustomerDomain_019b2641-c652-771c-aed3-b3efe012f8a2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_OneCustomerMember_019b2641-c652-75f6-9f13-3e00129c0e92" xlink:href="rxrx-20251231.xsd#rxrx_OneCustomerMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_019b2641-c652-771c-aed3-b3efe012f8a2" xlink:to="loc_rxrx_OneCustomerMember_019b2641-c652-75f6-9f13-3e00129c0e92" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_TwoCustomersMember_019b2641-c652-7bf8-b60f-9d4b41cb3e97" xlink:href="rxrx-20251231.xsd#rxrx_TwoCustomersMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_019b2641-c652-771c-aed3-b3efe012f8a2" xlink:to="loc_rxrx_TwoCustomersMember_019b2641-c652-7bf8-b60f-9d4b41cb3e97" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_019b2641-c652-728a-a2f3-a4b5c115842a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019b263e-832a-7ae8-a81a-688538f698fe" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_019b2641-c652-728a-a2f3-a4b5c115842a" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_019b2641-c652-728a-a2f3-a4b5c115842a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_019b2641-c652-728a-a2f3-a4b5c115842a" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_019b2641-c652-728a-a2f3-a4b5c115842a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_019b2641-c652-72dd-86f8-6ec2830610d1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_019b2641-c652-728a-a2f3-a4b5c115842a" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_019b2641-c652-72dd-86f8-6ec2830610d1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesRevenueNetMember_019b2641-c652-779a-bef1-2f8e734be0a6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SalesRevenueNetMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_019b2641-c652-72dd-86f8-6ec2830610d1" xlink:to="loc_us-gaap_SalesRevenueNetMember_019b2641-c652-779a-bef1-2f8e734be0a6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_019b2641-c652-717c-b0c6-fe9a985b0eb2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ConcentrationRiskByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019b263e-832a-7ae8-a81a-688538f698fe" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_019b2641-c652-717c-b0c6-fe9a985b0eb2" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_019b2641-c652-717c-b0c6-fe9a985b0eb2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_019b2641-c652-717c-b0c6-fe9a985b0eb2" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_019b2641-c652-717c-b0c6-fe9a985b0eb2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_019b2641-c652-7655-bbc5-24dbf4df31ab" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_019b2641-c652-717c-b0c6-fe9a985b0eb2" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_019b2641-c652-7655-bbc5-24dbf4df31ab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerConcentrationRiskMember_019b2641-c652-7878-8a1b-91bad833f120" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CustomerConcentrationRiskMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_019b2641-c652-7655-bbc5-24dbf4df31ab" xlink:to="loc_us-gaap_CustomerConcentrationRiskMember_019b2641-c652-7878-8a1b-91bad833f120" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ContractWithCustomerNumberOfNovelSmallMoleculeCandidates_019b263e-832a-7970-8e58-faaf6f4fc5b7" xlink:href="rxrx-20251231.xsd#rxrx_ContractWithCustomerNumberOfNovelSmallMoleculeCandidates"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019b263e-832a-740c-ad7f-225a2bbfe183" xlink:to="loc_rxrx_ContractWithCustomerNumberOfNovelSmallMoleculeCandidates_019b263e-832a-7970-8e58-faaf6f4fc5b7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiability_019b263e-832a-7487-940d-809897c9bbe6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContractWithCustomerLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019b263e-832a-740c-ad7f-225a2bbfe183" xlink:to="loc_us-gaap_ContractWithCustomerLiability_019b263e-832a-7487-940d-809897c9bbe6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_CollaborativeArrangementMilestonePaymentReceived_019b263e-832a-790e-9dcd-720d05690ce0" xlink:href="rxrx-20251231.xsd#rxrx_CollaborativeArrangementMilestonePaymentReceived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019b263e-832a-740c-ad7f-225a2bbfe183" xlink:to="loc_rxrx_CollaborativeArrangementMilestonePaymentReceived_019b263e-832a-790e-9dcd-720d05690ce0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_019b263e-832a-7179-80a3-8f2fe9ff4784" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContractWithCustomerLiabilityRevenueRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019b263e-832a-740c-ad7f-225a2bbfe183" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_019b263e-832a-7179-80a3-8f2fe9ff4784" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_RevenuePerformanceObligationNumberOfObligations_019b263e-832a-76e5-8351-8d442e3fe688" xlink:href="rxrx-20251231.xsd#rxrx_RevenuePerformanceObligationNumberOfObligations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019b263e-832a-740c-ad7f-225a2bbfe183" xlink:to="loc_rxrx_RevenuePerformanceObligationNumberOfObligations_019b263e-832a-76e5-8351-8d442e3fe688" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligation_019b263e-832a-7ab6-bed6-cf737737bf44" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueRemainingPerformanceObligation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019b263e-832a-740c-ad7f-225a2bbfe183" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligation_019b263e-832a-7ab6-bed6-cf737737bf44" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_RevenueRemainingPerformanceObligationVariableConsiderationAmount_019b263e-832a-7266-a3fd-db4d53e102f3" xlink:href="rxrx-20251231.xsd#rxrx_RevenueRemainingPerformanceObligationVariableConsiderationAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019b263e-832a-740c-ad7f-225a2bbfe183" xlink:to="loc_rxrx_RevenueRemainingPerformanceObligationVariableConsiderationAmount_019b263e-832a-7266-a3fd-db4d53e102f3" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ContractWithCustomerMaximumAcceptedProduct_019b263e-832a-7e32-81cf-c2b38e654aab" xlink:href="rxrx-20251231.xsd#rxrx_ContractWithCustomerMaximumAcceptedProduct"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019b263e-832a-740c-ad7f-225a2bbfe183" xlink:to="loc_rxrx_ContractWithCustomerMaximumAcceptedProduct_019b263e-832a-7e32-81cf-c2b38e654aab" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_RevenueRemainingPerformanceObligationNumberOfProjectsThatMayBeInitiated_019b263e-832a-7349-a1a2-b93d42b09753" xlink:href="rxrx-20251231.xsd#rxrx_RevenueRemainingPerformanceObligationNumberOfProjectsThatMayBeInitiated"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019b263e-832a-740c-ad7f-225a2bbfe183" xlink:to="loc_rxrx_RevenueRemainingPerformanceObligationNumberOfProjectsThatMayBeInitiated_019b263e-832a-7349-a1a2-b93d42b09753" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_019b2641-c652-718d-858a-8dfc7702f28c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ConcentrationRiskPercentage1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019b263e-832a-740c-ad7f-225a2bbfe183" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_019b2641-c652-718d-858a-8dfc7702f28c" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_019b263e-832a-79ef-aba3-5bf66b14c51b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContractWithCustomerLiabilityRevenueRecognized"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetNetCurrent_019b263e-832a-70ae-bc14-94660134ef02" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContractWithCustomerAssetNetCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019b263e-832a-740c-ad7f-225a2bbfe183" xlink:to="loc_us-gaap_ContractWithCustomerAssetNetCurrent_019b263e-832a-70ae-bc14-94660134ef02" xlink:type="arc" order="11"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/StockBasedCompensationNarrativeDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#StockBasedCompensationNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/StockBasedCompensationNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019b265e-3c6e-7d7d-ad7f-54caac8cb6c7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019b265e-3c6e-77f4-9f9d-82172b4246a1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019b265e-3c6e-7d7d-ad7f-54caac8cb6c7" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019b265e-3c6e-77f4-9f9d-82172b4246a1" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_019b265e-3c6e-75c5-9b39-cb5be28a4b6c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019b265e-3c6e-77f4-9f9d-82172b4246a1" xlink:to="loc_us-gaap_PlanNameAxis_019b265e-3c6e-75c5-9b39-cb5be28a4b6c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_019b265e-3c6e-75c5-9b39-cb5be28a4b6c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_019b265e-3c6e-75c5-9b39-cb5be28a4b6c" xlink:to="loc_us-gaap_PlanNameDomain_019b265e-3c6e-75c5-9b39-cb5be28a4b6c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_019b265e-3c6e-7f16-8d51-dd1c4c7ce259" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_019b265e-3c6e-75c5-9b39-cb5be28a4b6c" xlink:to="loc_us-gaap_PlanNameDomain_019b265e-3c6e-7f16-8d51-dd1c4c7ce259" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_A2021EquityIncentivePlanMember_019b265e-3c6e-7a44-b1e8-c6249b3b5cf9" xlink:href="rxrx-20251231.xsd#rxrx_A2021EquityIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_019b265e-3c6e-7f16-8d51-dd1c4c7ce259" xlink:to="loc_rxrx_A2021EquityIncentivePlanMember_019b265e-3c6e-7a44-b1e8-c6249b3b5cf9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_A2024InducementEquityIncentivePlanMember_019b265e-3c6e-72f1-90e3-ccba96539c8d" xlink:href="rxrx-20251231.xsd#rxrx_A2024InducementEquityIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_019b265e-3c6e-7f16-8d51-dd1c4c7ce259" xlink:to="loc_rxrx_A2024InducementEquityIncentivePlanMember_019b265e-3c6e-72f1-90e3-ccba96539c8d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ExscientiaLegacyAwardsMember_019c2dea-aeb3-75f8-b8cb-1c82a8b2dec0" xlink:href="rxrx-20251231.xsd#rxrx_ExscientiaLegacyAwardsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_019b265e-3c6e-7f16-8d51-dd1c4c7ce259" xlink:to="loc_rxrx_ExscientiaLegacyAwardsMember_019c2dea-aeb3-75f8-b8cb-1c82a8b2dec0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_RetentionProgramForEmployeesMember_019c2dea-aeb3-7850-822a-50e75d12d47d" xlink:href="rxrx-20251231.xsd#rxrx_RetentionProgramForEmployeesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_019b265e-3c6e-7f16-8d51-dd1c4c7ce259" xlink:to="loc_rxrx_RetentionProgramForEmployeesMember_019c2dea-aeb3-7850-822a-50e75d12d47d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_019c2de5-697d-74fc-ab9f-8083c2337f0f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019b265e-3c6e-77f4-9f9d-82172b4246a1" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_019c2de5-697d-74fc-ab9f-8083c2337f0f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019c2de5-697d-74fc-ab9f-8083c2337f0f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019c2de5-697d-74fc-ab9f-8083c2337f0f" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019c2de5-697d-74fc-ab9f-8083c2337f0f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019c2de5-697d-7fcc-9ca0-44aa8b7c77b6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019c2de5-697d-74fc-ab9f-8083c2337f0f" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019c2de5-697d-7fcc-9ca0-44aa8b7c77b6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ExscientiaPlcMember_019c2de5-697d-7b59-aca9-8a72f275f5ba" xlink:href="rxrx-20251231.xsd#rxrx_ExscientiaPlcMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019c2de5-697d-7fcc-9ca0-44aa8b7c77b6" xlink:to="loc_rxrx_ExscientiaPlcMember_019c2de5-697d-7b59-aca9-8a72f275f5ba" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_019b265e-3c6e-7ddb-9793-efe803085adc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019b265e-3c6e-77f4-9f9d-82172b4246a1" xlink:to="loc_us-gaap_AwardTypeAxis_019b265e-3c6e-7ddb-9793-efe803085adc" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019b265e-3c6e-7ddb-9793-efe803085adc_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_019b265e-3c6e-7ddb-9793-efe803085adc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019b265e-3c6e-7ddb-9793-efe803085adc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019b265e-3c6e-7a47-8a1d-8a86eb260191" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_019b265e-3c6e-7ddb-9793-efe803085adc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019b265e-3c6e-7a47-8a1d-8a86eb260191" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_019b265e-3c6e-77af-ade7-1fa6c2d3ddb3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019b265e-3c6e-7a47-8a1d-8a86eb260191" xlink:to="loc_us-gaap_EmployeeStockOptionMember_019b265e-3c6e-77af-ade7-1fa6c2d3ddb3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_019b265e-3c6e-7ccd-840d-52de29c4879a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019b265e-3c6e-7a47-8a1d-8a86eb260191" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_019b265e-3c6e-7ccd-840d-52de29c4879a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_019b265e-3c6e-7a3c-8f1d-f0b8583e2413" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019b265e-3c6e-7d7d-ad7f-54caac8cb6c7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_019b265e-3c6e-7a3c-8f1d-f0b8583e2413" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_019c677a-0460-7024-bd0f-1474e0cb62c0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019b265e-3c6e-7d7d-ad7f-54caac8cb6c7" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_019c677a-0460-7024-bd0f-1474e0cb62c0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_019b265e-3c6e-7cb8-9fb4-9e5952e2dad7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019b265e-3c6e-7d7d-ad7f-54caac8cb6c7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_019b265e-3c6e-7cb8-9fb4-9e5952e2dad7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_019b265e-3c6e-78eb-8a04-2da5d5e76453" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019b265e-3c6e-7d7d-ad7f-54caac8cb6c7" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_019b265e-3c6e-78eb-8a04-2da5d5e76453" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_019c2de5-697d-7895-bc8b-7581df83d89f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019b265e-3c6e-7d7d-ad7f-54caac8cb6c7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_019c2de5-697d-7895-bc8b-7581df83d89f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019b265e-3c6e-7f08-9467-c652a6c0668e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019b265e-3c6e-7d7d-ad7f-54caac8cb6c7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019b265e-3c6e-7f08-9467-c652a6c0668e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_019b265e-3c6e-7245-a113-536e02fb5b18" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019b265e-3c6e-7d7d-ad7f-54caac8cb6c7" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_019b265e-3c6e-7245-a113-536e02fb5b18" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_019b265e-3c6e-7a22-ad40-e77f9f83af97" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019b265e-3c6e-7d7d-ad7f-54caac8cb6c7" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_019b265e-3c6e-7a22-ad40-e77f9f83af97" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_019c2dea-aeb3-7ff8-b34d-31a3e2ee10c6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019b265e-3c6e-7d7d-ad7f-54caac8cb6c7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_019c2dea-aeb3-7ff8-b34d-31a3e2ee10c6" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodTotalFairValue_019b265e-3c6e-7895-b526-760a80932878" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodTotalFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019b265e-3c6e-7d7d-ad7f-54caac8cb6c7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodTotalFairValue_019b265e-3c6e-7895-b526-760a80932878" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions_019b265e-3c6e-70b3-bf21-56b0510af787" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019b265e-3c6e-7d7d-ad7f-54caac8cb6c7" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions_019b265e-3c6e-70b3-bf21-56b0510af787" xlink:type="arc" order="10"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/StockBasedCompensationScheduleofStockBasedCompensationExpenseDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#StockBasedCompensationScheduleofStockBasedCompensationExpenseDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/StockBasedCompensationScheduleofStockBasedCompensationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_7daf77b8-0afc-484e-ad5e-136850779c16" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_1e997315-9a93-4bf7-ac98-043ed30e2e6e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_7daf77b8-0afc-484e-ad5e-136850779c16" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_1e997315-9a93-4bf7-ac98-043ed30e2e6e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_83db71e6-5a1b-4126-a92d-7012fb10a7fe" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_1e997315-9a93-4bf7-ac98-043ed30e2e6e" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_83db71e6-5a1b-4126-a92d-7012fb10a7fe" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_83db71e6-5a1b-4126-a92d-7012fb10a7fe_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_83db71e6-5a1b-4126-a92d-7012fb10a7fe" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_83db71e6-5a1b-4126-a92d-7012fb10a7fe_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_b316e8a7-cebf-4c07-b9e7-33e5dc93448f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_83db71e6-5a1b-4126-a92d-7012fb10a7fe" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_b316e8a7-cebf-4c07-b9e7-33e5dc93448f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfSalesMember_d8eb78fe-81cf-48f5-ad09-2bc56b12a57b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostOfSalesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_b316e8a7-cebf-4c07-b9e7-33e5dc93448f" xlink:to="loc_us-gaap_CostOfSalesMember_d8eb78fe-81cf-48f5-ad09-2bc56b12a57b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_f52d06d8-4ba6-4ef2-886f-db3cc9527cba" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_b316e8a7-cebf-4c07-b9e7-33e5dc93448f" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_f52d06d8-4ba6-4ef2-886f-db3cc9527cba" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpenseMember_17ee778d-512c-43b7-b80c-c6e528fd0848" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GeneralAndAdministrativeExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_b316e8a7-cebf-4c07-b9e7-33e5dc93448f" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpenseMember_17ee778d-512c-43b7-b80c-c6e528fd0848" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_019c2de4-c650-792f-ab0b-68e56bc66b2b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_1e997315-9a93-4bf7-ac98-043ed30e2e6e" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_019c2de4-c650-792f-ab0b-68e56bc66b2b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019c2de4-c650-792f-ab0b-68e56bc66b2b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019c2de4-c650-792f-ab0b-68e56bc66b2b" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019c2de4-c650-792f-ab0b-68e56bc66b2b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019c2de4-c650-71fd-bddb-6da121bc2430" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019c2de4-c650-792f-ab0b-68e56bc66b2b" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019c2de4-c650-71fd-bddb-6da121bc2430" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ExscientiaPlcMember_019c2de4-c650-72fb-b245-37e5741bb6a3" xlink:href="rxrx-20251231.xsd#rxrx_ExscientiaPlcMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019c2de4-c650-71fd-bddb-6da121bc2430" xlink:to="loc_rxrx_ExscientiaPlcMember_019c2de4-c650-72fb-b245-37e5741bb6a3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_bc7e973c-195b-44fc-bf43-3d0fb02439e6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_7daf77b8-0afc-484e-ad5e-136850779c16" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_bc7e973c-195b-44fc-bf43-3d0fb02439e6" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/StockBasedCompensationScheduleofWeightedAverageAssumptionsUsedtoCalculateGrantDateFairValueofStockOptionsDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#StockBasedCompensationScheduleofWeightedAverageAssumptionsUsedtoCalculateGrantDateFairValueofStockOptionsDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/StockBasedCompensationScheduleofWeightedAverageAssumptionsUsedtoCalculateGrantDateFairValueofStockOptionsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_94376e66-bbd8-497a-b98a-05e75c9764a8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_de3e1b66-1b2c-432d-b920-da9bdb61917e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_94376e66-bbd8-497a-b98a-05e75c9764a8" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_de3e1b66-1b2c-432d-b920-da9bdb61917e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_f1f61c03-b59a-4cef-8dc5-670bf68123ba" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_de3e1b66-1b2c-432d-b920-da9bdb61917e" xlink:to="loc_us-gaap_AwardTypeAxis_f1f61c03-b59a-4cef-8dc5-670bf68123ba" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_f1f61c03-b59a-4cef-8dc5-670bf68123ba_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_f1f61c03-b59a-4cef-8dc5-670bf68123ba" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_f1f61c03-b59a-4cef-8dc5-670bf68123ba_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_a2ac7c7d-20b8-45a5-8af8-3615530f9461" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_f1f61c03-b59a-4cef-8dc5-670bf68123ba" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_a2ac7c7d-20b8-45a5-8af8-3615530f9461" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_ae77a79f-3347-4bd3-8a15-5eb7eb789ea9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_a2ac7c7d-20b8-45a5-8af8-3615530f9461" xlink:to="loc_us-gaap_EmployeeStockOptionMember_ae77a79f-3347-4bd3-8a15-5eb7eb789ea9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_480769ff-775b-4833-aa63-34476e7f7c15" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_94376e66-bbd8-497a-b98a-05e75c9764a8" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_480769ff-775b-4833-aa63-34476e7f7c15" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_41d55086-dac2-4dfe-807c-94887121f17c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_94376e66-bbd8-497a-b98a-05e75c9764a8" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_41d55086-dac2-4dfe-807c-94887121f17c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_0cb19d2c-3564-48a8-adc7-ad8fc8ab4eef" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_94376e66-bbd8-497a-b98a-05e75c9764a8" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_0cb19d2c-3564-48a8-adc7-ad8fc8ab4eef" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_308eb4d6-eeff-425f-8c43-5816d1f21630" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_94376e66-bbd8-497a-b98a-05e75c9764a8" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_308eb4d6-eeff-425f-8c43-5816d1f21630" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/StockBasedCompensationScheduleofRSUActivityDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#StockBasedCompensationScheduleofRSUActivityDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/StockBasedCompensationScheduleofRSUActivityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_9a22d495-a7ee-4186-be87-c5d6b2813a29" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_5d57a9e7-31d3-42c3-a205-dfa441cf15f6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_9a22d495-a7ee-4186-be87-c5d6b2813a29" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_5d57a9e7-31d3-42c3-a205-dfa441cf15f6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_2193d58e-f0a2-4e98-828a-6d31b2ece142" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_5d57a9e7-31d3-42c3-a205-dfa441cf15f6" xlink:to="loc_us-gaap_AwardTypeAxis_2193d58e-f0a2-4e98-828a-6d31b2ece142" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_2193d58e-f0a2-4e98-828a-6d31b2ece142_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_2193d58e-f0a2-4e98-828a-6d31b2ece142" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_2193d58e-f0a2-4e98-828a-6d31b2ece142_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_59726f62-84b6-4aa9-9118-98b0d15fe48e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_2193d58e-f0a2-4e98-828a-6d31b2ece142" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_59726f62-84b6-4aa9-9118-98b0d15fe48e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_a6fe8238-a331-4c3a-bbf3-e366be9d143e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_59726f62-84b6-4aa9-9118-98b0d15fe48e" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_a6fe8238-a331-4c3a-bbf3-e366be9d143e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_88293e44-95a5-42e8-80da-7f985a5603df" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_9a22d495-a7ee-4186-be87-c5d6b2813a29" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_88293e44-95a5-42e8-80da-7f985a5603df" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_631d806b-d113-432f-a90c-f7e890bff679" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_88293e44-95a5-42e8-80da-7f985a5603df" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_631d806b-d113-432f-a90c-f7e890bff679" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_ef294992-f3ec-4edf-a9ee-37e54ddc1543" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_88293e44-95a5-42e8-80da-7f985a5603df" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_ef294992-f3ec-4edf-a9ee-37e54ddc1543" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_88f74512-bcdd-4864-ad81-4357b8080903" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_88293e44-95a5-42e8-80da-7f985a5603df" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_88f74512-bcdd-4864-ad81-4357b8080903" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_cf2d53bd-d852-4bde-a063-b57dca624c1b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_88293e44-95a5-42e8-80da-7f985a5603df" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_cf2d53bd-d852-4bde-a063-b57dca624c1b" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_d20d56e5-75ed-443b-aadd-5b87d5cf2961" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_360bdd84-81b0-43ff-b9c0-77ce6a1b72d8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_9a22d495-a7ee-4186-be87-c5d6b2813a29" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_360bdd84-81b0-43ff-b9c0-77ce6a1b72d8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_e7ebc45e-8402-4285-86cc-c4c4700c0039" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_360bdd84-81b0-43ff-b9c0-77ce6a1b72d8" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_e7ebc45e-8402-4285-86cc-c4c4700c0039" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_1413e147-b4b7-4a37-9129-ba238e5b65f2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_360bdd84-81b0-43ff-b9c0-77ce6a1b72d8" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_1413e147-b4b7-4a37-9129-ba238e5b65f2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_4409f13e-64df-4c23-bc79-3e3faa7b81d0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_360bdd84-81b0-43ff-b9c0-77ce6a1b72d8" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_4409f13e-64df-4c23-bc79-3e3faa7b81d0" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_6072bc81-f7f6-4e69-9cbf-7c8102c99c8d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_360bdd84-81b0-43ff-b9c0-77ce6a1b72d8" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_6072bc81-f7f6-4e69-9cbf-7c8102c99c8d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_0999ea33-5c92-4332-aea7-2d8c5c742892" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/EmployeebenefitplansDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#EmployeebenefitplansDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/EmployeebenefitplansDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_019bfdca-9660-7697-96ce-9141510184df" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DefinedBenefitPlanDisclosureLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_019bfdca-9660-7ab5-a7cc-d7e0049dd868" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_019bfdca-9660-7697-96ce-9141510184df" xlink:to="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_019bfdca-9660-7ab5-a7cc-d7e0049dd868" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019bfdca-9660-797c-b7bb-00baf66175ce" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_019bfdca-9660-7ab5-a7cc-d7e0049dd868" xlink:to="loc_srt_RangeAxis_019bfdca-9660-797c-b7bb-00baf66175ce" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019bfdca-9660-797c-b7bb-00baf66175ce_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019bfdca-9660-797c-b7bb-00baf66175ce" xlink:to="loc_srt_RangeMember_019bfdca-9660-797c-b7bb-00baf66175ce_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019bfdca-9660-7c82-aae8-0b0b77627f12" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019bfdca-9660-797c-b7bb-00baf66175ce" xlink:to="loc_srt_RangeMember_019bfdca-9660-7c82-aae8-0b0b77627f12" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_019bfdca-d70f-7124-bef6-8832cc94b56a" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019bfdca-9660-7c82-aae8-0b0b77627f12" xlink:to="loc_srt_MinimumMember_019bfdca-d70f-7124-bef6-8832cc94b56a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019bfdca-f74a-7039-ac8a-604a44624935" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019bfdca-9660-7c82-aae8-0b0b77627f12" xlink:to="loc_srt_MaximumMember_019bfdca-f74a-7039-ac8a-604a44624935" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedContributionPlanMaximumAnnualContributionsPerEmployeePercent_019bfdcb-e192-7d84-8aec-ce3e28bdc17b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DefinedContributionPlanMaximumAnnualContributionsPerEmployeePercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_019bfdca-9660-7697-96ce-9141510184df" xlink:to="loc_us-gaap_DefinedContributionPlanMaximumAnnualContributionsPerEmployeePercent_019bfdcb-e192-7d84-8aec-ce3e28bdc17b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedContributionPlanEmployerMatchingContributionPercentOfMatch_019bfdcb-e193-7826-a68c-062a2f5a3e4a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DefinedContributionPlanEmployerMatchingContributionPercentOfMatch"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_019bfdca-9660-7697-96ce-9141510184df" xlink:to="loc_us-gaap_DefinedContributionPlanEmployerMatchingContributionPercentOfMatch_019bfdcb-e193-7826-a68c-062a2f5a3e4a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedContributionPlanEmployerMatchingContributionPercent_019bfdcb-e193-75bd-b760-e251ac34b907" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DefinedContributionPlanEmployerMatchingContributionPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_019bfdca-9660-7697-96ce-9141510184df" xlink:to="loc_us-gaap_DefinedContributionPlanEmployerMatchingContributionPercent_019bfdcb-e193-75bd-b760-e251ac34b907" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedContributionPlanCostRecognized_019bfdcb-e193-79f7-bee4-9607899a6b39" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DefinedContributionPlanCostRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_019bfdca-9660-7697-96ce-9141510184df" xlink:to="loc_us-gaap_DefinedContributionPlanCostRecognized_019bfdcb-e193-79f7-bee4-9607899a6b39" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/IncomeTaxesScheduleofEffectiveIncomeTaxRateReconciliationDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#IncomeTaxesScheduleofEffectiveIncomeTaxRateReconciliationDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/IncomeTaxesScheduleofEffectiveIncomeTaxRateReconciliationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationLineItems_019c45bc-c1d2-79a6-9f6c-baad55023fa0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTable_019c45bc-c1d2-79d8-8cc8-008d9bcc5350" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateReconciliationLineItems_019c45bc-c1d2-79a6-9f6c-baad55023fa0" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTable_019c45bc-c1d2-79d8-8cc8-008d9bcc5350" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_019c45bc-c1d2-78bd-a79c-9720c4fdbb7d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxAuthorityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTable_019c45bc-c1d2-79d8-8cc8-008d9bcc5350" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_019c45bc-c1d2-78bd-a79c-9720c4fdbb7d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_019c45bc-c1d2-78bd-a79c-9720c4fdbb7d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_019c45bc-c1d2-78bd-a79c-9720c4fdbb7d" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_019c45bc-c1d2-78bd-a79c-9720c4fdbb7d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_019c45bc-c1d2-7aea-924e-23fce8621659" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_019c45bc-c1d2-78bd-a79c-9720c4fdbb7d" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_019c45bc-c1d2-7aea-924e-23fce8621659" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DomesticCountryMember_019c67c6-8625-7e97-a8e4-47a1ea71112c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DomesticCountryMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_019c45bc-c1d2-7aea-924e-23fce8621659" xlink:to="loc_us-gaap_DomesticCountryMember_019c67c6-8625-7e97-a8e4-47a1ea71112c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_US_019c67b9-70b1-7bac-94a7-c43292d7cc5a" xlink:href="https://xbrl.sec.gov/country/2025/country-2025.xsd#country_US"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DomesticCountryMember_019c67c6-8625-7e97-a8e4-47a1ea71112c" xlink:to="loc_country_US_019c67b9-70b1-7bac-94a7-c43292d7cc5a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCountryMember_019c67c7-670e-7671-a2b3-2db4a4f3ffa7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ForeignCountryMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_019c45bc-c1d2-7aea-924e-23fce8621659" xlink:to="loc_us-gaap_ForeignCountryMember_019c67c7-670e-7671-a2b3-2db4a4f3ffa7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_GB_019c45bc-c1d2-78eb-878d-ad7309441c32" xlink:href="https://xbrl.sec.gov/country/2025/country-2025.xsd#country_GB"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ForeignCountryMember_019c67c7-670e-7671-a2b3-2db4a4f3ffa7" xlink:to="loc_country_GB_019c45bc-c1d2-78eb-878d-ad7309441c32" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_AT_019c5721-f9bf-7e22-b619-01b7a7030d98" xlink:href="https://xbrl.sec.gov/country/2025/country-2025.xsd#country_AT"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ForeignCountryMember_019c67c7-670e-7671-a2b3-2db4a4f3ffa7" xlink:to="loc_country_AT_019c5721-f9bf-7e22-b619-01b7a7030d98" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignTaxJurisdictionOtherMember_019c45bc-c1d2-74ae-926b-d4acbbdb9f54" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ForeignTaxJurisdictionOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ForeignCountryMember_019c67c7-670e-7671-a2b3-2db4a4f3ffa7" xlink:to="loc_us-gaap_ForeignTaxJurisdictionOtherMember_019c45bc-c1d2-74ae-926b-d4acbbdb9f54" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_019c45be-acad-7111-af9a-4bfa910b1044" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateReconciliationLineItems_019c45bc-c1d2-79a6-9f6c-baad55023fa0" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_019c45be-acad-7111-af9a-4bfa910b1044" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_019c45bc-c1d2-7eed-8bff-b9a4a57085fc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_019c45be-acad-7111-af9a-4bfa910b1044" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_019c45bc-c1d2-7eed-8bff-b9a4a57085fc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_019c571c-5cc1-77ea-962e-29855ca06a17" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_019c45be-acad-7111-af9a-4bfa910b1044" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_019c571c-5cc1-77ea-962e-29855ca06a17" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_019c45bc-c1d2-7def-9847-d2a3d37d3480" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_019c45be-acad-7111-af9a-4bfa910b1044" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_019c45bc-c1d2-7def-9847-d2a3d37d3480" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationDispositionOfBusiness_019c45bc-c1d2-7e91-a17a-5abd1802973c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationDispositionOfBusiness"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_019c45be-acad-7111-af9a-4bfa910b1044" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationDispositionOfBusiness_019c45bc-c1d2-7e91-a17a-5abd1802973c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential_019c45bc-c1d2-721b-93cc-926370aaf1d7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_019c45be-acad-7111-af9a-4bfa910b1044" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential_019c45bc-c1d2-721b-93cc-926370aaf1d7" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost_019c45bc-c1d2-7e8b-83f7-5f8d505b7359" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_019c45be-acad-7111-af9a-4bfa910b1044" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost_019c45bc-c1d2-7e8b-83f7-5f8d505b7359" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments_019c45bc-c1d2-7192-967f-624220feb7ab" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_019c45be-acad-7111-af9a-4bfa910b1044" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments_019c45bc-c1d2-7192-967f-624220feb7ab" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther_019c45bc-c1d2-781e-a17b-52e4ad766aae" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_019c45be-acad-7111-af9a-4bfa910b1044" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther_019c45bc-c1d2-781e-a17b-52e4ad766aae" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationCrossBorderTaxEffectPercent_019c45bc-c1d2-7997-8997-20e1e0476554" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationCrossBorderTaxEffectPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_019c45be-acad-7111-af9a-4bfa910b1044" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationCrossBorderTaxEffectPercent_019c45bc-c1d2-7997-8997-20e1e0476554" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCreditsResearch_019c45bc-c1d2-776d-b8fa-8fe70d3c392c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationTaxCreditsResearch"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_019c45be-acad-7111-af9a-4bfa910b1044" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCreditsResearch_019c45bc-c1d2-776d-b8fa-8fe70d3c392c" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_EffectiveIncomeTaxRateReconciliationTaxCreditOrphanDrugPercent_019c45bc-c1d2-7fb0-aefa-8b92152f9c62" xlink:href="rxrx-20251231.xsd#rxrx_EffectiveIncomeTaxRateReconciliationTaxCreditOrphanDrugPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_019c45be-acad-7111-af9a-4bfa910b1044" xlink:to="loc_rxrx_EffectiveIncomeTaxRateReconciliationTaxCreditOrphanDrugPercent_019c45bc-c1d2-7fb0-aefa-8b92152f9c62" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxContingencies_019c45bc-c1d2-7122-a242-f04d36409059" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationTaxContingencies"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_019c45be-acad-7111-af9a-4bfa910b1044" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxContingencies_019c45bc-c1d2-7122-a242-f04d36409059" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019c45bc-c1d2-73ff-806b-1b31412b1241" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_019c45be-acad-7111-af9a-4bfa910b1044" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019c45bc-c1d2-73ff-806b-1b31412b1241" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_019c45be-fd41-7e6e-bf85-4dbfc54cc26d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateReconciliationLineItems_019c45bc-c1d2-79a6-9f6c-baad55023fa0" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_019c45be-fd41-7e6e-bf85-4dbfc54cc26d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_019c45bf-487f-7bc9-929c-76e68a2b2fdf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_019c45be-fd41-7e6e-bf85-4dbfc54cc26d" xlink:to="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_019c45bf-487f-7bc9-929c-76e68a2b2fdf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_019c571c-8b93-7ef0-bc2f-bae75e14ea82" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_019c45be-fd41-7e6e-bf85-4dbfc54cc26d" xlink:to="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_019c571c-8b93-7ef0-bc2f-bae75e14ea82" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_019c45bf-487f-7438-a41d-6181bd225e19" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_019c45be-fd41-7e6e-bf85-4dbfc54cc26d" xlink:to="loc_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_019c45bf-487f-7438-a41d-6181bd225e19" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationDispositionOfBusiness_019c45bf-487f-75c0-a45c-72c3f5e750c8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationDispositionOfBusiness"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_019c45be-fd41-7e6e-bf85-4dbfc54cc26d" xlink:to="loc_us-gaap_IncomeTaxReconciliationDispositionOfBusiness_019c45bf-487f-75c0-a45c-72c3f5e750c8" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationForeignIncomeTaxRateDifferential_019c45bf-487f-7769-bf77-5affcf88bc1c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationForeignIncomeTaxRateDifferential"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_019c45be-fd41-7e6e-bf85-4dbfc54cc26d" xlink:to="loc_us-gaap_IncomeTaxReconciliationForeignIncomeTaxRateDifferential_019c45bf-487f-7769-bf77-5affcf88bc1c" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost_019c45bf-487f-7925-a3ad-93f4f18116a0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_019c45be-fd41-7e6e-bf85-4dbfc54cc26d" xlink:to="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost_019c45bf-487f-7925-a3ad-93f4f18116a0" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_019c45bf-487f-7918-8a06-f76b38fe1d4e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationOtherAdjustments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_019c45be-fd41-7e6e-bf85-4dbfc54cc26d" xlink:to="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_019c45bf-487f-7918-8a06-f76b38fe1d4e" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseOther_019c45bf-487f-75b2-b853-e3ba314b4969" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationNondeductibleExpenseOther"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_019c45be-fd41-7e6e-bf85-4dbfc54cc26d" xlink:to="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseOther_019c45bf-487f-75b2-b853-e3ba314b4969" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationCrossBorderTaxEffectAmount_019c45bf-487f-79d5-9650-83e0c3d71857" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationCrossBorderTaxEffectAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_019c45be-fd41-7e6e-bf85-4dbfc54cc26d" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationCrossBorderTaxEffectAmount_019c45bf-487f-79d5-9650-83e0c3d71857" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxCreditsResearch_019c45bf-487f-7eeb-9e08-5db7c1c6a346" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationTaxCreditsResearch"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_019c45be-fd41-7e6e-bf85-4dbfc54cc26d" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxCreditsResearch_019c45bf-487f-7eeb-9e08-5db7c1c6a346" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_EffectiveIncomeTaxRateReconciliationTaxCreditOrphanDrugAmount_019c45bf-487f-7bc8-bdf1-9e48cd2d65cf" xlink:href="rxrx-20251231.xsd#rxrx_EffectiveIncomeTaxRateReconciliationTaxCreditOrphanDrugAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_019c45be-fd41-7e6e-bf85-4dbfc54cc26d" xlink:to="loc_rxrx_EffectiveIncomeTaxRateReconciliationTaxCreditOrphanDrugAmount_019c45bf-487f-7bc8-bdf1-9e48cd2d65cf" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxContingencies_019c45bf-487f-7b37-9fae-ba1170e73291" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationTaxContingencies"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_019c45be-fd41-7e6e-bf85-4dbfc54cc26d" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxContingencies_019c45bf-487f-7b37-9fae-ba1170e73291" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019c45bf-487f-7f56-aaa8-cd006d17a953" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_019c45be-fd41-7e6e-bf85-4dbfc54cc26d" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019c45bf-487f-7f56-aaa8-cd006d17a953" xlink:type="arc" order="13"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/IncomeTaxesNarrativeDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#IncomeTaxesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/IncomeTaxesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxContingencyLineItems_019c45c9-e3d5-7914-aae2-a7bc871823e9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxContingencyLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxContingencyTable_9c10f0cd-cacd-475c-a945-97c5e2650cd4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxContingencyTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_019c45c9-e3d5-7914-aae2-a7bc871823e9" xlink:to="loc_us-gaap_IncomeTaxContingencyTable_9c10f0cd-cacd-475c-a945-97c5e2650cd4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_019c45c9-e3d5-744b-9035-dc9b23d57257" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxAuthorityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeTaxContingencyTable_9c10f0cd-cacd-475c-a945-97c5e2650cd4" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_019c45c9-e3d5-744b-9035-dc9b23d57257" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_019c45c9-e3d5-744b-9035-dc9b23d57257_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_019c45c9-e3d5-744b-9035-dc9b23d57257" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_019c45c9-e3d5-744b-9035-dc9b23d57257_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_019c45c9-e3d5-784b-b0e9-c0e332dfec09" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_019c45c9-e3d5-744b-9035-dc9b23d57257" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_019c45c9-e3d5-784b-b0e9-c0e332dfec09" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DomesticCountryMember_019c45c9-e3d5-764d-8bf2-ea8f461cb0e4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DomesticCountryMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_019c45c9-e3d5-784b-b0e9-c0e332dfec09" xlink:to="loc_us-gaap_DomesticCountryMember_019c45c9-e3d5-764d-8bf2-ea8f461cb0e4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StateAndLocalJurisdictionMember_019c45c9-e3d5-766f-aa34-e444805a8270" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StateAndLocalJurisdictionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_019c45c9-e3d5-784b-b0e9-c0e332dfec09" xlink:to="loc_us-gaap_StateAndLocalJurisdictionMember_019c45c9-e3d5-766f-aa34-e444805a8270" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCountryMember_019c45c9-e3d5-7932-8693-87f9adf4d592" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ForeignCountryMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_019c45c9-e3d5-784b-b0e9-c0e332dfec09" xlink:to="loc_us-gaap_ForeignCountryMember_019c45c9-e3d5-7932-8693-87f9adf4d592" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardAxis_019c45e5-036a-79fb-a044-9f5631bd4537" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TaxCreditCarryforwardAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeTaxContingencyTable_9c10f0cd-cacd-475c-a945-97c5e2650cd4" xlink:to="loc_us-gaap_TaxCreditCarryforwardAxis_019c45e5-036a-79fb-a044-9f5631bd4537" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardNameDomain_019c45e5-036a-79fb-a044-9f5631bd4537_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TaxCreditCarryforwardNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TaxCreditCarryforwardAxis_019c45e5-036a-79fb-a044-9f5631bd4537" xlink:to="loc_us-gaap_TaxCreditCarryforwardNameDomain_019c45e5-036a-79fb-a044-9f5631bd4537_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardNameDomain_019c45e5-036a-7e3e-8e15-08fe5a931c15" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TaxCreditCarryforwardNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TaxCreditCarryforwardAxis_019c45e5-036a-79fb-a044-9f5631bd4537" xlink:to="loc_us-gaap_TaxCreditCarryforwardNameDomain_019c45e5-036a-7e3e-8e15-08fe5a931c15" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchMember_019c45e5-036a-72d3-a361-c58b5d5eb9af" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_019c45e5-036a-7e3e-8e15-08fe5a931c15" xlink:to="loc_us-gaap_ResearchMember_019c45e5-036a-72d3-a361-c58b5d5eb9af" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_OrphanDrugCreditCarryforwardMember_019c45e5-036a-78a6-888f-14749b3115ce" xlink:href="rxrx-20251231.xsd#rxrx_OrphanDrugCreditCarryforwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_019c45e5-036a-7e3e-8e15-08fe5a931c15" xlink:to="loc_rxrx_OrphanDrugCreditCarryforwardMember_019c45e5-036a-78a6-888f-14749b3115ce" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwards_019c45c9-e3d5-7253-9142-e8d40aecad9c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLossCarryforwards"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_019c45c9-e3d5-7914-aae2-a7bc871823e9" xlink:to="loc_us-gaap_OperatingLossCarryforwards_019c45c9-e3d5-7253-9142-e8d40aecad9c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_OperatingLossCarryforwardsSubjectToExpiration_019c45c9-e3d5-76f1-bd0e-aaddbb3a908f" xlink:href="rxrx-20251231.xsd#rxrx_OperatingLossCarryforwardsSubjectToExpiration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_019c45c9-e3d5-7914-aae2-a7bc871823e9" xlink:to="loc_rxrx_OperatingLossCarryforwardsSubjectToExpiration_019c45c9-e3d5-76f1-bd0e-aaddbb3a908f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_OperatingLossCarryforwardsNotSubjectToExpiration_019c45c9-e3d5-7c24-a894-78cd51cfb018" xlink:href="rxrx-20251231.xsd#rxrx_OperatingLossCarryforwardsNotSubjectToExpiration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_019c45c9-e3d5-7914-aae2-a7bc871823e9" xlink:to="loc_rxrx_OperatingLossCarryforwardsNotSubjectToExpiration_019c45c9-e3d5-7c24-a894-78cd51cfb018" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardAmount_019c45e5-036a-7a4f-a0ab-45f4b8342527" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TaxCreditCarryforwardAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_019c45c9-e3d5-7914-aae2-a7bc871823e9" xlink:to="loc_us-gaap_TaxCreditCarryforwardAmount_019c45e5-036a-7a4f-a0ab-45f4b8342527" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardValuationAllowance_019c45e5-30d2-764c-91fb-43b7489d70ef" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TaxCreditCarryforwardValuationAllowance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_019c45c9-e3d5-7914-aae2-a7bc871823e9" xlink:to="loc_us-gaap_TaxCreditCarryforwardValuationAllowance_019c45e5-30d2-764c-91fb-43b7489d70ef" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_019c45e5-f03e-70fc-8c67-6d1cb7f68362" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsValuationAllowance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_019c45c9-e3d5-7914-aae2-a7bc871823e9" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_019c45e5-f03e-70fc-8c67-6d1cb7f68362" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_019c45e5-f03e-74b3-ad6d-008d46a488d4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_019c45c9-e3d5-7914-aae2-a7bc871823e9" xlink:to="loc_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_019c45e5-f03e-74b3-ad6d-008d46a488d4" xlink:type="arc" order="6"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/NetLossPerShareScheduleofAntidilutiveSecuritiesExcludedfromComputationofNetLossPerShareDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#NetLossPerShareScheduleofAntidilutiveSecuritiesExcludedfromComputationofNetLossPerShareDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/NetLossPerShareScheduleofAntidilutiveSecuritiesExcludedfromComputationofNetLossPerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019b266a-4f49-795b-a55e-051ab10df15f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019b266a-4f49-7db8-b065-fa9ea76f8756" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019b266a-4f49-795b-a55e-051ab10df15f" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019b266a-4f49-7db8-b065-fa9ea76f8756" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019b266a-4f49-782f-b9b0-119744f61217" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019b266a-4f49-7db8-b065-fa9ea76f8756" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019b266a-4f49-782f-b9b0-119744f61217" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019b266a-4f49-782f-b9b0-119744f61217_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019b266a-4f49-782f-b9b0-119744f61217" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019b266a-4f49-782f-b9b0-119744f61217_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019b266a-4f49-73b8-810f-fa4acccad93d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019b266a-4f49-782f-b9b0-119744f61217" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019b266a-4f49-73b8-810f-fa4acccad93d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockCompensationPlanMember_019b266a-4f49-7c2b-acf0-c5259b001389" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockCompensationPlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019b266a-4f49-73b8-810f-fa4acccad93d" xlink:to="loc_us-gaap_StockCompensationPlanMember_019b266a-4f49-7c2b-acf0-c5259b001389" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_TempusAgreementMember_019b266a-4f49-7d86-b7ce-52c35d12f3bb" xlink:href="rxrx-20251231.xsd#rxrx_TempusAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019b266a-4f49-73b8-810f-fa4acccad93d" xlink:to="loc_rxrx_TempusAgreementMember_019b266a-4f49-7d86-b7ce-52c35d12f3bb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ContingentStockRelatingToREVentures1AgreementMember_019b266a-4f49-73ae-b398-5d98586613e4" xlink:href="rxrx-20251231.xsd#rxrx_ContingentStockRelatingToREVentures1AgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019b266a-4f49-73b8-810f-fa4acccad93d" xlink:to="loc_rxrx_ContingentStockRelatingToREVentures1AgreementMember_019b266a-4f49-73ae-b398-5d98586613e4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_019b266a-4f49-7f08-a7e0-4f9c1a2b0589" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019b266a-4f49-795b-a55e-051ab10df15f" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_019b266a-4f49-7f08-a7e0-4f9c1a2b0589" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/FairValueMeasurementsScheduleofAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#FairValueMeasurementsScheduleofAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/FairValueMeasurementsScheduleofAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_019b266d-aad8-7158-bf6c-4d87e744d914" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByBalanceSheetGroupingTable_019b266d-aad8-7029-aedd-8e5506a9ad28" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueByBalanceSheetGroupingTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_019b266d-aad8-7158-bf6c-4d87e744d914" xlink:to="loc_us-gaap_FairValueByBalanceSheetGroupingTable_019b266d-aad8-7029-aedd-8e5506a9ad28" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019b266d-aad8-74a1-9eb3-13066939c0f1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_019b266d-aad8-7029-aedd-8e5506a9ad28" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019b266d-aad8-74a1-9eb3-13066939c0f1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019b266d-aad8-74a1-9eb3-13066939c0f1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019b266d-aad8-74a1-9eb3-13066939c0f1" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019b266d-aad8-74a1-9eb3-13066939c0f1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019b266d-aad8-7802-95ca-e0981923a1ab" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019b266d-aad8-74a1-9eb3-13066939c0f1" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019b266d-aad8-7802-95ca-e0981923a1ab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_019b266d-aad8-708d-a74b-6b48a9415b54" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019b266d-aad8-7802-95ca-e0981923a1ab" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_019b266d-aad8-708d-a74b-6b48a9415b54" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_019b266d-aad8-71d1-82d6-58af99b32bc4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019b266d-aad8-7802-95ca-e0981923a1ab" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_019b266d-aad8-71d1-82d6-58af99b32bc4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_019b266d-aad8-7ecc-bf3b-38ae3f0f7889" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019b266d-aad8-7802-95ca-e0981923a1ab" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_019b266d-aad8-7ecc-bf3b-38ae3f0f7889" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAxis_019b266d-aad8-7d6a-8e39-01e9f85c4199" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_019b266d-aad8-7029-aedd-8e5506a9ad28" xlink:to="loc_us-gaap_CashAndCashEquivalentsAxis_019b266d-aad8-7d6a-8e39-01e9f85c4199" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019b266d-aad8-7d6a-8e39-01e9f85c4199_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_019b266d-aad8-7d6a-8e39-01e9f85c4199" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019b266d-aad8-7d6a-8e39-01e9f85c4199_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019b266d-aad8-7938-9818-192ce59bd6e4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_019b266d-aad8-7d6a-8e39-01e9f85c4199" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019b266d-aad8-7938-9818-192ce59bd6e4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashMember_019b266d-aad8-7cff-90b8-bd5f76755d1e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019b266d-aad8-7938-9818-192ce59bd6e4" xlink:to="loc_us-gaap_CashMember_019b266d-aad8-7cff-90b8-bd5f76755d1e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_019b266d-aad8-715c-8bb4-e39f20d18a37" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019b266d-aad8-7938-9818-192ce59bd6e4" xlink:to="loc_us-gaap_MoneyMarketFundsMember_019b266d-aad8-715c-8bb4-e39f20d18a37" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankTimeDepositsMember_019b266d-aad8-71ad-b272-f28d521f8f0b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BankTimeDepositsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019b266d-aad8-7938-9818-192ce59bd6e4" xlink:to="loc_us-gaap_BankTimeDepositsMember_019b266d-aad8-71ad-b272-f28d521f8f0b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019b266d-aad8-7516-a950-0e938822b1f5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_019b266d-aad8-7158-bf6c-4d87e744d914" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019b266d-aad8-7516-a950-0e938822b1f5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_RestrictedCashAndCashEquivalentsFairValueDisclosure_019b266d-aad8-7e2b-a414-4f1cb46f50bc" xlink:href="rxrx-20251231.xsd#rxrx_RestrictedCashAndCashEquivalentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_019b266d-aad8-7158-bf6c-4d87e744d914" xlink:to="loc_rxrx_RestrictedCashAndCashEquivalentsFairValueDisclosure_019b266d-aad8-7e2b-a414-4f1cb46f50bc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_019b266d-aad8-7f3f-9c93-aa8e7d1d998b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_019b266d-aad8-7158-bf6c-4d87e744d914" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_019b266d-aad8-7f3f-9c93-aa8e7d1d998b" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/FairValueMeasurementsScheduleofFinancialInstrumentsNotMeasuredatFairValueDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#FairValueMeasurementsScheduleofFinancialInstrumentsNotMeasuredatFairValueDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/FairValueMeasurementsScheduleofFinancialInstrumentsNotMeasuredatFairValueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosureAssetAndLiabilityNotMeasuredAtFairValueLineItems_eb56a17a-afbe-404f-a9b0-0719e7fca35e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueDisclosureAssetAndLiabilityNotMeasuredAtFairValueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosureOfAssetAndLiabilityNotMeasuredAtFairValueTable_640b5c6a-55ac-4d17-b7b9-bf8aef906cdd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueDisclosureOfAssetAndLiabilityNotMeasuredAtFairValueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueDisclosureAssetAndLiabilityNotMeasuredAtFairValueLineItems_eb56a17a-afbe-404f-a9b0-0719e7fca35e" xlink:to="loc_us-gaap_FairValueDisclosureOfAssetAndLiabilityNotMeasuredAtFairValueTable_640b5c6a-55ac-4d17-b7b9-bf8aef906cdd" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_ee120149-4f0c-48b7-be41-84dcc42332cb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueByMeasurementBasisAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueDisclosureOfAssetAndLiabilityNotMeasuredAtFairValueTable_640b5c6a-55ac-4d17-b7b9-bf8aef906cdd" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_ee120149-4f0c-48b7-be41-84dcc42332cb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_ee120149-4f0c-48b7-be41-84dcc42332cb_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_ee120149-4f0c-48b7-be41-84dcc42332cb" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_ee120149-4f0c-48b7-be41-84dcc42332cb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_f0b839ee-ccb0-45fc-8f41-76187070b34f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueDisclosureItemAmountsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_ee120149-4f0c-48b7-be41-84dcc42332cb" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_f0b839ee-ccb0-45fc-8f41-76187070b34f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_b7ad54ec-4060-4ae0-aa36-29d37a9527e5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_f0b839ee-ccb0-45fc-8f41-76187070b34f" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_b7ad54ec-4060-4ae0-aa36-29d37a9527e5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtOtherThanFairValueFairValueDisclosureMember_868d00e6-d67e-4edf-bdfa-1dd123447a6f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PortionAtOtherThanFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_b7ad54ec-4060-4ae0-aa36-29d37a9527e5" xlink:to="loc_us-gaap_PortionAtOtherThanFairValueFairValueDisclosureMember_868d00e6-d67e-4edf-bdfa-1dd123447a6f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_ba76f409-bb82-4807-901a-4b6300ac372e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EstimateOfFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_b7ad54ec-4060-4ae0-aa36-29d37a9527e5" xlink:to="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_ba76f409-bb82-4807-901a-4b6300ac372e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_1af85f11-76ec-42ad-9a7c-7d7cc6ff417e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueDisclosureOfAssetAndLiabilityNotMeasuredAtFairValueTable_640b5c6a-55ac-4d17-b7b9-bf8aef906cdd" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_1af85f11-76ec-42ad-9a7c-7d7cc6ff417e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_1af85f11-76ec-42ad-9a7c-7d7cc6ff417e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_1af85f11-76ec-42ad-9a7c-7d7cc6ff417e" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_1af85f11-76ec-42ad-9a7c-7d7cc6ff417e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_e5634f90-9f97-4038-ac46-b9238c4f49fa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_1af85f11-76ec-42ad-9a7c-7d7cc6ff417e" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_e5634f90-9f97-4038-ac46-b9238c4f49fa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesPayableOtherPayablesMember_87ec3d70-2be1-4b6c-868d-0e598c8e5f40" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NotesPayableOtherPayablesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_e5634f90-9f97-4038-ac46-b9238c4f49fa" xlink:to="loc_us-gaap_NotesPayableOtherPayablesMember_87ec3d70-2be1-4b6c-868d-0e598c8e5f40" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsCurrent_fd0e8b0d-ba74-40c3-bae1-87b7ab0cc18f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtAndCapitalLeaseObligationsCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureAssetAndLiabilityNotMeasuredAtFairValueLineItems_eb56a17a-afbe-404f-a9b0-0719e7fca35e" xlink:to="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsCurrent_fd0e8b0d-ba74-40c3-bae1-87b7ab0cc18f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtAndCapitalLeaseObligations_c97ae1f3-b30a-4184-b237-7ab211acaa5d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtAndCapitalLeaseObligations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureAssetAndLiabilityNotMeasuredAtFairValueLineItems_eb56a17a-afbe-404f-a9b0-0719e7fca35e" xlink:to="loc_us-gaap_LongTermDebtAndCapitalLeaseObligations_c97ae1f3-b30a-4184-b237-7ab211acaa5d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_c9825351-aa5f-4111-bf8f-f3db4b17b532" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureAssetAndLiabilityNotMeasuredAtFairValueLineItems_eb56a17a-afbe-404f-a9b0-0719e7fca35e" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosure_c9825351-aa5f-4111-bf8f-f3db4b17b532" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/SegmentInformationScheduleofSegmentNetLossandReconciliationsofSegmentOperatingLosstoLossBeforeIncomeTaxBenefitDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#SegmentInformationScheduleofSegmentNetLossandReconciliationsofSegmentOperatingLosstoLossBeforeIncomeTaxBenefitDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/SegmentInformationScheduleofSegmentNetLossandReconciliationsofSegmentOperatingLosstoLossBeforeIncomeTaxBenefitDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_5b906afc-4750-4093-bc41-03d43bf35b7a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_e6b7d8b1-f1b5-4e2b-83b6-328afcf1df31" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_5b906afc-4750-4093-bc41-03d43bf35b7a" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_e6b7d8b1-f1b5-4e2b-83b6-328afcf1df31" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_8f4e7002-8374-4a30-9d45-289332f5464c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_e6b7d8b1-f1b5-4e2b-83b6-328afcf1df31" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_8f4e7002-8374-4a30-9d45-289332f5464c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_8f4e7002-8374-4a30-9d45-289332f5464c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_8f4e7002-8374-4a30-9d45-289332f5464c" xlink:to="loc_us-gaap_SegmentDomain_8f4e7002-8374-4a30-9d45-289332f5464c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_f9b9e747-81a9-4f40-8202-81a10a91b98b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_8f4e7002-8374-4a30-9d45-289332f5464c" xlink:to="loc_us-gaap_SegmentDomain_f9b9e747-81a9-4f40-8202-81a10a91b98b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ReportableSegmentMember_28b8a6b5-6cc1-4494-9ecc-5de686e31de3" xlink:href="rxrx-20251231.xsd#rxrx_ReportableSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_f9b9e747-81a9-4f40-8202-81a10a91b98b" xlink:to="loc_rxrx_ReportableSegmentMember_28b8a6b5-6cc1-4494-9ecc-5de686e31de3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_96c12ae7-68a6-4d97-8874-ef69c4232b97" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_5b906afc-4750-4093-bc41-03d43bf35b7a" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_96c12ae7-68a6-4d97-8874-ef69c4232b97" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_SignificantSegmentExpensesAbstract_b7b19a3d-fcd4-4ad2-8e01-b6b47136b782" xlink:href="rxrx-20251231.xsd#rxrx_SignificantSegmentExpensesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_5b906afc-4750-4093-bc41-03d43bf35b7a" xlink:to="loc_rxrx_SignificantSegmentExpensesAbstract_b7b19a3d-fcd4-4ad2-8e01-b6b47136b782" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense_062f6a6e-af59-4bb2-a694-cafb21c6ca21" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_SignificantSegmentExpensesAbstract_b7b19a3d-fcd4-4ad2-8e01-b6b47136b782" xlink:to="loc_us-gaap_LaborAndRelatedExpense_062f6a6e-af59-4bb2-a694-cafb21c6ca21" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ConsumableExpense_6fa0dc7a-86b0-49ae-9f0b-68002427e76c" xlink:href="rxrx-20251231.xsd#rxrx_ConsumableExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_SignificantSegmentExpensesAbstract_b7b19a3d-fcd4-4ad2-8e01-b6b47136b782" xlink:to="loc_rxrx_ConsumableExpense_6fa0dc7a-86b0-49ae-9f0b-68002427e76c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_PlatformFeeExpense_8273ec06-784d-434d-9f88-3e91887747d1" xlink:href="rxrx-20251231.xsd#rxrx_PlatformFeeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_SignificantSegmentExpensesAbstract_b7b19a3d-fcd4-4ad2-8e01-b6b47136b782" xlink:to="loc_rxrx_PlatformFeeExpense_8273ec06-784d-434d-9f88-3e91887747d1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_DiscoveryExpense_c41f0e65-0766-40fb-81d3-1b8882c39f0d" xlink:href="rxrx-20251231.xsd#rxrx_DiscoveryExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_SignificantSegmentExpensesAbstract_b7b19a3d-fcd4-4ad2-8e01-b6b47136b782" xlink:to="loc_rxrx_DiscoveryExpense_c41f0e65-0766-40fb-81d3-1b8882c39f0d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ClinicalDevelopmentExpense_61aac2df-5352-4f9d-928c-0120ac8902c8" xlink:href="rxrx-20251231.xsd#rxrx_ClinicalDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_SignificantSegmentExpensesAbstract_b7b19a3d-fcd4-4ad2-8e01-b6b47136b782" xlink:to="loc_rxrx_ClinicalDevelopmentExpense_61aac2df-5352-4f9d-928c-0120ac8902c8" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSoldDepreciationAndAmortization_19f4cf5c-ed27-41ba-a142-565fc0a7f55c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostOfGoodsAndServicesSoldDepreciationAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_SignificantSegmentExpensesAbstract_b7b19a3d-fcd4-4ad2-8e01-b6b47136b782" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSoldDepreciationAndAmortization_19f4cf5c-ed27-41ba-a142-565fc0a7f55c" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingOtherItemAmount_764c1ccd-3281-4f4b-82f7-ae481cf210bc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SegmentReportingOtherItemAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_SignificantSegmentExpensesAbstract_b7b19a3d-fcd4-4ad2-8e01-b6b47136b782" xlink:to="loc_us-gaap_SegmentReportingOtherItemAmount_764c1ccd-3281-4f4b-82f7-ae481cf210bc" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_b89ab2c7-107e-4c43-9467-7b97903e63c7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_SignificantSegmentExpensesAbstract_b7b19a3d-fcd4-4ad2-8e01-b6b47136b782" xlink:to="loc_us-gaap_OperatingIncomeLoss_b89ab2c7-107e-4c43-9467-7b97903e63c7" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_47391db3-e68a-49b2-90bd-370bf568b840" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_SignificantSegmentExpensesAbstract_b7b19a3d-fcd4-4ad2-8e01-b6b47136b782" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_47391db3-e68a-49b2-90bd-370bf568b840" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_8ddfbb3c-6f99-49cc-a83d-382295bc439b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_SignificantSegmentExpensesAbstract_b7b19a3d-fcd4-4ad2-8e01-b6b47136b782" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_8ddfbb3c-6f99-49cc-a83d-382295bc439b" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_98ba6ea8-012b-4bee-ac03-72bf96ebedff" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_SignificantSegmentExpensesAbstract_b7b19a3d-fcd4-4ad2-8e01-b6b47136b782" xlink:to="loc_us-gaap_NetIncomeLoss_98ba6ea8-012b-4bee-ac03-72bf96ebedff" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_SupplementalAssetInformationAbstract_07370345-fb88-4145-b3f4-502bd5a3dce7" xlink:href="rxrx-20251231.xsd#rxrx_SupplementalAssetInformationAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_5b906afc-4750-4093-bc41-03d43bf35b7a" xlink:to="loc_rxrx_SupplementalAssetInformationAbstract_07370345-fb88-4145-b3f4-502bd5a3dce7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentExpenditureAdditionToLongLivedAssets_796aba58-fada-4c97-b4ce-b18874c384cb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SegmentExpenditureAdditionToLongLivedAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_SupplementalAssetInformationAbstract_07370345-fb88-4145-b3f4-502bd5a3dce7" xlink:to="loc_us-gaap_SegmentExpenditureAdditionToLongLivedAssets_796aba58-fada-4c97-b4ce-b18874c384cb" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/SegmentInformationScheduleofRevenueandLongLivedAssetsBasedonGeographicAreasDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#SegmentInformationScheduleofRevenueandLongLivedAssetsBasedonGeographicAreasDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/SegmentInformationScheduleofRevenueandLongLivedAssetsBasedonGeographicAreasDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_148b5f3a-26f1-4a9a-96f1-e655f23326c5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_54898e18-57ae-4559-96d5-cea8a80fefd9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_148b5f3a-26f1-4a9a-96f1-e655f23326c5" xlink:to="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_54898e18-57ae-4559-96d5-cea8a80fefd9" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_87d0888b-0355-4456-b0bf-71b8ab104476" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_54898e18-57ae-4559-96d5-cea8a80fefd9" xlink:to="loc_srt_StatementGeographicalAxis_87d0888b-0355-4456-b0bf-71b8ab104476" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_87d0888b-0355-4456-b0bf-71b8ab104476_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_87d0888b-0355-4456-b0bf-71b8ab104476" xlink:to="loc_srt_SegmentGeographicalDomain_87d0888b-0355-4456-b0bf-71b8ab104476_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_a482ca90-6079-4976-a73c-0b1ed6b76cc8" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_87d0888b-0355-4456-b0bf-71b8ab104476" xlink:to="loc_srt_SegmentGeographicalDomain_a482ca90-6079-4976-a73c-0b1ed6b76cc8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_US_c9513601-4731-47cb-af5a-561d810edc9b" xlink:href="https://xbrl.sec.gov/country/2025/country-2025.xsd#country_US"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_a482ca90-6079-4976-a73c-0b1ed6b76cc8" xlink:to="loc_country_US_c9513601-4731-47cb-af5a-561d810edc9b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_GB_a3f0339f-8f80-4042-a14e-af71f6a4fdf2" xlink:href="https://xbrl.sec.gov/country/2025/country-2025.xsd#country_GB"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_a482ca90-6079-4976-a73c-0b1ed6b76cc8" xlink:to="loc_country_GB_a3f0339f-8f80-4042-a14e-af71f6a4fdf2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_CA_4eec9d33-cf73-480c-b3e3-4da6e73b971b" xlink:href="https://xbrl.sec.gov/country/2025/country-2025.xsd#country_CA"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_a482ca90-6079-4976-a73c-0b1ed6b76cc8" xlink:to="loc_country_CA_4eec9d33-cf73-480c-b3e3-4da6e73b971b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_OtherCountriesMember_a90694b7-9781-449e-a8c7-8fe026230e00" xlink:href="rxrx-20251231.xsd#rxrx_OtherCountriesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_a482ca90-6079-4976-a73c-0b1ed6b76cc8" xlink:to="loc_rxrx_OtherCountriesMember_a90694b7-9781-449e-a8c7-8fe026230e00" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019b2676-4cac-70db-92a0-0a0431a9e9f6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_148b5f3a-26f1-4a9a-96f1-e655f23326c5" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019b2676-4cac-70db-92a0-0a0431a9e9f6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncurrentAssets_6ef2250f-30de-4129-ba54-9f37b032660a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_148b5f3a-26f1-4a9a-96f1-e655f23326c5" xlink:to="loc_us-gaap_NoncurrentAssets_6ef2250f-30de-4129-ba54-9f37b032660a" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/SubsequentEventsDetails" xlink:type="simple" xlink:href="rxrx-20251231.xsd#SubsequentEventsDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/SubsequentEventsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventLineItems_9c4c3cda-09c8-4f65-89d6-163ba7aa0d39" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SubsequentEventLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTable_a19bf449-1a3f-4a9c-bfad-af88434a8175" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SubsequentEventTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SubsequentEventLineItems_9c4c3cda-09c8-4f65-89d6-163ba7aa0d39" xlink:to="loc_us-gaap_SubsequentEventTable_a19bf449-1a3f-4a9c-bfad-af88434a8175" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_fa4dfc4f-6512-43a6-bfa1-30d1cb31eb65" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_a19bf449-1a3f-4a9c-bfad-af88434a8175" xlink:to="loc_us-gaap_StatementClassOfStockAxis_fa4dfc4f-6512-43a6-bfa1-30d1cb31eb65" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_fa4dfc4f-6512-43a6-bfa1-30d1cb31eb65_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_fa4dfc4f-6512-43a6-bfa1-30d1cb31eb65" xlink:to="loc_us-gaap_ClassOfStockDomain_fa4dfc4f-6512-43a6-bfa1-30d1cb31eb65_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_d3e152d3-dd83-4763-b710-ca6b275adc59" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_fa4dfc4f-6512-43a6-bfa1-30d1cb31eb65" xlink:to="loc_us-gaap_ClassOfStockDomain_d3e152d3-dd83-4763-b710-ca6b275adc59" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_e46cb1a7-73db-436c-aa88-7ae37021eeff" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_d3e152d3-dd83-4763-b710-ca6b275adc59" xlink:to="loc_us-gaap_CommonClassAMember_e46cb1a7-73db-436c-aa88-7ae37021eeff" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_7f3dac4e-2413-4e91-a7a5-b828670c3437" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_a19bf449-1a3f-4a9c-bfad-af88434a8175" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_7f3dac4e-2413-4e91-a7a5-b828670c3437" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_7f3dac4e-2413-4e91-a7a5-b828670c3437_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_7f3dac4e-2413-4e91-a7a5-b828670c3437" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_7f3dac4e-2413-4e91-a7a5-b828670c3437_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_bfca1d8c-885b-4d39-b029-f45f9483db03" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_7f3dac4e-2413-4e91-a7a5-b828670c3437" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_bfca1d8c-885b-4d39-b029-f45f9483db03" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_2658a519-4ca0-4bd3-b93b-ce88331e9bc3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_bfca1d8c-885b-4d39-b029-f45f9483db03" xlink:to="loc_us-gaap_SubsequentEventMember_2658a519-4ca0-4bd3-b93b-ce88331e9bc3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_3343d58a-0ede-4dd2-92a1-48042ee3d6a0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_a19bf449-1a3f-4a9c-bfad-af88434a8175" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_3343d58a-0ede-4dd2-92a1-48042ee3d6a0" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_3343d58a-0ede-4dd2-92a1-48042ee3d6a0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_3343d58a-0ede-4dd2-92a1-48042ee3d6a0" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_3343d58a-0ede-4dd2-92a1-48042ee3d6a0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_eb1d4386-a100-4032-ab10-8dff140b225d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_3343d58a-0ede-4dd2-92a1-48042ee3d6a0" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_eb1d4386-a100-4032-ab10-8dff140b225d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_AtTheMarketOfferingProgramTDCowenMember_019c6787-138e-715e-a11d-3feb5902ba86" xlink:href="rxrx-20251231.xsd#rxrx_AtTheMarketOfferingProgramTDCowenMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_eb1d4386-a100-4032-ab10-8dff140b225d" xlink:to="loc_rxrx_AtTheMarketOfferingProgramTDCowenMember_019c6787-138e-715e-a11d-3feb5902ba86" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_SaleOfStockValueAuthorized_4991d765-78a4-496e-a0b8-4d979d6bcd9d" xlink:href="rxrx-20251231.xsd#rxrx_SaleOfStockValueAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_9c4c3cda-09c8-4f65-89d6-163ba7aa0d39" xlink:to="loc_rxrx_SaleOfStockValueAuthorized_4991d765-78a4-496e-a0b8-4d979d6bcd9d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_SaleOfStockPercentageOfCommission_3e36b4b1-5821-4aed-aa11-4d8245b18a9f" xlink:href="rxrx-20251231.xsd#rxrx_SaleOfStockPercentageOfCommission"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_9c4c3cda-09c8-4f65-89d6-163ba7aa0d39" xlink:to="loc_rxrx_SaleOfStockPercentageOfCommission_3e36b4b1-5821-4aed-aa11-4d8245b18a9f" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://fasb.org/us-gaap/role/eedm/ExtensibleEnumerationLists" xlink:type="simple" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-roles-2025.xsd#eedm"/>
  <link:definitionLink xlink:role="http://fasb.org/us-gaap/role/eedm/ExtensibleEnumerationLists" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrentAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsCurrent" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtAndCapitalLeaseObligationsCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract" xlink:to="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsCurrent" xlink:type="arc" order="41"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://xbrl.sec.gov/ecd/role/IndividualsOnly" xlink:type="simple" xlink:href="https://xbrl.sec.gov/ecd/2025/ecd-2025.xsd#IndividualsOnly"/>
  <link:definitionLink xlink:role="http://xbrl.sec.gov/ecd/role/IndividualsOnly" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AllIndividualsMember" xlink:href="https://xbrl.sec.gov/ecd/2025/ecd-2025.xsd#ecd_AllIndividualsMember"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_RobertHershbergMember_019c45f9-a1d0-7734-8be2-fd387c9af519" xlink:href="rxrx-20251231.xsd#rxrx_RobertHershbergMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ecd_AllIndividualsMember" xlink:to="loc_rxrx_RobertHershbergMember_019c45f9-a1d0-7734-8be2-fd387c9af519" xlink:type="arc" order="2"/>
  </link:definitionLink>
</link:linkbase>
